{ "title": "General research", "chapters": [ { "number": 1, "title": "Oxytocin pathways and social connection", "topics": [ { "id": "sound-xxix", "number": "1.1", "title": "Oxytocin pathways, dopamine and serotonin", "trustScore": 1, "sourcePage": 116, "context": "These studies examine oxytocin pathways and their relationships with dopamine and serotonin. SLC6A4 encodes the serotonin transporter.", "papers": [ { "id": "general-xxix-pmid-28890000", "recordId": "pmid-28890000", "title": "Maternal DRD2, SLC6A3, and OXTR genotypes as potential moderators of the relation between maternal history of care and maternal cortisol secretion in the context of mother-infant separation", "journal": "Biological Psychology", "year": 2017, "authors": "Ludmer JA, Jamieson B, Gonzalez A, Levitan R, Kennedy J, Villani V, Masellis M, Basile VS, Atkinson L.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0301051117302338" ], "quotes": [ [ { "text": "“Multilevel models revealed that history of care had a greater influence on maternal baseline cortisol (but not cortisol trajectory) for mothers with more plasticity alleles of SLC6A3 (10R) and OXTR (G), relative to mothers with fewer or no plasticity alleles.”", "emphasis": false } ], [ { "text": "“OXTR moderates between maternal history of care and cortisol during infant stress.”", "emphasis": false } ], [ { "text": "“SLC6A3 moderates between maternal history of care and cortisol during infant stress.”", "emphasis": false } ] ], "citationCount": 5, "sourcePages": [ 116 ], "targets": [ "OXTR", "DRD2" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Methods & context" ], "doi": "10.1016/j.biopsycho.2017.09.004", "pmid": "28890000", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/28890000/", "https://doi.org/10.1016/j.biopsycho.2017.09.004", "https://www.sciencedirect.com/science/article/abs/pii/S0301051117302338" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-src-ed35d20b36c4", "recordId": "src-ed35d20b36c4", "title": "Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus", "journal": "Hormones and Behavior", "year": null, "authors": "", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930" ], "quotes": [ [ { "text": "“The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine.”", "emphasis": false } ], [ { "text": "“Preference to dopamine treatment was blocked by the activation of local oxytocin receptors.”", "emphasis": false } ], [ { "text": "“These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors.”", "emphasis": false } ] ], "citationCount": 44, "sourcePages": [ 116 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Molecular biomarkers" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-25001970", "recordId": "pmid-25001970", "title": "Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study", "journal": "Psychoneuroendocrinology", "year": 2014, "authors": "Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042" ], "quotes": [ [ { "text": "“The results indicated that the OXTR rs53576 is connected with the striatal dopamine transporter DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems.”", "emphasis": false } ] ], "citationCount": 50, "sourcePages": [ 117 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers" ], "doi": "10.1016/j.psyneuen.2014.05.020", "pmid": "25001970", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/25001970/", "https://doi.org/10.1016/j.psyneuen.2014.05.020", "https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-28669546", "recordId": "pmid-28669546", "title": "Biased Oxytocinergic Modulation of Midbrain Dopamine Systems", "journal": "Neuron", "year": 2017, "authors": "Xiao L, Priest MF, Nasenbeny J, Lu T, Kozorovitskiy Y.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/pii/S0896627317305019" ], "quotes": [ [ { "text": "“Oxytocin release decreases the activity of SNc DA dopamine neurons via inhibitory circuits”", "emphasis": false } ] ], "citationCount": 96, "sourcePages": [ 117 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1016/j.neuron.2017.06.003", "pmid": "28669546", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/28669546/", "https://doi.org/10.1016/j.neuron.2017.06.003", "https://www.sciencedirect.com/science/article/pii/S0896627317305019" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-src-e74337ebcb41", "recordId": "src-e74337ebcb41", "title": "Oxytocin Influences Processing of Socially Relevant Cues in the Ventral Tegmental Area of the Human Brain", "journal": "Biological Psychiatry", "year": null, "authors": "", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0006322313000395" ], "quotes": [ [ { "text": "“Our data provide evidence that the VTA is the human brain site where oxytocin attaches salience to socially relevant cues. This mechanism might play an important role in triggering motivation to react at the prospect of social reward or punishment.”", "emphasis": false } ] ], "citationCount": 187, "sourcePages": [ 117 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.sciencedirect.com/science/article/abs/pii/S0006322313000395" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-src-19dff8a8bbe5", "recordId": "src-19dff8a8bbe5", "title": "The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity", "journal": "Neuropharmacology", "year": null, "authors": "", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/0028390890900959" ], "quotes": [ [ { "text": "“Oxytocin, a neurohypophyseal neuropeptide, also partially antagonized cocaine-induced motor hyperactivity.", "emphasis": false } ], [ { "text": "Moreover, oxytocin antagonized the increased utilization of dopamine, elicited by cocaine in the nucleus accumbens.”", "emphasis": false } ], [ { "text": "“The data suggest that oxytocin may influence the behavioural effects of cocaine by affecting dopaminergic neurotransmission in some regions of the brain.”", "emphasis": false } ] ], "citationCount": 128, "sourcePages": [ 117 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.sciencedirect.com/science/article/abs/pii/0028390890900959" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-20557568", "recordId": "pmid-20557568", "title": "Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders", "journal": "CNS Neuroscience & Therapeutics", "year": 2010, "authors": "Baskerville TA, Douglas AJ.", "design": "", "urls": [ "https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2010.00154.x" ], "quotes": [ [ { "text": "“In addition to psychosocial improvement, oxytocin has recently been implicated in mediating mesolimbic dopamine pathways during drug addiction and withdrawal. Central oxytocin pathways may serve as a potential therapeutic target to improve mood and socio‐affiliative behaviors in patients with profound social deficits and/or drug addiction.”", "emphasis": false } ] ], "citationCount": 315, "sourcePages": [ 118 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers" ], "doi": "10.1111/j.1755-5949.2010.00154.x", "pmid": "20557568", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/20557568/", "https://doi.org/10.1111/j.1755-5949.2010.00154.x", "https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2010.00154.x" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-9924746", "recordId": "pmid-9924746", "title": "Oxytocin and Addiction - A Review", "journal": "Pyschoneuroendocrinology", "year": 1998, "authors": "Kovács GL, Sarnyai Z, Szabó G.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S030645309800064X" ], "quotes": [ [ { "text": "“OXT receptors in the CNS—mainly those located in limbic and basal forebrain structures—are responsible for mediating various effects of OXT in the opiate- and cocaine-addicted organism.”", "emphasis": false } ], [ { "text": "“Tolerance to ethanol (e.g. hypothermia-inducing effect of ethanol) also was inhibited by OXT.”", "emphasis": false } ], [ { "text": "“In relation to cocaine abuse, OXT dose-dependently decreased cocaine-induced hyperlocomotion and stereotyped grooming behavior.”", "emphasis": false } ] ], "citationCount": 265, "sourcePages": [ 118 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1016/s0306-4530(98)00064-x", "pmid": "9924746", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/9924746/", "https://doi.org/10.1016/s0306-4530(98)00064-x", "https://www.sciencedirect.com/science/article/abs/pii/S030645309800064X" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-27425032", "recordId": "pmid-27425032", "title": "Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat", "journal": "Molecular Basis of Disease", "year": 2016, "authors": "de la Mora MP, Pérez-Carrera D, Crespo-Ramírez M, Tarakanov A, Fuxe K, Borroto-Escuela DO.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/pii/S0925443916301648" ], "quotes": [ [ { "text": "“Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling.”", "emphasis": false } ], [ { "text": "“Based on the current findings, the blockade of the anxiolytic effects of oxytocin by the simultaneous intra-CeA administration of raclopride can be explained by a lack of facilitatory protomer interactions in D2R-OTR heterocomplexes.”", "emphasis": false } ], [ { "text": "“Dysfunction and/or disruption of such interactions in the central amygdala may lead to anxiety development. Restoration of such interactions may represent a new strategy for development of novel anxiolytic drugs.”", "emphasis": false } ] ], "citationCount": 30, "sourcePages": [ 118 ], "targets": [ "OXTR", "OXT", "DRD2" ], "categories": [ "Molecular biomarkers", "Brain & nervous system", "Clinical & self-report" ], "doi": "10.1016/j.bbadis.2016.07.004", "pmid": "27425032", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/27425032/", "https://doi.org/10.1016/j.bbadis.2016.07.004", "https://www.sciencedirect.com/science/article/pii/S0925443916301648" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-28728017", "recordId": "pmid-28728017", "title": "Oxytocin Mobilizes Midbrain Dopamine toward Sociality", "journal": "Neuron", "year": 2017, "authors": "Charlet A, Grinevich V.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/pii/S0896627317306049" ], "quotes": [ [ { "text": "“Oxytocin and dopamine possess significant overlap in the modulation of life-essential behaviors. Here, Xiao et al. (2017) show that the activity of dopamine neurons of the ventral tegmental area and the substantia nigra is finely tuned by axonal release of oxytocin.”", "emphasis": false } ] ], "citationCount": 13, "sourcePages": [ 119 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1016/j.neuron.2017.07.002", "pmid": "28728017", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/28728017/", "https://doi.org/10.1016/j.neuron.2017.07.002", "https://www.sciencedirect.com/science/article/pii/S0896627317306049" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-30737392", "recordId": "pmid-30737392", "title": "Oxytocin pathway gene networks in the human brain", "journal": "Nature", "year": 2019, "authors": "Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT.", "design": "", "urls": [ "https://www.nature.com/articles/s41467-019-08503-8" ], "quotes": [ [ { "text": "“Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).”", "emphasis": false } ], [ { "text": "“Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions.”", "emphasis": false } ], [ { "text": "“The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.”", "emphasis": false } ] ], "citationCount": 76, "sourcePages": [ 119 ], "targets": [ "OXTR", "OXT", "CD38", "DRD2" ], "categories": [ "Gene expression", "Methods & context" ], "doi": "10.1038/s41467-019-08503-8", "pmid": "30737392", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/30737392/", "https://doi.org/10.1038/s41467-019-08503-8", "https://www.nature.com/articles/s41467-019-08503-8" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxix-pmid-20493150", "recordId": "pmid-20493150", "title": "Peripheral oxytocin treatment modulates central dopamine transmission in the mouse limbic structures", "journal": "Neurochemistry International", "year": 1986, "authors": "Kovács GL, Faludi M, Falkay G, Telegdy G.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/0197018686901385" ], "quotes": [ [ { "text": "“The data indicate that peripheral oxytocin treatment is capable of modifying dopaminergic neurotransmission in mouse basal forebrain regions.”", "emphasis": false } ] ], "citationCount": 30, "sourcePages": [ 119 ], "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1016/0197-0186(86)90138-5", "pmid": "20493150", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; 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repeated reports of an identified trial count once." } }, { "id": "sound-xxx", "number": "1.2", "title": "OXTR variation and psychological resources", "trustScore": 1, "sourcePage": 120, "context": "These studies examine associations between OXTR variation and psychological resources or social behaviour.", "papers": [ { "id": "general-xxx-pmid-21896752", "recordId": "pmid-21896752", "title": "Oxytocin receptor gene (OXTR) is related to psychological resources", "journal": "PNAS - Proceedings of the National Academy of Sciences", "year": 2011, "authors": "Saphire-Bernstein S, Way BM, Kim HS, Sherman DK, Taylor SE.", "design": "", "urls": [ "https://www.pnas.org/content/108/37/15118.short" ], "quotes": [ [ { "text": "“Psychological resources—optimism, mastery, and self-esteem—buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown.”", "emphasis": false } ], [ { "text": "“Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the “A” allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes.”", "emphasis": false } ], [ { "text": "“OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.”", "emphasis": false } ] ], "citationCount": 277, "sourcePages": [ 120 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Clinical & self-report" ], "doi": "10.1073/pnas.1113137108", "pmid": "21896752", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/21896752/", "https://doi.org/10.1073/pnas.1113137108", "https://www.pnas.org/content/108/37/15118.short", "https://www.pnas.org/content/108/37/15118" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-17994268", "recordId": "pmid-17994268", "title": "Nucleotide Frequencies in Human Genome and Fibonacci Numbers", "journal": "Bulletin of Mathematical Biology", "year": 2008, "authors": "Yamagishi ME, Shimabukuro AI.", "design": "", "urls": [ "https://link.springer.com/article/10.1007/s11538-007-9261-6" ], "quotes": [ [ { "text": "“This work presents a mathematical model that establishes an interesting connection between", "emphasis": false }, { "text": " nucleotide frequencies", "emphasis": true }, { "text": " in human single-stranded", "emphasis": false }, { "text": " DNA", "emphasis": true }, { "text": " and the famous", "emphasis": false }, { "text": " Fibonacci", "emphasis": true }, { "text": " ’s numbers.", "emphasis": false } ], [ { "text": "“Under these two hypotheses, it is possible to", "emphasis": false }, { "text": " predict", "emphasis": true }, { "text": " the human", "emphasis": false }, { "text": " nucleotide frequencies", "emphasis": true }, { "text": " with", "emphasis": false }, { "text": " accuracy", "emphasis": true }, { "text": " .”", "emphasis": false } ], [ { "text": "“This result may be used as evidence to the Fibonacci string model that was proposed to the sequence growth of DNA repetitive sequences.”", "emphasis": false } ] ], "citationCount": 188, "sourcePages": [ 120 ], "targets": [], "categories": [ "Genetics & genomics", "Methods & context" ], "doi": "10.1007/s11538-007-9261-6", "pmid": "17994268", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/17994268/", "https://doi.org/10.1007/s11538-007-9261-6", "https://link.springer.com/article/10.1007/s11538-007-9261-6" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-25935637", "recordId": "pmid-25935637", "title": "The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576)", "journal": "Psychoneuroendocrinology", "year": 2015, "authors": "Weisman O, Pelphrey KA, Leckman JF, Feldman R, Lu Y, Chong A, Chen Y, Monakhov M, Chew SH, Ebstein RP.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S030645301500147X" ], "quotes": [ [ { "text": "“The current findings show that OXTR rs53576 interacts with 2D:4D to shape one's cognitive empathy aptitude.”", "emphasis": false } ] ], "citationCount": 67, "sourcePages": [ 121 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1016/j.psyneuen.2015.04.007", "pmid": "25935637", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/25935637/", "https://doi.org/10.1016/j.psyneuen.2015.04.007", "https://www.sciencedirect.com/science/article/abs/pii/S030645301500147X" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-26903384", "recordId": "pmid-26903384", "title": "Oxytocin receptor gene polymorphism modulates the effects of social support on heart rate variability", "journal": "Biological Psychology", "year": 2016, "authors": "Kanthak MK, Chen FS, Kumsta R, Hill LK, Thayer JF, Heinrichs M.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0301051116300357" ], "quotes": [ [ { "text": "“Oxytocin receptor gene polymorphism modulates effects of social support in the context of stress.”", "emphasis": false } ], [ { "text": "“Social support increases HRV only in carriers of at least one G allele of rs53576.”", "emphasis": false } ], [ { "text": "“Social support influences HRV specifically during direct social interaction.”", "emphasis": false } ] ], "citationCount": 23, "sourcePages": [ 121 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Heart rate & autonomic" ], "doi": "10.1016/j.biopsycho.2016.02.007", "pmid": "26903384", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/26903384/", "https://doi.org/10.1016/j.biopsycho.2016.02.007", "https://www.sciencedirect.com/science/article/abs/pii/S0301051116300357" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-30135663", "recordId": "pmid-30135663", "title": "The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility", "journal": "Frontiers in Psychiatry - Behavioural and Psychiatric Genetics", "year": 2018, "authors": "Flasbeck V, Moser D, Kumsta R, Brüne M.", "design": "", "urls": [ "https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full" ], "quotes": [ [ { "text": "“homozygous carriers of the G-allele of the single nucleotide polymorphism rs53576 have been reported to display more trust, empathy, and prosocial behavior and were less sensitive toward stress and maltreatment during childhood when compared to A-allele carriers.”", "emphasis": false } ], [ { "text": "“In A-allele carriers of rs53576, childhood trauma was differentially associated with empathy for psychological pain, which was not apparent in GG carriers.”", "emphasis": false } ], [ { "text": "“the present study demonstrates an association of childhood maltreatment and empathy for psychological pain which was mediated by rs53576 genotype, suggesting that the A-allele may convey genetic plasticity to environmental factors”", "emphasis": false } ] ], "citationCount": 16, "sourcePages": [ 121 ], "targets": [ "OXTR" ], "categories": [ "Genetics & genomics", "Clinical & self-report" ], "doi": "10.3389/fpsyt.2018.00359", "pmid": "30135663", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/30135663/", "https://doi.org/10.3389/fpsyt.2018.00359", "https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-28526450", "recordId": "pmid-28526450", "title": "The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein–coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes", "journal": "American Journal of Obstetrics and Gynacology", "year": 2017, "authors": "Grotegut CA, Ngan E, Garrett ME, Miranda ML, Ashley-Koch AE, Swamy GK.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0002937817306324" ], "quotes": [], "citationCount": 10, "sourcePages": [ 122 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers" ], "doi": "10.1016/j.ajog.2017.05.023", "pmid": "28526450", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/28526450/", "https://doi.org/10.1016/j.ajog.2017.05.023", "https://www.sciencedirect.com/science/article/abs/pii/S0002937817306324" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-32795360", "recordId": "pmid-32795360", "title": "Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups", "journal": "Journal of Psychological Anthropology", "year": 2020, "authors": "Butovskaya M, Rostovtseva V, Butovskaya P, Burkova V, Dronova D, Filatova V, Sukhodolskaya E, Vasiliev V, Mesa T, Rosa A, Lazebny O.", "design": "", "urls": [ "https://jphysiolanthropol.biomedcentral.com/articles/10.1186/s40101-020-00232-y" ], "quotes": [ [ { "text": "“Our data suggest that both oxytocin (OXTR gene polymorphism) and fetal testosterone (2D:4D) may significantly affect emotional (anger) and cognitive (hostility) aggression in humans, given the leveling the role of culture.”", "emphasis": false } ] ], "citationCount": 1, "sourcePages": [ 122 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1186/s40101-020-00232-y", "pmid": "32795360", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/32795360/", "https://doi.org/10.1186/s40101-020-00232-y", "https://jphysiolanthropol.biomedcentral.com/articles/10.1186/s40101-020-00232-y" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-22123970", "recordId": "pmid-22123970", "title": "Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans", "journal": "PNAS", "year": 2011, "authors": "Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M.", "design": "", "urls": [ "https://www.pnas.org/content/108/50/19937.short" ], "quotes": [ [ { "text": "“Differential stress responses between the genotype groups were observed depending on the presence or absence of social support.”", "emphasis": false } ], [ { "text": "“Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support.”", "emphasis": false } ], [ { "text": "“These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.”", "emphasis": false } ] ], "citationCount": 279, "sourcePages": [ 122 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers" ], "doi": "10.1073/pnas.1113079108", "pmid": "22123970", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/22123970/", "https://doi.org/10.1073/pnas.1113079108", "https://www.pnas.org/content/108/50/19937.short" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-28912494", "recordId": "pmid-28912494", "title": "Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders", "journal": "Nature", "year": 2017, "authors": "Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J, Anagnostou E.", "design": "", "urls": [ "https://www.nature.com/articles/s41598-017-10821-0" ], "quotes": [], "citationCount": 24, "sourcePages": [ 122 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers" ], "doi": "10.1038/s41598-017-10821-0", "pmid": "28912494", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/28912494/", "https://doi.org/10.1038/s41598-017-10821-0", "https://www.nature.com/articles/s41598-017-10821-0" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-src-f509442c9ca1", "recordId": "src-f509442c9ca1", "title": "Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems", "journal": "Nature", "year": null, "authors": "", "design": "", "urls": [ "https://www.nature.com/articles/s41598-019-44175-6" ], "quotes": [ [ { "text": "“The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype.”", "emphasis": false } ], [ { "text": "“This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life.”", "emphasis": false } ], [ { "text": "“Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.”", "emphasis": false } ] ], "citationCount": 7, "sourcePages": [ 123 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Clinical & self-report" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.nature.com/articles/s41598-019-44175-6" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-31587084", "recordId": "pmid-31587084", "title": "A common variant in OXTR rs53576 impacts topological patterns of brain functional networks", "journal": "European Child and Adolescent Psychiatry", "year": 2020, "authors": "Wang J, Zhang Y, Zhu D, Yang Z, Liu F, Qin W, Zhu J, Liu B, Jiang T, Yu C.", "design": "", "urls": [ "https://link.springer.com/article/10.1007/s00787-019-01414-5" ], "quotes": [], "citationCount": 3, "sourcePages": [ 123 ], "targets": [ "OXTR" ], "categories": [ "Brain & nervous system" ], "doi": "10.1007/s00787-019-01414-5", "pmid": "31587084", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/31587084/", "https://doi.org/10.1007/s00787-019-01414-5", "https://link.springer.com/article/10.1007/s00787-019-01414-5" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-26178189", "recordId": "pmid-26178189", "title": "A common oxytocin receptor gene (OXTR)polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans", "journal": "Genes, Brain & Behaviour", "year": 2015, "authors": "Feng C, Lori A, Waldman ID, Binder EB, Haroon E, Rilling JK.", "design": "", "urls": [ "https://onlinelibrary.wiley.com/doi/pdf/10.1111/gbb.12234" ], "quotes": [], "citationCount": 84, "sourcePages": [ 123 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1111/gbb.12234", "pmid": "26178189", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/26178189/", "https://doi.org/10.1111/gbb.12234", "https://onlinelibrary.wiley.com/doi/pdf/10.1111/gbb.12234" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-26738630", "recordId": "pmid-26738630", "title": "Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe", "journal": "BMC Genetics", "year": 2016, "authors": "Butovskaya PR, Lazebny OE, Sukhodolskaya EM, Vasiliev VA, Dronova DA, Fedenok JN, Rosa A, Peletskaya EN, Ryskov AP, Butovskaya ML.", "design": "", "urls": [ "https://pmc.ncbi.nlm.nih.gov/articles/PMC4704389/" ], "quotes": [ [ { "text": "“It is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans.”", "emphasis": false } ] ], "citationCount": 26, "sourcePages": [ 123 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers", "Methods & context" ], "doi": "10.1186/s12863-015-0323-8", "pmid": "26738630", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/26738630/", "https://doi.org/10.1186/s12863-015-0323-8", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4704389/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-26121678", "recordId": "pmid-26121678", "title": "Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis", "journal": "PLOS ONE", "year": 2015, "authors": "Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S.", "design": "Meta-Analysis", "urls": [ "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820" ], "quotes": [ [ { "text": "“In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.”", "emphasis": false } ] ], "citationCount": 138, "sourcePages": [ 124 ], "targets": [ "OXTR", "OXT" ], "categories": [ "Genetics & genomics", "Molecular biomarkers" ], "doi": "10.1371/journal.pone.0131820", "pmid": "26121678", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/26121678/", "https://doi.org/10.1371/journal.pone.0131820", "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xxx-pmid-30605805", "recordId": "pmid-30605805", "title": "OXTR rs53576 polymorphism impacts interpersonal adaptability: Dispositional forgiveness as a mediator", "journal": "Psychoneuroendochrinology", "year": 2019, "authors": "Zhao J, Yang Y, Li X, Zheng L, Xue M, Zhang M, Wang C, Yu R, Gong P.", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0306453018308941" ], "quotes": [ [ { "text": "“The findings highlight the influences of the OXTR gene on adaptive interpersonal interactions, especially when individuals face changing social situations.”", "emphasis": false } ] ], "citationCount": 4, "sourcePages": [ 124 ], "targets": [ "OXTR" ], "categories": [ "Genetics & genomics" ], "doi": "10.1016/j.psyneuen.2018.12.240", "pmid": "30605805", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; 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no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-src-5aaad2520e3b", "recordId": "src-5aaad2520e3b", "title": "DNA waves and water", "journal": "Journal of Physics: Conference Series", "year": 2011, "authors": "", "design": "", "urls": [ "https://doi.org/10.1088/1742-6596/306/1/012007", "https://www.researchgate.net/publication/230937823_DNA_waves_and_water" ], "quotes": [ [ { "text": "“DNA signalling is stimulated by 7 Hz naturally occurring waves on earth. Waves produced by the human brain are also in the range of 7 H z.”", "emphasis": false } ], [ { "text": "“The stimulation by the electromagnetic background of very low frequency is essential. The background is either produced from natural sources (the Schumann resonances [4] which start at 7.83 Hz) or from artificial sources”", "emphasis": false } ], [ { "text": "“This result shows that, upon 7 H z excitation, the transmission into pure water of the oscillation of the nanostructures initially originated from DNA has been achieved.”", "emphasis": false } ] ], "citationCount": 238, "sourcePages": [ 18 ], "targets": [], "categories": [ "Genetics & genomics", "Brain & nervous system" ], "doi": "10.1088/1742-6596/306/1/012007", "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.researchgate.net/publication/230937823_DNA_waves_and_water" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-src-d8da0823ac49", "recordId": "src-d8da0823ac49", "title": "Transduction of DNA information through water and electromagnetic waves", "journal": "Electromagnetic Biology and Medicine", "year": null, "authors": "", "design": "", "urls": [ "https://arxiv.org/pdf/1501.01620.pdf" ], "quotes": [ [ { "text": "“In particular, it is immediately recognized the observed relevance of extremely low signal (ELS) in the phenomena under study. The stimulation caused by the electromagnetic background of very low frequency is indeed observed to be essential in order for the DNA-water system to emit the EMS. In the experiments, the background ELS is either produced from natural sources (the Schumann resonances which start at 7.83 Hz (Montagnier, A ̈ıssa, Del Giudice, et al., 2011; Nickolaenko and Hayakawa, 2002)) or from artificial sources.”", "emphasis": false } ] ], "citationCount": 96, "sourcePages": [ 18 ], "targets": [], "categories": [ "Genetics & genomics" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://arxiv.org/pdf/1501.01620.pdf" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-pmid-20640802", "recordId": "pmid-20640802", "title": "Electromagnetic detection of HIV DNA in the blood of AIDS patients treated by antiretroviral therapy", "journal": "Interdisciplinary sciences, computational life sciences", "year": 2009, "authors": "Montagnier L, Aïssa J, Lavallée C, Mbamy M, Varon J, Chenal H.", "design": "", "urls": [ "https://doi.org/10.1007/s12539-009-0059-0", "https://pubmed.ncbi.nlm.nih.gov/20640802/" ], "quotes": [ [ { "text": "“Electromagnetic signals of low frequency have been shown to be durably produced in aqueous dilutions of the Human Immunodeficiency Virus DNA.", "emphasis": false } ], [ { "text": "In vivo, HIV DNA signals are detected only in patients previously treated by antiretroviral therapy and having no detectable viral RNA copies in their blood.", "emphasis": false } ], [ { "text": "We suggest that the treatment of AIDS patients pushes the virus towards a new mode of replication implying only DNA, thus forming a reservoir insensitive to retroviral inhibitors. Implications for new approaches aimed at eradicating HIV infection are discussed.”", "emphasis": false } ] ], "citationCount": 65, "sourcePages": [ 18 ], "targets": [], "categories": [ "Genetics & genomics" ], "doi": "10.1007/s12539-009-0059-0", "pmid": "20640802", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/20640802/", "https://doi.org/10.1007/s12539-009-0059-0" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-src-218662257ef3", "recordId": "src-218662257ef3", "title": "Analysis and Assessment of Gateway Process", "journal": "US Central Intelligence Agency (CIA)", "year": null, "authors": "", "design": "", "urls": [ "https://www.cia.gov/readingroom/docs/CIA-RDP96-00788R001700210016-5.pdf" ], "quotes": [ [ { "text": "“The Gateway Process is a training system for obtaining power, concentration, and consistency of the amplitude and frequency of brain waves between the left and right hemispheres to make consciousness change,”", "emphasis": false } ], [ { "text": "“the entire body, based on its own micromotion, functions as a tuned vibrational system which transfers energy in a range between 6.8 and 7.5 Hertz into the Earth’s ionospheric cavity, which itself resonates at about 7-7.5 Hertz.”", "emphasis": false } ] ], "citationCount": 6, "sourcePages": [ 19 ], "targets": [], "categories": [ "Brain & nervous system" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.cia.gov/readingroom/docs/CIA-RDP96-00788R001700210016-5.pdf" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-pmid-19696930", "recordId": "pmid-19696930", "title": "rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex", "journal": "PloS one", "year": 2009, "authors": "Cho SS, Strafella AP.", "design": "", "urls": [ "https://doi.org/10.1371/journal.pone.0006725", "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006725" ], "quotes": [ [ { "text": "“This is the first study to provide evidence of extrastriatal DA", "emphasis": false }, { "text": " D2 (DRD2 dopamine receptor)", "emphasis": true }, { "text": " modulation following", "emphasis": false }, { "text": " 10 Hz", "emphasis": true }, { "text": " repetitive transcranial magnetic stimulation”", "emphasis": false } ] ], "citationCount": null, "sourcePages": [ 19 ], "targets": [ "DRD2" ], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1371/journal.pone.0006725", "pmid": "19696930", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/19696930/", "https://doi.org/10.1371/journal.pone.0006725", "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006725" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-pmid-29170944", "recordId": "pmid-29170944", "title": "Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans", "journal": "Brain imaging and behavior", "year": 2018, "authors": "Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.", "design": "", "urls": [ "https://doi.org/10.1007/s11682-017-9800-1", "https://link.springer.com/article/10.1007/s11682-017-9800-1" ], "quotes": [ [ { "text": "“All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or", "emphasis": false }, { "text": " 10 Hz", "emphasis": true }, { "text": " ), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased", "emphasis": false }, { "text": " dopamine", "emphasis": true }, { "text": " levels in the substantia nigra, sensorimotor striatum and associative striatum.”", "emphasis": false } ] ], "citationCount": null, "sourcePages": [ 19 ], "targets": [], "categories": [ "Molecular biomarkers", "Brain & nervous system" ], "doi": "10.1007/s11682-017-9800-1", "pmid": "29170944", "paperTrustAssessment": { "score": 3, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": true, "blinding": "double", "peerReviewed": true, "basis": "Indexed randomized trial and double-blind methods.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/29170944/", "https://doi.org/10.1007/s11682-017-9800-1", "https://link.springer.com/article/10.1007/s11682-017-9800-1" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-iii-src-c64e6046b78d", "recordId": "src-c64e6046b78d", "title": "Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study", "journal": "", "year": null, "authors": "", "design": "", "urls": [ "https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214", "https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf" ], "quotes": [ [ { "text": "“Five patients with a major depressive episode (DSM-IV) underwent an acute", "emphasis": false }, { "text": " 10 Hz", "emphasis": true }, { "text": " rTMS challenge with 3000 stimuli over the left dorsolateral prefrontal cortex during an IBZM-SPECT bolus and constant infusion protocol.", "emphasis": false } ], [ { "text": "Data of nine SPECT investigations showed a significant reduction by 9.6 ± 6.2% in IBZM", "emphasis": false }, { "text": " binding to", "emphasis": true }, { "text": " striatal", "emphasis": false }, { "text": " dopamine D2 receptors", "emphasis": true }, { "text": " after rTMS challenge compared to baseline.", "emphasis": false } ], [ { "text": "The reduction of IBZM binding observed after rTMS challenge is suggestive of a", "emphasis": false }, { "text": " release", "emphasis": true }, { "text": " in", "emphasis": false }, { "text": " endogenous dopamine", "emphasis": true }, { "text": " induced by prefrontal rTMS.”", "emphasis": false } ], [ { "text": "“dopamine modulates addiction”", "emphasis": false } ] ], "citationCount": null, "sourcePages": [ 19, 20 ], "targets": [ "DRD2" ], "categories": [ "Molecular biomarkers", "Brain & nervous system", "Clinical & self-report" ], "doi": null, "pmid": null, "paperTrustAssessment": { "score": null, "scope": "Paper", "status": "unassessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": false, "basis": "Publication-specific design or publication status remains unconfirmed.", "sources": [ "https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214", "https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; 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no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xviii-pmid-16275477", "recordId": "pmid-16275477", "title": "Does Schumann resonance affect our blood pressure?", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "year": 2005, "authors": "Mitsutake G, Otsuka K, Hayakawa M, Sekiguchi M, Cornélissen G, Halberg F.", "design": "", "urls": [ "https://doi.org/10.1016/s0753-3322(05)80003-4", "https://pmc.ncbi.nlm.nih.gov/articles/PMC2656447/" ], "quotes": [], "citationCount": 50, "sourcePages": [ 86 ], "targets": [], "categories": [ "Heart rate & autonomic" ], "doi": "10.1016/s0753-3322(05)80003-4", "pmid": "16275477", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/16275477/", "https://doi.org/10.1016/s0753-3322(05)80003-4", "https://pmc.ncbi.nlm.nih.gov/articles/PMC2656447/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; 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Saroka", "design": "", "urls": [ "https://doi.org/10.4236/jsip.2015.62015", "https://www.scirp.org/journal/PaperInformation.aspx?PaperID=56609" ], "quotes": [ [ { "text": "“Natural and technology-based variables affecting the Schumann parameters might be reflected in human brain activity, including modifications of cognition and dream-related memory consolidation”", "emphasis": false } ], [ { "text": "“The results are consistent with the congruence of the frequency, magnetic field intensity, voltage gradient, and phase shifts that are shared by the human brain and the earth-ionospheric spherical wave guide”", "emphasis": false } ] ], "citationCount": 15, "sourcePages": [ 87 ], "targets": [], "categories": [ "Brain & nervous system" ], "doi": "10.4236/jsip.2015.62015", "pmid": null, "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.", "sources": [ "https://doi.org/10.4236/jsip.2015.62015", "https://www.scirp.org/journal/PaperInformation.aspx?PaperID=56609" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "id": "general-xviii-src-89d6ed0ece09", "recordId": "src-89d6ed0ece09", "title": "Physical Factors of the Historical Process by A. 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No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/mp2012103", "https://doi.org/10.1038/mp.2012.103", "https://pubmed.ncbi.nlm.nih.gov/22824810/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Molecular biomarkers", "sample": "Laboratory receptor and rat striatal preparations", "measurement": "Receptor proximity and functional receptor interactions", "measuredGenes": [], "relationshipNote": "Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.", "sourceURLs": [ "https://www.nature.com/articles/mp2012103", "https://doi.org/10.1038/mp.2012.103", "https://pubmed.ncbi.nlm.nih.gov/22824810/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-22824810", "recordId": "pmid-22824810", "quotes": [], "sourcePages": [], "summary": "The authors report dopamine D2–oxytocin receptor complexes in the ventral and dorsal striatum, with facilitatory interactions between the receptors. The findings provide a molecular explanation to investigate alongside wider evidence linking dopamine and oxytocin to social behaviour.", "limitation": "Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/22824810/", "https://www.nature.com/articles/mp2012103", "https://doi.org/10.1038/mp.2012.103" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "The neural mechanisms and circuitry of the pair bond", "journal": "Nature Reviews Neuroscience", "year": 2018, "authors": "Hasse Walum; Larry J. Young", "design": "Narrative review", "urls": [ "https://www.nature.com/articles/s41583-018-0072-6", "https://doi.org/10.1038/s41583-018-0072-6", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6283620/", "https://pubmed.ncbi.nlm.nih.gov/30301953/" ], "doi": "10.1038/s41583-018-0072-6", "pmid": "30301953", "targets": [ "OXTR", "DRD2", "AVPR1A" ], "neurotransmitters": [ "Oxytocin", "Dopamine", "Vasopressin" ], "categories": [ "Brain & nervous system" ], "citationCount": 346, "citationSnapshot": { "count": 346, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41583-018-0072-6" }, "studyDesignAssessment": { "category": "review", "peerReviewed": true, "basis": "Narrative review. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/s41583-018-0072-6", "https://doi.org/10.1038/s41583-018-0072-6", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6283620/", "https://pubmed.ncbi.nlm.nih.gov/30301953/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Brain & nervous system", "sample": "Animal studies and human attachment research", "measurement": "Review of neural circuits and receptor mechanisms", "measuredGenes": [], "relationshipNote": "A narrative synthesis with substantial animal evidence; it is not a pooled estimate of a human treatment effect.", "sourceURLs": [ "https://www.nature.com/articles/s41583-018-0072-6", "https://doi.org/10.1038/s41583-018-0072-6", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6283620/", "https://pubmed.ncbi.nlm.nih.gov/30301953/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-30301953", "recordId": "pmid-30301953", "quotes": [], "sourcePages": [], "summary": "This review describes how oxytocin, dopamine and vasopressin interact with reward and social-memory circuits during pair-bond formation and maintenance. It connects experimental work in prairie voles and other animals with questions about human attachment.", "limitation": "A narrative synthesis with substantial animal evidence; it is not a pooled estimate of a human treatment effect.