{
  "version": 1,
  "method": "Labels identify explicit conditions or symptoms in publication titles and transcribed study participants or measurements. They do not assert a diagnosis, effectiveness, or full-text appraisal. Empty labels mean not yet classified. The name Mindfulness-Based Stress Reduction alone is not a stress outcome; oxidative and cellular stress alone are not mental-health symptom labels.",
  "taxonomy": [
    {
      "id": "anxiety",
      "label": "Anxiety"
    },
    {
      "id": "ptsd",
      "label": "PTSD"
    },
    {
      "id": "trauma",
      "label": "Trauma-related symptoms"
    },
    {
      "id": "depression",
      "label": "Depression"
    },
    {
      "id": "psychosis",
      "label": "Psychosis"
    },
    {
      "id": "schizophrenia",
      "label": "Schizophrenia"
    },
    {
      "id": "bipolar",
      "label": "Bipolar disorder"
    },
    {
      "id": "mania",
      "label": "Mania / hypomania"
    },
    {
      "id": "adhd",
      "label": "ADHD"
    },
    {
      "id": "ocd",
      "label": "Obsessive-compulsive disorder"
    },
    {
      "id": "stress",
      "label": "Stress"
    },
    {
      "id": "sleep",
      "label": "Sleep problems / insomnia"
    },
    {
      "id": "substance-use",
      "label": "Substance use / addiction"
    },
    {
      "id": "autism",
      "label": "Autism"
    },
    {
      "id": "eating-disorders",
      "label": "Eating disorders"
    },
    {
      "id": "dementia",
      "label": "Dementia / Alzheimer’s disease"
    }
  ],
  "records": {
    "doi-10.1007-s12671-026-02877-9": [
      {
        "id": "dementia",
        "evidence": [
          {
            "field": "title",
            "text": "Dynamic Methylation Changes in Alzheimer’s Disease-Related Genes During Mindfulness Practice – a Proof-of-Concept Study",
            "matchedText": "Alzheimer"
          }
        ]
      }
    ],
    "pmid-42519422": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.",
            "matchedText": "trauma"
          }
        ]
      },
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.",
            "matchedText": "depression"
          }
        ]
      }
    ],
    "pmid-42615937": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Shared Transcriptomic and Epigenomic Signatures Between Traumatic Brain Injury and Music Exposure: An Integrative Proof of Concept",
            "matchedText": "Traumatic"
          }
        ]
      }
    ],
    "pmid-41367385": [
      {
        "id": "autism",
        "evidence": [
          {
            "field": "title",
            "text": "Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing",
            "matchedText": "autism"
          }
        ]
      }
    ],
    "pmid-40281224": [
      {
        "id": "anxiety",
        "evidence": [
          {
            "field": "title",
            "text": "Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome",
            "matchedText": "anxiety"
          }
        ]
      }
    ],
    "pmid-40749778": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-41020112": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Psychological assessments, allostatic load and gene expression analyses in a randomized controlled trial comparing meditation, yoga, and stress education",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-39060246": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.",
            "matchedText": "posttraumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.",
            "matchedText": "posttraumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-38362742": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.",
            "matchedText": "trauma"
          }
        ]
      },
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.",
            "matchedText": "depression"
          }
        ]
      }
    ],
    "pmid-38671329": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD",
            "matchedText": "PTSD"
          },
          {
            "field": "evidence.sample",
            "text": "72 veterans with PTSD",
            "matchedText": "PTSD"
          }
        ]
      }
    ],
    "pmid-36658116": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy",
            "matchedText": "posttraumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy",
            "matchedText": "traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-36819725": [
      {
        "id": "dementia",
        "evidence": [
          {
            "field": "title",
            "text": "Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics",
            "matchedText": "Alzheimer"
          }
        ]
      }
    ],
    "doi-14a5c17359f1dfcb": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients",
            "matchedText": "Trauma"
          }
        ]
      },
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients",
            "matchedText": "Depression"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-35070159": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.",
            "matchedText": "trauma"
          }
        ]
      },
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.",
            "matchedText": "depressed"
          }
        ]
      }
    ],
    "pmid-31645664": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.",
            "matchedText": "post-traumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.",
            "matchedText": "post-traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-28795405": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD",
            "matchedText": "PTSD"
          }
        ]
      }
    ],