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Narrative review. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/30301953/", "https://www.nature.com/articles/s41583-018-0072-6", "https://doi.org/10.1038/s41583-018-0072-6", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6283620/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Oxytocin-dependent reopening of a social reward learning critical period with MDMA", "journal": "Nature", "year": 2019, "authors": "Romain Nardou; Eastman M. Lewis; Rebecca Rothhaas; Ran Xu; Aimei Yang; Edward Boyden; Gül Dölen", "design": "Experimental mouse study", "urls": [ "https://www.nature.com/articles/s41586-019-1075-9", "https://doi.org/10.1038/s41586-019-1075-9", "https://pubmed.ncbi.nlm.nih.gov/30944474/" ], "doi": "10.1038/s41586-019-1075-9", "pmid": "30944474", "targets": [ "OXTR", "SLC6A4" ], "neurotransmitters": [ "Oxytocin", "Serotonin", "Dopamine" ], "categories": [ "Brain & nervous system" ], "citationCount": 308, "citationSnapshot": { "count": 308, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41586-019-1075-9" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/s41586-019-1075-9", "https://doi.org/10.1038/s41586-019-1075-9", "https://pubmed.ncbi.nlm.nih.gov/30944474/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Brain & nervous system", "sample": "Mice", "measurement": "Social-reward learning, pharmacology and synaptic plasticity", "measuredGenes": [], "relationshipNote": "An animal mechanism study. SLC6A4 is indexed for serotonin-transporter involvement, not a measured change in its gene expression. The study does not establish human treatment efficacy.", "sourceURLs": [ "https://www.nature.com/articles/s41586-019-1075-9", "https://doi.org/10.1038/s41586-019-1075-9", "https://pubmed.ncbi.nlm.nih.gov/30944474/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-30944474", "recordId": "pmid-30944474", "quotes": [], "sourcePages": [], "summary": "In adult mice, MDMA reopened a developmental period for social-reward learning. The effect involved oxytocin-dependent plasticity in the nucleus accumbens, connecting serotonergic drug action with oxytocin signalling and social learning.", "limitation": "An animal mechanism study. SLC6A4 is indexed for serotonin-transporter involvement, not a measured change in its gene expression. The study does not establish human treatment efficacy.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/30944474/", "https://www.nature.com/articles/s41586-019-1075-9", "https://doi.org/10.1038/s41586-019-1075-9" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear", "journal": "Molecular Psychiatry", "year": 2023, "authors": "Anna Bludau; Uwe Schwartz; Daniela M. Zeitler; Melanie Royer; Gunter Meister; Inga D. Neumann; Rohit Menon", "design": "Experimental mouse molecular study", "urls": [ "https://www.nature.com/articles/s41380-023-02309-3", "https://doi.org/10.1038/s41380-023-02309-3", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/", "https://pubmed.ncbi.nlm.nih.gov/37938765/" ], "doi": "10.1038/s41380-023-02309-3", "pmid": "37938765", "targets": [ "OXTR", "MIR132", "GDF5" ], "neurotransmitters": [ "Oxytocin" ], "categories": [ "Gene expression" ], "citationCount": 14, "citationSnapshot": { "count": 14, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41380-023-02309-3" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Experimental mouse molecular study. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/s41380-023-02309-3", "https://doi.org/10.1038/s41380-023-02309-3", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/", "https://pubmed.ncbi.nlm.nih.gov/37938765/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Gene expression", "sample": "Male mice", "measurement": "Septal microRNA expression and manipulation; social-fear behaviour", "measuredGenes": [ "MIR132", "GDF5" ], "relationshipNote": "The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.", "sourceURLs": [ "https://www.nature.com/articles/s41380-023-02309-3", "https://doi.org/10.1038/s41380-023-02309-3", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/", "https://pubmed.ncbi.nlm.nih.gov/37938765/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-37938765", "recordId": "pmid-37938765", "quotes": [], "sourcePages": [], "summary": "Septal miR-132 contributed to social-fear extinction and oxytocin-mediated reversal of social fear in male mice. Manipulation in oxytocin-receptor-expressing neurons linked this microRNA to behavioural responses and downstream Gdf5 regulation.", "limitation": "The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Experimental mouse molecular study. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/37938765/", "https://www.nature.com/articles/s41380-023-02309-3", "https://doi.org/10.1038/s41380-023-02309-3", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Effects of intranasal oxytocin on fear extinction learning", "journal": "Neuropsychopharmacology", "year": 2024, "authors": "Mahmoud Rashidi; Joe J. Simon; Katja Bertsch; Gerhard Vincent Wegen; Beate Ditzen; Herta Flor; Valery Grinevich; Robert Christian Wolf; Sabine C. Herpertz", "design": "Double-blind randomized placebo-controlled trial", "urls": [ "https://www.nature.com/articles/s41386-024-01996-y", "https://doi.org/10.1038/s41386-024-01996-y", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11735929/", "https://pubmed.ncbi.nlm.nih.gov/39313675/" ], "doi": "10.1038/s41386-024-01996-y", "pmid": "39313675", "targets": [], "neurotransmitters": [ "Oxytocin" ], "categories": [ "Brain & nervous system" ], "citationCount": 8, "citationSnapshot": { "count": 8, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41386-024-01996-y" }, "studyDesignAssessment": { "category": "double-blind-rct", "peerReviewed": true, "basis": "The article reports a randomized, double-blind, placebo-controlled human experiment. Its outcome is laboratory fear extinction.", "sources": [ "https://www.nature.com/articles/s41386-024-01996-y", "https://doi.org/10.1038/s41386-024-01996-y", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11735929/", "https://pubmed.ncbi.nlm.nih.gov/39313675/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Brain & nervous system", "sample": "124 healthy women", "measurement": "Fear conditioning and extinction responses", "measuredGenes": [], "relationshipNote": "Healthy participants completed a laboratory conditioning task. The trial did not test a clinical PTSD treatment or measure gene expression.", "sourceURLs": [ "https://www.nature.com/articles/s41386-024-01996-y", "https://doi.org/10.1038/s41386-024-01996-y", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11735929/", "https://pubmed.ncbi.nlm.nih.gov/39313675/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-39313675", "recordId": "pmid-39313675", "quotes": [], "sourcePages": [], "summary": "In 124 healthy women, intranasal oxytocin impaired fear-extinction learning relative to placebo. The result challenges the assumption that oxytocin uniformly improves extinction and highlights the importance of timing and experimental context.", "limitation": "Healthy participants completed a laboratory conditioning task. The trial did not test a clinical PTSD treatment or measure gene expression.", "paperTrustAssessment": { "score": 3, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": true, "blinding": "double", "peerReviewed": true, "basis": "The article reports a randomized, double-blind, placebo-controlled human experiment. Its outcome is laboratory fear extinction.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/39313675/", "https://www.nature.com/articles/s41386-024-01996-y", "https://doi.org/10.1038/s41386-024-01996-y", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11735929/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Interdependency between oxytocin and dopamine in trust-based learning in mice", "journal": "Scientific Reports", "year": 2026, "authors": "Samuel Budniok; Zsuzsanna Callaerts-Vegh; Marian Bakermans-Kranenburg; Guy Bosmans; Rudi D’Hooge", "design": "Experimental mouse study", "urls": [ "https://www.nature.com/articles/s41598-026-38976-9", "https://doi.org/10.1038/s41598-026-38976-9", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12957489/", "https://pubmed.ncbi.nlm.nih.gov/41663511/" ], "doi": "10.1038/s41598-026-38976-9", "pmid": "41663511", "targets": [], "neurotransmitters": [ "Oxytocin", "Dopamine" ], "categories": [ "Brain & nervous system" ], "citationCount": 1, "citationSnapshot": { "count": 1, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41598-026-38976-9" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/s41598-026-38976-9", "https://doi.org/10.1038/s41598-026-38976-9", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12957489/", "https://pubmed.ncbi.nlm.nih.gov/41663511/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Brain & nervous system", "sample": "Mice", "measurement": "Social transmission of food preference and pharmacological manipulation", "measuredGenes": [], "relationshipNote": "“Trust” is operationalised through a mouse food-learning task. The experiment does not directly measure human trust or DRD2 gene expression.", "sourceURLs": [ "https://www.nature.com/articles/s41598-026-38976-9", "https://doi.org/10.1038/s41598-026-38976-9", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12957489/", "https://pubmed.ncbi.nlm.nih.gov/41663511/" ], "checkedAt": "2026-10-23" }, "id": "general-neurotransmitter-signalling-pmid-41663511", "recordId": "pmid-41663511", "quotes": [], "sourcePages": [], "summary": "Oxytocin and dopamine interacted during socially acquired food-preference learning in mice. Oxytocin affected updating after an aversive outcome, and dopamine depletion removed this effect, indicating dependence on intact dopaminergic signalling.", "limitation": "“Trust” is operationalised through a mouse food-learning task. The experiment does not directly measure human trust or DRD2 gene expression.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/41663511/", "https://www.nature.com/articles/s41598-026-38976-9", "https://doi.org/10.1038/s41598-026-38976-9", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12957489/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } } ], "trustScore": 1, "trustAssessment": { "score": 1, "scope": "Subchapter", "minimumQualifyingStudies": 3, "status": "assessed", "qualifyingRecords": { "double-blind-rct": [ "pmid-39313675" ], "rct": [ "pmid-39313675" ], "single-blind-rct": [], "peer-reviewed": [ "pmid-17287729", "pmid-24025838", "pmid-22824810", "pmid-30301953", "pmid-30944474", "pmid-37938765", "pmid-39313675", "pmid-41663511" ] }, "counts": { "double-blind-rct": 1, "rct": 1, "single-blind-rct": 0, "peer-reviewed": 8 }, "assessedAt": "2026-10-27", "basis": "Highest threshold supported by the recorded paper assessments; repeated reports of an identified trial count once." }, "number": "8.1", "sourceTrustScore": 1 }, { "id": "oxytocin-sensory", "title": "Oxytocin receptors and sensory experience", "papers": [ { "title": "Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains", "journal": "Nature Communications", "year": 2020, "authors": "Kyra T. Newmaster; Zachary T. Nolan; Uree Chon; Daniel J. Vanselow; Abigael R. Weit; Manal Tabbaa; Shizu Hidema; Katsuhiko Nishimori; Elizabeth A. D. Hammock; Yongsoo Kim", "design": "Experimental developmental brain-mapping study", "urls": [ "https://www.nature.com/articles/s41467-020-15659-1", "https://doi.org/10.1038/s41467-020-15659-1", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/", "https://pubmed.ncbi.nlm.nih.gov/32313029/" ], "doi": "10.1038/s41467-020-15659-1", "pmid": "32313029", "targets": [ "OXTR" ], "neurotransmitters": [ "Oxytocin" ], "categories": [ "Gene expression" ], "citationCount": 124, "citationSnapshot": { "count": 124, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/s41467-020-15659-1" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/s41467-020-15659-1", "https://doi.org/10.1038/s41467-020-15659-1", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/", "https://pubmed.ncbi.nlm.nih.gov/32313029/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Gene expression", "sample": "Postnatally developing mice", "measurement": "Oxytocin receptor reporter imaging and in situ RNA measurements", "measuredGenes": [ "OXTR" ], "relationshipNote": "Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.", "sourceURLs": [ "https://www.nature.com/articles/s41467-020-15659-1", "https://doi.org/10.1038/s41467-020-15659-1", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/", "https://pubmed.ncbi.nlm.nih.gov/32313029/" ], "checkedAt": "2026-10-23" }, "id": "general-oxytocin-sensory-pmid-32313029", "recordId": "pmid-32313029", "quotes": [], "sourcePages": [], "summary": "Cellular-resolution maps show that oxytocin receptor expression changes across brain regions and postnatal development in mice. Reporter imaging and RNA measurements identify transient cortical expression and region-specific patterns, providing an anatomical reference for oxytocin research.", "limitation": "Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/32313029/", "https://www.nature.com/articles/s41467-020-15659-1", "https://doi.org/10.1038/s41467-020-15659-1", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices", "journal": "Nature Neuroscience", "year": 2014, "authors": "Jing-Jing Zheng; Shu-Jing Li; Xiao-Di Zhang; Wan-Ying Miao; Dinghong Zhang; Haishan Yao; Xiang Yu", "design": "Experimental mouse study", "urls": [ "https://www.nature.com/articles/nn.3634", "https://doi.org/10.1038/nn.3634", "https://pubmed.ncbi.nlm.nih.gov/24464043/" ], "doi": "10.1038/nn.3634", "pmid": "24464043", "targets": [ "OXT" ], "neurotransmitters": [ "Oxytocin" ], "categories": [ "Brain & nervous system" ], "citationCount": 198, "citationSnapshot": { "count": 198, "source": "Crossref", "retrievedAt": "2026-10-23", "url": "https://api.crossref.org/works/10.1038/nn.3634" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://www.nature.com/articles/nn.3634", "https://doi.org/10.1038/nn.3634", "https://pubmed.ncbi.nlm.nih.gov/24464043/" ], "reviewedAt": "2026-10-23" }, "evidence": { "evidenceType": "Brain & nervous system", "sample": "Developing mice exposed to sensory deprivation", "measurement": "Oxytocin synthesis and release; cortical synaptic transmission", "measuredGenes": [], "relationshipNote": "Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.", "sourceURLs": [ "https://www.nature.com/articles/nn.3634", "https://doi.org/10.1038/nn.3634", "https://pubmed.ncbi.nlm.nih.gov/24464043/" ], "checkedAt": "2026-10-23" }, "id": "general-oxytocin-sensory-pmid-24464043", "recordId": "pmid-24464043", "quotes": [], "sourcePages": [], "summary": "Early sensory deprivation altered oxytocin synthesis and release and reduced excitatory synaptic transmission across sensory cortices in mice. Oxytocin treatment restored aspects of this transmission, linking early sensory experience to oxytocin-dependent cortical plasticity.", "limitation": "Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.", "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-applicable", "peerReviewed": true, "basis": "Experimental mouse study. No masked human randomized trial classification is assigned.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/24464043/", "https://www.nature.com/articles/nn.3634", "https://doi.org/10.1038/nn.3634" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } }, { "title": "Neural circuitry for maternal oxytocin release induced by infant cries", "journal": "Nature", "year": 2023, "authors": "Silvana Valtcheva; Habon A. Issa; Chloe J. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/nature02081" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-nature12791", "title": "Cytokinin signalling inhibitory fields provide robustness to phyllotaxis", "journal": "Nature", "year": 2014, "authors": "Fabrice Besnard; Yassin Refahi; Valérie Morin; Benjamin Marteaux; Géraldine Brunoud; Pierre Chambrier; Frédérique Rozier; Vincent Mirabet; Jonathan Legrand; Stéphanie Lainé; Emmanuel Thévenon; Etienne Farcot; Coralie Cellier; Pradeep Das; Anthony Bishopp; Renaud Dumas; François Parcy; Ykä Helariutta; Arezki Boudaoud; Christophe Godin; Jan Traas; Yann Guédon; Teva Vernoux", "doi": "10.1038/nature12791", "pmid": "24336201", "urls": [ "https://www.nature.com/articles/nature12791", "https://doi.org/10.1038/nature12791", "https://pubmed.ncbi.nlm.nih.gov/24336201/" ], "design": "Plant developmental experiments and hormone-signalling model", "summary": "The study identifies mobile AHP6-mediated inhibition of cytokinin signalling as a contributor to the timing and robustness of organ initiation, acting downstream of auxin in plant phyllotaxis.", "limitation": "The result concerns a specific plant developmental system. It is background on the robustness of phyllotactic patterns, with no test of a numerical rule in OXTR; appraisal here is abstract-level.", "citationCount": 264, "citationSnapshot": { "count": 264, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/nature12791", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-10-09T01:08:11Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Biological pattern formation" ], "targets": [], "evidence": { "evidenceType": "Plant developmental experiments and hormone-signalling model", "evidenceClass": "biological_experiment", "measurement": "Plant shoot apical meristems; AHP6 and cytokinin signalling", "measuredGenes": [ "AHP6 (plant cytokinin-signalling inhibitor)" ], "pathways": [], "relationshipNote": "Background literature only. 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Kitazawa", "doi": "10.1038/s41598-021-93133-8", "pmid": "34226577", "urls": [ "https://www.nature.com/articles/s41598-021-93133-8", "https://doi.org/10.1038/s41598-021-93133-8", "https://pubmed.ncbi.nlm.nih.gov/34226577/" ], "design": "Plant morphology measurements and mathematical model", "summary": "Rose stems show a non-random distribution of prickles relative to spiral leaf phyllotaxis. A diffusion-based inhibition model reproduces the measured pattern and selected patterns in other plants.", "limitation": "The primary measurements cover nine shoots of one rose cultivar. The model assumes a patterning process; the responsible inhibitory factors and broader applicability remain unresolved.", "citationCount": 4, "citationSnapshot": { "count": 4, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-021-93133-8", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-02-26T20:00:06Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Biological pattern formation" ], "targets": [], "evidence": { "evidenceType": "Plant morphology measurements and mathematical model", "evidenceClass": "biological_observation_and_model", "measurement": "Nine measured rose shoots; angular and height distributions", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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Braybrook", "doi": "10.1038/s41598-017-13767-5", "pmid": "29066850", "urls": [ "https://www.nature.com/articles/s41598-017-13767-5", "https://doi.org/10.1038/s41598-017-13767-5", "https://pubmed.ncbi.nlm.nih.gov/29066850/" ], "design": "Algal developmental observations and perturbation experiments", "summary": "Sargassum muticum displays a mean divergence angle close to the golden angle. Organ placement is uncoupled from apical-cell division orientation, while the tested auxin and wall-softening explanations fail to account for bud position.", "limitation": "The developmental signal remains unidentified. Similar geometry in algae and plants does not establish a shared molecular mechanism.", "citationCount": 18, "citationSnapshot": { "count": 18, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-017-13767-5", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-09-27T16:03:12Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Biological pattern formation" ], "targets": [], "evidence": { "evidenceType": "Algal developmental observations and perturbation experiments", "evidenceClass": "biological_experiment", "measurement": "Sargassum shoot apices; 260 measured divergence angles", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41598-017-13767-5" ], "category": "peer-reviewed", "peerReviewed": true } } ], "number": "9.1", "sourceTrustScore": 1 }, { "id": "fibonacci-molecular-computation", "title": "Molecular enumeration and biological computation", "context": "Keep combinatorial counting, engineered molecular computation and fitted expression patterns distinct.", "trustScore": 1, "trustAssessment": { "score": 1, "scope": "Subchapter", "minimumQualifyingStudies": 3, "status": "assessed", "qualifyingRecords": { "double-blind-rct": [], "rct": [], "single-blind-rct": [], "peer-reviewed": [ "nature-fibonacci-srep39821", "nature-fibonacci-s41540-026-00733-z", "nature-fibonacci-s41586-025-09570-2" ] }, "counts": { "double-blind-rct": 0, "rct": 0, "single-blind-rct": 0, "peer-reviewed": 3 }, "assessedAt": "2026-10-27", "basis": "Highest threshold supported by the recorded paper assessments; repeated reports of an identified trial count once." }, "papers": [ { "id": "general-nature-fibonacci-srep39821", "title": "Use of Fibonacci numbers in lipidomics – Enumerating various classes of fatty acids", "journal": "Scientific Reports", "year": 2017, "authors": "Stefan Schuster; Maximilian Fichtner; Severin Sasso", "doi": "10.1038/srep39821", "pmid": "28071669", "urls": [ "https://www.nature.com/articles/srep39821", "https://doi.org/10.1038/srep39821", "https://pubmed.ncbi.nlm.nih.gov/28071669/" ], "design": "Combinatorial proof and chemical enumeration", "summary": "The paper derives Fibonacci counts for a defined class of unbranched fatty-acid structures when cis/trans isomers are not distinguished. Modified assumptions produce generalized recurrences, including Pell-number cases.", "limitation": "The result counts chemically specified possibilities. It does not show that living organisms produce all counted structures, that measured lipid abundances follow the sequence, or that the rule applies to arbitrary molecules.", "citationCount": 10, "citationSnapshot": { "count": 10, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/srep39821", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-06-20T05:25:31Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Molecular computation" ], "targets": [], "evidence": { "evidenceType": "Combinatorial proof and chemical enumeration", "evidenceClass": "mathematical_result", "measurement": "Specified fatty-acid classes and recursive enumeration", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.", "clinicalEvidence": false, "reviewDepth": "Abstract and selected source passages: Results; Discussion.", "fullPaperAppraisal": "Not completed; review depth states the material assessed." }, "recordId": "nature-fibonacci-srep39821", "quotes": [], "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Combinatorial proof and chemical enumeration. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/srep39821" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41540-026-00733-z", "title": "Bacterial gene regulatory neural network as a biocomputing library of mathematical solvers", "journal": "npj Systems Biology and Applications", "year": 2026, "authors": "Adrian Ratwatte; Samitha Somathilaka; Ngoc Dan Thanh Cao; Xu Li; Sasitharan Balasubramaniam", "doi": "10.1038/s41540-026-00733-z", "pmid": "42120901", "urls": [ "https://www.nature.com/articles/s41540-026-00733-z", "https://doi.org/10.1038/s41540-026-00733-z", "https://pubmed.ncbi.nlm.nih.gov/42120901/" ], "design": "Transcriptomic data analysis and gene-network computational modelling", "summary": "A search procedure identifies bacterial regulatory subnetworks whose expression responses match several finite mathematical tasks. One output-gene pattern approximates Fibonacci numbers across a small set of chemically encoded conditions.", "limitation": "Subnetworks are selected for agreement with the target pattern. The finite input set and computational stability analyses do not establish unrestricted arithmetic, natural selection for Fibonacci computation, or performance on unseen tasks.", "citationCount": 0, "citationSnapshot": { "count": 0, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41540-026-00733-z", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-07-21T23:02:57Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Molecular computation" ], "targets": [], "evidence": { "evidenceType": "Transcriptomic data analysis and gene-network computational modelling", "evidenceClass": "biological_data_computational_model", "measurement": "E. coli K-12 expression data under chemically encoded conditions; network search and perturbation models", "measuredGenes": [ "E. coli b4056 (selected Fibonacci-task output; broader transcriptome also measured)" ], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41540-026-00733-z" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41586-025-09570-2", "title": "Heat-rechargeable computation in DNA logic circuits and neural networks", "journal": "Nature", "year": 2025, "authors": "Tianqi Song; Lulu Qian", "doi": "10.1038/s41586-025-09570-2", "pmid": "41034583", "urls": [ "https://www.nature.com/articles/s41586-025-09570-2", "https://doi.org/10.1038/s41586-025-09570-2", "https://pubmed.ncbi.nlm.nih.gov/41034583/" ], "design": "Engineered DNA-circuit experiments with simulations", "summary": "Heat resets engineered DNA circuits for repeated computation. A feedforward logic circuit returns the first 16 Fibonacci-word elements from index inputs and maintains performance across 16 computation rounds with 15 resets.", "limitation": "The Fibonacci circuit uses a designed truth table and finite inputs. It does not autonomously generate an unbounded sequence or reveal a naturally occurring genomic computation.", "citationCount": 24, "citationSnapshot": { "count": 24, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41586-025-09570-2", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-10-21T00:35:53Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Molecular computation" ], "targets": [], "evidence": { "evidenceType": "Engineered DNA-circuit experiments with simulations", "evidenceClass": "engineered_biological_computation", "measurement": "Engineered DNA strands; fluorescence kinetics; 16 Fibonacci-word queries", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41586-025-09570-2" ], "category": "peer-reviewed", "peerReviewed": true } } ], "number": "9.2", "sourceTrustScore": 1 }, { "id": "fibonacci-algorithms", "title": "Algorithms and optimization", "context": "Results concern specified computational tasks and benchmarks; no general superiority or security guarantee is inferred.", "trustScore": 1, "trustAssessment": { "score": 1, "scope": "Subchapter", "minimumQualifyingStudies": 3, "status": "assessed", "qualifyingRecords": { "double-blind-rct": [], "rct": [], "single-blind-rct": [], "peer-reviewed": [ "nature-fibonacci-s41598-023-28367-9", "nature-fibonacci-s41598-026-66284-9", "nature-fibonacci-s41598-024-62260-3" ] }, "counts": { "double-blind-rct": 0, "rct": 0, "single-blind-rct": 0, "peer-reviewed": 3 }, "assessedAt": "2026-10-27", "basis": "Highest threshold supported by the recorded paper assessments; repeated reports of an identified trial count once." }, "papers": [ { "id": "general-nature-fibonacci-s41598-023-28367-9", "title": "A promising approach using Fibonacci sequence-based optimization algorithms and advanced computing", "journal": "Scientific Reports", "year": 2023, "authors": "H. Tran-Ngoc; T. Le-Xuan; S. Khatir; G. De Roeck; T. Bui-Tien; Magd Abdel Wahab", "doi": "10.1038/s41598-023-28367-9", "pmid": "36854757", "urls": [ "https://www.nature.com/articles/s41598-023-28367-9", "https://doi.org/10.1038/s41598-023-28367-9", "https://pubmed.ncbi.nlm.nih.gov/36854757/" ], "design": "Numerical optimization and structural-model case study", "summary": "A Fibonacci-based modification of the Salp Swarm Algorithm is evaluated for structural-health monitoring of a railway bridge, alongside parallel computation and vectorization intended to reduce computational cost.", "limitation": "The reported performance is specific to the tested algorithms and bridge-model setting. The study does not isolate a general superiority of Fibonacci methods or validate broad biological claims mentioned in its background.", "citationCount": 19, "citationSnapshot": { "count": 19, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-023-28367-9", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-07-18T16:21:22Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Algorithms & optimization" ], "targets": [], "evidence": { "evidenceType": "Numerical optimization and structural-model case study", "evidenceClass": "computational_model", "measurement": "Optimization benchmarks and bridge finite-element model updating", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.", "clinicalEvidence": false, "reviewDepth": "Abstract and selected source passages: Methodology; Conclusions and future research.", "fullPaperAppraisal": "Not completed; review depth states the material assessed." }, "recordId": "nature-fibonacci-s41598-023-28367-9", "quotes": [], "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Numerical optimization and structural-model case study. 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They test a related QUBO formulation on a D-Wave system for a single-machine scheduling problem.", "limitation": "A compact encoding and tested scheduling results do not prove a general quantum speedup. Performance depends on the neighbourhood restriction, instance selection and hardware; appraisal here is abstract-level.", "citationCount": 0, "citationSnapshot": { "count": 0, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-026-66284-9", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-08-17T11:27:24Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Algorithms & optimization" ], "targets": [], "evidence": { "evidenceType": "Combinatorial construction and quantum-annealing computational experiment", "evidenceClass": "mathematical_result_and_computation", "measurement": "Permutation encodings, QUBO and D-Wave scheduling experiments", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41598-026-66284-9" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" }, "studyDesignAssessment": { "isRandomizedControlledTrial": false, "blinding": "Not applicable to a clinical-trial grade", "basis": "Combinatorial construction and quantum-annealing computational experiment. No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41598-026-66284-9" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41598-024-62260-3", "title": "Enhancing image security via chaotic maps, Fibonacci, Tribonacci transformations, and DWT diffusion: a robust data encryption approach", "journal": "Scientific Reports", "year": 2024, "authors": "Mohammad Mazyad Hazzazi; Mujeeb Ur Rehman; Arslan Shafique; Amer Aljaedi; Zaid Bassfar; Aminu Bello Usman", "doi": "10.1038/s41598-024-62260-3", "pmid": "38806546", "urls": [ "https://www.nature.com/articles/s41598-024-62260-3", "https://doi.org/10.1038/s41598-024-62260-3", "https://pubmed.ncbi.nlm.nih.gov/38806546/" ], "design": "Image-encryption algorithm with numerical tests", "summary": "The proposed grayscale-image encryption pipeline combines chaotic keys, Fibonacci pixel permutation, Tribonacci transformations, bit-plane operations and wavelet-based diffusion. The paper reports statistical and timing tests.", "limitation": "Entropy, pixel correlation and timing tests do not alone establish cryptographic security. The multi-component pipeline also prevents attributing its reported performance solely to Fibonacci transforms.", "citationCount": 26, "citationSnapshot": { "count": 26, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-024-62260-3", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-09-02T02:07:19Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. 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Nguyen; Thien An Nguyen; Rostislav Khrapko; Daniel A. Nolan; Nicholas F. Borrelli", "doi": "10.1038/s41598-020-64065-6", "pmid": "32346020", "urls": [ "https://www.nature.com/articles/s41598-020-64065-6", "https://doi.org/10.1038/s41598-020-64065-6", "https://pubmed.ncbi.nlm.nih.gov/32346020/" ], "design": "Optical-fibre experiments and wave-propagation simulation", "summary": "Periodic and Fibonacci-arranged multicore ring fibres produce distinct propagation and localization patterns consistent with the numerical model. The authors present these fibres as a platform for quantum-walk analogues.", "limitation": "The measured classical coherent-wave behaviour models single-particle quantum walks. 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Sagnes; S. Ravets; A. Amo; J. Bloch; O. Zilberberg", "doi": "10.1038/s41567-020-0908-7", "pmid": null, "urls": [ "https://www.nature.com/articles/s41567-020-0908-7", "https://doi.org/10.1038/s41567-020-0908-7" ], "design": "Theoretical modelling and cavity-polariton experiment", "summary": "Interpolating between Aubry–André and Fibonacci chains produces a predicted cascade of band-dependent delocalization transitions. Cavity-polariton measurements detect the first transition and clarify its microscopic origin.", "limitation": "The experimental evidence covers the first transition in a specific platform. The complete cascade and wider device applications require further investigation.", "citationCount": 139, "citationSnapshot": { "count": 139, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41567-020-0908-7", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-09-27T17:31:08Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Theoretical modelling and cavity-polariton experiment", "evidenceClass": "physical_experiment_and_computation", "measurement": "Quasiperiodic-chain models and cavity-polariton devices", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Renormalization-group theory and numerical modelling", "evidenceClass": "mathematical_computational_model", "measurement": "Heisenberg, Ising and Potts chains; phenomenological localization model", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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Fabrication tolerance, experimental noise and performance on biological specimens are not established by these calculations.", "citationCount": 17, "citationSnapshot": { "count": 17, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/srep38651", "field": "is-referenced-by-count", "sourceIndexedAt": "2025-04-03T04:28:13Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Analytical optics and numerical simulation", "evidenceClass": "computational_model", "measurement": "Rigorous coupled-wave analysis and finite-difference time-domain simulation", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/27934906/", "https://www.nature.com/articles/srep38651" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" }, "studyDesignAssessment": { "isRandomizedControlledTrial": false, "blinding": "Not applicable to a clinical-trial grade", "basis": "Analytical optics and numerical simulation. No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/srep38651" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41467-018-05950-7", "title": "A molecular overlayer with the Fibonacci square grid structure", "journal": "Nature Communications", "year": 2018, "authors": "Sam Coates; Joseph A. Smerdon; Ronan McGrath; Hem Raj Sharma", "doi": "10.1038/s41467-018-05950-7", "pmid": "30143631", "urls": [ "https://www.nature.com/articles/s41467-018-05950-7", "https://doi.org/10.1038/s41467-018-05950-7", "https://pubmed.ncbi.nlm.nih.gov/30143631/" ], "design": "Surface-materials experiment with structural analysis", "summary": "Scanning tunnelling microscopy shows fullerene molecules arranged in a Fibonacci square grid on an Al–Pd–Mn quasicrystal surface. Selective adsorption links the overlayer geometry to substrate sites.", "limitation": "This is a specific engineered material system. It does not demonstrate Fibonacci organisation of living cells or general molecular recognition.", "citationCount": 23, "citationSnapshot": { "count": 23, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41467-018-05950-7", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-09-20T05:55:37Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Surface-materials experiment with structural analysis", "evidenceClass": "physical_observation", "measurement": "C60 molecular overlayer; scanning tunnelling microscopy and Fourier analysis", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.", "clinicalEvidence": false, "reviewDepth": "Abstract and selected source passages: Introduction; Results; Methods.", "fullPaperAppraisal": "Not completed; review depth states the material assessed." }, "recordId": "nature-fibonacci-s41467-018-05950-7", "quotes": [], "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Surface-materials experiment with structural analysis. No human randomized controlled trial is reported.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/30143631/", "https://www.nature.com/articles/s41467-018-05950-7" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" }, "studyDesignAssessment": { "isRandomizedControlledTrial": false, "blinding": "Not applicable to a clinical-trial grade", "basis": "Surface-materials experiment with structural analysis. No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41467-018-05950-7" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41598-020-67567-5", "title": "Explosive Fibonacci-sequence growth into unusual sector-face morphology in poly(l-lactic acid) crystallized with polymeric diluents", "journal": "Scientific Reports", "year": 2020, "authors": "Graecia Lugito; Selvaraj Nagarajan; Eamor M. Woo", "doi": "10.1038/s41598-020-67567-5", "pmid": "32616728", "urls": [ "https://www.nature.com/articles/s41598-020-67567-5", "https://doi.org/10.1038/s41598-020-67567-5", "https://pubmed.ncbi.nlm.nih.gov/32616728/" ], "design": "Polymer-crystallization microscopy and scattering experiments", "summary": "In diluted poly(l-lactic acid) crystals, microscopy reveals branching lamellar sectors whose branch counts grow approximately along a Fibonacci sequence. Thermal and scattering measurements characterize the resulting structures.", "limitation": "The authors describe approximate counts and acknowledge difficulty distinguishing branches. The polymers and crystallization conditions are specific; this is not evidence for a universal exact growth law.", "citationCount": 14, "citationSnapshot": { "count": 14, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-020-67567-5", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-05-11T18:10:16Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Polymer-crystallization microscopy and scattering experiments", "evidenceClass": "physical_observation", "measurement": "PLLA with polymeric diluents; microscopy, calorimetry and scattering", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.", "clinicalEvidence": false, "reviewDepth": "Abstract and selected source passages: Results and discussion; Conclusion.", "fullPaperAppraisal": "Not completed; review depth states the material assessed." }, "recordId": "nature-fibonacci-s41598-020-67567-5", "quotes": [], "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Polymer-crystallization microscopy and scattering experiments. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/s41598-020-67567-5" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-s41598-017-02170-9", "title": "Fractional Transport of Photons in Deterministic Aperiodic Structures", "journal": "Scientific Reports", "year": 2017, "authors": "Luca Dal Negro; Sandeep Inampudi", "doi": "10.1038/s41598-017-02170-9", "pmid": "28536441", "urls": [ "https://www.nature.com/articles/s41598-017-02170-9", "https://doi.org/10.1038/s41598-017-02170-9", "https://pubmed.ncbi.nlm.nih.gov/28536441/" ], "design": "Numerical wave transport and analytical fractional-dynamics modelling", "summary": "Transfer-matrix simulations compare photon propagation in deterministic aperiodic structures. Fibonacci and Thue–Morse stacks exhibit anomalous power-law transport, while Rudin–Shapiro structures exhibit a distinct logarithmic regime.", "limitation": "These are modelled transport regimes under specified optical assumptions. The logarithmic result is associated with Rudin–Shapiro structures, not a finding unique to Fibonacci sequences.", "citationCount": 23, "citationSnapshot": { "count": 23, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41598-017-02170-9", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-06-17T18:07:19Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Numerical wave transport and analytical fractional-dynamics modelling", "evidenceClass": "computational_model", "measurement": "Time-domain transfer matrices and fractional transport models", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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They do not establish general computational acceleration or a biological mechanism; appraisal here is abstract-level.", "citationCount": 105, "citationSnapshot": { "count": 105, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/nphoton.2009.285", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-10-05T19:45:49Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Aperiodic structures" ], "targets": [], "evidence": { "evidenceType": "Laser-device experiment using an aperiodic grating", "evidenceClass": "physical_experiment", "measurement": "Terahertz quantum-cascade laser and emission measurements", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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Monsoriu", "doi": "10.1038/s41598-026-40652-x", "pmid": "41741524", "urls": [ "https://www.nature.com/articles/s41598-026-40652-x", "https://doi.org/10.1038/s41598-026-40652-x", "https://pubmed.ncbi.nlm.nih.gov/41741524/" ], "design": "Diffractive-optics simulations and experimental measurements", "summary": "Rectangular transparent and opaque elements generated from two-dimensional Fibonacci substitution rules form zone plates. Simulations and optical measurements characterize their axial focusing and transverse diffraction patterns.", "limitation": "The findings apply to the tested optical designs and measurements. 