    "pmid-29306937": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "The Effects of Stress and Meditation on the Immune System, Human Microbiota, & Epigenetics",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-25749595": [
      {
        "id": "sleep",
        "evidence": [
          {
            "field": "title",
            "text": "Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial",
            "matchedText": "insomnia"
          }
        ]
      }
    ],
    "pmid-22123970": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-18833581": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans",
            "matchedText": "Posttraumatic Stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans",
            "matchedText": "Posttraumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-18596974": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Genomic counter-stress changes induced by the relaxation response",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-15668624": [
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Recreational music-making modulates the human stress response: a preliminary individualized gene expression strategy",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "src-f509442c9ca1": [
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems",
            "matchedText": "depression"
          }
        ]
      }
    ],
    "src-473becc5048a": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "The intergenerational transference of Post-Traumatic Stress Disorder amongst children and grandchildren of Vietnam veterans in Australia: An argument for a genetic origin. Review of current literature",
            "matchedText": "Post-Traumatic Stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "The intergenerational transference of Post-Traumatic Stress Disorder amongst children and grandchildren of Vietnam veterans in Australia: An argument for a genetic origin. Review of current literature",
            "matchedText": "Post-Traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "The intergenerational transference of Post-Traumatic Stress Disorder amongst children and grandchildren of Vietnam veterans in Australia: An argument for a genetic origin. Review of current literature",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "src-e9b23a765f28": [
      {
        "id": "dementia",
        "evidence": [
          {
            "field": "title",
            "text": "Yogic meditation reverses NF- κ B and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial",
            "matchedText": "dementia"
          }
        ]
      }
    ],
    "pmid-41974356": [
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial",
            "matchedText": "depression"
          }
        ]
      }
    ],
    "pmid-42880055": [
      {
        "id": "anxiety",
        "evidence": [
          {
            "field": "title",
            "text": "Efficacy of eye movement desensitization and reprocessing for anxiety: An umbrella review and meta-meta-analysis of randomized controlled trials.",
            "matchedText": "anxiety"
          }
        ]
      }
    ],
    "pmid-42703195": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Efficacy of the Adapted Integrative Group EMDR Therapy Protocol for Ongoing Traumatic Stress in Adolescents after a Traumatic Event.",
            "matchedText": "Traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Efficacy of the Adapted Integrative Group EMDR Therapy Protocol for Ongoing Traumatic Stress in Adolescents after a Traumatic Event.",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "portal-66ebe89ad390": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Is the Group Traumatic Episode Protocol (G-TEP) Effective for Post-Traumatic Stress Disorder? A Meta-Analysis.",
            "matchedText": "Post-Traumatic Stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Is the Group Traumatic Episode Protocol (G-TEP) Effective for Post-Traumatic Stress Disorder? A Meta-Analysis.",
            "matchedText": "Traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Is the Group Traumatic Episode Protocol (G-TEP) Effective for Post-Traumatic Stress Disorder? A Meta-Analysis.",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-42411718": [
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Peer-delivered combined EMD and imagery rescripting for traumatized Chinese university students: a RCT.",
            "matchedText": "traumatized"
          }
        ]
      }
    ],
    "pmid-42254728": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Remote EMDR versus CBT for PTSD after the Kahramanmaraş earthquakes: a randomized trial.",
            "matchedText": "PTSD"
          }
        ]
      }
    ],
    "pmid-42773467": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "The immediate and follow-up effects of EMDR therapy for adults with post-traumatic stress disorder: a meta-analysis of randomized controlled trials.",
            "matchedText": "post-traumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "The immediate and follow-up effects of EMDR therapy for adults with post-traumatic stress disorder: a meta-analysis of randomized controlled trials.",
            "matchedText": "post-traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "The immediate and follow-up effects of EMDR therapy for adults with post-traumatic stress disorder: a meta-analysis of randomized controlled trials.",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "portal-e25cb1d2bb79": [
      {
        "id": "anxiety",
        "evidence": [
          {
            "field": "title",
            "text": "Theta binaural beats for pain, cognition and anxiety",
            "matchedText": "anxiety"
          }
        ]
      }
    ],
    "pmid-42324567": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Trauma-focused treatments for refugee children and adolescents with PTSD: a three-arm randomized controlled trial comparing the efficacy of EMDR and KIDNET versus a waitlist control group (the KIEM study).",
            "matchedText": "PTSD"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Trauma-focused treatments for refugee children and adolescents with PTSD: a three-arm randomized controlled trial comparing the efficacy of EMDR and KIDNET versus a waitlist control group (the KIEM study).",
            "matchedText": "Trauma"
          }
        ]
      }
    ],
    "pmid-41340540": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.",
            "matchedText": "Post-Traumatic Stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.",
            "matchedText": "Post-Traumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-39835632": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Effectiveness of an intensive outpatient treatment programme combining prolonged exposure and EMDR therapy for adolescents and young adults with PTSD in a naturalistic setting.",
            "matchedText": "PTSD"
          }
        ]
      }
    ],
    "pmid-40243164": [
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Effects of eye movement desensitisation and reprocessing on depressive symptoms, stress and rumination in adolescents with depression: a randomised controlled trial.",
            "matchedText": "depressive"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Effects of eye movement desensitisation and reprocessing on depressive symptoms, stress and rumination in adolescents with depression: a randomised controlled trial.",
            "matchedText": "stress"
          }
        ]
      }
    ],
    "pmid-40379363": [
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial",
            "matchedText": "depression"
          },
          {
            "field": "evidence.sample",
            "text": "234 adults with depression persisting after psychological therapy",
            "matchedText": "depression"
          },
          {
            "field": "evidence.measurement",
            "text": "PHQ-9 depression symptoms",
            "matchedText": "depression"
          }
        ]
      }
    ],
    "pmid-40547443": [
      {
        "id": "anxiety",
        "evidence": [
          {
            "field": "title",
            "text": "Music therapy for the treatment of anxiety: a systematic review with multilevel meta-analyses",
            "matchedText": "anxiety"
          }
        ]
      }
    ],
    "pmid-39630422": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Psychological Interventions for Pediatric Posttraumatic Stress Disorder: A Systematic Review and Network Meta-Analysis.",
            "matchedText": "Posttraumatic Stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Psychological Interventions for Pediatric Posttraumatic Stress Disorder: A Systematic Review and Network Meta-Analysis.",
            "matchedText": "Posttraumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Psychological Interventions for Pediatric Posttraumatic Stress Disorder: A Systematic Review and Network Meta-Analysis.",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-40706348": [
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.",
            "matchedText": "posttraumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.",
            "matchedText": "posttraumatic"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
          {
            "field": "title",
            "text": "Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.",
            "matchedText": "Stress"
          }
        ]
      }
    ],
    "pmid-40417270": [
      {
        "id": "anxiety",
        "evidence": [
          {
            "field": "title",
            "text": "The effectiveness of online Eye Movement Desensitization and Reprocessing 2.0 Group Protocol on post-traumatic stress disorders symptoms, depression, anxiety, and stress in individuals who have experienced a traffic accident: a randomized-controlled study.",
            "matchedText": "anxiety"
          }
        ]
      },
      {
        "id": "ptsd",
        "evidence": [
          {
            "field": "title",
            "text": "The effectiveness of online Eye Movement Desensitization and Reprocessing 2.0 Group Protocol on post-traumatic stress disorders symptoms, depression, anxiety, and stress in individuals who have experienced a traffic accident: a randomized-controlled study.",
            "matchedText": "post-traumatic stress"
          }
        ]
      },
      {
        "id": "trauma",
        "evidence": [
          {
            "field": "title",
            "text": "The effectiveness of online Eye Movement Desensitization and Reprocessing 2.0 Group Protocol on post-traumatic stress disorders symptoms, depression, anxiety, and stress in individuals who have experienced a traffic accident: a randomized-controlled study.",
            "matchedText": "post-traumatic"
          }
        ]
      },
      {
        "id": "depression",
        "evidence": [
          {
            "field": "title",
            "text": "The effectiveness of online Eye Movement Desensitization and Reprocessing 2.0 Group Protocol on post-traumatic stress disorders symptoms, depression, anxiety, and stress in individuals who have experienced a traffic accident: a randomized-controlled study.",
            "matchedText": "depression"
          }
        ]
      },
      {
        "id": "stress",
        "evidence": [
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    "review": "Initial rule-assisted labels checked for intervention-name and cellular-stress ambiguity. Full-text review can expand condition coverage."
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}