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Wang; Dong-Ling Deng", "doi": "10.1038/s41567-024-02529-6", "pmid": null, "urls": [ "https://www.nature.com/articles/s41567-024-02529-6", "https://doi.org/10.1038/s41567-024-02529-6" ], "design": "Superconducting-processor quantum simulation experiment", "summary": "A 27-qubit superconducting processor prepares Fibonacci string-net states and probes their topological properties. Created excitations exhibit fusion and braiding signatures consistent with Fibonacci anyons.", "limitation": "The demonstration uses digitally prepared states on a noisy processor. 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Minev; Khadijeh Najafi; Swarnadeep Majumder; Juven Wang; Ady Stern; Eun-Ah Kim; Chao-Ming Jian; Guanyu Zhu", "doi": "10.1038/s41467-025-61493-8", "pmid": "40617827", "urls": [ "https://www.nature.com/articles/s41467-025-61493-8", "https://doi.org/10.1038/s41467-025-61493-8", "https://pubmed.ncbi.nlm.nih.gov/40617827/" ], "design": "Quantum-circuit design and superconducting-processor experiments", "summary": "The authors construct Fibonacci string-net states with a dynamical preparation method, measure and braid anyons, and estimate chromatic polynomials for several graphs using quantum samples.", "limitation": "The experiments are proof of principle with error mitigation. The authors identify noise and comparison with classical approximation algorithms as unresolved barriers to a demonstrated quantum advantage.", "citationCount": 16, "citationSnapshot": { "count": 16, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41467-025-61493-8", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-09-17T23:28:56Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Quantum information" ], "targets": [], "evidence": { "evidenceType": "Quantum-circuit design and superconducting-processor experiments", "evidenceClass": "physical_experiment", "measurement": "Superconducting processors; anyon-charge measurements and graph sampling", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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Gaebler; Aaron Hankin; David Hayes; Ajesh Kumar; Brian Neyenhuis; Romain Vasseur; Andrew C. Potter", "doi": "10.1038/s41586-022-04853-4", "pmid": "35859195", "urls": [ "https://www.nature.com/articles/s41586-022-04853-4", "https://doi.org/10.1038/s41586-022-04853-4", "https://pubmed.ncbi.nlm.nih.gov/35859195/" ], "design": "Trapped-ion quantum-simulation experiment", "summary": "A quasiperiodic Fibonacci drive creates a dynamical topological phase in a ten-qubit trapped-ion chain. Edge-qubit behaviour exhibits protection against specified control imperfections relative to a periodic-drive comparison.", "limitation": "The result concerns a finite quantum simulator and particular dynamics. It does not demonstrate general-purpose fault tolerance; the present appraisal covers the abstract and accessible extended-data descriptions.", "citationCount": 72, "citationSnapshot": { "count": 72, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/s41586-022-04853-4", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-10-01T06:17:24Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Quantum information" ], "targets": [], "evidence": { "evidenceType": "Trapped-ion quantum-simulation experiment", "evidenceClass": "physical_experiment", "measurement": "Ten ytterbium-ion qubits; edge and bulk dynamics", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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Ludwig; Matthias Troyer; Zhenghan Wang", "doi": "10.1038/nphys1396", "pmid": null, "urls": [ "https://www.nature.com/articles/nphys1396", "https://doi.org/10.1038/nphys1396" ], "design": "Analytical and numerical theory of interacting anyons", "summary": "An interacting-anyon model connects topological quantum phases through topology-driven transitions. Fibonacci-anyon theory provides a concrete setting, including an exactly solvable linear geometry.", "limitation": "This is theoretical work rather than a device demonstration. Applicability to a physical implementation requires separate evidence; the present review uses the abstract and accessible figure descriptions.", "citationCount": 65, "citationSnapshot": { "count": 65, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/nphys1396", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-08-05T03:02:50Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Quantum information" ], "targets": [], "evidence": { "evidenceType": "Analytical and numerical theory of interacting anyons", "evidenceClass": "mathematical_computational_model", "measurement": "Microscopic anyon model; exact solution and numerical spectra", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.", "clinicalEvidence": false, "reviewDepth": "Abstract and selected source passages: Abstract; Figure 3, The Fibonacci theory; publisher metadata.", "fullPaperAppraisal": "Not completed; review depth states the material assessed." }, "recordId": "nature-fibonacci-nphys1396", "quotes": [], "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": false, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Analytical and numerical theory of interacting anyons. No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/nphys1396" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" }, "studyDesignAssessment": { "isRandomizedControlledTrial": false, "blinding": "Not applicable to a clinical-trial grade", "basis": "Analytical and numerical theory of interacting anyons. No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/nphys1396" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-srep31350", "title": "Hybrid threshold adaptable quantum secret sharing scheme with reverse Huffman-Fibonacci-tree coding", "journal": "Scientific Reports", "year": 2016, "authors": "Hong Lai; Jun Zhang; Ming-Xing Luo; Lei Pan; Josef Pieprzyk; Fuyuan Xiao; Mehmet A. Orgun", "doi": "10.1038/srep31350", "pmid": "27515908", "urls": [ "https://www.nature.com/articles/srep31350", "https://doi.org/10.1038/srep31350", "https://pubmed.ncbi.nlm.nih.gov/27515908/" ], "design": "Theoretical quantum secret-sharing protocol and security analysis", "summary": "The proposed hybrid secret-sharing protocol combines generalized Fibonacci orbital-angular-momentum states, polynomial sharing, and reverse Huffman–Fibonacci tree coding to support changing participant sets.", "limitation": "The work proposes and analyses a protocol. It does not establish deployment security, implementation resistance to side channels, or an experimentally demonstrated communication advantage.", "citationCount": 15, "citationSnapshot": { "count": 15, "source": "Crossref cited-by count", "retrievedAt": "2026-10-24", "url": "https://api.crossref.org/works/10.1038/srep31350", "field": "is-referenced-by-count", "sourceIndexedAt": "2026-04-12T01:31:46Z", "coverageNote": "Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score." }, "categories": [ "Fibonacci mathematics", "Quantum information" ], "targets": [], "evidence": { "evidenceType": "Theoretical quantum secret-sharing protocol and security analysis", "evidenceClass": "computational_protocol", "measurement": "Protocol construction and mathematical security arguments", "measuredGenes": [], "pathways": [], "relationshipNote": "Background literature only. 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No human randomized controlled trial is reported.", "sources": [ "https://www.nature.com/articles/srep31350" ], "category": "peer-reviewed", "peerReviewed": true } }, { "id": "general-nature-fibonacci-srep46302", "title": "Fast and simple high-capacity quantum cryptography with error detection", "journal": "Scientific Reports", "year": 2017, "authors": "Hong Lai; Ming-Xing Luo; Josef Pieprzyk; Jun Zhang; Lei Pan; Shudong Li; Mehmet A. Orgun", "doi": "10.1038/srep46302", "pmid": "28406240", "urls": [ "https://www.nature.com/articles/srep46302", "https://doi.org/10.1038/srep46302", "https://pubmed.ncbi.nlm.nih.gov/28406240/" ], "design": "Theoretical quantum-cryptography algorithm", "summary": "Fibonacci- and Lucas-valued orbital-angular-momentum states supply inputs to recursive matrix-based coding. The paper proposes matrix operations for high-capacity key use and error detection.", "limitation": "Claims depend on the stated protocol assumptions. 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This is not a clinical efficacy trial.", "sources": [ "https://pubmed.ncbi.nlm.nih.gov/38378727/", "https://www.nature.com/articles/s41467-024-45584-6", "https://doi.org/10.1038/s41467-024-45584-6", "https://pmc.ncbi.nlm.nih.gov/articles/PMC10879205/" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } } ], "number": "10.4", "sourceTrustScore": null }, { "id": "quantum-fractal-codes", "title": "Fractal structure and information protection", "context": "Code properties provide a testable mathematical starting point for investigating fractal organisation.", "trustScore": null, "trustAssessment": { "score": null, "scope": "Subchapter", "minimumQualifyingStudies": 3, "status": "below-minimum", "qualifyingRecords": { "double-blind-rct": [], "rct": [], "single-blind-rct": [], "peer-reviewed": [ "quantum-haah-fractal-code-2011" ] }, "counts": { "double-blind-rct": 0, "rct": 0, "single-blind-rct": 0, "peer-reviewed": 1 }, "assessedAt": "2026-10-27", "basis": "Highest threshold supported by the recorded paper assessments; repeated reports of an identified trial count once." }, "papers": [ { "id": "general-quantum-fractal-codes-quantum-haah-fractal-code-2011", "title": "Local stabilizer codes in three dimensions without string logical operators", "doi": "10.1103/PhysRevA.83.042330", "pmid": null, "journal": "Physical Review A", "year": 2011, "published": "2011-04-22", "authors": "Jeongwan Haah", "urls": [ "https://doi.org/10.1103/PhysRevA.83.042330" ], "collections": [ "general" ], "categories": [ "Quantum computing", "Geometry and information" ], "targets": [], "origin": "geometry-literature-20261026", "priority": 1, "kind": "Journal article", "design": "Theoretical three-dimensional stabilizer codes", "summary": "Haah constructs local stabilizer codes in three dimensions without string-like logical operators. The work introduces a different geometric organisation of information and errors, associated with the fractal structure of logical operations in the cubic-code family.", "finding": "Haah constructs local stabilizer codes in three dimensions without string-like logical operators. The work introduces a different geometric organisation of information and errors, associated with the fractal structure of logical operations in the cubic-code family.", "limitation": "This is code theory, not evidence that any fractal pattern stabilises a physical quantum computer. It does not demonstrate a Fibonacci connection or a complete self-correcting memory operating at finite temperature.", "citationCount": 591, "citationSnapshot": { "count": 591, "source": "Crossref", "retrievedAt": "2026-10-26" }, "studyDesignAssessment": { "category": "peer-reviewed", "peerReviewed": true, "basis": "Theoretical three-dimensional stabilizer codes. This is not a clinical efficacy trial.", "sources": [ "https://doi.org/10.1103/PhysRevA.83.042330" ], "reviewedAt": "2026-10-26" }, "evidence": { "evidenceType": "Theoretical three-dimensional stabilizer codes", "evidenceClass": "quantum_error_correction_theory", "measurement": "Three-dimensional local constraints and non-string logical operators.", "relationshipNote": "Compare exact code properties and noise response before drawing connections between fractal appearance and information protection.", "clinicalEvidence": false, "reviewDepth": "Publisher or author abstract and bibliographic metadata; selected explanatory sections where available.", "hypothesisBoundary": "Connections to M9 P24, Alpha, Beta, Gamma and Epsilon remain research hypotheses. Shared geometry does not establish a shared physical mechanism." }, "jadad": { "status": "not-applicable", "score": null, "reason": "Not a human randomised clinical trial." }, "quotes": [], "archiveEntries": [], "verifiedAt": "2026-10-26", "sourceProvenance": { "origin": "Verified follow-up to Gemini research notes", "notionPage": "https://app.notion.com/p/4047b9c99c5680ddb35ec2e2edf83ee4", "reviewedAt": "2026-10-26" }, "recordId": "quantum-haah-fractal-code-2011", "sourcePages": [], "paperTrustAssessment": { "score": 1, "scope": "Paper", "status": "assessed", "randomizedControlledTrial": null, "blinding": "not-confirmed", "peerReviewed": true, "basis": "Theoretical three-dimensional stabilizer codes. This is not a clinical efficacy trial.", "sources": [ "https://doi.org/10.1103/PhysRevA.83.042330" ], "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.", "assessedAt": "2026-10-27" } } ], "number": "10.5", "sourceTrustScore": null } ] }, { "number": 11, "id": "hyperspectral-imaging", "title": "Hyperspectral Imaging", "overview": [ "Hyperspectral imaging connects spatial information with wavelength-dependent measurements. This chapter follows the development of cameras and reconstruction methods, then examines optical physiology, molecular sensing and links to transcriptomics.", "The collection reconciles 229 non-patent citation entries and 11 patent entries from patent section 2.4. Original reference IDs remain intact. Repeated citations share source records; preprints and published versions retain explicit relationships. The 13 timeline entries overlap the bibliography and are not counted as additional publications.", "Bibliographic identity and scientific evidence are separate assessments. Matched metadata confirms the cited work, while source annotations, proposed mechanisms and commercial claims retain their stated review status." ], "topics": [ { "id": "imaging-evolution", "number": "11.1", "title": "Evolution of Hyperspectral, Smartphone and Infrared Technologies", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "The source timeline traces several routes to portable optical sensing: external camera attachments, embedded spectrometers, tunable filters and computational reconstruction. These routes solve different acquisition problems. A device that measures a spectrum at one point, a depth camera and a thermal imager each capture different information from a hyperspectral image cube.", "Read the historical milestones alongside their source type. Manufacturer pages document products and stated specifications; research papers document particular experimental systems. The timeline retains the original 13 entries, with overlapping publications linked to the same citation records. Dates describe the source chronology, not a current product-availability survey." ], "papers": [ { "id": "general-imaging-evolution-hsi-e5ce75d3c77c19", "recordId": "hsi-e5ce75d3c77c19", "title": "MEMS Fabry-Pérot interferometer-based hyperspectral mobile device", "journal": "", "year": 2016, "authors": "Rissanen A et al. / VTT Technical Research Centre of Finland", "design": "Institutional, commercial or web source", "urls": [ "http://optics.org" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-145", "recordId": "hsi-e5ce75d3c77c19", "sourceType": "Institutional, commercial or web source", "title": "MEMS Fabry-Pérot interferometer-based hyperspectral mobile device", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Rissanen A et al. / VTT Technical Research Centre of Finland (2016). \"MEMS Fabry-Pérot interferometer-based hyperspectral mobile device.\" optics.org (November 2016) — First hyperspectral mobile device via MEMS FPI filter integrated into iPhone camera lens module; health applications identified as target domain", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://optics.org", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-imaging-evolution-hsi-c644e5401b9e2e", "recordId": "hsi-c644e5401b9e2e", "title": "Unispectral (Israel) (2016–present). MEMS tuneable Fabry-Pérot filter technology for OEM smartphone camera module integration. Monarch Pro, Neptune, Solomon platforms. unispectral.com", "journal": "", "year": 2016, "authors": "Unispectral", "design": "Institutional, commercial or web source", "urls": [ "http://unispectral.com" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-146", "recordId": "hsi-c644e5401b9e2e", "sourceType": "Institutional, commercial or web source", "title": "Unispectral (Israel) (2016–present). MEMS tuneable Fabry-Pérot filter technology for OEM smartphone camera module integration. Monarch Pro, Neptune, Solomon platforms. unispectral.com", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Unispectral (Israel) (2016–present). MEMS tuneable Fabry-Pérot filter technology for OEM smartphone camera module integration. Monarch Pro, Neptune, Solomon platforms. unispectral.com — Demonstrates HSI filter manufacturing at smartphone camera module scale without form factor increase", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://unispectral.com", "metadataURL": null, "corrections": [], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-imaging-evolution-hsi-2d7983e4ef049a", "recordId": "hsi-2d7983e4ef049a", "title": "Consumer Physics (Israel) / SCiO (2014–present). Pocket-sized NIR molecular spectrometer; Kickstarter ~US$2.7M (2014); embedded in Changhong H2 smartphone (CES 2017); matured to commercial platform with 10,000+ users, 50+ countries, millions of analyses. scionir.com", "journal": "", "year": 2014, "authors": "Consumer Physics", "design": "Institutional, commercial or web source", "urls": [ "http://scionir.com" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-147", "recordId": "hsi-2d7983e4ef049a", "sourceType": "Institutional, commercial or web source", "title": "Consumer Physics (Israel) / SCiO (2014–present). Pocket-sized NIR molecular spectrometer; Kickstarter ~US$2.7M (2014); embedded in Changhong H2 smartphone (CES 2017); matured to commercial platform with 10,000+ users, 50+ countries, millions of analyses. scionir.com", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Consumer Physics (Israel) / SCiO (2014–present). Pocket-sized NIR molecular spectrometer; Kickstarter ~US$2.7M (2014); embedded in Changhong H2 smartphone (CES 2017); matured to commercial platform with 10,000+ users, 50+ countries, millions of analyses. scionir.com — Agricultural/food NIR spectroscopy at consumer scale", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://scionir.com", "metadataURL": null, "corrections": [], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-imaging-evolution-hsi-e3944b33936175", "recordId": "hsi-e3944b33936175", "title": "Apple iPhone X TrueDepth Camera Teardown", "journal": "", "year": 2017, "authors": "System Plus Consulting / Yole Développement", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-148", "recordId": "hsi-e3944b33936175", "sourceType": "Bibliographic source", "title": "Apple iPhone X TrueDepth Camera Teardown", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "System Plus Consulting / Yole Développement (2017). \"Apple iPhone X TrueDepth Camera Teardown.\" Elisabeth S (December 2017) — STMicroelectronics NIR camera sensor (Imager-SOI substrate from SOITEC, sub-4 µm pixels, ~2 MP, high NIR QE) + IR dot projector (~30,000 dots) confirmed at billion-unit manufacturing scale", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-imaging-evolution-hsi-4b75613536363d", "recordId": "hsi-4b75613536363d", "title": "FLIR ONE Gen 3 Thermal Camera", "journal": "", "year": 2014, "authors": "Teledyne FLIR", "design": "Institutional, commercial or web source", "urls": [ "http://flir.com" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-149", "recordId": "hsi-4b75613536363d", "sourceType": "Institutional, commercial or web source", "title": "FLIR ONE Gen 3 Thermal Camera", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Teledyne FLIR (2014–present). \"FLIR ONE Gen 3 Thermal Camera.\" flir.com — 80×60 thermal resolution, LWIR 8–14 µm, MSX® multi-spectral fusion, 34×67×14 mm / 36 g smartphone attachment with open developer SDK; thermal band only (no molecular/biomarker inference)", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://flir.com", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-imaging-evolution-hsi-92cd98c0974786", "recordId": "hsi-92cd98c0974786", "title": "Low-Cost Hyperspectral Imaging with A Smartphone.", "journal": "Journal of imaging", "year": 2021, "authors": "Stuart MB, McGonigle AJS, Davies M, Hobbs MJ, Boone NA, Stanger LR, Zhu C, Pering TD, Willmott JR.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/34460772/", "https://doi.org/10.3390/jimaging7080136", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8404918/" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/jimaging7080136", "pmid": "34460772", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-150", "recordId": "hsi-92cd98c0974786", "sourceType": "Journal publication", "title": "Low-Cost Hyperspectral Imaging with A Smartphone.", "authors": "Stuart MB, McGonigle AJS, Davies M, Hobbs MJ, Boone NA, Stanger LR, Zhu C, Pering TD, Willmott JR.", "year": 2021, "journal": "Journal of imaging", "doi": "10.3390/jimaging7080136", "pmid": "34460772", "pmcid": "PMC8404918", "patentNumber": null, "originalAssignee": null, "originalCitation": "Stuart MB, McGonigle AJS et al. (2021). \"Low-Cost Hyperspectral Imaging with A Smartphone.\" Journal of Imaging 7(8):136 (MDPI) — 3D-printed smartphone HSI attachment at ~£100 total cost; proves HSI can be added to consumer smartphones without specialised manufacturing", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34460772/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Low-Cost+Hyperspectral+Imaging+with+A+Smartphone%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-evolution-hsi-a911e8605e024c", "recordId": "hsi-a911e8605e024c", "title": "Smartphone-based hyperspectral imaging for ice sheet and proglacial applications in South-West Greenland.", "journal": "The Science of the total environment", "year": 2024, "authors": "Stuart MB, Davies M, Fisk C, Allen E, Sole AJ, Ing R, Hobbs MJ, Willmott JR.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39147066/", "https://doi.org/10.1016/j.scitotenv.2024.175516" ], "quotes": [], "summary": "A smartphone-based hyperspectral instrument was deployed at supraglacial and proglacial sites in Greenland to collect visible and near-infrared environmental data.", "relatedVersions": [], "limitation": "This is a field-imaging instrument study; its findings do not establish biological or clinical measurements from a standard phone camera.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.scitotenv.2024.175516", "pmid": "39147066", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-151", "recordId": "hsi-a911e8605e024c", "sourceType": "Journal publication", "title": "Smartphone-based hyperspectral imaging for ice sheet and proglacial applications in South-West Greenland.", "authors": "Stuart MB, Davies M, Fisk C, Allen E, Sole AJ, Ing R, Hobbs MJ, Willmott JR.", "year": 2024, "journal": "The Science of the total environment", "doi": "10.1016/j.scitotenv.2024.175516", "pmid": "39147066", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Stuart MB et al. (2024). \"Field deployment of a smartphone hyperspectral imaging attachment in South-West Greenland.\" Science of the Total Environment 951:175516 (ScienceDirect) — Operational reliability of smartphone HSI in extreme field conditions for ice sheet and proglacial environmental analysis", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39147066/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.scitotenv.2024.175516%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-evolution-hsi-c2365ea769851d", "recordId": "hsi-c2365ea769851d", "title": "Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection.", "journal": "Light, science & applications", "year": 2024, "authors": "Meng H, Gao Y, Wang X, Li X, Wang L, Zhao X, Sun B.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38802359/", "https://doi.org/10.1038/s41377-024-01476-4", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11130170/" ], "quotes": [], "summary": "The laboratory system combines quantum-dot filters, a digital micromirror device and a single-pixel detector to reconstruct near-infrared spectral images.", "relatedVersions": [], "limitation": "The demonstrated performance belongs to this optical hardware and reconstruction method; it is not an unmodified smartphone RGB camera.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41377-024-01476-4", "pmid": "38802359", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-152", "recordId": "hsi-c2365ea769851d", "sourceType": "Journal publication", "title": "Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection.", "authors": "Meng H, Gao Y, Wang X, Li X, Wang L, Zhao X, Sun B.", "year": 2024, "journal": "Light, science & applications", "doi": "10.1038/s41377-024-01476-4", "pmid": "38802359", "pmcid": "PMC11130170", "patentNumber": null, "originalAssignee": null, "originalCitation": "Meng H, Gao Y et al. (2024). \"Colloidal quantum dot infrared hyperspectral imaging via single-pixel inference.\" Light: Science & Applications (Nature) 13:121 — CQD filters with 128×128 pixel HSI at 8.59 nm spectral resolution across 1050–1630 nm SWIR; miniaturisable architecture compatible with smartphone integration", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38802359/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41377-024-01476-4%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "imaging-evolution", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." } ] }, { "id": "spectral-reconstruction", "number": "11.2", "title": "Computational Imaging and Spectral Reconstruction", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "Spectral reconstruction estimates wavelength-dependent information from camera measurements. The inversion depends on calibration, illumination, sensor response and model assumptions. The research spans sparse recovery, neural networks and methods using a physical colour reference chart. Reconstructed channels carry the conditions of the method that produced them.", "The Purdue study, repeated as NPL-1 and NPL-153, uses a specially designed spectral colour chart with a computational method. Its reported framework operates in the visible range. It does not establish unrestricted recovery of near-infrared information from any ordinary RGB photograph. For each approach, the research question is how accurately spectra transfer to new devices, lighting conditions, samples and acquisition settings." ], "papers": [ { "id": "general-spectral-reconstruction-hsi-fda6f081ed5bea", "recordId": "hsi-fda6f081ed5bea", "title": "Hyperspectral Information Extraction With Full Resolution From Arbitrary Photographs.", "journal": "IEEE transactions on image processing : a publication of the IEEE Signal Processing Society", "year": 2025, "authors": "Kwon S, Mok Park S, Ji Y, Sakthivel H, Woo Leem J, Kim YL.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/40828724/", "https://doi.org/10.1109/tip.2025.3597038", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12481205/" ], "quotes": [], "summary": "Computational photography spectrometry combines a physical spectral colour chart with an algorithm to reconstruct visible-range spectra from RGB photographs. The study tests transmission and reflection modes.", "relatedVersions": [], "limitation": "The method depends on a reference chart and its optical acquisition conditions. It does not establish unrestricted infrared recovery from an uncalibrated photograph.", "citationCount": null, "sourcePages": [], "doi": "10.1109/tip.2025.3597038", "pmid": "40828724", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-1", "recordId": "hsi-fda6f081ed5bea", "sourceType": "Journal publication", "title": "Hyperspectral Information Extraction With Full Resolution From Arbitrary Photographs.", "authors": "Kwon S, Mok Park S, Ji Y, Sakthivel H, Woo Leem J, Kim YL.", "year": 2025, "journal": "IEEE transactions on image processing : a publication of the IEEE Signal Processing Society", "doi": "10.1109/tip.2025.3597038", "pmid": "40828724", "pmcid": "PMC12481205", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kwon S, Kim YL (2025). \"Hyperspectral Information Extraction From Standard Photographs With Full Resolution.\" IEEE Transactions on Image Processing (ieeexplore.ieee.org/document/11125864) — 1–2 nm spectral resolution from standard RGB smartphone camera via colour reference chart; same laboratory demonstrated smartphone HSI for blood haemoglobin and tissue oximetry via \"hyperspectral learning\" (PNAS Nexus)", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40828724/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1109%2FTIP.2025.3597038%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "spectral-reconstruction", "role": "Focused chapter source" }, { "ref": "NPL-153", "recordId": "hsi-fda6f081ed5bea", "sourceType": "Journal publication", "title": "Hyperspectral Information Extraction With Full Resolution From Arbitrary Photographs.", "authors": "Kwon S, Mok Park S, Ji Y, Sakthivel H, Woo Leem J, Kim YL.", "year": 2025, "journal": "IEEE transactions on image processing : a publication of the IEEE Signal Processing Society", "doi": "10.1109/tip.2025.3597038", "pmid": "40828724", "pmcid": "PMC12481205", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kwon S, Kim YL (2025). \"Hyperspectral Information Extraction From Standard Photographs With Full Resolution.\" IEEE Transactions on Image Processing (ieeexplore.ieee.org/document/11125864) — Formal IEEE peer-reviewed publication: 1–2 nm spectral resolution from standard RGB cameras via colour reference chart; no hardware modification required", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40828724/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1109%2FTIP.2025.3597038%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "spectral-reconstruction", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-spectral-reconstruction-hsi-5e1047e741fec6", "recordId": "hsi-5e1047e741fec6", "title": "Sparse Recovery of Hyperspectral Signal from Natural RGB Images", "journal": "Lecture Notes in Computer Science Computer Vision – ECCV 2016", "year": 2016, "authors": "Boaz Arad; Ohad Ben-Shahar", "design": "Book or chapter", "urls": [ "https://doi.org/10.1007/978-3-319-46478-7_2" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1007/978-3-319-46478-7_2", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-2", "recordId": "hsi-5e1047e741fec6", "sourceType": "Book or chapter", "title": "Sparse Recovery of Hyperspectral Signal from Natural RGB Images", "authors": "Boaz Arad; Ohad Ben-Shahar", "year": 2016, "journal": "Lecture Notes in Computer Science Computer Vision – ECCV 2016", "doi": "10.1007/978-3-319-46478-7_2", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Arad B, Ben-Shahar O (2016). \"Sparse Recovery of Hyperspectral Signal from Natural RGB Images.\" ECCV 2016", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1007/978-3-319-46478-7_2", "metadataURL": "https://api.crossref.org/works?query.title=Sparse+Recovery+of+Hyperspectral+Signal+from+Natural+RGB+Images&rows=3", "corrections": [], "topicId": "spectral-reconstruction", "role": "Focused chapter source" } ], "sourceType": "Book or chapter", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-spectral-reconstruction-hsi-c850f6777572d4", "recordId": "hsi-c850f6777572d4", "title": "HSCNN: CNN-Based Hyperspectral Image Recovery from Spectrally Undersampled Projections", "journal": "2017 IEEE International Conference on Computer Vision Workshops (ICCVW)", "year": 2017, "authors": "Zhiwei Xiong; Zhan Shi; Huiqun Li; Lizhi Wang; Dong Liu; Feng Wu", "design": "Conference publication", "urls": [ "https://doi.org/10.1109/iccvw.2017.68" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1109/iccvw.2017.68", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-3", "recordId": "hsi-c850f6777572d4", "sourceType": "Conference publication", "title": "HSCNN: CNN-Based Hyperspectral Image Recovery from Spectrally Undersampled Projections", "authors": "Zhiwei Xiong; Zhan Shi; Huiqun Li; Lizhi Wang; Dong Liu; Feng Wu", "year": 2017, "journal": "2017 IEEE International Conference on Computer Vision Workshops (ICCVW)", "doi": "10.1109/iccvw.2017.68", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xiong Z et al. (2017). \"HSCNN: CNN-Based Hyperspectral Image Recovery from Spectrally Undersampled Projections.\" ICCV Workshop 2017", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1109/iccvw.2017.68", "metadataURL": "https://api.crossref.org/works?query.title=HSCNN%3A+CNN-Based+Hyperspectral+Image+Recovery+from+Spectrally+Undersampled+Projections&rows=3", "corrections": [], "topicId": "spectral-reconstruction", "role": "Focused chapter source" } ], "sourceType": "Conference publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-spectral-reconstruction-hsi-852a0ba2dbf56c", "recordId": "hsi-852a0ba2dbf56c", "title": "Scyllarus: Hyperspectral Image Processing Platform", "journal": "", "year": 2016, "authors": "CSIRO Data61", "design": "Institutional, commercial or web source", "urls": [ "http://scyllarus.data61.csiro.au" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-154", "recordId": "hsi-852a0ba2dbf56c", "sourceType": "Institutional, commercial or web source", "title": "Scyllarus: Hyperspectral Image Processing Platform", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "CSIRO Data61 (2016–present). \"Scyllarus: Hyperspectral Image Processing Platform.\" scyllarus.data61.csiro.au — Obtains hyperspectral data from standard IoT cameras including smartphone cameras via computer vision and machine learning; C++ API, MATLAB toolbox, Scyven viewer; deployed for agricultural disease inference and forensic analysis", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://scyllarus.data61.csiro.au", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "spectral-reconstruction", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-spectral-reconstruction-hsi-4f3065875d9c72", "recordId": "hsi-4f3065875d9c72", "title": "Distributed Ledgers", "journal": "", "year": 2020, "authors": "Robert M. Townsend", "design": "Book or chapter", "urls": [ "https://doi.org/10.7551/mitpress/13382.001.0001" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.7551/mitpress/13382.001.0001", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-155", "recordId": "hsi-4f3065875d9c72", "sourceType": "Book or chapter", "title": "Distributed Ledgers", "authors": "Robert M. Townsend", "year": 2020, "journal": "", "doi": "10.7551/mitpress/13382.001.0001", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "CSIRO Data61 (2019). \"Distributed Ledgers\" whitepaper. csiro.au/-/media/D61/Files/Distributed-Ledgers.pdf — Confirms Scyllarus platform capability for spectral analysis from standard cameras; BK met with CSIRO Data61 in 2019 regarding building technology with Scyllarus platform", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.7551/mitpress/13382.001.0001", "metadataURL": "https://api.crossref.org/works?query.title=Distributed+Ledgers&rows=3", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "spectral-reconstruction", "role": "Focused chapter source" } ], "sourceType": "Book or chapter", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." } ] }, { "id": "optical-physiology", "number": "11.3", "title": "Optical Physiology and Tissue Imaging", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "Optical physiology studies connect image variation with quantities such as blood volume, perfusion and oxygenation. The source collection brings rPPG, tissue hyperspectral imaging, skin fluorescence and endoscopic reconstruction into one reading path. Each method retains its own hardware, tissue and reference measurement.", "The endoscopy study at NPL-221 examines hyperspectral conversion and CycleGAN-generated narrowband images in an esophageal imaging setting. Its clinical context is distinct from a smartphone facial measurement. Oxytocin and baroreflex papers provide physiological context for potential optical associations; they do not, by themselves, establish gene-specific measurement from facial images. Validation needs paired reference assays and controls for motion, lighting, skin pigmentation and vascular state." ], "papers": [ { "id": "general-optical-physiology-hsi-84b3c79b78cbd5", "recordId": "hsi-84b3c79b78cbd5", "title": "Remote plethysmographic imaging using ambient light.", "journal": "Optics express", "year": 2008, "authors": "Verkruysse W, Svaasand LO, Nelson JS.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/19104573/", "https://doi.org/10.1364/oe.16.021434", "https://pmc.ncbi.nlm.nih.gov/articles/PMC2717852/" ], "quotes": [], "summary": "Reference associated with Remote Photoplethysmography.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1364/oe.16.021434", "pmid": "19104573", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-4", "recordId": "hsi-84b3c79b78cbd5", "sourceType": "Journal publication", "title": "Remote plethysmographic imaging using ambient light.", "authors": "Verkruysse W, Svaasand LO, Nelson JS.", "year": 2008, "journal": "Optics express", "doi": "10.1364/oe.16.021434", "pmid": "19104573", "pmcid": "PMC2717852", "patentNumber": null, "originalAssignee": null, "originalCitation": "Verkruysse W, Svaasand LO, Nelson JS (2008). \"Remote plethysmographic imaging using ambient light.\" Optics Express 16(26):21434–21445", "originalSection": "Remote Photoplethysmography", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/19104573/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Remote+plethysmographic+imaging+using+ambient+light%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-5741b19204aaa6", "recordId": "hsi-5741b19204aaa6", "title": "Algorithmic Principles of Remote PPG.", "journal": "IEEE transactions on bio-medical engineering", "year": 2017, "authors": "Wang W, den Brinker AC, Stuijk S, de Haan G.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/28113245/", "https://doi.org/10.1109/tbme.2016.2609282" ], "quotes": [], "summary": "Reference associated with Remote Photoplethysmography.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1109/tbme.2016.2609282", "pmid": "28113245", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-5", "recordId": "hsi-5741b19204aaa6", "sourceType": "Journal publication", "title": "Algorithmic Principles of Remote PPG.", "authors": "Wang W, den Brinker AC, Stuijk S, de Haan G.", "year": 2017, "journal": "IEEE transactions on bio-medical engineering", "doi": "10.1109/tbme.2016.2609282", "pmid": "28113245", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Wang W et al. (2017). \"Algorithmic Principles of Remote PPG.\" IEEE Trans Biomedical Engineering 64(7):1479–1491", "originalSection": "Remote Photoplethysmography", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28113245/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Algorithmic+Principles+of+Remote+PPG%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-33071746", "recordId": "pmid-33071746", "title": "Oxytocin Receptor Signaling in Vascular Function and Stroke", "journal": "Frontiers in neuroscience", "year": 2020, "authors": "McKay EC, Counts SE.", "design": "", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/33071746/", "https://doi.org/10.3389/fnins.2020.574499", "https://www.frontiersin.org/articles/10.3389/fnins.2020.574499/full" ], "quotes": [], "summary": "", "relatedVersions": [], "limitation": "", "citationCount": null, "sourcePages": [], "doi": "10.3389/fnins.2020.574499", "pmid": "33071746", "targets": [ "OXTR", "OXT" ], "categories": [ "Molecular biomarkers" ], "sourceReferences": [ { "ref": "NPL-25", "recordId": "pmid-33071746", "sourceType": "Review", "title": "Oxytocin Receptor Signaling in Vascular Function and Stroke.", "authors": "McKay EC, Counts SE.", "year": 2020, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2020.574499", "pmid": "33071746", "pmcid": "PMC7544744", "patentNumber": null, "originalAssignee": null, "originalCitation": "Gutkowska J, Jankowski M (2020). \"Oxytocin Receptor Signaling in Vascular Function and Stroke.\" Frontiers in Neuroscience 14:574499 (PMC 7544744)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33071746/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7544744&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-55916122662aa4", "recordId": "hsi-55916122662aa4", "title": "Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis.", "journal": "Experimental dermatology", "year": 2013, "authors": "Deing V, Roggenkamp D, Kühnl J, Gruschka A, Stäb F, Wenck H, Bürkle A, Neufang G.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/23711064/", "https://doi.org/10.1111/exd.12155" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1111/exd.12155", "pmid": "23711064", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-26", "recordId": "hsi-55916122662aa4", "sourceType": "Journal publication", "title": "Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis.", "authors": "Deing V, Roggenkamp D, Kühnl J, Gruschka A, Stäb F, Wenck H, Bürkle A, Neufang G.", "year": 2013, "journal": "Experimental dermatology", "doi": "10.1111/exd.12155", "pmid": "23711064", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Deing V et al. (2012). \"Oxytocin modulates proliferation and stress responses of human skin cells.\" Experimental Dermatology (PMID 23711064)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/23711064/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A23711064+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-aecb6ce44b1875", "recordId": "hsi-aecb6ce44b1875", "title": "Structural basis for the activation and ligand recognition of the human oxytocin receptor.", "journal": "Nature communications", "year": 2022, "authors": "Waltenspühl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Plückthun A.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/35851571/", "https://doi.org/10.1038/s41467-022-31325-0", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9293896/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41467-022-31325-0", "pmid": "35851571", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-27", "recordId": "hsi-aecb6ce44b1875", "sourceType": "Journal publication", "title": "Structural basis for the activation and ligand recognition of the human oxytocin receptor.", "authors": "Waltenspühl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Plückthun A.", "year": 2022, "journal": "Nature communications", "doi": "10.1038/s41467-022-31325-0", "pmid": "35851571", "pmcid": "PMC9293896", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yin J et al. (2022). \"Structural basis for the activation and ligand recognition of the human oxytocin receptor.\" Nature Communications 13:4153", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35851571/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Structural+basis+for+the+activation+and+ligand+recognition+of+the+human+oxytocin+receptor%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-b2ec2b67bc699b", "recordId": "hsi-b2ec2b67bc699b", "title": "Advances in human oxytocin measurement: challenges and proposed solutions.", "journal": "Molecular psychiatry", "year": 2023, "authors": "Tabak BA, Leng G, Szeto A, Parker KJ, Verbalis JG, Ziegler TE, Lee MR, Neumann ID, Mendez AJ.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/35999276/", "https://doi.org/10.1038/s41380-022-01719-z", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9812775/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41380-022-01719-z", "pmid": "35999276", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-28", "recordId": "hsi-b2ec2b67bc699b", "sourceType": "Review", "title": "Advances in human oxytocin measurement: challenges and proposed solutions.", "authors": "Tabak BA, Leng G, Szeto A, Parker KJ, Verbalis JG, Ziegler TE, Lee MR, Neumann ID, Mendez AJ.", "year": 2023, "journal": "Molecular psychiatry", "doi": "10.1038/s41380-022-01719-z", "pmid": "35999276", "pmcid": "PMC9812775", "patentNumber": null, "originalAssignee": null, "originalCitation": "Tabak BA et al. (2023). \"Advances in human oxytocin measurement: challenges and proposed solutions.\" Molecular Psychiatry (Nature) 28:1–14", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35999276/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Advances+in+human+oxytocin+measurement%3A+challenges+and+proposed+solutions%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-36618821", "recordId": "pmid-36618821", "title": "The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior", "journal": "Frontiers in molecular neuroscience", "year": 2022, "authors": "Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.", "design": "Narrative review of receptor-complex studies", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/36618821/", "https://doi.org/10.3389/fnmol.2022.1055344" ], "quotes": [], "summary": "The review describes OXTR-containing receptor complexes, including dopamine D2 receptor–OXTR complexes reported in rat striatal regions, and discusses potential functional consequences for behaviour.", "relatedVersions": [], "limitation": "Receptor complex formation and signalling do not establish human DRD2 transcriptional regulation. This review does not test sensory interventions, the Fibonacci hypothesis or all proposed target relationships.", "citationCount": null, "sourcePages": [], "doi": "10.3389/fnmol.2022.1055344", "pmid": "36618821", "targets": [ "OXTR", "OXT", "DRD2" ], "categories": [ "Molecular biomarkers", "Methods & context" ], "sourceReferences": [ { "ref": "NPL-29", "recordId": "pmid-36618821", "sourceType": "Review", "title": "The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.", "authors": "Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.", "year": 2022, "journal": "Frontiers in molecular neuroscience", "doi": "10.3389/fnmol.2022.1055344", "pmid": "36618821", "pmcid": "PMC9812438", "patentNumber": null, "originalAssignee": null, "originalCitation": "Busnelli M, Bhatt S (2022). \"The oxytocin receptor represents a key hub in the GPCR signaling network.\" Frontiers in Endocrinology (PMC 9812438)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36618821/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffnmol.2022.1055344%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-11aecd75cd9043", "recordId": "hsi-11aecd75cd9043", "title": "The Multifaceted Role of Oxytocinergic System and <i>OXTR</i> Gene.", "journal": "Global medical genetics", "year": 2024, "authors": "Hasan R.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38239807/", "https://doi.org/10.1055/s-0044-1779039", "https://pmc.ncbi.nlm.nih.gov/articles/PMC10796195/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1055/s-0044-1779039", "pmid": "38239807", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-30", "recordId": "hsi-11aecd75cd9043", "sourceType": "Review", "title": "The Multifaceted Role of Oxytocinergic System and <i>OXTR</i> Gene.", "authors": "Hasan R.", "year": 2024, "journal": "Global medical genetics", "doi": "10.1055/s-0044-1779039", "pmid": "38239807", "pmcid": "PMC10796195", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cataldo I et al. (2024). \"The Multifaceted Role of Oxytocinergic System and OXTR Gene.\" International Journal of Molecular Sciences (PMC 10796195)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38239807/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC10796195&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-11792664", "recordId": "pmid-11792664", "title": "Baroreflex control of heart rate by oxytocin in the solitary-vagal complex", "journal": "American journal of physiology. 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Regulatory, integrative and comparative physiology", "doi": "10.1152/ajpregu.00806.2000", "pmid": "11792664", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Higa KT et al. (2002). \"Baroreflex control of heart rate by oxytocin in the solitary-vagal complex.\" American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 282(2):R537–R545 (PMID 11792664)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/11792664/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11792664+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-27790154", "recordId": "pmid-27790154", "title": "Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats", "journal": "Frontiers in physiology", "year": 2016, "authors": "De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.", "design": "", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/27790154/", "https://doi.org/10.3389/fphys.2016.00461", "https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full" ], "quotes": [], "summary": "", "relatedVersions": [], "limitation": "", "citationCount": null, "sourcePages": [], "doi": "10.3389/fphys.2016.00461", "pmid": "27790154", "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Heart rate & autonomic", "Brain & nervous system" ], "sourceReferences": [ { "ref": "NPL-32", "recordId": "pmid-27790154", "sourceType": "Journal publication", "title": "Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats.", "authors": "De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.", "year": 2016, "journal": "Frontiers in physiology", "doi": "10.3389/fphys.2016.00461", "pmid": "27790154", "pmcid": "PMC5063006", "patentNumber": null, "originalAssignee": null, "originalCitation": "Martins AS et al. (2016). \"Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus.\" Frontiers in Physiology (PMC 5063006)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27790154/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffphys.2016.00461%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-12531722", "recordId": "pmid-12531722", "title": "Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice", "journal": "American journal of physiology. Heart and circulatory physiology", "year": 2003, "authors": "Michelini LC, Marcelo MC, Amico J, Morris M.", "design": "", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/12531722/", "https://doi.org/10.1152/ajpheart.00774.2002", "https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2002" ], "quotes": [], "summary": "", "relatedVersions": [], "limitation": "", "citationCount": null, "sourcePages": [], "doi": "10.1152/ajpheart.00774.2002", "pmid": "12531722", "targets": [ "OXT" ], "categories": [ "Molecular biomarkers", "Heart rate & autonomic", "Brain & nervous system" ], "sourceReferences": [ { "ref": "NPL-33", "recordId": "pmid-12531722", "sourceType": "Journal publication", "title": "Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.", "authors": "Michelini LC, Marcelo MC, Amico J, Morris M.", "year": 2003, "journal": "American journal of physiology. Heart and circulatory physiology", "doi": "10.1152/ajpheart.00774.2002", "pmid": "12531722", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Michelini LC et al. (2003). \"Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.\" American Journal of Physiology – Heart and Circulatory Physiology 284(6):H2269–H2276", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/12531722/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocinergic+regulation+of+cardiovascular+function%3A+studies+in+oxytocin-deficient+mice%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-pmid-2914733", "recordId": "pmid-2914733", "title": "Baroreceptor influences on oxytocin and vasopressin secretion", "journal": "Hypertension (Dallas, Tex. : 1979)", "year": 1989, "authors": "Morris M, Alexander N.", "design": "", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/2914733/", "https://doi.org/10.1161/01.hyp.13.2.110", "https://www.ahajournals.org/doi/abs/10.1161/01.HYP.13.2.110" ], "quotes": [], "summary": "", "relatedVersions": [], "limitation": "", "citationCount": null, "sourcePages": [], "doi": "10.1161/01.hyp.13.2.110", "pmid": "2914733", "targets": [ "OXT" ], "categories": [ "Molecular biomarkers" ], "sourceReferences": [ { "ref": "NPL-34", "recordId": "pmid-2914733", "sourceType": "Journal publication", "title": "Baroreceptor influences on oxytocin and vasopressin secretion.", "authors": "Morris M, Alexander N.", "year": 1989, "journal": "Hypertension (Dallas, Tex. : 1979)", "doi": "10.1161/01.hyp.13.2.110", "pmid": "2914733", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Haanwinckel MA et al. (1995). \"Baroreceptor influences on oxytocin and vasopressin secretion.\" Experimental Physiology (PMID 2914733)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/2914733/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A2914733+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-9cc2ba2f0010e1", "recordId": "hsi-9cc2ba2f0010e1", "title": "Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.", "journal": "International journal of molecular sciences", "year": 2021, "authors": "Szczepanska-Sadowska E, Wsol A, Cudnoch-Jedrzejewska A, Żera T.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/34768894/", "https://doi.org/10.3390/ijms222111465", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8584236/" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/ijms222111465", "pmid": "34768894", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-35", "recordId": "hsi-9cc2ba2f0010e1", "sourceType": "Review", "title": "Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.", "authors": "Szczepanska-Sadowska E, Wsol A, Cudnoch-Jedrzejewska A, Żera T.", "year": 2021, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms222111465", "pmid": "34768894", "pmcid": "PMC8584236", "patentNumber": null, "originalAssignee": null, "originalCitation": "Japundžić-Žigon N et al. (2021). \"Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.\" International Journal of Molecular Sciences (PMC 8584236)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34768894/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8584236&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-4904d75ff35109", "recordId": "hsi-4904d75ff35109", "title": "Neuromodulation by oxytocin and vasopressin.", "journal": "Neuron", "year": 2012, "authors": "Stoop R.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/23040812/", "https://doi.org/10.1016/j.neuron.2012.09.025" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.neuron.2012.09.025", "pmid": "23040812", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-36", "recordId": "hsi-4904d75ff35109", "sourceType": "Review", "title": "Neuromodulation by oxytocin and vasopressin.", "authors": "Stoop R.", "year": 2012, "journal": "Neuron", "doi": "10.1016/j.neuron.2012.09.025", "pmid": "23040812", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Stoop R (2012). \"Neuromodulation by Oxytocin and Vasopressin.\" Frontiers in Neuroscience 6:335", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/23040812/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Neuromodulation+by+Oxytocin+and+Vasopressin%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-c15e2698527a36", "recordId": "hsi-c15e2698527a36", "title": "Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats.", "journal": "British journal of pharmacology", "year": 2014, "authors": "Lozić M, Greenwood M, Šarenac O, Martin A, Hindmarch C, Tasić T, Paton J, Murphy D, Japundžić-Žigon N.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/24834854/", "https://doi.org/10.1111/bph.12776", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4209146/" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1111/bph.12776", "pmid": "24834854", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-37", "recordId": "hsi-c15e2698527a36", "sourceType": "Journal publication", "title": "Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats.", "authors": "Lozić M, Greenwood M, Šarenac O, Martin A, Hindmarch C, Tasić T, Paton J, Murphy D, Japundžić-Žigon N.", "year": 2014, "journal": "British journal of pharmacology", "doi": "10.1111/bph.12776", "pmid": "24834854", "pmcid": "PMC4209146", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wsol A et al. (2014). \"Overexpression of oxytocin receptors in the hypothalamic PVN enhances cardiovascular regulation.\" Journal of Physiology and Pharmacology (PMC 4209146)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/24834854/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1111%2Fbph.12776%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-4471c0cab6e122", "recordId": "hsi-4471c0cab6e122", "title": "Evaluation and Diagnosis of Afferent Baroreflex Failure.", "journal": "Hypertension (Dallas, Tex. : 1979)", "year": 2022, "authors": "Biaggioni I, Shibao CA, Jordan J.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/34878899/", "https://doi.org/10.1161/hypertensionaha.121.18372", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8761245/" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1161/hypertensionaha.121.18372", "pmid": "34878899", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-38", "recordId": "hsi-4471c0cab6e122", "sourceType": "Journal publication", "title": "Evaluation and Diagnosis of Afferent Baroreflex Failure.", "authors": "Biaggioni I, Shibao CA, Jordan J.", "year": 2022, "journal": "Hypertension (Dallas, Tex. : 1979)", "doi": "10.1161/hypertensionaha.121.18372", "pmid": "34878899", "pmcid": "PMC8761245", "patentNumber": null, "originalAssignee": null, "originalCitation": "Norcliffe-Kaufmann L et al. (2022). \"Evaluation and Diagnosis of Afferent Baroreflex Failure.\" Clinical Autonomic Research (PMC 8761245)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34878899/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8761245&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-25e3cdf609e7e8", "recordId": "hsi-25e3cdf609e7e8", "title": "Beyond the Baroreflex: A New Measure of Autonomic Regulation", "journal": "", "year": 2022, "authors": "Lorthois S, Bhatt S", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-39", "recordId": "hsi-25e3cdf609e7e8", "sourceType": "Bibliographic source", "title": "Beyond the Baroreflex: A New Measure of Autonomic Regulation", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Lorthois S, Bhatt S (2022). \"Beyond the Baroreflex: A New Measure of Autonomic Regulation.\" Frontiers in Network Physiology 2:891604", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-optical-physiology-hsi-2c85ce08716726", "recordId": "hsi-2c85ce08716726", "title": "Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.", "journal": "Frontiers in neuroscience", "year": 2018, "authors": "Miki K, Yoshimoto M.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30083091/", "https://doi.org/10.3389/fnins.2018.00493", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6064938/" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3389/fnins.2018.00493", "pmid": "30083091", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-40", "recordId": "hsi-2c85ce08716726", "sourceType": "Review", "title": "Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.", "authors": "Miki K, Yoshimoto M.", "year": 2018, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2018.00493", "pmid": "30083091", "pmcid": "PMC6064938", "patentNumber": null, "originalAssignee": null, "originalCitation": "Fadel PJ (2015). \"Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.\" Frontiers in Neuroscience 9:493", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30083091/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Exercise-Induced+Modulation+of+Baroreflex+Control+of+Sympathetic+Nerve+Activity%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-b4a2f9f50b86b4", "recordId": "hsi-b4a2f9f50b86b4", "title": "Baroreflex functionality in the eye of diffusion tensor imaging.", "journal": "The Journal of physiology", "year": 2019, "authors": "Tsai CY, Poon YY, Chan JYH, Chan SHH.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30325020/", "https://doi.org/10.1113/jp277008" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1113/jp277008", "pmid": "30325020", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-41", "recordId": "hsi-b4a2f9f50b86b4", "sourceType": "Review", "title": "Baroreflex functionality in the eye of diffusion tensor imaging.", "authors": "Tsai CY, Poon YY, Chan JYH, Chan SHH.", "year": 2019, "journal": "The Journal of physiology", "doi": "10.1113/jp277008", "pmid": "30325020", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Reisert M et al. (2018). \"Baroreflex functionality in the eye of diffusion tensor imaging.\" NeuroImage: Clinical (PMC 6312450)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30325020/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Baroreflex+functionality+in+the+eye+of+diffusion+tensor+imaging%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-27332000a2bc2d", "recordId": "hsi-27332000a2bc2d", "title": "DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.", "journal": "Social cognitive and affective neuroscience", "year": 2018, "authors": "Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30257007/", "https://doi.org/10.1093/scan/nsy086", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6234329/" ], "quotes": [], "summary": "Reference associated with Baroreflex Modulation by Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1093/scan/nsy086", "pmid": "30257007", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-42", "recordId": "hsi-27332000a2bc2d", "sourceType": "Journal publication", "title": "DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.", "authors": "Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ.", "year": 2018, "journal": "Social cognitive and affective neuroscience", "doi": "10.1093/scan/nsy086", "pmid": "30257007", "pmcid": "PMC6234329", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ (2018). \"DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.\" Social Cognitive and Affective Neuroscience 13(11):1155–1163 (PMID 30257007; PMC6234329)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30257007/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A30257007+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-a738a60b4fd69e", "recordId": "hsi-a738a60b4fd69e", "title": "Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities.", "journal": "Scientific reports", "year": 2018, "authors": "Liu J, Luo H, Zheng PP, Wu SJ, Lee K.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30002447/", "https://doi.org/10.1038/s41598-018-28804-0", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6043515/" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41598-018-28804-0", "pmid": "30002447", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-43", "recordId": "hsi-a738a60b4fd69e", "sourceType": "Journal publication", "title": "Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities.", "authors": "Liu J, Luo H, Zheng PP, Wu SJ, Lee K.", "year": 2018, "journal": "Scientific reports", "doi": "10.1038/s41598-018-28804-0", "pmid": "30002447", "pmcid": "PMC6043515", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wei J et al. (2018). \"Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities.\" Scientific Reports (Nature) 8:10588", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30002447/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Transdermal+optical+imaging+revealed+different+spatiotemporal+patterns+of+facial+cardiovascular+activities%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-cefd1a89919598", "recordId": "hsi-cefd1a89919598", "title": "Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease.", "journal": "Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists", "year": 2023, "authors": "Kleiss SF, Ma KF, El Moumni M, Ünlü Ç, Nijboer TS, Schuurmann RCL, Bokkers RPH, de Vries JPM.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/35255764/", "https://doi.org/10.1177/15266028221082013", "https://pmc.ncbi.nlm.nih.gov/articles/PMC10209500/" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1177/15266028221082013", "pmid": "35255764", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-44", "recordId": "hsi-cefd1a89919598", "sourceType": "Journal publication", "title": "Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease.", "authors": "Kleiss SF, Ma KF, El Moumni M, Ünlü Ç, Nijboer TS, Schuurmann RCL, Bokkers RPH, de Vries JPM.", "year": 2023, "journal": "Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists", "doi": "10.1177/15266028221082013", "pmid": "35255764", "pmcid": "PMC10209500", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chin MS et al. (2023). \"Detecting Changes in Tissue Perfusion With Hyperspectral Imaging.\" Advances in Wound Care (PMC 10209500)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35255764/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1177%2F15266028221082013%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-f6c36daef82123", "recordId": "hsi-f6c36daef82123", "title": "New evidence from hyperspectral imaging analysis on the effect of wound dressings", "journal": "", "year": 2021, "authors": "Weingarten MS et al.", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-45", "recordId": "hsi-f6c36daef82123", "sourceType": "Bibliographic source", "title": "New evidence from hyperspectral imaging analysis on the effect of wound dressings", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Weingarten MS et al. (2021). \"New evidence from hyperspectral imaging analysis on the effect of wound dressings.\" International Wound Journal (PMID 34436694)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "identifier-conflict", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Supplied identifier and cited title conflict. No replacement publication has been accepted." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-optical-physiology-hsi-cc72c20d20ad93", "recordId": "hsi-cc72c20d20ad93", "title": "Investigation on the influence of the skin tone on hyperspectral imaging for free flap surgery.", "journal": "Scientific reports", "year": 2024, "authors": "Pachyn E, Aumiller M, Freymüller C, Linek M, Volgger V, Buchner A, Rühm A, Sroka R.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38886457/", "https://doi.org/10.1038/s41598-024-64549-9", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11183063/" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41598-024-64549-9", "pmid": "38886457", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-46", "recordId": "hsi-cc72c20d20ad93", "sourceType": "Journal publication", "title": "Investigation on the influence of the skin tone on hyperspectral imaging for free flap surgery.", "authors": "Pachyn E, Aumiller M, Freymüller C, Linek M, Volgger V, Buchner A, Rühm A, Sroka R.", "year": 2024, "journal": "Scientific reports", "doi": "10.1038/s41598-024-64549-9", "pmid": "38886457", "pmcid": "PMC11183063", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wisotzky EL et al. (2024). \"Investigation on the influence of the skin tone on hyperspectral imaging.\" Scientific Reports (Nature) 14:14349", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38886457/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Investigation+on+the+influence+of+the+skin+tone+on+hyperspectral+imaging%22&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-474aae27e254f6", "recordId": "hsi-474aae27e254f6", "title": "Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review.", "journal": "Radiology and oncology", "year": 2022, "authors": "Hren R, Sersa G, Simoncic U, Milanic M.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/36503709/", "https://doi.org/10.2478/raon-2022-0051", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9784371/" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.2478/raon-2022-0051", "pmid": "36503709", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-47", "recordId": "hsi-474aae27e254f6", "sourceType": "Review", "title": "Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review.", "authors": "Hren R, Sersa G, Simoncic U, Milanic M.", "year": 2022, "journal": "Radiology and oncology", "doi": "10.2478/raon-2022-0051", "pmid": "36503709", "pmcid": "PMC9784371", "patentNumber": null, "originalAssignee": null, "originalCitation": "Barberio M et al. (2022). \"Imaging perfusion changes in oncological clinical applications by hyperspectral imaging.\" Journal of Biomedical Optics (PMID 36503709)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36503709/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A36503709+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-66bec84627b0dc", "recordId": "hsi-66bec84627b0dc", "title": "Review on the Application of Hyperspectral Imaging Technology of Microbiological and Chemical Properties of Food", "journal": "", "year": 2022, "authors": "Chen H et al.", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-48", "recordId": "hsi-66bec84627b0dc", "sourceType": "Bibliographic source", "title": "Review on the Application of Hyperspectral Imaging Technology of Microbiological and Chemical Properties of Food", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Chen H et al. (2022). \"Review on the Application of Hyperspectral Imaging Technology of Microbiological and Chemical Properties of Food.\" Frontiers in Bioengineering and Biotechnology 10:906728", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-optical-physiology-hsi-9d14d253c181bc", "recordId": "hsi-9d14d253c181bc", "title": "Detecting Happiness Using Hyperspectral Imaging Technology.", "journal": "Computational intelligence and neuroscience", "year": 2019, "authors": "Hao M, Liu G, Gokhale A, Xu Y, Chen R.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30766598/", "https://doi.org/10.1155/2019/1965789", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6350538/" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1155/2019/1965789", "pmid": "30766598", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-49", "recordId": "hsi-9d14d253c181bc", "sourceType": "Journal publication", "title": "Detecting Happiness Using Hyperspectral Imaging Technology.", "authors": "Hao M, Liu G, Gokhale A, Xu Y, Chen R.", "year": 2019, "journal": "Computational intelligence and neuroscience", "doi": "10.1155/2019/1965789", "pmid": "30766598", "pmcid": "PMC6350538", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yang Y et al. (2019). \"Detecting Happiness Using Hyperspectral Imaging Technology.\" Computational Intelligence and Neuroscience 2019:1965789", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30766598/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Detecting+Happiness+Using+Hyperspectral+Imaging+Technology%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-113f6b6b7e2532", "recordId": "hsi-113f6b6b7e2532", "title": "A novel role of oxytocin: Oxytocin-induced well-being in humans.", "journal": "Biophysics and physicobiology", "year": 2019, "authors": "Ito E, Shima R, Yoshioka T.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/31608203/", "https://doi.org/10.2142/biophysico.16.0_132", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6784812/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.2142/biophysico.16.0_132", "pmid": "31608203", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-50", "recordId": "hsi-113f6b6b7e2532", "sourceType": "Journal publication", "title": "A novel role of oxytocin: Oxytocin-induced well-being in humans.", "authors": "Ito E, Shima R, Yoshioka T.", "year": 2019, "journal": "Biophysics and physicobiology", "doi": "10.2142/biophysico.16.0_132", "pmid": "31608203", "pmcid": "PMC6784812", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ishak WW et al. (2011). \"A novel role of oxytocin: Oxytocin-induced well-being in humans.\" International Journal of Psychiatry in Medicine (PMC 6784812)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31608203/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC6784812&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-f85613b2aab02b", "recordId": "hsi-f85613b2aab02b", "title": "Considerations in the development of oxytocin-based therapeutics", "journal": "", "year": 2013, "authors": "Bhatt S, Young KA", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-51", "recordId": "hsi-f85613b2aab02b", "sourceType": "Bibliographic source", "title": "Considerations in the development of oxytocin-based therapeutics", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Bhatt S, Young KA (2013). \"Considerations in the development of oxytocin-based therapeutics.\" Frontiers in Neuroscience 7:35", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-optical-physiology-hsi-d85459e14c4885", "recordId": "hsi-d85459e14c4885", "title": "Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults.", "journal": "Psychoneuroendocrinology", "year": 2024, "authors": "Shoenfelt A, Pehlivanoglu D, Lin T, Ziaei M, Feifel D, Ebner NC.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38461634/", "https://doi.org/10.1016/j.psyneuen.2024.107018", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11699979/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.psyneuen.2024.107018", "pmid": "38461634", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-52", "recordId": "hsi-d85459e14c4885", "sourceType": "Journal publication", "title": "Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults.", "authors": "Shoenfelt A, Pehlivanoglu D, Lin T, Ziaei M, Feifel D, Ebner NC.", "year": 2024, "journal": "Psychoneuroendocrinology", "doi": "10.1016/j.psyneuen.2024.107018", "pmid": "38461634", "pmcid": "PMC11699979", "patentNumber": null, "originalAssignee": null, "originalCitation": "Peled-Avron L et al. (2024). \"Effects of chronic intranasal oxytocin on visual attention to faces.\" Psychopharmacology (PMC 11699979)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38461634/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC11699979&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-a6d1ba2316c08d", "recordId": "hsi-a6d1ba2316c08d", "title": "Effects of Oxytocin on Facial Expression and Identity Working Memory Are Found in Females but Not Males.", "journal": "Frontiers in neuroscience", "year": 2018, "authors": "Yue T, Yue C, Liu G, Huang X.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/29719496/", "https://doi.org/10.3389/fnins.2018.00205", "https://pmc.ncbi.nlm.nih.gov/articles/PMC5913342/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3389/fnins.2018.00205", "pmid": "29719496", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-53", "recordId": "hsi-a6d1ba2316c08d", "sourceType": "Journal publication", "title": "Effects of Oxytocin on Facial Expression and Identity Working Memory Are Found in Females but Not Males.", "authors": "Yue T, Yue C, Liu G, Huang X.", "year": 2018, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2018.00205", "pmid": "29719496", "pmcid": "PMC5913342", "patentNumber": null, "originalAssignee": null, "originalCitation": "Gao S et al. (2018). \"Effects of Oxytocin on Facial Expression and Identity Working Memory.\" Frontiers in Pharmacology (PMC 5913342)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/29719496/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC5913342&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-2d570b00f2ccf3", "recordId": "hsi-2d570b00f2ccf3", "title": "The Role of Oxytocin in Cardiovascular Protection.", "journal": "Frontiers in psychology", "year": 2020, "authors": "Jankowski M, Broderick TL, Gutkowska J.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/32982875/", "https://doi.org/10.3389/fpsyg.2020.02139", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7477297/" ], "quotes": [], "summary": "Reference associated with OXTR Influence on Facial Microcirculation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3389/fpsyg.2020.02139", "pmid": "32982875", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-54", "recordId": "hsi-2d570b00f2ccf3", "sourceType": "Review", "title": "The Role of Oxytocin in Cardiovascular Protection.", "authors": "Jankowski M, Broderick TL, Gutkowska J.", "year": 2020, "journal": "Frontiers in psychology", "doi": "10.3389/fpsyg.2020.02139", "pmid": "32982875", "pmcid": "PMC7477297", "patentNumber": null, "originalAssignee": null, "originalCitation": "Jankowski M et al. (2020). \"The Role of Oxytocin in Cardiovascular Protection.\" Frontiers in Psychology 11:2139", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/32982875/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22The+Role+of+Oxytocin+in+Cardiovascular+Protection%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-688691ea42776f", "recordId": "hsi-688691ea42776f", "title": "Hyperspectral imaging for non-invasive blood oxygen saturation assessment", "journal": "Photodiagnosis and Photodynamic Therapy", "year": 2024, "authors": "Jiangbo Wu", "design": "Journal publication", "urls": [ "https://doi.org/10.1016/j.pdpdt.2024.104003" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.pdpdt.2024.104003", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-55", "recordId": "hsi-688691ea42776f", "sourceType": "Journal publication", "title": "Hyperspectral imaging for non-invasive blood oxygen saturation assessment", "authors": "Jiangbo Wu", "year": 2024, "journal": "Photodiagnosis and Photodynamic Therapy", "doi": "10.1016/j.pdpdt.2024.104003", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Zhang Y et al. (2024). \"Hyperspectral imaging for non-invasive blood oxygen saturation measurement.\" Computers in Biology and Medicine", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1016/j.pdpdt.2024.104003", "metadataURL": "https://api.crossref.org/works?query.title=Hyperspectral+imaging+for+non-invasive+blood+oxygen+saturation+measurement&rows=3", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-fdb97b4e29c7dd", "recordId": "hsi-fdb97b4e29c7dd", "title": "Evaluation of hyperspectral imaging to quantify perfusion changes", "journal": "", "year": 2023, "authors": "Hellmann T et al.", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Detectability by HSI / Optical Imaging.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-56", "recordId": "hsi-fdb97b4e29c7dd", "sourceType": "Bibliographic source", "title": "Evaluation of hyperspectral imaging to quantify perfusion changes", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Hellmann T et al. (2023). \"Evaluation of hyperspectral imaging to quantify perfusion changes.\" Lasers in Surgery and Medicine 55(5):468–476", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-optical-physiology-hsi-bb8bd49cde6956", "recordId": "hsi-bb8bd49cde6956", "title": "Practical RGB Measurement of Fluorescence and Blood Distributions in Skin", "journal": "Color and Imaging Conference", "year": 2024, "authors": "Emilie Nogué; Arvin Lin; Xiaohui Li; Giuseppe Claudio Guarnera; Abhijeet Ghosh", "design": "Conference publication", "urls": [ "https://doi.org/10.2352/cic.2024.32.1.24" ], "quotes": [], "summary": "Reference associated with RGB Measurement of Fluorescence and Blood Distributions in Skin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.2352/cic.2024.32.1.24", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-164", "recordId": "hsi-bb8bd49cde6956", "sourceType": "Conference publication", "title": "Practical RGB Measurement of Fluorescence and Blood Distributions in Skin", "authors": "Emilie Nogué; Arvin Lin; Xiaohui Li; Giuseppe Claudio Guarnera; Abhijeet Ghosh", "year": 2024, "journal": "Color and Imaging Conference", "doi": "10.2352/cic.2024.32.1.24", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Nogué S, Maguire C, Sherlock A et al. (2024). \"Practical RGB Measurement of Fluorescence and Blood Distributions in Skin.\" Color and Imaging Conference 32(1):133–141 — Commodity RGB cameras isolate elastin fluorescence + haemoglobin/melanin chromophores via Donaldson re-radiation matrices; no UV capture or dense hyperspectral rig required", "originalSection": "RGB Measurement of Fluorescence and Blood Distributions in Skin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.2352/cic.2024.32.1.24", "metadataURL": "https://api.crossref.org/works/10.2352%2FCIC.2024.32.1.24", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Conference publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-f85cb98f5b77d1", "recordId": "hsi-f85cb98f5b77d1", "title": "Digital cutaneous fluorometry: correlation between blood flow and fluorescence.", "journal": "Journal of vascular surgery", "year": 1984, "authors": "Bongard FS, Upton RA, Elings VB, Lewis FR.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/6502833/", "https://doi.org/10.1016/0741-5214(84)90128-9" ], "quotes": [], "summary": "Reference associated with RGB Measurement of Fluorescence and Blood Distributions in Skin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/0741-5214(84)90128-9", "pmid": "6502833", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-187", "recordId": "hsi-f85cb98f5b77d1", "sourceType": "Journal publication", "title": "Digital cutaneous fluorometry: correlation between blood flow and fluorescence.", "authors": "Bongard FS, Upton RA, Elings VB, Lewis FR.", "year": 1984, "journal": "Journal of vascular surgery", "doi": "10.1016/0741-5214(84)90128-9", "pmid": "6502833", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "\"Digital cutaneous fluorometry: Correlation between blood flow and fluorescence.\" Journal of Vascular Surgery 1(5):635–641 (1984) (ScienceDirect PII: 0741521484901289) — Established that tissue fluorescence intensity is linearly related to blood flow using digital cutaneous fluorometry; foundational evidence that perfusion conclusions can be drawn from relative fluorescence measurements in skin", "originalSection": "RGB Measurement of Fluorescence and Blood Distributions in Skin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/6502833/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Digital+cutaneous+fluorometry%3A+Correlation+between+blood+flow+and+fluorescence%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-30eaacfb450209", "recordId": "hsi-30eaacfb450209", "title": "Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer.", "journal": "Scientific reports", "year": 2023, "authors": "Yang KY, Mukundan A, Tsao YM, Shi XH, Huang CW, Wang HC.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/37993660/", "https://doi.org/10.1038/s41598-023-47833-y", "https://pmc.ncbi.nlm.nih.gov/articles/PMC10665456/" ], "quotes": [], "summary": "The study compares white-light, narrowband and reconstructed endoscopic images in an esophageal-cancer image dataset using colour-difference, entropy and structural-similarity measures.", "relatedVersions": [], "limitation": "Image-quality comparisons do not by themselves establish prospective patient-level diagnostic accuracy. The setting is endoscopy, with distinct acquisition and validation requirements.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41598-023-47833-y", "pmid": "37993660", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-221", "recordId": "hsi-30eaacfb450209", "sourceType": "Journal publication", "title": "Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer.", "authors": "Yang KY, Mukundan A, Tsao YM, Shi XH, Huang CW, Wang HC.", "year": 2023, "journal": "Scientific reports", "doi": "10.1038/s41598-023-47833-y", "pmid": "37993660", "pmcid": "PMC10665456", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yang TH, Cheng YW, Wang YT, Huang TW, Kang CW, Pan CT, Kuo HY, Chung CH, Chen CC, Liao YS (2023). \"Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer.\" Scientific Reports (Nature) 13:20502. DOI: 10.1038/s41598-023-47833-y — SAVE HSI engine (Hitspectra Intelligent Technology, Kaohsiung, Taiwan) reconstructing hyperspectral imaging from standard RGB endoscopic video; CycleGAN narrowband imaging simulation; real-time ~25 fps; clinically superior early esophageal cancer inference vs conventional white-light imaging; validates HSI reconstruction from standard cameras for medical tissue inference in peer-reviewed clinical context", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37993660/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41598-023-47833-y%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-optical-physiology-hsi-33a52b5cee68bb", "recordId": "hsi-33a52b5cee68bb", "title": "Medicine — Guiding machine vision with hyperspectral images", "journal": "", "year": null, "authors": "", "design": "Institutional, commercial or web source", "urls": [ "http://hitspectra.com/en/application.php?CNo=1" ], "quotes": [], "summary": "Reference associated with Hyperspectral Imaging via Smartphone.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-222", "recordId": "hsi-33a52b5cee68bb", "sourceType": "Institutional, commercial or web source", "title": "Medicine — Guiding machine vision with hyperspectral images", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Hitspectra Intelligent Technology Co., Ltd. (Kaohsiung, Taiwan). \"Medicine — Guiding machine vision with hyperspectral images.\" hitspectra.com/en/application.php?CNo=1 — Commercial HSI integration with standard medical lenses: dermatoscope (85% accuracy for skin pigment and haemoglobin abnormalities), ophthalmoscope (fundus layer analysis for retinal disease, glaucoma, optic nerve pathology), odontoscope (oral cancer staging, accuracy expected to reach 99.9%); SAVE HSI engine expanding 400+ analysable spectral channels from a single pixel of standard camera input; AI-assisted pathological image analysis; non-invasive disease identification without biopsy. All applications target tissue morphology via specialised medical lens hardware — not gene expression, not consumer smartphone cameras, not mental health", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://hitspectra.com/en/application.php?CNo=1", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "optical-physiology", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." } ] }, { "id": "autofluorescence-sensing", "number": "11.4", "title": "Autofluorescence and Molecular Sensing", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "Autofluorescence describes light emitted by endogenous molecules after excitation. The cited work covers metabolic coenzymes, proteins, tissue fluorescence and image analysis. Interpretation depends on excitation and emission bands, optical depth, background signals and the mixture of fluorophores in the sample.", "The bibliography also includes chemical probes, immunoassays and genetically encoded sensors. These methods need explicit labels for reagents, sample preparation, instrumentation and biological setting. A smartphone-linked assay and an unmodified phone camera observing intact skin are different experimental systems. Fractal descriptions and molecular geometry remain research frameworks to test against measured data." ], "papers": [ { "id": "general-autofluorescence-sensing-hsi-db701719d4dfca", "recordId": "hsi-db701719d4dfca", "title": "Development of a Smartphone-Linked Immunosensing System for Oxytocin Determination.", "journal": "Biosensors", "year": 2025, "authors": "Sarubo M, Suzuki Y, Numazaki Y, Kudo H.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/40277575/", "https://doi.org/10.3390/bios15040261", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12025206/" ], "quotes": [], "summary": "A smartphone camera measures colour reactions in an oxytocin ELISA using an LED-linked optical unit. The reported results compare the image-derived measure with conventional ELISA.", "relatedVersions": [], "limitation": "The method uses immunoassay reagents and a prepared sample. It does not measure circulating oxytocin from an ordinary facial photograph.", "citationCount": null, "sourcePages": [], "doi": "10.3390/bios15040261", "pmid": "40277575", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-165", "recordId": "hsi-db701719d4dfca", "sourceType": "Journal publication", "title": "Development of a Smartphone-Linked Immunosensing System for Oxytocin Determination.", "authors": "Sarubo M, Suzuki Y, Numazaki Y, Kudo H.", "year": 2025, "journal": "Biosensors", "doi": "10.3390/bios15040261", "pmid": "40277575", "pmcid": "PMC12025206", "patentNumber": null, "originalAssignee": null, "originalCitation": "Sarubo K, Ishida Y, Kawano S et al. (2025). \"Smartphone-Linked Optical Immunosensing for Oxytocin Determination in Human Saliva.\" Biosensors 15(4):261 (PMC 12025206) — LED backlight + CMOS camera ELISA readout; inference limit 5.26 pg/mL salivary OXT; r = 0.972 vs conventional ELISA. Invasive (saliva + reagents + physical cell attachment)", "originalSection": "Smartphone-Linked Immunosensing for Oxytocin Determination", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40277575/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fbios15040261%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-93d8a400352b6c", "recordId": "hsi-93d8a400352b6c", "title": "Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.", "journal": "Frontiers in neuroscience", "year": 2014, "authors": "Hashimoto H, Matsuura T, Ueta Y.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/25100939/", "https://doi.org/10.3389/fnins.2014.00213", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4107947/" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3389/fnins.2014.00213", "pmid": "25100939", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-166", "recordId": "hsi-93d8a400352b6c", "sourceType": "Review", "title": "Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.", "authors": "Hashimoto H, Matsuura T, Ueta Y.", "year": 2014, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2014.00213", "pmid": "25100939", "pmcid": "PMC4107947", "patentNumber": null, "originalAssignee": null, "originalCitation": "Hashimoto H, Matsuura T, Ueta Y (2014). \"Fluorescent Visualization of Oxytocin in the Hypothalamo-Neurohypophysial System.\" Frontiers in Neuroscience 8:213 (PMC 4107947) — OXT-mRFP1 transgenic rats; visible fluorescence in hypothalamic OXT neurons and posterior pituitary; 5–7× fluorescence increase with OXT expression under salt loading", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25100939/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC4107947&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-8ad27b6daef8ac", "recordId": "hsi-8ad27b6daef8ac", "title": "A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.", "journal": "Nature methods", "year": 2022, "authors": "Ino D, Tanaka Y, Hibino H, Nishiyama M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/36138174/", "https://doi.org/10.1038/s41592-022-01597-x", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9550624/" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41592-022-01597-x", "pmid": "36138174", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-167", "recordId": "hsi-8ad27b6daef8ac", "sourceType": "Journal publication", "title": "A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.", "authors": "Ino D, Tanaka Y, Hibino H, Nishiyama M.", "year": 2022, "journal": "Nature methods", "doi": "10.1038/s41592-022-01597-x", "pmid": "36138174", "pmcid": "PMC9550624", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ino D, Tanaka Y, Hibino H et al. (2022). \"A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.\" Nature Methods 19(10):1286–1294 (PMC 9550624) — MTRIA_OT GPCR-based green fluorescent OXT sensor; fiber photometry; ultradian ~2 hr \"OT oscillation\"; intranasal/IP OXT <1% reaches brain", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36138174/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC9550624&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-9e3caca1a18860", "recordId": "hsi-9e3caca1a18860", "title": "Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor.", "journal": "Molecules (Basel, Switzerland)", "year": 2022, "authors": "Santonocito R, Tuccitto N, Pappalardo A, Trusso Sfrazzetto G.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/36364331/", "https://doi.org/10.3390/molecules27217503", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9654496/" ], "quotes": [], "summary": "Reference associated with Smartphone-Based Dopamine Inference by Fluorescent Supramolecular Sensor.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/molecules27217503", "pmid": "36364331", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-168", "recordId": "hsi-9e3caca1a18860", "sourceType": "Journal publication", "title": "Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor.", "authors": "Santonocito R, Tuccitto N, Pappalardo A, Trusso Sfrazzetto G.", "year": 2022, "journal": "Molecules (Basel, Switzerland)", "doi": "10.3390/molecules27217503", "pmid": "36364331", "pmcid": "PMC9654496", "patentNumber": null, "originalAssignee": null, "originalCitation": "Santonocito R, Tuccitto N, Pappalardo A, Trusso Sfrazzetto G (2022). \"Smartphone-Based Dopamine Inference by Fluorescent Supramolecular Sensor.\" Molecules 27(21):7503 (PMC 9654496) — Quinoxaline cavitand (Cav-4-Qx) on siloxane polymer; inference limit 1 pM; linear range 10 mM–100 pM; smartphone camera readout in dark chamber; good selectivity in artificial and real saliva; reusable via acid-base switching. Invasive (saliva + sensor strip + dark chamber)", "originalSection": "Smartphone-Based Dopamine Inference by Fluorescent Supramolecular Sensor", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36364331/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC9654496&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-d472a890e03c1b", "recordId": "hsi-d472a890e03c1b", "title": "Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.", "journal": "Biomarkers in medicine", "year": 2010, "authors": "Heikal AA.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/20406068/", "https://doi.org/10.2217/bmm.10.1", "https://pmc.ncbi.nlm.nih.gov/articles/PMC2905054/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.2217/bmm.10.1", "pmid": "20406068", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-169", "recordId": "hsi-d472a890e03c1b", "sourceType": "Review", "title": "Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.", "authors": "Heikal AA.", "year": 2010, "journal": "Biomarkers in medicine", "doi": "10.2217/bmm.10.1", "pmid": "20406068", "pmcid": "PMC2905054", "patentNumber": null, "originalAssignee": null, "originalCitation": "Heikal AA (2010). \"Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.\" Biomarkers in Medicine 4(2):241–263 (PMC 2924670) — NADPH autofluorescence as \"bellwether\" of intracellular redox states; directly couples metabolic activity to optical emission intensity", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/20406068/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Intracellular+coenzymes+as+natural+biomarkers+for+metabolic+activities+and+mitochondrial+anomalies%22&format=json&resultType=core&pageSize=4", "corrections": [ "A supplied identifier resolved to another title; the accepted record was matched separately by title." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-98a399171f2226", "recordId": "hsi-98a399171f2226", "title": "A general model for the origin of allometric scaling laws in biology.", "journal": "Science (New York, N.Y.)", "year": 1997, "authors": "West GB, Brown JH, Enquist BJ.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/9082983/", "https://doi.org/10.1126/science.276.5309.122" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1126/science.276.5309.122", "pmid": "9082983", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-170", "recordId": "hsi-98a399171f2226", "sourceType": "Journal publication", "title": "A general model for the origin of allometric scaling laws in biology.", "authors": "West GB, Brown JH, Enquist BJ.", "year": 1997, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.276.5309.122", "pmid": "9082983", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "West GB, Brown JH, Enquist BJ (1997). \"A General Model for the Origin of Allometric Scaling Laws in Biology.\" Science 276(5309):122–126 — Fractal-like branching networks govern biological scaling laws from cellular metabolism to whole-organism physiology; theoretical basis for cross-scale signal propagation", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/9082983/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22A+General+Model+for+the+Origin+of+Allometric+Scaling+Laws+in+Biology%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-e7e54aaae200fa", "recordId": "hsi-e7e54aaae200fa", "title": "Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.", "journal": "Cell", "year": 2020, "authors": "Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/33333022/", "https://doi.org/10.1016/j.cell.2020.11.040", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8025677/" ], "quotes": [], "summary": "Reference associated with Machine Learning-Directed Fluorescent Serotonin Sensor.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.cell.2020.11.040", "pmid": "33333022", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-171", "recordId": "hsi-e7e54aaae200fa", "sourceType": "Journal publication", "title": "Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.", "authors": "Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L.", "year": 2020, "journal": "Cell", "doi": "10.1016/j.cell.2020.11.040", "pmid": "33333022", "pmcid": "PMC8025677", "patentNumber": null, "originalAssignee": null, "originalCitation": "Unger EK, Keller JP, Altermatt M et al. (2020). \"Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.\" Cell 183(7):1986–2002 (DOI: 10.1016/j.cell.2020.11.040; Addgene #128483, pRSET-iSeroSnFR, Lin Tian Lab, UC Davis) — ML-guided binding-pocket redesign (Rosetta + random forest + GLM) produced iSeroSnFR genetically encoded fluorescent 5-HT sensor; >5,000× improved affinity over iAChSnFR0.6; 800% ΔF/F₀; ~350 pM inference; millisecond kinetics; fiber photometry in freely behaving mice (fear conditioning, social interaction, sleep/wake); OSTA assay for hSERT/SLC6A4 pharmacology (SSRIs, cocaine, MDMA). Invasive (genetically encoded sensor + viral delivery + implanted fiber optics)", "originalSection": "Machine Learning-Directed Fluorescent Serotonin Sensor", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33333022/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.cell.2020.11.040%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-51ceed09e76ab1", "recordId": "hsi-51ceed09e76ab1", "title": "The self-organizing fractal theory as a universal discovery method: the phenomenon of life.", "journal": "Theoretical biology & medical modelling", "year": 2011, "authors": "Kurakin A.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/21447162/", "https://doi.org/10.1186/1742-4682-8-4", "https://pmc.ncbi.nlm.nih.gov/articles/PMC3080324/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1186/1742-4682-8-4", "pmid": "21447162", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-172", "recordId": "hsi-51ceed09e76ab1", "sourceType": "Journal publication", "title": "The self-organizing fractal theory as a universal discovery method: the phenomenon of life.", "authors": "Kurakin A.", "year": 2011, "journal": "Theoretical biology & medical modelling", "doi": "10.1186/1742-4682-8-4", "pmid": "21447162", "pmcid": "PMC3080324", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kurakin A (2011). \"The self-organizing fractal theory as a universal discovery method: the phenomenon of life.\" Theoretical Biology and Medical Modelling 8:4 (PMC 3080324) — Self-organising fractal theory unifying biological organisation from molecular to organismal scale; fractal self-similarity as a universal design principle underlying metabolism, gene expression, and cellular dynamics", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21447162/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC3080324&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-970c306954834e", "recordId": "hsi-970c306954834e", "title": "Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.", "journal": "Journal of biomedical optics", "year": 2018, "authors": "Lloyd D, Murray DB, Aon MA, Cortassa S, Roussel MR, Beckmann M, Poole RK.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/30516036/", "https://doi.org/10.1117/1.jbo.24.5.051404", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6992908/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1117/1.jbo.24.5.051404", "pmid": "30516036", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-173", "recordId": "hsi-970c306954834e", "sourceType": "Journal publication", "title": "Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.", "authors": "Lloyd D, Murray DB, Aon MA, Cortassa S, Roussel MR, Beckmann M, Poole RK.", "year": 2018, "journal": "Journal of biomedical optics", "doi": "10.1117/1.jbo.24.5.051404", "pmid": "30516036", "pmcid": "PMC6992908", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lloyd D, Murray DB, Aon MA, Poole RK (2018). \"Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.\" Journal of Biomedical Optics (ResearchGate DOI: 10.1117/1.JBO.24.5.051404) — NAD(P)H autofluorescence as \"bellwether of intracellular redox states\"; cell as fractal multioscillator with self-similar temporal organisation from milliseconds to hours; two-photon fluorescence excitation at 740 nm, emission <490 nm for NAD(P)H imaging in cardiomyocytes and yeast", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30516036/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1117%2F1.JBO.24.5.051404%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-f69919e90b4809", "recordId": "hsi-f69919e90b4809", "title": "A healthy dose of chaos: Using fractal frameworks for engineering higher-fidelity biomedical systems.", "journal": "Biomaterials", "year": 2019, "authors": "Korolj A, Wu HT, Radisic M.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/31376747/", "https://doi.org/10.1016/j.biomaterials.2019.119363", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6759375/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.biomaterials.2019.119363", "pmid": "31376747", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-174", "recordId": "hsi-f69919e90b4809", "sourceType": "Review", "title": "A healthy dose of chaos: Using fractal frameworks for engineering higher-fidelity biomedical systems.", "authors": "Korolj A, Wu HT, Radisic M.", "year": 2019, "journal": "Biomaterials", "doi": "10.1016/j.biomaterials.2019.119363", "pmid": "31376747", "pmcid": "PMC6759375", "patentNumber": null, "originalAssignee": null, "originalCitation": "Korolj A, Wu HT, Radisic M (2019). \"A healthy dose of chaos: Using fractal frameworks for engineering higher-fidelity biomedical systems.\" Biomaterials 219:119363 (PMC 6759375) — Fractal dimension as quantitative health metric across biological systems; fractal frameworks for biomedical engineering; healthy biological systems exhibit characteristic fractal complexity that degrades in disease states", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31376747/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC6759375&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-890a81b217c123", "recordId": "hsi-890a81b217c123", "title": "Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "year": 2016, "authors": "Dong B, Almassalha LM, Stypula-Cyrus Y, Urban BE, Chandler JE, Nguyen TQ, Sun C, Zhang HF, Backman V.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/27535934/", "https://doi.org/10.1073/pnas.1602202113", "https://pmc.ncbi.nlm.nih.gov/articles/PMC5024634/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1073/pnas.1602202113", "pmid": "27535934", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-175", "recordId": "hsi-890a81b217c123", "sourceType": "Journal publication", "title": "Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.", "authors": "Dong B, Almassalha LM, Stypula-Cyrus Y, Urban BE, Chandler JE, Nguyen TQ, Sun C, Zhang HF, Backman V.", "year": 2016, "journal": "Proceedings of the National Academy of Sciences of the United States of America", "doi": "10.1073/pnas.1602202113", "pmid": "27535934", "pmcid": "PMC5024634", "patentNumber": null, "originalAssignee": null, "originalCitation": "Dong B, Almassalha LM et al. (2016). \"Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.\" Proceedings of the National Academy of Sciences 113(35):9716–9721 (DOI: 10.1073/pnas.1602202113) — Label-free DNA partial-wave spectroscopic (PWS) microscopy at sub-20 nm resolution; chromatin follows fractal globule power-law scaling (D ≈ 3) at nanoscale; intrinsic nucleic acid fluorescence used as endogenous contrast for chromatin organisation imaging", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27535934/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1073%2Fpnas.1602202113%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-c847bd10379570", "recordId": "hsi-c847bd10379570", "title": "Short-time fractal analysis of biological autoluminescence.", "journal": "PloS one", "year": 2019, "authors": "Dlask M, Kukal J, Poplová M, Sovka P, Cifra M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/31348777/", "https://doi.org/10.1371/journal.pone.0214427", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6660117/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1371/journal.pone.0214427", "pmid": "31348777", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-176", "recordId": "hsi-c847bd10379570", "sourceType": "Journal publication", "title": "Short-time fractal analysis of biological autoluminescence.", "authors": "Dlask M, Kukal J, Poplová M, Sovka P, Cifra M.", "year": 2019, "journal": "PloS one", "doi": "10.1371/journal.pone.0214427", "pmid": "31348777", "pmcid": "PMC6660117", "patentNumber": null, "originalAssignee": null, "originalCitation": "Dlask M, Kukal J, Poplová M, Sovka P, Cifra M (2019). \"Short-time fractal analysis of biological autoluminescence.\" PLoS ONE 14(7):e0214427 (PMID 31348777) — Fractal analysis of biological autoluminescence (ultra-weak photon emission) time series; negative memory in photon count signals from germinating mung beans; Hurst exponent analysis reveals anti-persistent fractal dynamics in endogenous biophoton emission", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31348777/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A31348777+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-8b0c28afb02b86", "recordId": "hsi-8b0c28afb02b86", "title": "Fractal geometry: a design principle for living organisms.", "journal": "The American journal of physiology", "year": 1991, "authors": "Weibel ER.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/1767856/", "https://doi.org/10.1152/ajplung.1991.261.6.l361" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1152/ajplung.1991.261.6.l361", "pmid": "1767856", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-177", "recordId": "hsi-8b0c28afb02b86", "sourceType": "Review", "title": "Fractal geometry: a design principle for living organisms.", "authors": "Weibel ER.", "year": 1991, "journal": "The American journal of physiology", "doi": "10.1152/ajplung.1991.261.6.l361", "pmid": "1767856", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Weibel ER (1991). \"Fractal geometry: a design principle for living organisms.\" American Journal of Physiology 261(6 Pt 1):L361–L369 (PMID 1767856) — Foundational paper: fractal geometry as biological design principle; self-similar branching networks in lungs, vasculature, and bronchial trees; efficient genetic programming of biological form through fractal algorithms; fractal dimension as measure of space-filling efficiency across biological scales", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/1767856/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A1767856+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-3338d715ddefac", "recordId": "hsi-3338d715ddefac", "title": "Fractal Analysis of Multiscale Biological Systems", "journal": "", "year": 2024, "authors": "Muhammad Y.", "design": "Preprint", "urls": [ "https://doi.org/10.20944/preprints202412.1952.v1" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.20944/preprints202412.1952.v1", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-178", "recordId": "hsi-3338d715ddefac", "sourceType": "Preprint", "title": "Fractal Analysis of Multiscale Biological Systems", "authors": "Muhammad Y.", "year": 2024, "journal": "", "doi": "10.20944/preprints202412.1952.v1", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Muhammad Y (2024). \"Fractal Analysis of Multiscale Biological Systems.\" Preprints.org 2024121952 (posted 23 December 2024; ResearchGate presentation, Ain Shams University, January 2025) — Comprehensive review of fractal analysis across biological scales: chromatin (fractal globule D ≈ 1.02–1.40 for normal-to-cancerous), cell surface (healthy D ≈ 1.1–1.3, cancerous D ≈ 1.3–1.6), branching networks (circulatory D ≈ 1.6–1.9, lungs D ≈ 1.8–2.2, kidneys D ≈ 1.7–2.0, nervous system D ≈ 1.4–1.6), radiomics, physiological signals; fractal dimension as unique signature for healthy-versus-pathological state transitions", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.20944/preprints202412.1952.v1", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Fractal+Analysis+of+Multiscale+Biological+Systems%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Preprint", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-a969f74bedb780", "recordId": "hsi-a969f74bedb780", "title": "A Fractal Approach to Pattern Formation in Biological Systems", "journal": "", "year": 2008, "authors": "Dobrescu R, Ichim L, Mocanu S, Popa S", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-179", "recordId": "hsi-a969f74bedb780", "sourceType": "Bibliographic source", "title": "A Fractal Approach to Pattern Formation in Biological Systems", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Dobrescu R, Ichim L, Mocanu S, Popa S (2008). \"A Fractal Approach to Pattern Formation in Biological Systems.\" WSEAS Transactions on Biology and Biomedicine 5(6):107–116 — Reaction-diffusion systems as fractal pattern generators; connection between morphogenesis, nonlinear dynamics, and fractal structures; diffusion-limited aggregation (DLA) model of bacterial colony growth; attractor theory linking fractal patterns to stable biological states", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-autofluorescence-sensing-hsi-c97f9a5a073dee", "recordId": "hsi-c97f9a5a073dee", "title": "Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.", "journal": "International journal of molecular sciences", "year": 2023, "authors": "Sakr N, Glazova O, Shevkova L, Onyanov N, Kaziakhmedova S, Shilova A, Vorontsova MV, Volchkov P.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/36834842/", "https://doi.org/10.3390/ijms24043432", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9968082/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/ijms24043432", "pmid": "36834842", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-180", "recordId": "hsi-c97f9a5a073dee", "sourceType": "Journal publication", "title": "Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.", "authors": "Sakr N, Glazova O, Shevkova L, Onyanov N, Kaziakhmedova S, Shilova A, Vorontsova MV, Volchkov P.", "year": 2023, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms24043432", "pmid": "36834842", "pmcid": "PMC9968082", "patentNumber": null, "originalAssignee": null, "originalCitation": "Sakr N, Glazova O, Shevkova L, Onyanov N, Kaziakhmedova S, Shilova A, Vorontsova MV, Volchkov P (2023). \"Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.\" International Journal of Molecular Sciences 24(4):3432 (DOI: 10.3390/ijms24043432) — Broad-spectrum endogenous autofluorescence characterisation in adrenal cortex tissue; intracellular fluorophores (lipofuscin, lipids, NADH, flavins) emit across 405–488 nm excitation bands; autofluorescence originates from cortical cell cytoplasm; lipofuscin accumulation increases autofluorescence with age; lambda scanning quantification of autofluorescence emission profiles", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36834842/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fijms24043432%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-a7e89452d57b51", "recordId": "hsi-a7e89452d57b51", "title": "Classifying T cell activity in autofluorescence intensity images with convolutional neural networks.", "journal": "Journal of biophotonics", "year": 2020, "authors": "Wang ZJ, Walsh AJ, Skala MC, Gitter A.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/31661592/", "https://doi.org/10.1002/jbio.201960050", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7065628/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1002/jbio.201960050", "pmid": "31661592", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-181", "recordId": "hsi-a7e89452d57b51", "sourceType": "Journal publication", "title": "Classifying T cell activity in autofluorescence intensity images with convolutional neural networks.", "authors": "Wang ZJ, Walsh AJ, Skala MC, Gitter A.", "year": 2020, "journal": "Journal of biophotonics", "doi": "10.1002/jbio.201960050", "pmid": "31661592", "pmcid": "PMC7065628", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wang ZJ, Walsh AJ, Skala MC, Gitter A (2020). \"Classifying T cell activity in autofluorescence intensity images with convolutional neural networks.\" Journal of Biophotonics 13(3):e201960050 (PMC 7065628) — CNN classification of T cell activation states from NAD(P)H autofluorescence intensity images; endogenous metabolic co-enzyme fluorescence reflects immune cell functional state; label-free optical metabolic imaging distinguishes quiescent from activated T cells", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31661592/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7065628&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-672c477cf92f2c", "recordId": "hsi-672c477cf92f2c", "title": "Fluorescence spectroscopy of neoplastic and non-neoplastic tissues.", "journal": "Neoplasia (New York, N.Y.)", "year": 2000, "authors": "Ramanujam N.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/10933071/", "https://doi.org/10.1038/sj.neo.7900077", "https://pmc.ncbi.nlm.nih.gov/articles/PMC1531869/" ], "quotes": [], "summary": "Reference associated with Systems Biology Framework for Fractal Autofluorescence.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/sj.neo.7900077", "pmid": "10933071", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-182", "recordId": "hsi-672c477cf92f2c", "sourceType": "Review", "title": "Fluorescence spectroscopy of neoplastic and non-neoplastic tissues.", "authors": "Ramanujam N.", "year": 2000, "journal": "Neoplasia (New York, N.Y.)", "doi": "10.1038/sj.neo.7900077", "pmid": "10933071", "pmcid": "PMC1531869", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ramanujam N (2000). \"Fluorescence Spectroscopy of Neoplastic and Non-Neoplastic Tissues.\" Neoplasia 2(1-2):89–117 (PMC 1531869) — Comprehensive review of endogenous tissue fluorophores (NADH, FAD, collagen, elastin, porphyrins) for non-invasive tissue characterisation; fluorophore distributions across tissue architectural layers; spectral signatures distinguish neoplastic from normal tissue; establishes fluorescence spectroscopy as diagnostic tool for tissue state determination", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/10933071/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC1531869&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-b89b11771190f7", "recordId": "hsi-b89b11771190f7", "title": "[Imaging Analyses of Oxytocin: Visualization of Oxytocin and Its Implications].", "journal": "Brain and nerve = Shinkei kenkyu no shinpo", "year": 2023, "authors": "Nuriya M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/37537742/", "https://doi.org/10.11477/mf.1416202450" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.11477/mf.1416202450", "pmid": "37537742", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-183", "recordId": "hsi-b89b11771190f7", "sourceType": "Journal publication", "title": "[Imaging Analyses of Oxytocin: Visualization of Oxytocin and Its Implications].", "authors": "Nuriya M.", "year": 2023, "journal": "Brain and nerve = Shinkei kenkyu no shinpo", "doi": "10.11477/mf.1416202450", "pmid": "37537742", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 37537742 (2023). \"Imaging analyses of oxytocin: alkyne-tagging strategy for visualization of oxytocin and its implications for brain action.\" IGAKU-SHOIN — Alkyne-tagging chemical strategy for direct visualisation of oxytocin distribution; implications for understanding OXT brain action mechanisms", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37537742/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A37537742+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-37b2d379bb9681", "recordId": "hsi-37b2d379bb9681", "title": "Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.", "journal": "Journal of neuroendocrinology", "year": 2021, "authors": "Paiva L, Lozic M, Allchorne A, Grinevich V, Ludwig M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/33851744/", "https://doi.org/10.1111/jne.12970" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1111/jne.12970", "pmid": "33851744", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-184", "recordId": "hsi-37b2d379bb9681", "sourceType": "Journal publication", "title": "Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.", "authors": "Paiva L, Lozic M, Allchorne A, Grinevich V, Ludwig M.", "year": 2021, "journal": "Journal of neuroendocrinology", "doi": "10.1111/jne.12970", "pmid": "33851744", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 33851744 (2021). \"Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.\" Journal of Neuroendocrinology — Confirmed OXT expression via fluorescence in enteric nervous system ganglia, pancreatic islets of Langerhans, and testicular Leydig cells using systemically applied AAV vector; demonstrates peripheral OXT-expressing cell populations beyond hypothalamus", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33851744/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A33851744+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-4d0943da705896", "recordId": "hsi-4d0943da705896", "title": "Specificity of oxytocin and vasopressin immunofluorescence.", "journal": "The Journal of endocrinology", "year": 1975, "authors": "Swaab DF, Pool CW.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/1100756/", "https://doi.org/10.1677/joe.0.0660263" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1677/joe.0.0660263", "pmid": "1100756", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-185", "recordId": "hsi-4d0943da705896", "sourceType": "Journal publication", "title": "Specificity of oxytocin and vasopressin immunofluorescence.", "authors": "Swaab DF, Pool CW.", "year": 1975, "journal": "The Journal of endocrinology", "doi": "10.1677/joe.0.0660263", "pmid": "1100756", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 1100756 (1976). \"Specificity of oxytocin and vasopressin immunofluorescence.\" — Classic study on immunofluorescence specificity for OXT and AVP using CNBr-activated agarose beads and quantitative fluorescence measurement; demonstrated antibody purification for specific OXT/AVP visualisation including validation in Brattleboro rats (vasopressin-deficient model)", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/1100756/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A1100756+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-bb4d6be95a6fbf", "recordId": "hsi-bb4d6be95a6fbf", "title": "Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization.", "journal": "Angewandte Chemie (International ed. in English)", "year": 2025, "authors": "Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M, Kremsmayr T, Meunier FA, Langer T, Gruber CW, Keimpema E, Muttenthaler M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/41001975/", "https://doi.org/10.1002/anie.202515180", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12603982/" ], "quotes": [], "summary": "Reference associated with Fluorescent Visualisation and Real-Time Sensing of Oxytocin.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1002/anie.202515180", "pmid": "41001975", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-186", "recordId": "hsi-bb4d6be95a6fbf", "sourceType": "Journal publication", "title": "Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization.", "authors": "Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M, Kremsmayr T, Meunier FA, Langer T, Gruber CW, Keimpema E, Muttenthaler M.", "year": 2025, "journal": "Angewandte Chemie (International ed. in English)", "doi": "10.1002/anie.202515180", "pmid": "41001975", "pmcid": "PMC12603982", "patentNumber": null, "originalAssignee": null, "originalCitation": "Perisic Böhm V, Kalaba P et al. (2025). \"Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization.\" Angewandte Chemie International Edition 64(46):e202515180 (PMC 12603982) — Potent, selective, bright fluorescent peptide tracers for OTR; live-cell and post-hoc imaging; single-molecule tracking; FACS sorting of OTR-positive cells; simultaneous receptor activation and visualisation", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/41001975/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12603982&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-507bbc03f5d2eb", "recordId": "hsi-507bbc03f5d2eb", "title": "Protein Fluorescence", "journal": "Principles of Fluorescence Spectroscopy", "year": 1999, "authors": "Joseph R. Lakowicz", "design": "Book or chapter", "urls": [ "https://doi.org/10.1007/978-1-4757-3061-6_16" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1007/978-1-4757-3061-6_16", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-188", "recordId": "hsi-507bbc03f5d2eb", "sourceType": "Book or chapter", "title": "Protein Fluorescence", "authors": "Joseph R. Lakowicz", "year": 1999, "journal": "Principles of Fluorescence Spectroscopy", "doi": "10.1007/978-1-4757-3061-6_16", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Lakowicz JR (2006). Principles of Fluorescence Spectroscopy. 3rd ed. Springer. Ch. 16: \"Protein Fluorescence\" — Tryptophan indole ring (fused hexagonal benzene + pentagonal pyrrole) as dominant intrinsic protein fluorophore; excitation ~280 nm, emission ~340 nm; π→π* transitions of delocalised electrons across aromatic ring geometry; quantum yield sensitivity to local microenvironment; >90% of total protein UV fluorescence from tryptophan; molar extinction coefficient ~5,500 M⁻¹cm⁻¹ at 280 nm", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1007/978-1-4757-3061-6_16", "metadataURL": "https://api.crossref.org/works?query.title=Protein+Fluorescence&rows=3", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Book or chapter", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-a8977d72a1a256", "recordId": "hsi-a8977d72a1a256", "title": "Intrinsic Tryptophan Fluorescence in the Detection and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques", "journal": "International Journal of Molecular Sciences", "year": 2014, "authors": "Amar Ghisaidoobe; Sang Chung", "design": "Journal publication", "urls": [ "https://doi.org/10.3390/ijms151222518" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/ijms151222518", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-189", "recordId": "hsi-a8977d72a1a256", "sourceType": "Journal publication", "title": "Intrinsic Tryptophan Fluorescence in the Detection and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques", "authors": "Amar Ghisaidoobe; Sang Chung", "year": 2014, "journal": "International Journal of Molecular Sciences", "doi": "10.3390/ijms151222518", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Ghisaidoobe ABT, Chung SJ (2014). \"Intrinsic Tryptophan Fluorescence in the Inference and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques.\" International Journal of Molecular Sciences 15(12):22518–22538 (PMC 4284740) — Comprehensive review of tryptophan intrinsic fluorescence; indole chromophore π→π* transitions; environmental sensitivity of emission wavelength and quantum yield; FRET applications exploiting tryptophan as endogenous donor", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.3390/ijms151222518", "metadataURL": "https://api.crossref.org/works?query.title=Intrinsic+Tryptophan+Fluorescence+in+the+Inference+and+Analysis+of+Proteins%3A+A+Focus+on+F%C3%B6rster+Resonance+Energy+Transfer+Techniques&rows=3", "corrections": [ "Published title reconciled with the metadata record.", "A supplied identifier resolved to another title; the accepted record was matched separately by title." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-d20e21db0f73d9", "recordId": "hsi-d20e21db0f73d9", "title": "Mechanisms of tryptophan fluorescence shifts in proteins.", "journal": "Biophysical journal", "year": 2001, "authors": "Vivian JT, Callis PR.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/11325713/", "https://doi.org/10.1016/s0006-3495(01)76183-8", "https://pmc.ncbi.nlm.nih.gov/articles/PMC1301402/" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/s0006-3495(01)76183-8", "pmid": "11325713", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-190", "recordId": "hsi-d20e21db0f73d9", "sourceType": "Journal publication", "title": "Mechanisms of tryptophan fluorescence shifts in proteins.", "authors": "Vivian JT, Callis PR.", "year": 2001, "journal": "Biophysical journal", "doi": "10.1016/s0006-3495(01)76183-8", "pmid": "11325713", "pmcid": "PMC1301402", "patentNumber": null, "originalAssignee": null, "originalCitation": "Vivian JT, Callis PR (2001). \"Mechanisms of Tryptophan Fluorescence Shifts in Proteins.\" Biophysical Journal 80(5):2093–2109 (PMC 1301402) — Computational and experimental analysis of tryptophan fluorescence wavelength shifts; electrostatic interactions between indole ring π-electron system and local protein matrix; charge transfer states modulating emission", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/11325713/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC1301402&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-33dac4910c8d78", "recordId": "hsi-33dac4910c8d78", "title": "¹Lₐ and ¹L_b Transitions of Tryptophan: Applications of Theory and Experiment", "journal": "", "year": 1997, "authors": "Callis PR", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-191", "recordId": "hsi-33dac4910c8d78", "sourceType": "Bibliographic source", "title": "¹Lₐ and ¹L_b Transitions of Tryptophan: Applications of Theory and Experiment", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Callis PR (1997). \"¹Lₐ and ¹L_b Transitions of Tryptophan: Applications of Theory and Experiment.\" Methods in Enzymology 278:113–150 — Theoretical treatment of the two overlapping electronic transitions (¹Lₐ and ¹L_b) in tryptophan indole ring; molecular orbital analysis of π-electron delocalisation pathways across hexagonal and pentagonal ring geometry; transition dipole directions and energies", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-autofluorescence-sensing-hsi-50b42dd5c5b578", "recordId": "hsi-50b42dd5c5b578", "title": "Label-Free Tryptophan Fluorescence Lifetime Imaging as a Marker of Protein Conformational States in Cells", "journal": "", "year": 2023, "authors": "Shah S, Bhatt A, Bhatt S et al.", "design": "Bibliographic source", "urls": [ "https://www.notion.so/3807b9c99c5680599be7d8337c817b15" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Citation identity unresolved; original bibliography retained for review.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-192", "recordId": "hsi-50b42dd5c5b578", "sourceType": "Bibliographic source", "title": "Label-Free Tryptophan Fluorescence Lifetime Imaging as a Marker of Protein Conformational States in Cells", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Shah S, Bhatt A, Bhatt S et al. (2023). \"Label-Free Tryptophan Fluorescence Lifetime Imaging as a Marker of Protein Conformational States in Cells.\" — FLIM distinguishing protein conformational states, folding intermediates, and aggregation from endogenous tryptophan autofluorescence in living cells without exogenous labels; demonstrates tryptophan fluorescence lifetime as a non-invasive readout of protein structure and translation state", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Bibliographic source", "sourceVerification": "Citation identity unresolved; original bibliography retained for review." }, { "id": "general-autofluorescence-sensing-hsi-0d33d222d235dd", "recordId": "hsi-0d33d222d235dd", "title": "Watching gene expression in color.", "journal": "eLife", "year": 2019, "authors": "Simpson JH.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/31348001/", "https://doi.org/10.7554/elife.49414", "https://pmc.ncbi.nlm.nih.gov/articles/PMC6660214/" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.7554/elife.49414", "pmid": "31348001", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-193", "recordId": "hsi-0d33d222d235dd", "sourceType": "Journal publication", "title": "Watching gene expression in color.", "authors": "Simpson JH.", "year": 2019, "journal": "eLife", "doi": "10.7554/elife.49414", "pmid": "31348001", "pmcid": "PMC6660214", "patentNumber": null, "originalAssignee": null, "originalCitation": "Simpson CL (2019). \"Transcriptional Reporters: Watching Gene Expression in Color.\" eLife 8:e49414 (PMC 6660214) — Insight on TransTimer dual-colour fluorescent transcriptional reporter; green-to-red colour shift encoding transcriptional history at single-cell resolution; protein translation as the mechanism linking gene transcription to visible fluorescence", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31348001/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.7554%2FeLife.49414%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-198", "recordId": "hsi-0d33d222d235dd", "sourceType": "Journal publication", "title": "Watching gene expression in color.", "authors": "Simpson JH.", "year": 2019, "journal": "eLife", "doi": "10.7554/elife.49414", "pmid": "31348001", "pmcid": "PMC6660214", "patentNumber": null, "originalAssignee": null, "originalCitation": "Simpson CL (2019). \"Watching Gene Expression in Color: TransTimer Dual-Colour Fluorescent Reporter.\" eLife 8:e49414 — TransTimer reporter system: slow-maturing green fluorescent protein and fast-maturing red fluorescent protein under same promoter; green/red ratio encodes time since transcriptional activation; real-time colour-coded visualisation of transcriptional history in living cells", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31348001/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.7554%2FeLife.49414%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-7d176d0ecb2d26", "recordId": "hsi-7d176d0ecb2d26", "title": "Tracking and measuring local protein synthesis in vivo.", "journal": "Development (Cambridge, England)", "year": 2024, "authors": "Kays I, Chen BE.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39373391/", "https://doi.org/10.1242/dev.202908" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1242/dev.202908", "pmid": "39373391", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-194", "recordId": "hsi-7d176d0ecb2d26", "sourceType": "Journal publication", "title": "Tracking and measuring local protein synthesis in vivo.", "authors": "Kays I, Chen BE.", "year": 2024, "journal": "Development (Cambridge, England)", "doi": "10.1242/dev.202908", "pmid": "39373391", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Bhogale S, Bhatt T, Bhatt S et al. (2024). \"Tracking and measuring local protein synthesis in vivo.\" Development 151(21) — Review of technologies for direct measurement of nascent protein synthesis including fluorescent reporters, non-canonical amino acid labelling (FUNCAT/BONCAT), ribosome profiling, and single-molecule imaging; establishes protein translation as a measurable, fluorescence-detectable event in living organisms", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39373391/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Tracking+and+measuring+local+protein+synthesis+in+vivo%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-320858d8be27a8", "recordId": "hsi-320858d8be27a8", "title": "A protein-tagging system for signal amplification in gene expression and fluorescence imaging.", "journal": "Cell", "year": 2014, "authors": "Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/25307933/", "https://doi.org/10.1016/j.cell.2014.09.039", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4252608/" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.cell.2014.09.039", "pmid": "25307933", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-195", "recordId": "hsi-320858d8be27a8", "sourceType": "Journal publication", "title": "A protein-tagging system for signal amplification in gene expression and fluorescence imaging.", "authors": "Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.", "year": 2014, "journal": "Cell", "doi": "10.1016/j.cell.2014.09.039", "pmid": "25307933", "pmcid": "PMC4252608", "patentNumber": null, "originalAssignee": null, "originalCitation": "Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD (2014). \"A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging.\" Cell 159(3):635–646 — SunTag: repeating GCN4 peptide epitope array recruiting up to 24 copies of scFv-GFP fusion per translation event; single-molecule imaging of translation dynamics; amplifies fluorescent signal of individual protein translation events to single-molecule detectability", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25307933/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22A+Protein-Tagging+System+for+Signal+Amplification+in+Gene+Expression+and+Fluorescence+Imaging%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-5383613370a770", "recordId": "hsi-5383613370a770", "title": "Understanding Protein Expression", "journal": "", "year": 2025, "authors": "Abcam", "design": "Institutional, commercial or web source", "urls": [ "http://abcam.com" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-196", "recordId": "hsi-5383613370a770", "sourceType": "Institutional, commercial or web source", "title": "Understanding Protein Expression", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Abcam (2025). \"Understanding Protein Expression.\" Abcam Knowledge Center (abcam.com) — Reviews central dogma pipeline (transcription → translation → protein); protein expression systems (bacterial, mammalian, cell-free); post-translational modifications; fluorescent protein tagging as standard methodology for visualising gene expression products", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://abcam.com", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-1bfd258cce7eef", "recordId": "hsi-1bfd258cce7eef", "title": "Imaging translation in single cells using fluorescent microscopy.", "journal": "Cold Spring Harbor perspectives in biology", "year": 2012, "authors": "Chao JA, Yoon YJ, Singer RH.", "design": "Review", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/22960595/", "https://doi.org/10.1101/cshperspect.a012310", "https://pmc.ncbi.nlm.nih.gov/articles/PMC3536344/" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1101/cshperspect.a012310", "pmid": "22960595", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-197", "recordId": "hsi-1bfd258cce7eef", "sourceType": "Review", "title": "Imaging translation in single cells using fluorescent microscopy.", "authors": "Chao JA, Yoon YJ, Singer RH.", "year": 2012, "journal": "Cold Spring Harbor perspectives in biology", "doi": "10.1101/cshperspect.a012310", "pmid": "22960595", "pmcid": "PMC3536344", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chao JA, Yoon YJ, Singer RH (2012). \"Imaging Translation in Single Cells Using Fluorescent Microscopy.\" Cold Spring Harbor Perspectives in Biology 4(11):a012310 (PMC 3536344) — FUNCAT, fluorescent puromycin, fl-tRNA FRET, photoconvertible reporters, MS2/PP7 dual-label systems for single-molecule and single-cell translation imaging; establishes fluorescent microscopy as primary modality for visualising protein synthesis in vivo", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/22960595/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC3536344&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Review", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-d9b2c705e7f695", "recordId": "hsi-d9b2c705e7f695", "title": "Introduction to Fluorescent Proteins", "journal": "", "year": null, "authors": "", "design": "Institutional, commercial or web source", "urls": [ "http://zeiss-campus.magnet.fsu.edu/articles/probes/fpintroduction.html" ], "quotes": [], "summary": "Reference associated with Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription.", "relatedVersions": [], "limitation": "Documentary source retained; publication status and claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": null, "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-199", "recordId": "hsi-d9b2c705e7f695", "sourceType": "Institutional, commercial or web source", "title": "Introduction to Fluorescent Proteins", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Piston DW, Campbell RE, Day RN, Davidson MW. \"Introduction to Fluorescent Proteins.\" ZEISS Microscopy Online Campus — Education in Microscopy and Digital Imaging, Carl Zeiss Microscopy (zeiss-campus.magnet.fsu.edu/articles/probes/fpintroduction.html) — Comprehensive tutorial on the structure, spectral properties, brightness, maturation, and oligomerisation of fluorescent proteins derived from Aequorea victoria GFP and Anthozoa reef corals; details the 11-stranded β-barrel scaffold that protects the chromophore; the self-catalysed tripeptide cyclisation and oxidation reaction forming extended π-electron conjugated systems responsible for fluorescence; chromophore engineering via site-directed mutagenesis; fusion chimera design; fluorescent protein reporters and biosensors for monitoring gene expression, protein kinase activity, ion concentration, voltage, and cyclic nucleotide signalling in living cells", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://zeiss-campus.magnet.fsu.edu/articles/probes/fpintroduction.html", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Institutional, commercial or web source", "sourceVerification": "Documentary source retained; publication status and claims await appraisal." }, { "id": "general-autofluorescence-sensing-hsi-33295070309002", "recordId": "hsi-33295070309002", "title": "Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.", "journal": "Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery", "year": 2014, "authors": "Klatt J, Gerich CE, Gröbe A, Opitz J, Schreiber J, Hanken H, Salomon G, Heiland M, Kluwe L, Blessmann M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/24444757/", "https://doi.org/10.1016/j.jcms.2013.12.004" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.jcms.2013.12.004", "pmid": "24444757", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-215", "recordId": "hsi-33295070309002", "sourceType": "Journal publication", "title": "Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.", "authors": "Klatt J, Gerich CE, Gröbe A, Opitz J, Schreiber J, Hanken H, Salomon G, Heiland M, Kluwe L, Blessmann M.", "year": 2014, "journal": "Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery", "doi": "10.1016/j.jcms.2013.12.004", "pmid": "24444757", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Klatt J, Gerich CE, Gröbe A, Opitz J, Horlitz F, Hanken H, Schwarz RA, Gilon A et al. (2014). \"Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.\" Journal of Cranio-Maxillo-Facial Surgery 42(6):852–854. PMID: 24444757 — Fractal D of tumour = 1.8 vs healthy = 1.6; 100% sensitivity, 86% specificity, AUC 99%; demonstrates fractal autofluorescence analysis as a tissue-state discriminator", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/24444757/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A24444757+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." } ] }, { "id": "imaging-transcriptomics", "number": "11.5", "title": "Imaging, Transcriptomics and Gene Regulation", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "SpectralSeq pairs hyperspectral autofluorescence microscopy and RNA sequencing from the same individual cells. The published study connects optical and morphological features with transcriptomic variation in the tested cell system. NPL-9b records the publication; NPL-9 and NPL-214 retain its HyperSeq preprint provenance.", "This supplies an experimental route for studying relationships between optical phenotype and molecular state. The proposed extension to facial imaging and gene-specific inference remains a hypothesis. The next questions concern paired ground truth, cell and tissue specificity, confounding, repeatability and independent validation. TFBS, chromatin and protein-structure publications provide supporting molecular context, with their distinct methods and scales retained." ], "papers": [ { "id": "general-imaging-transcriptomics-hsi-ee301b86285079", "recordId": "hsi-ee301b86285079", "title": "RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.", "journal": "Science (New York, N.Y.)", "year": 2015, "authors": "Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/25858977/", "https://doi.org/10.1126/science.aaa6090", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4662681/" ], "quotes": [], "summary": "Reference associated with Hyper-Seq / Transcriptomics.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1126/science.aaa6090", "pmid": "25858977", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-8", "recordId": "hsi-ee301b86285079", "sourceType": "Journal publication", "title": "RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.", "authors": "Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X.", "year": 2015, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.aaa6090", "pmid": "25858977", "pmcid": "PMC4662681", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chen KH, Boettiger AN, Moffitt JR et al. (2015). \"Spatially resolved, highly multiplexed RNA profiling in single cells.\" Science 348(6233):aaa6090", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25858977/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Spatially+resolved%2C+highly+multiplexed+RNA+profiling+in+single+cells%22&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-7ad76f3461e8f4", "recordId": "hsi-7ad76f3461e8f4", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq", "journal": "", "year": 2024, "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F.", "design": "Preprint", "urls": [ "https://doi.org/10.1101/2024.01.27.577536" ], "quotes": [], "summary": "Reference associated with Hyper-Seq / Transcriptomics.", "relatedVersions": [ { "ref": "NPL-9b", "recordId": "hsi-6fe5f46314bf49" } ], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1101/2024.01.27.577536", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-9", "recordId": "hsi-7ad76f3461e8f4", "sourceType": "Preprint", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F.", "year": 2024, "journal": "", "doi": "10.1101/2024.01.27.577536", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F (2024). \"Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq.\" bioRxiv preprint, doi:10.1101/2024.01.27.577536", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1101/2024.01.27.577536", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1101%2F2024.01.27.577536%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-214", "recordId": "hsi-7ad76f3461e8f4", "sourceType": "Preprint", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F.", "year": 2024, "journal": "", "doi": "10.1101/2024.01.27.577536", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Zanini F, Vukovic M, Nassiri R, Wang X, Cao Y, Anttila CJ, Dehkhoda F, Goldys EM, Tian L (2024). \"Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq.\" bioRxiv preprint. DOI: 10.1101/2024.01.27.577536 — Combines hyperspectral autofluorescence imaging with scRNA-seq in MCF-7 breast cancer cells; correlates cellular optical signatures with gene expression profiles at single-cell resolution; provides ground-truth data linking autofluorescence molecular signatures to TFBS activity", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1101/2024.01.27.577536", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1101%2F2024.01.27.577536%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Preprint", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-6fe5f46314bf49", "recordId": "hsi-6fe5f46314bf49", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq.", "journal": "Genome research", "year": 2025, "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Bailey J, Lin F, Gatt C, Johansson EMV, Chtanova T, Holst J, Goldys E, Zanini F.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/40628527/", "https://doi.org/10.1101/gr.280014.124", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12315715/" ], "quotes": [], "summary": "SpectralSeq combines hyperspectral autofluorescence imaging and transcriptomics from the same MCF-7 cell. The study relates optical and morphological features to gene-expression variation in this breast-cancer cell system.", "relatedVersions": [ { "ref": "NPL-9", "recordId": "hsi-7ad76f3461e8f4" }, { "ref": "NPL-214", "recordId": "hsi-7ad76f3461e8f4" } ], "limitation": "The evidence concerns paired laboratory assays in individual cells. Facial imaging and gene-specific inference in people remain unvalidated extensions.", "citationCount": null, "sourcePages": [], "doi": "10.1101/gr.280014.124", "pmid": "40628527", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-9b", "recordId": "hsi-6fe5f46314bf49", "sourceType": "Journal publication", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq.", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Bailey J, Lin F, Gatt C, Johansson EMV, Chtanova T, Holst J, Goldys E, Zanini F.", "year": 2025, "journal": "Genome research", "doi": "10.1101/gr.280014.124", "pmid": "40628527", "pmcid": "PMC12315715", "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Bailey J, Lin F, Gatt C, Johansson EMV, Chtanova T, Holst J, Goldys E, Zanini F (2025). \"Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq.\" Genome Research 35(8):1809–1820 (PMC12315715) — Peer-reviewed published version of NPL-9; renamed from HyperSeq to SpectralSeq during peer review", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40628527/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12315715&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-130fe722e2c413", "recordId": "hsi-130fe722e2c413", "title": "Expression-based monitoring of transcription factor activity: the TELiS database.", "journal": "Bioinformatics (Oxford, England)", "year": 2005, "authors": "Cole SW, Yan W, Galic Z, Arevalo J, Zack JA.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/15374858/", "https://doi.org/10.1093/bioinformatics/bti038" ], "quotes": [], "summary": "Reference associated with TeLIS Framework.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1093/bioinformatics/bti038", "pmid": "15374858", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-10", "recordId": "hsi-130fe722e2c413", "sourceType": "Journal publication", "title": "Expression-based monitoring of transcription factor activity: the TELiS database.", "authors": "Cole SW, Yan W, Galic Z, Arevalo J, Zack JA.", "year": 2005, "journal": "Bioinformatics (Oxford, England)", "doi": "10.1093/bioinformatics/bti038", "pmid": "15374858", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW, Yan W, Galic Z et al. (2005). \"Expression-based monitoring of transcription factor activity: The TELiS database.\" Bioinformatics 21(6):803–810", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/15374858/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Expression-based+monitoring+of+transcription+factor+activity%3A+The+TELiS+database%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-80a547fe5cffcd", "recordId": "hsi-80a547fe5cffcd", "title": "Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "year": 2015, "authors": "Cole SW, Capitanio JP, Chun K, Arevalo JM, Ma J, Cacioppo JT.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/26598672/", "https://doi.org/10.1073/pnas.1514249112", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4679065/" ], "quotes": [], "summary": "Reference associated with TeLIS Framework.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1073/pnas.1514249112", "pmid": "26598672", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-11", "recordId": "hsi-80a547fe5cffcd", "sourceType": "Journal publication", "title": "Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.", "authors": "Cole SW, Capitanio JP, Chun K, Arevalo JM, Ma J, Cacioppo JT.", "year": 2015, "journal": "Proceedings of the National Academy of Sciences of the United States of America", "doi": "10.1073/pnas.1514249112", "pmid": "26598672", "pmcid": "PMC4679065", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW et al. (2015). \"Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.\" PNAS 112(49):15142–15147", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/26598672/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Myeloid+differentiation+architecture+of+leukocyte+transcriptome+dynamics+in+perceived+social+isolation%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-743d6718e4798d", "recordId": "hsi-743d6718e4798d", "title": "The Conserved Transcriptional Response to Adversity", "journal": "Current Opinion in Behavioral Sciences", "year": 2019, "authors": "Steven W Cole", "design": "Journal publication", "urls": [ "https://doi.org/10.1016/j.cobeha.2019.01.008" ], "quotes": [], "summary": "Reference associated with TeLIS Framework.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.cobeha.2019.01.008", "pmid": null, "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-12", "recordId": "hsi-743d6718e4798d", "sourceType": "Journal publication", "title": "The Conserved Transcriptional Response to Adversity", "authors": "Steven W Cole", "year": 2019, "journal": "Current Opinion in Behavioral Sciences", "doi": "10.1016/j.cobeha.2019.01.008", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW (2019). \"The Conserved Transcriptional Response to Adversity.\" Current Opinion in Behavioral Sciences 28:31–37", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1016/j.cobeha.2019.01.008", "metadataURL": "https://api.crossref.org/works?query.title=The+Conserved+Transcriptional+Response+to+Adversity&rows=3", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-pmid-17854483", "recordId": "pmid-17854483", "title": "Social regulation of gene expression in human leukocytes", "journal": "Genome biology", "year": 2007, "authors": "Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT.", "design": "", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/17854483/", "https://doi.org/10.1186/gb-2007-8-9-r189" ], "quotes": [], "summary": "", "relatedVersions": [], "limitation": "", "citationCount": null, "sourcePages": [], "doi": "10.1186/gb-2007-8-9-r189", "pmid": "17854483", "targets": [], "categories": [ "Gene expression" ], "sourceReferences": [ { "ref": "NPL-13", "recordId": "pmid-17854483", "sourceType": "Journal publication", "title": "Social regulation of gene expression in human leukocytes.", "authors": "Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT.", "year": 2007, "journal": "Genome biology", "doi": "10.1186/gb-2007-8-9-r189", "pmid": "17854483", "pmcid": "PMC2375027", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW et al. (2007). \"Social regulation of gene expression in human leukocytes.\" Genome Biology 8(9):R189", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/17854483/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Social+regulation+of+gene+expression+in+human+leukocytes%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-c72f6f428330c2", "recordId": "hsi-c72f6f428330c2", "title": "Single-molecule analysis of transcription factor binding at transcription sites in live cells.", "journal": "Nature communications", "year": 2014, "authors": "Morisaki T, Müller WG, Golob N, Mazza D, McNally JG.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/25034201/", "https://doi.org/10.1038/ncomms5456", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4144071/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/ncomms5456", "pmid": "25034201", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-200", "recordId": "hsi-c72f6f428330c2", "sourceType": "Journal publication", "title": "Single-molecule analysis of transcription factor binding at transcription sites in live cells.", "authors": "Morisaki T, Müller WG, Golob N, Mazza D, McNally JG.", "year": 2014, "journal": "Nature communications", "doi": "10.1038/ncomms5456", "pmid": "25034201", "pmcid": "PMC4144071", "patentNumber": null, "originalAssignee": null, "originalCitation": "Morisaki T, Müller WG, Golob N, Mazza D, McNally JG (2014). \"Single-molecule analysis of transcription factor binding at transcription sites in live cells.\" Nature Communications 5:4456. DOI: 10.1038/ncomms5456", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25034201/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fncomms5456%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-ca225cf85be823", "recordId": "hsi-ca225cf85be823", "title": "The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.", "journal": "Scientific reports", "year": 2017, "authors": "Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/28117353/", "https://doi.org/10.1038/srep41061", "https://pmc.ncbi.nlm.nih.gov/articles/PMC5259786/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/srep41061", "pmid": "28117353", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-201", "recordId": "hsi-ca225cf85be823", "sourceType": "Journal publication", "title": "The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.", "authors": "Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V.", "year": 2017, "journal": "Scientific reports", "doi": "10.1038/srep41061", "pmid": "28117353", "pmcid": "PMC5259786", "patentNumber": null, "originalAssignee": null, "originalCitation": "Almassalha LM, Silverstein SD, Bauer GM et al. (2017). \"The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.\" Scientific Reports 7:41061. DOI: 10.1038/srep41061", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28117353/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep41061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-209", "recordId": "hsi-ca225cf85be823", "sourceType": "Journal publication", "title": "The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.", "authors": "Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V.", "year": 2017, "journal": "Scientific reports", "doi": "10.1038/srep41061", "pmid": "28117353", "pmcid": "PMC5259786", "patentNumber": null, "originalAssignee": null, "originalCitation": "Almassalha LM, Silverstein SD, Bauer GM et al. (2017). \"The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.\" Scientific Reports 7:41061. DOI: 10.1038/srep41061", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28117353/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep41061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-640ffd898d4f0f", "recordId": "hsi-640ffd898d4f0f", "title": "DNA-guided transcription factor interactions extend human gene regulatory code.", "journal": "Nature", "year": 2025, "authors": "Xie Z, Sokolov I, Osmala M, Yue X, Bower G, Pett JP, Chen Y, Wang K, Cavga AD, Popov A, Teichmann SA, Morgunova E, Kvon EZ, Yin Y, Taipale J.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/40205063/", "https://doi.org/10.1038/s41586-025-08844-z", "https://pmc.ncbi.nlm.nih.gov/articles/PMC12119339/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41586-025-08844-z", "pmid": "40205063", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-202", "recordId": "hsi-640ffd898d4f0f", "sourceType": "Journal publication", "title": "DNA-guided transcription factor interactions extend human gene regulatory code.", "authors": "Xie Z, Sokolov I, Osmala M, Yue X, Bower G, Pett JP, Chen Y, Wang K, Cavga AD, Popov A, Teichmann SA, Morgunova E, Kvon EZ, Yin Y, Taipale J.", "year": 2025, "journal": "Nature", "doi": "10.1038/s41586-025-08844-z", "pmid": "40205063", "pmcid": "PMC12119339", "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Z, Sokolov I, Osmala M, Yue X et al. (2025). \"DNA-guided transcription factor interactions extend human gene regulatory code.\" Nature 641:1329–1338. DOI: 10.1038/s41586-025-08844-z", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40205063/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-025-08844-z%22&format=json&resultType=core&pageSize=4", "corrections": [ "Publication notice: Erratum in; 40461788" ], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-c1f30e3f5d4055", "recordId": "hsi-c1f30e3f5d4055", "title": "Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity.", "journal": "Nature genetics", "year": 2024, "authors": "Taylor SJ, Stauber J, Bohorquez O, Tatsumi G, Kumari R, Chakraborty J, Bartholdy BA, Schwenger E, Sundaravel S, Farahat AA, Wheat JC, Goldfinger M, Verma A, Kumar A, Boykin DW, Stengel KR, Poon GMK, Steidl U.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39294495/", "https://doi.org/10.1038/s41588-024-01911-7", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11525197/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41588-024-01911-7", "pmid": "39294495", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-203", "recordId": "hsi-c1f30e3f5d4055", "sourceType": "Journal publication", "title": "Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity.", "authors": "Taylor SJ, Stauber J, Bohorquez O, Tatsumi G, Kumari R, Chakraborty J, Bartholdy BA, Schwenger E, Sundaravel S, Farahat AA, Wheat JC, Goldfinger M, Verma A, Kumar A, Boykin DW, Stengel KR, Poon GMK, Steidl U.", "year": 2024, "journal": "Nature genetics", "doi": "10.1038/s41588-024-01911-7", "pmid": "39294495", "pmcid": "PMC11525197", "patentNumber": null, "originalAssignee": null, "originalCitation": "Taylor SJ, Stauber J, Bohorquez O et al. (2024). \"Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity.\" Nature Genetics 56:2213–2227. DOI: 10.1038/s41588-024-01911-7", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39294495/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41588-024-01911-7%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-ce108c64ada154", "recordId": "hsi-ce108c64ada154", "title": "Position-dependent function of human sequence-specific transcription factors.", "journal": "Nature", "year": 2024, "authors": "Duttke SH, Guzman C, Chang M, Delos Santos NP, McDonald BR, Xie J, Carlin AF, Heinz S, Benner C.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39020164/", "https://doi.org/10.1038/s41586-024-07662-z", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11269187/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41586-024-07662-z", "pmid": "39020164", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-204", "recordId": "hsi-ce108c64ada154", "sourceType": "Journal publication", "title": "Position-dependent function of human sequence-specific transcription factors.", "authors": "Duttke SH, Guzman C, Chang M, Delos Santos NP, McDonald BR, Xie J, Carlin AF, Heinz S, Benner C.", "year": 2024, "journal": "Nature", "doi": "10.1038/s41586-024-07662-z", "pmid": "39020164", "pmcid": "PMC11269187", "patentNumber": null, "originalAssignee": null, "originalCitation": "Duttke SH, Guzman C, Chang M et al. (2024). \"Position-dependent function of human sequence-specific transcription factors.\" Nature 631:891–898. DOI: 10.1038/s41586-024-07662-z", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39020164/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-024-07662-z%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-347e099d5780a1", "recordId": "hsi-347e099d5780a1", "title": "Modeling and designing enhancers by introducing and harnessing transcription factor binding units.", "journal": "Nature communications", "year": 2025, "authors": "Li J, Zhang P, Xi X, Liu L, Wei L, Wang X.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39922842/", "https://doi.org/10.1038/s41467-025-56749-2", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11807178/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41467-025-56749-2", "pmid": "39922842", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-205", "recordId": "hsi-347e099d5780a1", "sourceType": "Journal publication", "title": "Modeling and designing enhancers by introducing and harnessing transcription factor binding units.", "authors": "Li J, Zhang P, Xi X, Liu L, Wei L, Wang X.", "year": 2025, "journal": "Nature communications", "doi": "10.1038/s41467-025-56749-2", "pmid": "39922842", "pmcid": "PMC11807178", "patentNumber": null, "originalAssignee": null, "originalCitation": "Li J, Zhang P, Xi X, Liu L, Wei L, Wang X (2025). \"Modeling and designing enhancers by introducing and harnessing transcription factor binding units.\" Nature Communications 16:1469. DOI: 10.1038/s41467-025-56749-2", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39922842/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41467-025-56749-2%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-3775d2078838e2", "recordId": "hsi-3775d2078838e2", "title": "Theoretical principles of transcription factor traffic on folded chromatin.", "journal": "Nature communications", "year": 2018, "authors": "Cortini R, Filion GJ.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/29712907/", "https://doi.org/10.1038/s41467-018-04130-x", "https://pmc.ncbi.nlm.nih.gov/articles/PMC5928121/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41467-018-04130-x", "pmid": "29712907", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-206", "recordId": "hsi-3775d2078838e2", "sourceType": "Journal publication", "title": "Theoretical principles of transcription factor traffic on folded chromatin.", "authors": "Cortini R, Filion GJ.", "year": 2018, "journal": "Nature communications", "doi": "10.1038/s41467-018-04130-x", "pmid": "29712907", "pmcid": "PMC5928121", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cortini R, Filion GJ (2018). \"Theoretical principles of transcription factor traffic on folded chromatin.\" Nature Communications 9:1740. DOI: 10.1038/s41467-018-04130-x", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/29712907/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41467-018-04130-x%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-43757b09c98745", "recordId": "hsi-43757b09c98745", "title": "Context transcription factors establish cooperative environments and mediate enhancer communication.", "journal": "Nature genetics", "year": 2024, "authors": "Kribelbauer-Swietek JF, Pushkarev O, Gardeux V, Faltejskova K, Russeil J, van Mierlo G, Deplancke B.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/39363017/", "https://doi.org/10.1038/s41588-024-01892-7", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11525195/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41588-024-01892-7", "pmid": "39363017", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-207", "recordId": "hsi-43757b09c98745", "sourceType": "Journal publication", "title": "Context transcription factors establish cooperative environments and mediate enhancer communication.", "authors": "Kribelbauer-Swietek JF, Pushkarev O, Gardeux V, Faltejskova K, Russeil J, van Mierlo G, Deplancke B.", "year": 2024, "journal": "Nature genetics", "doi": "10.1038/s41588-024-01892-7", "pmid": "39363017", "pmcid": "PMC11525195", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kribelbauer-Swietek JF, Pushkarev O, Gardeux V, Faltejskova K, Russeil J, van Mierlo G, Deplancke B (2024). \"Context transcription factors establish cooperative environments and mediate enhancer communication.\" Nature Genetics 56:2199–2212. DOI: 10.1038/s41588-024-01892-7", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39363017/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41588-024-01892-7%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-a2182f3ffa9feb", "recordId": "hsi-a2182f3ffa9feb", "title": "Positional distribution of transcription factor binding sites in Arabidopsis thaliana.", "journal": "Scientific reports", "year": 2016, "authors": "Yu CP, Lin JJ, Li WH, Li WH.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/27117388/", "https://doi.org/10.1038/srep25164", "https://pmc.ncbi.nlm.nih.gov/articles/PMC4846880/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/srep25164", "pmid": "27117388", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-208", "recordId": "hsi-a2182f3ffa9feb", "sourceType": "Journal publication", "title": "Positional distribution of transcription factor binding sites in Arabidopsis thaliana.", "authors": "Yu CP, Lin JJ, Li WH, Li WH.", "year": 2016, "journal": "Scientific reports", "doi": "10.1038/srep25164", "pmid": "27117388", "pmcid": "PMC4846880", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yu CP, Lin JJ, Li WH (2016). \"Positional distribution of transcription factor binding sites in Arabidopsis thaliana.\" Scientific Reports 6:25164. DOI: 10.1038/srep25164", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27117388/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep25164%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-e0d5c3805210ed", "recordId": "hsi-e0d5c3805210ed", "title": "Highly accurate protein structure prediction with AlphaFold.", "journal": "Nature", "year": 2021, "authors": "Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, Senior AW, Kavukcuoglu K, Kohli P, Hassabis D.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/34265844/", "https://doi.org/10.1038/s41586-021-03819-2", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8371605/" ], "quotes": [], "summary": "Reference associated with AI-Driven Protein Structure Prediction (AlphaFold).", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41586-021-03819-2", "pmid": "34265844", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-210", "recordId": "hsi-e0d5c3805210ed", "sourceType": "Journal publication", "title": "Highly accurate protein structure prediction with AlphaFold.", "authors": "Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, Senior AW, Kavukcuoglu K, Kohli P, Hassabis D.", "year": 2021, "journal": "Nature", "doi": "10.1038/s41586-021-03819-2", "pmid": "34265844", "pmcid": "PMC8371605", "patentNumber": null, "originalAssignee": null, "originalCitation": "Jumper J, Evans R, Pritzel A et al. (2021). \"Highly accurate protein structure prediction with AlphaFold.\" Nature 596:583–589. DOI: 10.1038/s41586-021-03819-2 — AlphaFold2: atomic-accuracy protein structure prediction from amino acid sequence; won CASP14; 2024 Nobel Prize in Chemistry (Hassabis & Jumper)", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34265844/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-021-03819-2%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-a767ad286ab4ab", "recordId": "hsi-a767ad286ab4ab", "title": "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.", "journal": "Nucleic acids research", "year": 2022, "authors": "Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, Žídek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/34791371/", "https://doi.org/10.1093/nar/gkab1061", "https://pmc.ncbi.nlm.nih.gov/articles/PMC8728224/" ], "quotes": [], "summary": "Reference associated with AI-Driven Protein Structure Prediction (AlphaFold).", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1093/nar/gkab1061", "pmid": "34791371", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-211", "recordId": "hsi-a767ad286ab4ab", "sourceType": "Journal publication", "title": "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.", "authors": "Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, Žídek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S.", "year": 2022, "journal": "Nucleic acids research", "doi": "10.1093/nar/gkab1061", "pmid": "34791371", "pmcid": "PMC8728224", "patentNumber": null, "originalAssignee": null, "originalCitation": "Varadi M, Anyango S, Deshpande M et al. (2022). \"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.\" Nucleic Acids Research 50(D1):D439–D444. DOI: 10.1093/nar/gkab1061 — 200M+ predicted protein structures; EMBL-EBI partnership; 3M+ researchers across 190+ countries", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34791371/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1093%2Fnar%2Fgkab1061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-a69099559ecd76", "recordId": "hsi-a69099559ecd76", "title": "Accurate structure prediction of biomolecular interactions with AlphaFold 3.", "journal": "Nature", "year": 2024, "authors": "Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, Bodenstein SW, Evans DA, Hung CC, O'Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Žemgulytė A, Arvaniti E, Beattie C, Bertolli O, Bridgland A, Cherepanov A, Congreve M, Cowen-Rivers AI, Cowie A, Figurnov M, Fuchs FB, Gladman H, Jain R, Khan YA, Low CMR, Perlin K, Potapenko A, Savy P, Singh S, Stecula A, Thillaisundaram A, Tong C, Yakneen S, Zhong ED, Zielinski M, Žídek A, Bapst V, Kohli P, Jaderberg M, Hassabis D, Jumper JM.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38718835/", "https://doi.org/10.1038/s41586-024-07487-w", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11168924/" ], "quotes": [], "summary": "Reference associated with AI-Driven Protein Structure Prediction (AlphaFold).", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1038/s41586-024-07487-w", "pmid": "38718835", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-212", "recordId": "hsi-a69099559ecd76", "sourceType": "Journal publication", "title": "Accurate structure prediction of biomolecular interactions with AlphaFold 3.", "authors": "Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, Bodenstein SW, Evans DA, Hung CC, O'Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Žemgulytė A, Arvaniti E, Beattie C, Bertolli O, Bridgland A, Cherepanov A, Congreve M, Cowen-Rivers AI, Cowie A, Figurnov M, Fuchs FB, Gladman H, Jain R, Khan YA, Low CMR, Perlin K, Potapenko A, Savy P, Singh S, Stecula A, Thillaisundaram A, Tong C, Yakneen S, Zhong ED, Zielinski M, Žídek A, Bapst V, Kohli P, Jaderberg M, Hassabis D, Jumper JM.", "year": 2024, "journal": "Nature", "doi": "10.1038/s41586-024-07487-w", "pmid": "38718835", "pmcid": "PMC11168924", "patentNumber": null, "originalAssignee": null, "originalCitation": "Abramson J, Adler J, Dunger J et al. (2024). \"Accurate structure prediction of biomolecular interactions with AlphaFold 3.\" Nature 630:493–500. DOI: 10.1038/s41586-024-07487-w — Protein–DNA, protein–RNA, protein–ligand, and protein–ion complex structure prediction; ≥50% accuracy improvement over existing methods", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38718835/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-024-07487-w%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-adeb0509f25117", "recordId": "hsi-adeb0509f25117", "title": "Accurate proteome-wide missense variant effect prediction with AlphaMissense.", "journal": "Science (New York, N.Y.)", "year": 2023, "authors": "Cheng J, Novati G, Pan J, Bycroft C, Žemgulytė A, Applebaum T, Pritzel A, Wong LH, Zielinski M, Sargeant T, Schneider RG, Senior AW, Jumper J, Hassabis D, Kohli P, Avsec Ž.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/37733863/", "https://doi.org/10.1126/science.adg7492" ], "quotes": [], "summary": "Reference associated with AI-Driven Protein Structure Prediction (AlphaFold).", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1126/science.adg7492", "pmid": "37733863", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-213", "recordId": "hsi-adeb0509f25117", "sourceType": "Journal publication", "title": "Accurate proteome-wide missense variant effect prediction with AlphaMissense.", "authors": "Cheng J, Novati G, Pan J, Bycroft C, Žemgulytė A, Applebaum T, Pritzel A, Wong LH, Zielinski M, Sargeant T, Schneider RG, Senior AW, Jumper J, Hassabis D, Kohli P, Avsec Ž.", "year": 2023, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.adg7492", "pmid": "37733863", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cheng J, Novati G, Pan J et al. (2023). \"Accurate proteome-wide missense variant effect prediction with AlphaMissense.\" Science 381(6664):eadg7492. DOI: 10.1126/science.adg7492 — 71 million missense variants classified across human proteome; 89% categorised as likely benign or likely pathogenic", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37733863/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1126%2Fscience.adg7492%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-d4f9970183960d", "recordId": "hsi-d4f9970183960d", "title": "Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.", "journal": "Mechanisms of development", "year": 2016, "authors": "Pettie KP, Dresch JM, Drewell RA.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/27264535/", "https://doi.org/10.1016/j.mod.2016.06.001", "https://pmc.ncbi.nlm.nih.gov/articles/PMC5441388/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.mod.2016.06.001", "pmid": "27264535", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-216", "recordId": "hsi-d4f9970183960d", "sourceType": "Journal publication", "title": "Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.", "authors": "Pettie KP, Dresch JM, Drewell RA.", "year": 2016, "journal": "Mechanisms of development", "doi": "10.1016/j.mod.2016.06.001", "pmid": "27264535", "pmcid": "PMC5441388", "patentNumber": null, "originalAssignee": null, "originalCitation": "Pettie KP, Dresch JM, Drewell RA (2016). \"Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.\" Mechanisms of Development 141:51–61. PMC5441388 — TFBS broadly distributed across ChIP peaks rather than narrowly centred; multiple sites per peak; establishes that TFBS positional distribution within regulatory regions carries functional significance", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27264535/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC5441388&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-49e12e857b5371", "recordId": "hsi-49e12e857b5371", "title": "Transcription factor binding sites and other features in human and Drosophila proximal promoters.", "journal": "Sub-cellular biochemistry", "year": 2011, "authors": "Vinson C, Chatterjee R, Fitzgerald P.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/21557085/", "https://doi.org/10.1007/978-90-481-9069-0_10", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7394279/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1007/978-90-481-9069-0_10", "pmid": "21557085", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-217", "recordId": "hsi-49e12e857b5371", "sourceType": "Journal publication", "title": "Transcription factor binding sites and other features in human and Drosophila proximal promoters.", "authors": "Vinson C, Chatterjee R, Fitzgerald P.", "year": 2011, "journal": "Sub-cellular biochemistry", "doi": "10.1007/978-90-481-9069-0_10", "pmid": "21557085", "pmcid": "PMC7394279", "patentNumber": null, "originalAssignee": null, "originalCitation": "Vinson C, Chatterjee R, Fitzgerald P (2011). \"Transcription Factor Binding Sites and Other Features in Human and Drosophila Proximal Promoters.\" Subcellular Biochemistry 52:205–222. PMC7394279 — TFBS architecture differs fundamentally between species; CpG islands play distinctive organisational role in human proximal promoters; cross-species comparative evidence for evolved TFBS positional grammar", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21557085/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7394279&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-22a43f552b2b2f", "recordId": "hsi-22a43f552b2b2f", "title": "TF-COMB - Discovering grammar of transcription factor binding sites.", "journal": "Computational and structural biotechnology journal", "year": 2022, "authors": "Bentsen M, Heger V, Schultheis H, Kuenne C, Looso M.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/35983231/", "https://doi.org/10.1016/j.csbj.2022.07.025", "https://pmc.ncbi.nlm.nih.gov/articles/PMC9358416/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.csbj.2022.07.025", "pmid": "35983231", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-218", "recordId": "hsi-22a43f552b2b2f", "sourceType": "Journal publication", "title": "TF-COMB - Discovering grammar of transcription factor binding sites.", "authors": "Bentsen M, Heger V, Schultheis H, Kuenne C, Looso M.", "year": 2022, "journal": "Computational and structural biotechnology journal", "doi": "10.1016/j.csbj.2022.07.025", "pmid": "35983231", "pmcid": "PMC9358416", "patentNumber": null, "originalAssignee": null, "originalCitation": "Bentsen M, Heger V, Schütte H, Lim CH, Kchouk C, Braun T, Looso M (2022). \"TF-COMB — Discovering grammar of transcription factor binding sites.\" Computational and Structural Biotechnology Journal 20:4040–4051. DOI: 10.1016/j.csbj.2022.07.025 — Market basket analysis framework for global TF co-occurrence inference across eight ENCODE cell lines; reveals preferred binding distances, orientations, and network relationships; TF pairs exhibit grammar-level features (distance periodicity, directional preferences) encoding biological function", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35983231/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.csbj.2022.07.025%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-6963bd6166bcd0", "recordId": "hsi-6963bd6166bcd0", "title": "Predicting Transcription Factor Binding Sites with Deep Learning.", "journal": "International journal of molecular sciences", "year": 2024, "authors": "Ghosh N, Santoni D, Saha I, Felici G.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/38732207/", "https://doi.org/10.3390/ijms25094990", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11084193/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.3390/ijms25094990", "pmid": "38732207", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-219", "recordId": "hsi-6963bd6166bcd0", "sourceType": "Journal publication", "title": "Predicting Transcription Factor Binding Sites with Deep Learning.", "authors": "Ghosh N, Santoni D, Saha I, Felici G.", "year": 2024, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms25094990", "pmid": "38732207", "pmcid": "PMC11084193", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ghosh N, Santoni D, Saha I, Felici G (2024). \"Predicting Transcription Factor Binding Sites with Deep Learning.\" International Journal of Molecular Sciences 25(9):4990. DOI: 10.3390/ijms25094990 — DNABERT-Cap: transformer-based capsule network for TFBS prediction; AUC > 0.91 across five ENCODE cell lines; cross-cell line prediction demonstrates intrinsic TFBS pattern transfer; TFs absent from training recognised with high accuracy (e.g., Znf143 AUC = 0.968, SMC3 AUC > 0.95)", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38732207/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fijms25094990%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." }, { "id": "general-imaging-transcriptomics-hsi-be9f5eccf3b27d", "recordId": "hsi-be9f5eccf3b27d", "title": "Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.", "journal": "Cell reports", "year": 2020, "authors": "Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, Van Horn JD, Kesselman C, Foster I, Madduri R, Price ND, Ament SA.", "design": "Journal publication", "urls": [ "https://pubmed.ncbi.nlm.nih.gov/32814038/", "https://doi.org/10.1016/j.celrep.2020.108029", "https://pmc.ncbi.nlm.nih.gov/articles/PMC7462736/" ], "quotes": [], "summary": "Reference associated with Fractal TFBS Analysis / Fractal Chromatin 3D Organisation.", "relatedVersions": [], "limitation": "Bibliographic metadata matched; scientific claims await appraisal.", "citationCount": null, "sourcePages": [], "doi": "10.1016/j.celrep.2020.108029", "pmid": "32814038", "targets": [], "categories": [ "Hyperspectral Imaging" ], "sourceReferences": [ { "ref": "NPL-220", "recordId": "hsi-be9f5eccf3b27d", "sourceType": "Journal publication", "title": "Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.", "authors": "Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, Van Horn JD, Kesselman C, Foster I, Madduri R, Price ND, Ament SA.", "year": 2020, "journal": "Cell reports", "doi": "10.1016/j.celrep.2020.108029", "pmid": "32814038", "pmcid": "PMC7462736", "patentNumber": null, "originalAssignee": null, "originalCitation": "Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, Van Horn JD, Kesselman C, Foster I, Madduri R, Price ND, Ament SA (2020). \"Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.\" Cell Reports 32(7):108029. PMC7462736 — Comprehensive atlas of genomic footprints across 27 human tissues from 192 DNase-seq experiments; predicted occupancy of 1,515 TFs; tissue-specific footprints span 9.8% of genome at optimal thresholds; strongly enriched for disease-associated SNPs; highest-scoring footprints contribute disproportionately to heritability for complex traits in disease-relevant tissues", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/32814038/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7462736&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" } ], "sourceType": "Journal publication", "sourceVerification": "Bibliographic metadata matched; scientific claims await appraisal." } ] }, { "id": "patent-landscape", "number": "11.6", "title": "Patent Landscape and Related Technologies", "trustScore": null, "trustAssessment": { "scope": "Subchapter", "status": "not-assessed", "score": null, "basis": "The source inventory is complete. Unresolved identities remain flagged, and topic evidence thresholds have not been assigned." }, "paragraphs": [ "The original list contains 11 patent entries spanning imaging, physiological sensing and related identity or reward systems. Each number is retained exactly as cited, alongside its resolved public title when available. Disagreements between the bibliography description and the public record remain visible.", "Patent documents establish what an applicant disclosed or claimed in that document. Experimental support, publication status and current legal status require separate checks. 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(2017). \"Algorithmic Principles of Remote PPG.\" IEEE Trans Biomedical Engineering 64(7):1479–1491", "originalSection": "Remote Photoplethysmography", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28113245/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Algorithmic+Principles+of+Remote+PPG%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-6", "recordId": "hsi-f2d9fb354d5d0b", "sourceType": "Journal publication", "title": "Oxytocin is associated with human trustworthiness.", "authors": "Zak PJ, Kurzban R, Matzner WT.", "year": 2005, "journal": "Hormones and behavior", "doi": "10.1016/j.yhbeh.2005.07.009", "pmid": "16109416", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Zak PJ, Kurzban R, Matzner WT (2005). \"Oxytocin is associated with human trustworthiness.\" Hormones and Behavior 48(5):522–527", "originalSection": "Oxytocin Inference via Heart Rate", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/16109416/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocin+is+associated+with+human+trustworthiness%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-7", "recordId": "hsi-16f70e898521b3", "sourceType": "Review", "title": "Oxytocin and social affiliation in humans.", "authors": "Feldman R.", "year": 2012, "journal": "Hormones and behavior", "doi": "10.1016/j.yhbeh.2012.01.008", "pmid": "22285934", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Feldman R (2012). \"Oxytocin and social affiliation in humans.\" Hormones and Behavior 61(3):380–391", "originalSection": "Oxytocin Inference via Heart Rate", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/22285934/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocin+and+social+affiliation+in+humans%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-8", "recordId": "hsi-ee301b86285079", "sourceType": "Journal publication", "title": "RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.", "authors": "Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X.", "year": 2015, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.aaa6090", "pmid": "25858977", "pmcid": "PMC4662681", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chen KH, Boettiger AN, Moffitt JR et al. (2015). \"Spatially resolved, highly multiplexed RNA profiling in single cells.\" Science 348(6233):aaa6090", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25858977/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Spatially+resolved%2C+highly+multiplexed+RNA+profiling+in+single+cells%22&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-9", "recordId": "hsi-7ad76f3461e8f4", "sourceType": "Preprint", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F.", "year": 2024, "journal": "", "doi": "10.1101/2024.01.27.577536", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F (2024). \"Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq.\" bioRxiv preprint, doi:10.1101/2024.01.27.577536", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1101/2024.01.27.577536", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1101%2F2024.01.27.577536%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-9b", "recordId": "hsi-6fe5f46314bf49", "sourceType": "Journal publication", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq.", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Bailey J, Lin F, Gatt C, Johansson EMV, Chtanova T, Holst J, Goldys E, Zanini F.", "year": 2025, "journal": "Genome research", "doi": "10.1101/gr.280014.124", "pmid": "40628527", "pmcid": "PMC12315715", "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Bailey J, Lin F, Gatt C, Johansson EMV, Chtanova T, Holst J, Goldys E, Zanini F (2025). \"Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq.\" Genome Research 35(8):1809–1820 (PMC12315715) — Peer-reviewed published version of NPL-9; renamed from HyperSeq to SpectralSeq during peer review", "originalSection": "Hyper-Seq / Transcriptomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40628527/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12315715&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-10", "recordId": "hsi-130fe722e2c413", "sourceType": "Journal publication", "title": "Expression-based monitoring of transcription factor activity: the TELiS database.", "authors": "Cole SW, Yan W, Galic Z, Arevalo J, Zack JA.", "year": 2005, "journal": "Bioinformatics (Oxford, England)", "doi": "10.1093/bioinformatics/bti038", "pmid": "15374858", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW, Yan W, Galic Z et al. (2005). \"Expression-based monitoring of transcription factor activity: The TELiS database.\" Bioinformatics 21(6):803–810", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/15374858/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Expression-based+monitoring+of+transcription+factor+activity%3A+The+TELiS+database%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-11", "recordId": "hsi-80a547fe5cffcd", "sourceType": "Journal publication", "title": "Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.", "authors": "Cole SW, Capitanio JP, Chun K, Arevalo JM, Ma J, Cacioppo JT.", "year": 2015, "journal": "Proceedings of the National Academy of Sciences of the United States of America", "doi": "10.1073/pnas.1514249112", "pmid": "26598672", "pmcid": "PMC4679065", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW et al. (2015). \"Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.\" PNAS 112(49):15142–15147", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/26598672/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Myeloid+differentiation+architecture+of+leukocyte+transcriptome+dynamics+in+perceived+social+isolation%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-12", "recordId": "hsi-743d6718e4798d", "sourceType": "Journal publication", "title": "The Conserved Transcriptional Response to Adversity", "authors": "Steven W Cole", "year": 2019, "journal": "Current Opinion in Behavioral Sciences", "doi": "10.1016/j.cobeha.2019.01.008", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW (2019). \"The Conserved Transcriptional Response to Adversity.\" Current Opinion in Behavioral Sciences 28:31–37", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1016/j.cobeha.2019.01.008", "metadataURL": "https://api.crossref.org/works?query.title=The+Conserved+Transcriptional+Response+to+Adversity&rows=3", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-13", "recordId": "pmid-17854483", "sourceType": "Journal publication", "title": "Social regulation of gene expression in human leukocytes.", "authors": "Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT.", "year": 2007, "journal": "Genome biology", "doi": "10.1186/gb-2007-8-9-r189", "pmid": "17854483", "pmcid": "PMC2375027", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cole SW et al. (2007). \"Social regulation of gene expression in human leukocytes.\" Genome Biology 8(9):R189", "originalSection": "TeLIS Framework", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/17854483/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Social+regulation+of+gene+expression+in+human+leukocytes%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-14", "recordId": "hsi-73d87fc83f0d66", "sourceType": "Review", "title": "Quantum Chemistry in the Age of Quantum Computing.", "authors": "Cao Y, Romero J, Olson JP, Degroote M, Johnson PD, Kieferová M, Kivlichan ID, Menke T, Peropadre B, Sawaya NPD, Sim S, Veis L, Aspuru-Guzik A.", "year": 2019, "journal": "Chemical reviews", "doi": "10.1021/acs.chemrev.8b00803", "pmid": "31469277", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cao Y et al. (2019). \"Quantum Chemistry in the Age of Quantum Computing.\" Chemical Reviews 119(19):10856–10915", "originalSection": "Quantum Computing in Genomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31469277/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Quantum+Chemistry+in+the+Age+of+Quantum+Computing%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-15", "recordId": "hsi-fb26f28fd984a4", "sourceType": "Journal publication", "title": "VQE method: a short survey and recent developments", "authors": "Dmitry A. Fedorov; Bo Peng; Niranjan Govind; Yuri Alexeev", "year": 2022, "journal": "Materials Theory", "doi": "10.1186/s41313-021-00032-6", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Fedorov DA et al. (2022). \"VQE method: A short survey and recent developments.\" Materials Theory 6:2", "originalSection": "Quantum Computing in Genomics", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1186/s41313-021-00032-6", "metadataURL": "https://api.crossref.org/works?query.title=VQE+method%3A+A+short+survey+and+recent+developments&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-16", "recordId": "pmid-25694852", "sourceType": "Review", "title": "Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health risk.", "authors": "McCraty R, Shaffer F.", "year": 2015, "journal": "Global advances in health and medicine", "doi": "10.7453/gahmj.2014.073", "pmid": "25694852", "pmcid": "PMC4311559", "patentNumber": null, "originalAssignee": null, "originalCitation": "McCraty R, Shaffer F (2015). \"Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health Risk.\" Global Advances in Health and Medicine 4(1):46–61", "originalSection": "Prescription Sound / Biofeedback", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25694852/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Heart+Rate+Variability%3A+New+Perspectives+on+Physiological+Mechanisms%2C+Assessment+of+Self-regulatory+Capacity%2C+and+Health+Risk%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-17", "recordId": "hsi-4a1a5cee408d6c", "sourceType": "Journal publication", "title": "Heart rate variability biofeedback: how and why does it work?", "authors": "Lehrer PM, Gevirtz R.", "year": 2014, "journal": "Frontiers in psychology", "doi": "10.3389/fpsyg.2014.00756", "pmid": "25101026", "pmcid": "PMC4104929", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lehrer PM, Gevirtz R (2014). \"Heart rate variability biofeedback: how and why does it work?\" Frontiers in Psychology 5:756", "originalSection": "Prescription Sound / Biofeedback", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25101026/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Heart+rate+variability+biofeedback%3A+how+and+why+does+it+work%3F%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-18", "recordId": "hsi-4c43fe26667b32", "sourceType": "Conference publication", "title": "MedRec: Using Blockchain for Medical Data Access and Permission Management", "authors": "Asaph Azaria; Ariel Ekblaw; Thiago Vieira; Andrew Lippman", "year": 2016, "journal": "2016 2nd International Conference on Open and Big Data (OBD)", "doi": "10.1109/obd.2016.11", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Azaria A, Ekblaw A, Vieira T, Lippman A (2016). \"MedRec: Using Blockchain for Medical Data Access and Permission Management.\" IEEE 2nd International Conference on Open and Big Data", "originalSection": "Blockchain-Based Mental Health Rewards", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1109/obd.2016.11", "metadataURL": "https://api.crossref.org/works?query.title=MedRec%3A+Using+Blockchain+for+Medical+Data+Access+and+Permission+Management&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-19", "recordId": "pmid-22824810", "sourceType": "Journal publication", "title": "Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor-receptor interactions.", "authors": "Romero-Fernandez W, Borroto-Escuela DO, Agnati LF, Fuxe K.", "year": 2013, "journal": "Molecular psychiatry", "doi": "10.1038/mp.2012.103", "pmid": "22824810", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Romero-Fernandez W, Borroto-Escuela DO, Agnati LF, Fuxe K (2013). \"Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions.\" Molecular Psychiatry 18:849–850", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.nature.com/articles/mp2012103", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Evidence+for+the+existence+of+dopamine+D2-oxytocin+receptor+heteromers+in+the+ventral+and+dorsal+striatum+with+facilitatory+receptor%E2%80%93receptor+interactions%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-20", "recordId": "hsi-8e4034b8b289a9", "sourceType": "Journal publication", "title": "The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene-environment interaction in mood disorders.", "authors": "Shen G, Yang S, Wu L, Chen Y, Hu Y, Zhou F, Wang W, Liu P, Wu F, Liu Y, Wang F, Chen L.", "year": 2023, "journal": "Frontiers in psychiatry", "doi": "10.3389/fpsyt.2023.1085429", "pmid": "37520225", "pmcid": "PMC10380931", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chen L et al. (2023). \"The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders.\" Frontiers in Psychiatry 14:1085429", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37520225/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22The+oxytocin+receptor+rs2254298+polymorphism+and+alcohol+withdrawal+symptoms%3A+a+gene%E2%80%93environment+interaction+in+mood+disorders%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-21", "recordId": "hsi-3d163ae87207d0", "sourceType": "Journal publication", "title": "The Role of Oxytocin and Oxytocin Gene Receptor Methylation During Withdrawal Therapy in Males With Alcohol Use Disorder.", "authors": "Proskynitopoulos PJ, Haarmeyer AF, Bleich S, Frieling H, Hillemacher T, Glahn A, Rhein M.", "year": 2025, "journal": "Addiction biology", "doi": "10.1111/adb.70060", "pmid": "40658054", "pmcid": "PMC12257889", "patentNumber": null, "originalAssignee": null, "originalCitation": "Geisel O et al. (2025). \"The Role of Oxytocin and Oxytocin Gene Receptor Methylation During Withdrawal Therapy in Males With Alcohol Use Disorder.\" Alcoholism: Clinical and Experimental Research (PMC12257889)", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40658054/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12257889&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-22", "recordId": "hsi-28e5e7fe09245a", "sourceType": "Journal publication", "title": "Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.", "authors": "Bakermans-Kranenburg MJ, van Ijzendoorn MH.", "year": 2008, "journal": "Social cognitive and affective neuroscience", "doi": "10.1093/scan/nsn004", "pmid": "19015103", "pmcid": "PMC2555463", "patentNumber": null, "originalAssignee": null, "originalCitation": "Bakermans-Kranenburg MJ, van Ijzendoorn MH (2008). \"Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.\" Social Cognitive and Affective Neuroscience 3(2):128–134", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/19015103/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocin+receptor+%28OXTR%29+and+serotonin+transporter+%285-HTT%29+genes+associated+with+observed+parenting%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-23", "recordId": "hsi-d6215fd15c4e25", "sourceType": "Journal publication", "title": "Interaction of 5-HTTLPR and a variation on the oxytocin receptor gene influences negative emotionality.", "authors": "Montag C, Fiebach CJ, Kirsch P, Reuter M.", "year": 2011, "journal": "Biological psychiatry", "doi": "10.1016/j.biopsych.2010.10.026", "pmid": "21183159", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Montag C, Fiebach CJ, Kirsch P, Reuter M (2011). \"Interaction of 5-HTTLPR and a Variation on the Oxytocin Receptor Gene Influences Negative Emotionality.\" Biological Psychiatry 69(6):601–603", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21183159/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Interaction+of+5-HTTLPR+and+a+Variation+on+the+Oxytocin+Receptor+Gene+Influences+Negative+Emotionality%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-24", "recordId": "hsi-6b1d2def31c0db", "sourceType": "Journal publication", "title": "Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy.", "authors": "Laursen HR, Siebner HR, Haren T, Madsen K, Grønlund R, Hulme O, Henningsson S.", "year": 2014, "journal": "Frontiers in behavioral neuroscience", "doi": "10.3389/fnbeh.2014.00423", "pmid": "25538588", "pmcid": "PMC4257152", "patentNumber": null, "originalAssignee": null, "originalCitation": "Tong WH et al. (2014). \"Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy.\" Frontiers in Behavioral Neuroscience 8:423", "originalSection": "OXTR Modulation of DRD2/SLC6A4", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25538588/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Variation+in+the+oxytocin+receptor+gene+is+associated+with+behavioral+and+neural+correlates+of+empathic+accuracy%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-25", "recordId": "pmid-33071746", "sourceType": "Review", "title": "Oxytocin Receptor Signaling in Vascular Function and Stroke.", "authors": "McKay EC, Counts SE.", "year": 2020, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2020.574499", "pmid": "33071746", "pmcid": "PMC7544744", "patentNumber": null, "originalAssignee": null, "originalCitation": "Gutkowska J, Jankowski M (2020). \"Oxytocin Receptor Signaling in Vascular Function and Stroke.\" Frontiers in Neuroscience 14:574499 (PMC 7544744)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33071746/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7544744&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-26", "recordId": "hsi-55916122662aa4", "sourceType": "Journal publication", "title": "Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis.", "authors": "Deing V, Roggenkamp D, Kühnl J, Gruschka A, Stäb F, Wenck H, Bürkle A, Neufang G.", "year": 2013, "journal": "Experimental dermatology", "doi": "10.1111/exd.12155", "pmid": "23711064", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Deing V et al. (2012). \"Oxytocin modulates proliferation and stress responses of human skin cells.\" Experimental Dermatology (PMID 23711064)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/23711064/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A23711064+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-27", "recordId": "hsi-aecb6ce44b1875", "sourceType": "Journal publication", "title": "Structural basis for the activation and ligand recognition of the human oxytocin receptor.", "authors": "Waltenspühl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Plückthun A.", "year": 2022, "journal": "Nature communications", "doi": "10.1038/s41467-022-31325-0", "pmid": "35851571", "pmcid": "PMC9293896", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yin J et al. (2022). \"Structural basis for the activation and ligand recognition of the human oxytocin receptor.\" Nature Communications 13:4153", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35851571/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Structural+basis+for+the+activation+and+ligand+recognition+of+the+human+oxytocin+receptor%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-28", "recordId": "hsi-b2ec2b67bc699b", "sourceType": "Review", "title": "Advances in human oxytocin measurement: challenges and proposed solutions.", "authors": "Tabak BA, Leng G, Szeto A, Parker KJ, Verbalis JG, Ziegler TE, Lee MR, Neumann ID, Mendez AJ.", "year": 2023, "journal": "Molecular psychiatry", "doi": "10.1038/s41380-022-01719-z", "pmid": "35999276", "pmcid": "PMC9812775", "patentNumber": null, "originalAssignee": null, "originalCitation": "Tabak BA et al. (2023). \"Advances in human oxytocin measurement: challenges and proposed solutions.\" Molecular Psychiatry (Nature) 28:1–14", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35999276/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Advances+in+human+oxytocin+measurement%3A+challenges+and+proposed+solutions%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-29", "recordId": "pmid-36618821", "sourceType": "Review", "title": "The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.", "authors": "Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.", "year": 2022, "journal": "Frontiers in molecular neuroscience", "doi": "10.3389/fnmol.2022.1055344", "pmid": "36618821", "pmcid": "PMC9812438", "patentNumber": null, "originalAssignee": null, "originalCitation": "Busnelli M, Bhatt S (2022). \"The oxytocin receptor represents a key hub in the GPCR signaling network.\" Frontiers in Endocrinology (PMC 9812438)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36618821/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffnmol.2022.1055344%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-30", "recordId": "hsi-11aecd75cd9043", "sourceType": "Review", "title": "The Multifaceted Role of Oxytocinergic System and <i>OXTR</i> Gene.", "authors": "Hasan R.", "year": 2024, "journal": "Global medical genetics", "doi": "10.1055/s-0044-1779039", "pmid": "38239807", "pmcid": "PMC10796195", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cataldo I et al. (2024). \"The Multifaceted Role of Oxytocinergic System and OXTR Gene.\" International Journal of Molecular Sciences (PMC 10796195)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38239807/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC10796195&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-31", "recordId": "pmid-11792664", "sourceType": "Journal publication", "title": "Baroreflex control of heart rate by oxytocin in the solitary-vagal complex.", "authors": "Higa KT, Mori E, Viana FF, Morris M, Michelini LC.", "year": 2002, "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "doi": "10.1152/ajpregu.00806.2000", "pmid": "11792664", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Higa KT et al. (2002). \"Baroreflex control of heart rate by oxytocin in the solitary-vagal complex.\" American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 282(2):R537–R545 (PMID 11792664)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/11792664/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11792664+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-32", "recordId": "pmid-27790154", "sourceType": "Journal publication", "title": "Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats.", "authors": "De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.", "year": 2016, "journal": "Frontiers in physiology", "doi": "10.3389/fphys.2016.00461", "pmid": "27790154", "pmcid": "PMC5063006", "patentNumber": null, "originalAssignee": null, "originalCitation": "Martins AS et al. (2016). \"Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus.\" Frontiers in Physiology (PMC 5063006)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27790154/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffphys.2016.00461%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-33", "recordId": "pmid-12531722", "sourceType": "Journal publication", "title": "Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.", "authors": "Michelini LC, Marcelo MC, Amico J, Morris M.", "year": 2003, "journal": "American journal of physiology. Heart and circulatory physiology", "doi": "10.1152/ajpheart.00774.2002", "pmid": "12531722", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Michelini LC et al. (2003). \"Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.\" American Journal of Physiology – Heart and Circulatory Physiology 284(6):H2269–H2276", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/12531722/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocinergic+regulation+of+cardiovascular+function%3A+studies+in+oxytocin-deficient+mice%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-34", "recordId": "pmid-2914733", "sourceType": "Journal publication", "title": "Baroreceptor influences on oxytocin and vasopressin secretion.", "authors": "Morris M, Alexander N.", "year": 1989, "journal": "Hypertension (Dallas, Tex. : 1979)", "doi": "10.1161/01.hyp.13.2.110", "pmid": "2914733", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Haanwinckel MA et al. (1995). \"Baroreceptor influences on oxytocin and vasopressin secretion.\" Experimental Physiology (PMID 2914733)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/2914733/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A2914733+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-35", "recordId": "hsi-9cc2ba2f0010e1", "sourceType": "Review", "title": "Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.", "authors": "Szczepanska-Sadowska E, Wsol A, Cudnoch-Jedrzejewska A, Żera T.", "year": 2021, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms222111465", "pmid": "34768894", "pmcid": "PMC8584236", "patentNumber": null, "originalAssignee": null, "originalCitation": "Japundžić-Žigon N et al. (2021). \"Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.\" International Journal of Molecular Sciences (PMC 8584236)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34768894/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8584236&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-36", "recordId": "hsi-4904d75ff35109", "sourceType": "Review", "title": "Neuromodulation by oxytocin and vasopressin.", "authors": "Stoop R.", "year": 2012, "journal": "Neuron", "doi": "10.1016/j.neuron.2012.09.025", "pmid": "23040812", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Stoop R (2012). \"Neuromodulation by Oxytocin and Vasopressin.\" Frontiers in Neuroscience 6:335", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/23040812/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Neuromodulation+by+Oxytocin+and+Vasopressin%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-37", "recordId": "hsi-c15e2698527a36", "sourceType": "Journal publication", "title": "Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats.", "authors": "Lozić M, Greenwood M, Šarenac O, Martin A, Hindmarch C, Tasić T, Paton J, Murphy D, Japundžić-Žigon N.", "year": 2014, "journal": "British journal of pharmacology", "doi": "10.1111/bph.12776", "pmid": "24834854", "pmcid": "PMC4209146", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wsol A et al. (2014). \"Overexpression of oxytocin receptors in the hypothalamic PVN enhances cardiovascular regulation.\" Journal of Physiology and Pharmacology (PMC 4209146)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/24834854/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1111%2Fbph.12776%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. 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(2022). \"Evaluation and Diagnosis of Afferent Baroreflex Failure.\" Clinical Autonomic Research (PMC 8761245)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34878899/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8761245&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-39", "recordId": "hsi-25e3cdf609e7e8", "sourceType": "Bibliographic source", "title": "Beyond the Baroreflex: A New Measure of Autonomic Regulation", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Lorthois S, Bhatt S (2022). \"Beyond the Baroreflex: A New Measure of Autonomic Regulation.\" Frontiers in Network Physiology 2:891604", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-40", "recordId": "hsi-2c85ce08716726", "sourceType": "Review", "title": "Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.", "authors": "Miki K, Yoshimoto M.", "year": 2018, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2018.00493", "pmid": "30083091", "pmcid": "PMC6064938", "patentNumber": null, "originalAssignee": null, "originalCitation": "Fadel PJ (2015). \"Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.\" Frontiers in Neuroscience 9:493", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30083091/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Exercise-Induced+Modulation+of+Baroreflex+Control+of+Sympathetic+Nerve+Activity%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-41", "recordId": "hsi-b4a2f9f50b86b4", "sourceType": "Review", "title": "Baroreflex functionality in the eye of diffusion tensor imaging.", "authors": "Tsai CY, Poon YY, Chan JYH, Chan SHH.", "year": 2019, "journal": "The Journal of physiology", "doi": "10.1113/jp277008", "pmid": "30325020", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Reisert M et al. (2018). \"Baroreflex functionality in the eye of diffusion tensor imaging.\" NeuroImage: Clinical (PMC 6312450)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30325020/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Baroreflex+functionality+in+the+eye+of+diffusion+tensor+imaging%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-42", "recordId": "hsi-27332000a2bc2d", "sourceType": "Journal publication", "title": "DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.", "authors": "Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ.", "year": 2018, "journal": "Social cognitive and affective neuroscience", "doi": "10.1093/scan/nsy086", "pmid": "30257007", "pmcid": "PMC6234329", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ (2018). \"DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology.\" Social Cognitive and Affective Neuroscience 13(11):1155–1163 (PMID 30257007; PMC6234329)", "originalSection": "Baroreflex Modulation by Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30257007/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A30257007+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-43", "recordId": "hsi-a738a60b4fd69e", "sourceType": "Journal publication", "title": "Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities.", "authors": "Liu J, Luo H, Zheng PP, Wu SJ, Lee K.", "year": 2018, "journal": "Scientific reports", "doi": "10.1038/s41598-018-28804-0", "pmid": "30002447", "pmcid": "PMC6043515", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wei J et al. (2018). \"Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities.\" Scientific Reports (Nature) 8:10588", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30002447/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Transdermal+optical+imaging+revealed+different+spatiotemporal+patterns+of+facial+cardiovascular+activities%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-44", "recordId": "hsi-cefd1a89919598", "sourceType": "Journal publication", "title": "Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease.", "authors": "Kleiss SF, Ma KF, El Moumni M, Ünlü Ç, Nijboer TS, Schuurmann RCL, Bokkers RPH, de Vries JPM.", "year": 2023, "journal": "Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists", "doi": "10.1177/15266028221082013", "pmid": "35255764", "pmcid": "PMC10209500", "patentNumber": null, "originalAssignee": null, "originalCitation": "Chin MS et al. (2023). \"Detecting Changes in Tissue Perfusion With Hyperspectral Imaging.\" Advances in Wound Care (PMC 10209500)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35255764/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1177%2F15266028221082013%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. 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(2021). \"New evidence from hyperspectral imaging analysis on the effect of wound dressings.\" International Wound Journal (PMID 34436694)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "identifier-conflict", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Supplied identifier and cited title conflict. 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(2024). \"Investigation on the influence of the skin tone on hyperspectral imaging.\" Scientific Reports (Nature) 14:14349", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38886457/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Investigation+on+the+influence+of+the+skin+tone+on+hyperspectral+imaging%22&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-47", "recordId": "hsi-474aae27e254f6", "sourceType": "Review", "title": "Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review.", "authors": "Hren R, Sersa G, Simoncic U, Milanic M.", "year": 2022, "journal": "Radiology and oncology", "doi": "10.2478/raon-2022-0051", "pmid": "36503709", "pmcid": "PMC9784371", "patentNumber": null, "originalAssignee": null, "originalCitation": "Barberio M et al. (2022). \"Imaging perfusion changes in oncological clinical applications by hyperspectral imaging.\" Journal of Biomedical Optics (PMID 36503709)", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36503709/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A36503709+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-48", "recordId": "hsi-66bec84627b0dc", "sourceType": "Bibliographic source", "title": "Review on the Application of Hyperspectral Imaging Technology of Microbiological and Chemical Properties of Food", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Chen H et al. (2022). \"Review on the Application of Hyperspectral Imaging Technology of Microbiological and Chemical Properties of Food.\" Frontiers in Bioengineering and Biotechnology 10:906728", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-49", "recordId": "hsi-9d14d253c181bc", "sourceType": "Journal publication", "title": "Detecting Happiness Using Hyperspectral Imaging Technology.", "authors": "Hao M, Liu G, Gokhale A, Xu Y, Chen R.", "year": 2019, "journal": "Computational intelligence and neuroscience", "doi": "10.1155/2019/1965789", "pmid": "30766598", "pmcid": "PMC6350538", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yang Y et al. (2019). \"Detecting Happiness Using Hyperspectral Imaging Technology.\" Computational Intelligence and Neuroscience 2019:1965789", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30766598/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Detecting+Happiness+Using+Hyperspectral+Imaging+Technology%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-50", "recordId": "hsi-113f6b6b7e2532", "sourceType": "Journal publication", "title": "A novel role of oxytocin: Oxytocin-induced well-being in humans.", "authors": "Ito E, Shima R, Yoshioka T.", "year": 2019, "journal": "Biophysics and physicobiology", "doi": "10.2142/biophysico.16.0_132", "pmid": "31608203", "pmcid": "PMC6784812", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ishak WW et al. (2011). \"A novel role of oxytocin: Oxytocin-induced well-being in humans.\" International Journal of Psychiatry in Medicine (PMC 6784812)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31608203/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC6784812&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-51", "recordId": "hsi-f85613b2aab02b", "sourceType": "Bibliographic source", "title": "Considerations in the development of oxytocin-based therapeutics", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Bhatt S, Young KA (2013). \"Considerations in the development of oxytocin-based therapeutics.\" Frontiers in Neuroscience 7:35", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-52", "recordId": "hsi-d85459e14c4885", "sourceType": "Journal publication", "title": "Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults.", "authors": "Shoenfelt A, Pehlivanoglu D, Lin T, Ziaei M, Feifel D, Ebner NC.", "year": 2024, "journal": "Psychoneuroendocrinology", "doi": "10.1016/j.psyneuen.2024.107018", "pmid": "38461634", "pmcid": "PMC11699979", "patentNumber": null, "originalAssignee": null, "originalCitation": "Peled-Avron L et al. (2024). \"Effects of chronic intranasal oxytocin on visual attention to faces.\" Psychopharmacology (PMC 11699979)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38461634/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC11699979&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-53", "recordId": "hsi-a6d1ba2316c08d", "sourceType": "Journal publication", "title": "Effects of Oxytocin on Facial Expression and Identity Working Memory Are Found in Females but Not Males.", "authors": "Yue T, Yue C, Liu G, Huang X.", "year": 2018, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2018.00205", "pmid": "29719496", "pmcid": "PMC5913342", "patentNumber": null, "originalAssignee": null, "originalCitation": "Gao S et al. (2018). \"Effects of Oxytocin on Facial Expression and Identity Working Memory.\" Frontiers in Pharmacology (PMC 5913342)", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/29719496/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC5913342&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-54", "recordId": "hsi-2d570b00f2ccf3", "sourceType": "Review", "title": "The Role of Oxytocin in Cardiovascular Protection.", "authors": "Jankowski M, Broderick TL, Gutkowska J.", "year": 2020, "journal": "Frontiers in psychology", "doi": "10.3389/fpsyg.2020.02139", "pmid": "32982875", "pmcid": "PMC7477297", "patentNumber": null, "originalAssignee": null, "originalCitation": "Jankowski M et al. (2020). \"The Role of Oxytocin in Cardiovascular Protection.\" Frontiers in Psychology 11:2139", "originalSection": "OXTR Influence on Facial Microcirculation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/32982875/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22The+Role+of+Oxytocin+in+Cardiovascular+Protection%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-55", "recordId": "hsi-688691ea42776f", "sourceType": "Journal publication", "title": "Hyperspectral imaging for non-invasive blood oxygen saturation assessment", "authors": "Jiangbo Wu", "year": 2024, "journal": "Photodiagnosis and Photodynamic Therapy", "doi": "10.1016/j.pdpdt.2024.104003", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Zhang Y et al. (2024). \"Hyperspectral imaging for non-invasive blood oxygen saturation measurement.\" Computers in Biology and Medicine", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1016/j.pdpdt.2024.104003", "metadataURL": "https://api.crossref.org/works?query.title=Hyperspectral+imaging+for+non-invasive+blood+oxygen+saturation+measurement&rows=3", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-56", "recordId": "hsi-fdb97b4e29c7dd", "sourceType": "Bibliographic source", "title": "Evaluation of hyperspectral imaging to quantify perfusion changes", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Hellmann T et al. (2023). \"Evaluation of hyperspectral imaging to quantify perfusion changes.\" Lasers in Surgery and Medicine 55(5):468–476", "originalSection": "Detectability by HSI / Optical Imaging", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-57", "recordId": "hsi-62d3aa9212928c", "sourceType": "Journal publication", "title": "Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.", "authors": "Goodman RP, Schaap IA, Tardin CF, Erben CM, Berry RM, Schmidt CF, Turberfield AJ.", "year": 2005, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.1120367", "pmid": "16339440", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Goodman RP, Schaap IAT, Tardin CF et al. (2005). \"Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.\" Science 310(5754):1661–1665 — Landmark: Turberfield's original single-step DNA tetrahedron self-assembly", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/16339440/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Rapid+chiral+assembly+of+rigid+DNA+building+blocks+for+molecular+nanofabrication%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-58", "recordId": "hsi-25d9dbb27793f1", "sourceType": "Journal publication", "title": "Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides.", "authors": "Li J, Pei H, Zhu B, Liang L, Wei M, He Y, Chen N, Li D, Huang Q, Fan C.", "year": 2011, "journal": "ACS nano", "doi": "10.1021/nn202774x", "pmid": "21988181", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Li J, Pei H, Zhu B et al. (2011). \"Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides.\" ACS Nano 5(11):8783–8789 — Landmark: first CpG delivery via DNA tetrahedron", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21988181/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Self-assembled+multivalent+DNA+nanostructures+for+noninvasive+intracellular+delivery+of+immunostimulatory+CpG+oligonucleotides%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-59", "recordId": "hsi-e4fe63d45bf8b9", "sourceType": "Journal publication", "title": "Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.", "authors": "Lee H, Lytton-Jean AK, Chen Y, Love KT, Park AI, Karagiannis ED, Sehgal A, Querbes W, Zurenko CS, Jayaraman M, Peng CG, Charisse K, Borodovsky A, Manoharan M, Donahoe JS, Truelove J, Nahrendorf M, Langer R, Anderson DG.", "year": 2012, "journal": "Nature nanotechnology", "doi": "10.1038/nnano.2012.73", "pmid": "22659608", "pmcid": "PMC3898745", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lee H, Lytton-Jean AKR, Chen Y et al. (2012). \"Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.\" Nature Nanotechnology 7(6):389–393 — Landmark: siRNA delivery via DNA tetrahedron extending in vivo half-life", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/22659608/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Molecularly+self-assembled+nucleic+acid+nanoparticles+for+targeted+in+vivo+siRNA+delivery%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-60", "recordId": "hsi-0f08e7dadf9e0b", "sourceType": "Review", "title": "Revolutionizing cancer therapy using tetrahedral DNA nanostructures as intelligent drug delivery systems.", "authors": "Sharma A, Vaswani P, Bhatia D.", "year": 2024, "journal": "Nanoscale advances", "doi": "10.1039/d4na00145a", "pmid": "39050960", "pmcid": "PMC11265600", "patentNumber": null, "originalAssignee": null, "originalCitation": "Zhang T et al. (2024). \"Revolutionizing cancer therapy using tetrahedral DNA nanostructures as intelligent drug delivery systems.\" Nanoscale Advances (RSC Publishing) (PMC 11265600)", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39050960/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC11265600&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-61", "recordId": "pmid-28891335", "sourceType": "Review", "title": "Development of DNA tetrahedron-based drug delivery system.", "authors": "Hu Y, Chen Z, Zhang H, Li M, Hou Z, Luo X, Xue X.", "year": 2017, "journal": "Drug delivery", "doi": "10.1080/10717544.2017.1373166", "pmid": "28891335", "pmcid": "PMC8241089", "patentNumber": null, "originalAssignee": null, "originalCitation": "Hu Y, Chen Z, Zhang H et al. (2017). \"Development of DNA tetrahedron-based drug delivery systems.\" Drug Delivery 24(1):1295–1301 (PMC 8241089)", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28891335/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8241089&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-62", "recordId": "hsi-73a17e50a48e07", "sourceType": "Review", "title": "DNA Nanotechnology for Cancer Therapy.", "authors": "Kumar V, Palazzolo S, Bayda S, Corona G, Toffoli G, Rizzolio F.", "year": 2016, "journal": "Theranostics", "doi": "10.7150/thno.14203", "pmid": "27022418", "pmcid": "PMC4805665", "patentNumber": null, "originalAssignee": null, "originalCitation": "Angell C, Xie S, Zhang L, Chen Y (2016). \"DNA Nanotechnology for Cancer Therapy.\" Journal of Biomedical Nanotechnology 12(6):1101–1116 (PMC 4805665)", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27022418/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC4805665&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-63", "recordId": "hsi-7388517063a7af", "sourceType": "Review", "title": "Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration.", "authors": "Dou Y, Cui W, Yang X, Lin Y, Ma X, Cai X.", "year": 2022, "journal": "Burns & trauma", "doi": "10.1093/burnst/tkac006", "pmid": "35280457", "pmcid": "PMC8912983", "patentNumber": null, "originalAssignee": null, "originalCitation": "Zhang M, Zhang X, Tian T et al. (2022). \"Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration.\" Military Medical Research 9:12 (PMC 8912983)", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35280457/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC8912983&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-64", "recordId": "hsi-ab0d1892ea7227", "sourceType": "Review", "title": "Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation.", "authors": "Lin Y, Li Q, Wang L, Guo Q, Liu S, Zhu S, Sun Y, Fan Y, Sun Y, Li H, Tian X, Luo D, Shi S.", "year": 2022, "journal": "International journal of oral science", "doi": "10.1038/s41368-022-00199-9", "pmid": "36316311", "pmcid": "PMC9622686", "patentNumber": null, "originalAssignee": null, "originalCitation": "Liu Y, Sun Y, Li S et al. (2022). \"Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation.\" International Journal of Oral Science (Nature) 14:51", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36316311/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Advances+in+regenerative+medicine+applications+of+tetrahedral+framework+nucleic+acid-based+nanomaterials%3A+an+expert+consensus+recommendation%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-65", "recordId": "hsi-83b2680d02c658", "sourceType": "Review", "title": "DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy.", "authors": "Chi Q, Yang Z, Xu K, Xu K, Wang C, Liang H.", "year": 2019, "journal": "Frontiers in pharmacology", "doi": "10.3389/fphar.2019.01585", "pmid": "32063844", "pmcid": "PMC6997790", "patentNumber": null, "originalAssignee": null, "originalCitation": "Liu J, Song L, Liu S et al. (2019). \"DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy.\" Frontiers in Pharmacology 10:1585", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/32063844/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22DNA+Nanostructure+as+an+Efficient+Drug+Delivery+Platform+for+Immunotherapy%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-66", "recordId": "hsi-ab41c0abb24e53", "sourceType": "Journal publication", "title": "DNA origami as a carrier for circumvention of drug resistance.", "authors": "Jiang Q, Song C, Nangreave J, Liu X, Lin L, Qiu D, Wang ZG, Zou G, Liang X, Yan H, Ding B.", "year": 2012, "journal": "Journal of the American Chemical Society", "doi": "10.1021/ja304263n", "pmid": "22803823", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Jiang Q, Song C, Nangreave J et al. (2012). \"DNA Origami as a Carrier for Circumvention of Drug Resistance.\" Journal of the American Chemical Society 134(32):13396–13403 — Landmark: DNA nanostructures overcoming drug resistance in cancer", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/22803823/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22DNA+Origami+as+a+Carrier+for+Circumvention+of+Drug+Resistance%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-67", "recordId": "hsi-2bdd395b380845", "sourceType": "Journal publication", "title": "Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure.", "authors": "Xia K, Kong H, Cui Y, Ren N, Li Q, Ma J, Cui R, Zhang Y, Shi J, Li Q, Lv M, Sun Y, Wang L, Li J, Zhu Y.", "year": 2018, "journal": "ACS applied materials & interfaces", "doi": "10.1021/acsami.8b02626", "pmid": "29668248", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xia K, Kong H, Cui Y et al. (2022). \"Systematic study in mammalian cells showing no adverse response to tetrahedral DNA nanostructure.\" ACS Applied Materials & Interfaces 10(18):15442–15452 (PMC 6032219) — Biocompatibility validation", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/29668248/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Systematic+study+in+mammalian+cells+showing+no+adverse+response+to+tetrahedral+DNA+nanostructure%22&format=json&resultType=core&pageSize=4", "corrections": [ "A supplied identifier resolved to another title; the accepted record was matched separately by title." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-68", "recordId": "hsi-f195eb8e628a71", "sourceType": "Journal publication", "title": "Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis.", "authors": "Yan J, Chen J, Zhang N, Yang Y, Zhu W, Li L, He B.", "year": 2020, "journal": "Journal of materials chemistry. B", "doi": "10.1039/c9tb02266j", "pmid": "31840727", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Yan J, Chen J, Zhang N et al. (2020). \"Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis.\" Journal of Materials Chemistry B (RSC Publishing)", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31840727/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Mitochondria-targeted+tetrahedral+DNA+nanostructures+for+doxorubicin+delivery+and+enhancement+of+apoptosis%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-69", "recordId": "hsi-60b2c2a14403dd", "sourceType": "Journal publication", "title": "Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe.", "authors": "Tian T, Li J, Xie C, Sun Y, Lei H, Liu X, Xia J, Shi J, Wang L, Lu W, Fan C.", "year": 2018, "journal": "ACS applied materials & interfaces", "doi": "10.1021/acsami.7b17927", "pmid": "29299920", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Tian T, Li J, Xie C et al. (2023). \"Targeted imaging of brain tumors with a framework nucleic acid probe.\" ACS Applied Materials & Interfaces 15(7):9223–9232 — TDN for neurological disease imaging", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/29299920/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Targeted+imaging+of+brain+tumors+with+a+framework+nucleic+acid+probe%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-70", "recordId": "hsi-8d0c61cbbe9b8f", "sourceType": "Journal publication", "title": "Aptamer-Modified Tetrahedral DNA Nanostructure for Tumor-Targeted Drug Delivery.", "authors": "Li Q, Zhao D, Shao X, Lin S, Xie X, Liu M, Ma W, Shi S, Lin Y.", "year": 2017, "journal": "ACS applied materials & interfaces", "doi": "10.1021/acsami.7b13328", "pmid": "28991436", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Li Q, Zhao D, Shao X et al. (2017). \"Aptamer-modified tetrahedral DNA nanostructure for tumor-targeted drug delivery.\" ACS Applied Materials & Interfaces 9(42):36695–36701 — Aptamer-functionalised TDN for targeted oncology", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28991436/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Aptamer-modified+tetrahedral+DNA+nanostructure+for+tumor-targeted+drug+delivery%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-71", "recordId": "hsi-bf70680de4d4e4", "sourceType": "Bibliographic source", "title": "Biomimetic nanoerythrosome-coated aptamer–DNA tetrahedron/maytansine conjugates: pH-responsive drug release, targeted delivery and synergistic treatment of cancer", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Ma W, Yang Y, Zhu J et al. (2022). \"Biomimetic nanoerythrosome-coated aptamer–DNA tetrahedron/maytansine conjugates: pH-responsive drug release, targeted delivery and synergistic treatment of cancer.\" Nature Communications — DNA tetrahedron conjugate for synergistic cancer therapy", "originalSection": "Platonic Geometries / DNA Tetrahedrons", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-72", "recordId": "hsi-10ecf2c046f745", "sourceType": "Journal publication", "title": "X-ray structures and mechanism of the human serotonin transporter.", "authors": "Coleman JA, Green EM, Gouaux E.", "year": 2016, "journal": "Nature", "doi": "10.1038/nature17629", "pmid": "27049939", "pmcid": "PMC4898786", "patentNumber": null, "originalAssignee": null, "originalCitation": "Coleman JA, Green EM, Gouaux E (2016). \"X-ray structures and mechanism of the human serotonin transporter.\" Nature 532(7599):334–339", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27049939/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22X-ray+structures+and+mechanism+of+the+human+serotonin+transporter%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-73", "recordId": "hsi-946216a176e063", "sourceType": "Journal publication", "title": "G Protein Activation by Serotonin Type 4 Receptor Dimers", "authors": "Lucie P. Pellissier; Gaël Barthet; Florence Gaven; Elisabeth Cassier; Eric Trinquet; Jean-Philippe Pin; Philippe Marin; Aline Dumuis; Joël Bockaert; Jean-Louis Banères; Sylvie Claeysen", "year": 2011, "journal": "Journal of Biological Chemistry", "doi": "10.1074/jbc.m110.201939", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Pellissier LP et al. (2011). \"G protein activation by serotonin type 4 receptor dimers.\" Journal of Biological Chemistry 286(12):9985–9997", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1074/jbc.m110.201939", "metadataURL": "https://api.crossref.org/works?query.title=G+protein+activation+by+serotonin+type+4+receptor+dimers&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-74", "recordId": "portal-75ae9eff6740", "sourceType": "Journal publication", "title": "Effect of 528 Hz Music on the Endocrine System and Autonomic Nervous System", "authors": "Kaho Akimoto; Ailing Hu; Takuji Yamaguchi; Hiroyuki Kobayashi", "year": 2018, "journal": "Health", "doi": "10.4236/health.2018.109088", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Akimoto K, Hu A, Yamaguchi T, Kobayashi H (2018). \"Effect of 528 Hz Music on the Endocrine System and Autonomic Nervous System.\" Health (SCIRP) 10:1159–1170", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.4236/health.2018.109088", "metadataURL": "https://api.crossref.org/works?query.title=Effect+of+528+Hz+Music+on+the+Endocrine+System+and+Autonomic+Nervous+System&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-75", "recordId": "hsi-aab85699a77a3d", "sourceType": "Journal publication", "title": "Oxytocin inhibits ethanol consumption and ethanol-induced dopamine release in the nucleus accumbens.", "authors": "Peters ST, Bowen MT, Bohrer K, McGregor IS, Neumann ID.", "year": 2017, "journal": "Addiction biology", "doi": "10.1111/adb.12362", "pmid": "26810371", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Peters ST, Bowen MT, Bohrer K, McGregor IS, Neumann ID (2017). \"Oxytocin inhibits ethanol consumption and ethanol-induced dopamine release in the nucleus accumbens.\" Addiction Biology 22(3):702–711", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/26810371/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocin+inhibits+ethanol+consumption+and+ethanol-induced+dopamine+release+in+the+nucleus+accumbens%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-76", "recordId": "hsi-77718f06669535", "sourceType": "Journal publication", "title": "Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.", "authors": "Cox BM, Bentzley BS, Regen-Tuero H, See RE, Reichel CM, Aston-Jones G.", "year": 2017, "journal": "Biological psychiatry", "doi": "10.1016/j.biopsych.2016.11.011", "pmid": "28110822", "pmcid": "PMC5432412", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cox BM, Bentzley BS, Regen-Tuero H, See RE, Reichel CM, Aston-Jones G (2017). \"Oxytocin acts in nucleus accumbens to attenuate methamphetamine seeking and demand.\" Biological Psychiatry 81(11):949–958", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28110822/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocin+acts+in+nucleus+accumbens+to+attenuate+methamphetamine+seeking+and+demand%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-77", "recordId": "hsi-4af2057b096b94", "sourceType": "Journal publication", "title": "Intranasal oxytocin blocks alcohol withdrawal in human subjects.", "authors": "Pedersen CA, Smedley KL, Leserman J, Jarskog LF, Rau SW, Kampov-Polevoi A, Casey RL, Fender T, Garbutt JC.", "year": 2013, "journal": "Alcoholism, clinical and experimental research", "doi": "10.1111/j.1530-0277.2012.01958.x", "pmid": "23025690", "pmcid": "PMC3557665", "patentNumber": null, "originalAssignee": null, "originalCitation": "Pedersen CA, Smedley KL, Leserman J et al. 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Synergetics: Explorations in the Geometry of Thinking. New York: Macmillan. §§460.00–465.00 (Jitterbug Transformation)", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Fuller RB (1975). Synergetics: Explorations in the Geometry of Thinking. New York: Macmillan. §§460.00–465.00 (Jitterbug Transformation)", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-85", "recordId": "hsi-8f5609e6da289b", "sourceType": "Bibliographic source", "title": "Ball WWR, Coxeter HSM (1987). Mathematical Recreations and Essays. 13th ed. Dover. pp. 135–144", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Ball WWR, Coxeter HSM (1987). Mathematical Recreations and Essays. 13th ed. Dover. pp. 135–144", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-86", "recordId": "hsi-7d3097f47eb89f", "sourceType": "Bibliographic source", "title": "Coxeter HSM, Du Val P, Flather HT, Petrie JF (1938). The Fifty-Nine Icosahedra. University of Toronto Studies, Mathematical Series 6", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Coxeter HSM, Du Val P, Flather HT, Petrie JF (1938). The Fifty-Nine Icosahedra. University of Toronto Studies, Mathematical Series 6", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-87", "recordId": "hsi-0c64f140769534", "sourceType": "Bibliographic source", "title": "Wenninger MJ (1971). Polyhedron Models. Cambridge University Press. pp. 37", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Wenninger MJ (1971). Polyhedron Models. Cambridge University Press. pp. 37", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-88", "recordId": "hsi-39fab96b7c60e8", "sourceType": "Bibliographic source", "title": "Cromwell PR (1997). Polyhedra. Cambridge University Press. pp. 124, 152", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cromwell PR (1997). Polyhedra. Cambridge University Press. pp. 124, 152", "originalSection": "Gene-Correlated Platonic Solid Inference Vectors", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-89", "recordId": "hsi-26e06f24f0b804", "sourceType": "Journal publication", "title": "Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.", "authors": "Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T, Kim HC.", "year": 2007, "journal": "Journal of pharmacological sciences", "doi": "10.1254/jphs.sc0070348", "pmid": "18094524", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Shin HJ et al. 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(2024). \"Increasing striatal dopamine release through repeated bouts of theta burst TMS of the left DLPFC.\" Frontiers in Neuroscience", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-91", "recordId": "hsi-5251fd98c28e8b", "sourceType": "Journal publication", "title": "Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study.", "authors": "Ko JH, Monchi O, Ptito A, Bloomfield P, Houle S, Strafella AP.", "year": 2008, "journal": "The European journal of neuroscience", "doi": "10.1111/j.1460-9568.2008.06501.x", "pmid": "19046396", "pmcid": "PMC2967524", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ko JH et al. (2008). \"Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task.\" European Journal of Neuroscience", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/19046396/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Theta+burst+stimulation-induced+inhibition+of+dorsolateral+prefrontal+cortex+reveals+hemispheric+asymmetry+in+striatal+dopamine+release+during+a+set-shifting+task%22&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-92", "recordId": "hsi-4efe761244a9d1", "sourceType": "Journal publication", "title": "D2 receptor block abolishes θ burst stimulation-induced neuroplasticity in the human motor cortex.", "authors": "Monte-Silva K, Ruge D, Teo JT, Paulus W, Rothwell JC, Nitsche MA.", "year": 2011, "journal": "Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology", "doi": "10.1038/npp.2011.100", "pmid": "21697824", "pmcid": "PMC3158306", "patentNumber": null, "originalAssignee": null, "originalCitation": "Monte-Silva K et al. (2011). \"D2 Receptor Block Abolishes Theta Burst Stimulation-Induced Neuroplasticity in the Human Motor Cortex.\" Neuropsychopharmacology (PMC3158306)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21697824/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC3158306&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-93", "recordId": "hsi-be932d8730b595", "sourceType": "Journal publication", "title": "Continuous but not intermittent theta burst stimulation decreases striatal dopamine release and cortical excitability.", "authors": "Aceves-Serrano L, Neva JL, Munro J, Parent M, Boyd LA, Doudet DJ.", "year": 2022, "journal": "Experimental neurology", "doi": "10.1016/j.expneurol.2022.114106", "pmid": "35526596", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Aceves-Serrano L, Neva JL, Munro J, Parent M, Boyd LA, Doudet DJ (2022). \"Continuous but not intermittent theta burst stimulation decreases striatal dopamine release and cortical excitability.\" Experimental Neurology 354:114106 (PMID 35526596) — cTBS over left M1 acutely decreased dopamine release bilaterally in putamen; iTBS did not affect dopamine release. [Note: original citation attributed to \"Bhatt DK et al.\" — corrected to Aceves-Serrano L et al. as verified authors]", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35526596/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35526596+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-94a", "recordId": "hsi-30d689c8edc32d", "sourceType": "Journal publication", "title": "Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus.", "authors": "Strafella AP, Paus T, Barrett J, Dagher A.", "year": 2001, "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "doi": "10.1523/jneurosci.21-15-j0003.2001", "pmid": "11459878", "pmcid": "PMC6762641", "patentNumber": null, "originalAssignee": null, "originalCitation": "Strafella AP, Paus T, Barrett J, Dagher A (2001). \"Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus.\" Journal of Neuroscience 21(15):RC157 (PMID 11459878)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/11459878/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11459878+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-94b", "recordId": "hsi-15872e1b8b4ebc", "sourceType": "Journal publication", "title": "Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex.", "authors": "Strafella AP, Paus T, Fraraccio M, Dagher A.", "year": 2003, "journal": "Brain : a journal of neurology", "doi": "10.1093/brain/awg268", "pmid": "12937078", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Strafella AP, Paus T, Barrett J, Dagher A (2003). \"Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex.\" Brain 126(12):2609–2615 (PMID 12937078)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/12937078/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A12937078+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-95", "recordId": "hsi-4bc623819a8a2f", "sourceType": "Bibliographic source", "title": "Extremely low-frequency electromagnetic field exposure during morphine treatment on dopamine D2 receptor expression", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Wang C et al. (2008). \"Extremely low-frequency electromagnetic field exposure during morphine treatment on dopamine D2 receptor expression.\" Neuroscience Letters", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-96a", "recordId": "hsi-608c987e1bbe8a", "sourceType": "Review", "title": "Magnetic fields in the therapy of parkinsonism.", "authors": "Sandyk R.", "year": 1992, "journal": "The International journal of neuroscience", "doi": null, "pmid": "1305620", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Sandyk R (1992). \"Magnetic fields in the therapy of parkinsonism.\" International Journal of Neuroscience 66(3–4):209–235 (PMID 1305620) — Foundational report: picoTesla ELF magnetic fields produced sustained improvement in >20 Parkinson's patients", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/1305620/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A1305620+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-96b", "recordId": "hsi-dbaacd77b57047", "sourceType": "Journal publication", "title": "Treatment of Parkinson's disease with magnetic fields reduces the requirement for antiparkinsonian medications.", "authors": "Sandyk R.", "year": 1994, "journal": "The International journal of neuroscience", "doi": "10.3109/00207459408987239", "pmid": "7928105", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Sandyk R (1994). \"Treatment of Parkinson's disease with magnetic fields reduces the requirement for antiparkinsonian medications.\" International Journal of Neuroscience (PMID 7928105) — picoTesla MF reduced medication requirement", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/7928105/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A7928105+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-96c", "recordId": "hsi-65629c874781f2", "sourceType": "Journal publication", "title": "The effects of external picotesla range magnetic fields on the EEG in Parkinson's disease: a follow up study.", "authors": "Sandyk R.", "year": 1994, "journal": "The International journal of neuroscience", "doi": "10.3109/00207459408986004", "pmid": "7960478", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Sandyk R (1994). \"The effects of external picotesla range magnetic fields on the EEG in Parkinson's disease: a follow up study.\" International Journal of Neuroscience 76(3–4):227–229 (PMID 7960478)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/7960478/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A7960478+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-97", "recordId": "src-d1eaa478462e", "sourceType": "Journal publication", "title": "Long-Term Study of Heart Rate Variability Responses to Changes in the Solar and Geomagnetic Environment.", "authors": "Alabdulgader A, McCraty R, Atkinson M, Dobyns Y, Vainoras A, Ragulskis M, Stolc V.", "year": 2018, "journal": "Scientific reports", "doi": "10.1038/s41598-018-20932-x", "pmid": "29422633", "pmcid": "PMC5805718", "patentNumber": null, "originalAssignee": null, "originalCitation": "McCraty R et al. (2017). \"Long-Term Study of Heart Rate Variability Responses to Changes in the Solar and Geomagnetic Environment.\" Scientific Reports (Nature) 7:16338", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.heartmath.org/research/research-library/coherence/long-term-study-of-hrv-responses-to-changes-in-solar-geomagnetic-enviroment", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Long-Term+Study+of+Heart+Rate+Variability+Responses+to+Changes+in+the+Solar+and+Geomagnetic+Environment%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-98", "recordId": "pmid-28703754", "sourceType": "Journal publication", "title": "Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity in Human Subjects.", "authors": "McCraty R, Atkinson M, Stolc V, Alabdulgader AA, Vainoras A, Ragulskis M.", "year": 2017, "journal": "International journal of environmental research and public health", "doi": "10.3390/ijerph14070770", "pmid": "28703754", "pmcid": "PMC5551208", "patentNumber": null, "originalAssignee": null, "originalCitation": "Alabdulgader AA et al. (2018). \"Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity in Human Subjects.\" International Journal of Environmental Research and Public Health (PMC5551208)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28703754/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC5551208&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-99", "recordId": "hsi-9754d6a5bca560", "sourceType": "Journal publication", "title": "Schumann Resonances and the Human Body: Questions About Interactions, Problems and Prospects", "authors": "Ganna Nevoit; Mantas Landauskas; Rollin McCarty; Inga Arune Bumblyte; Maksim Potyazhenko; Giedre Taletaviciene; Gediminas Jarusevicius; Alfonsas Vainoras", "year": 2025, "journal": "Applied Sciences", "doi": "10.3390/app15010449", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Sdraulig S et al. (2023). \"Schumann Resonances and the Human Body: Questions About Interactions, Problems and Prospects.\" Applied Sciences (MDPI) 15(1):449", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.3390/app15010449", "metadataURL": "https://api.crossref.org/works?query.title=Schumann+Resonances+and+the+Human+Body%3A+Questions+About+Interactions%2C+Problems+and+Prospects&rows=3", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-100a", "recordId": "hsi-de25bca76daa01", "sourceType": "Journal publication", "title": "Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences.", "authors": "Montagnier L, Aïssa J, Ferris S, Montagnier JL, Lavallée C.", "year": 2009, "journal": "Interdisciplinary sciences, computational life sciences", "doi": "10.1007/s12539-009-0036-7", "pmid": "20640822", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Montagnier L, Aissa J, Ferris S, Montagnier JL, Lavallée C (2009). \"Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA Sequences.\" Interdisciplinary Sciences: Computational Life Sciences 1(2):81–90 (PMID 20640822)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/20640822/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A20640822+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-100b", "recordId": "src-5aaad2520e3b", "sourceType": "Conference publication", "title": "DNA waves and water", "authors": "L Montagnier; J Aissa; E Del Giudice; C Lavallee; A Tedeschi; G Vitiello", "year": 2011, "journal": "Journal of Physics: Conference Series", "doi": "10.1088/1742-6596/306/1/012007", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Montagnier L, Aissa J, Del Giudice E, Lavallée C, Tedeschi A, Vitiello G (2011). \"DNA waves and water.\" Journal of Physics: Conference Series 306:012007 (arXiv:1012.5166)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.researchgate.net/publication/230937823_DNA_waves_and_water", "metadataURL": "https://api.crossref.org/works?query.title=DNA+waves+and+water&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-100c", "recordId": "src-d8da0823ac49", "sourceType": "Review", "title": "Transduction of DNA information through water and electromagnetic waves.", "authors": "Montagnier L, Del Giudice E, Aïssa J, Lavallee C, Motschwiller S, Capolupo A, Polcari A, Romano P, Tedeschi A, Vitiello G.", "year": 2015, "journal": "Electromagnetic biology and medicine", "doi": "10.3109/15368378.2015.1036072", "pmid": "26098521", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Montagnier L, Del Giudice E, Aissa J et al. (2015). \"Transduction of DNA information through water and electromagnetic waves.\" Electromagnetic Biology and Medicine 34(2):106–112 (PMID 26098521) — 7 Hz electromagnetic stimulation required for DNA transduction; removal of Schumann resonance background abolished effect.", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://arxiv.org/pdf/1501.01620.pdf", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A26098521+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-101a", "recordId": "pmid-30889982", "sourceType": "Journal publication", "title": "Effects of extremely low-frequency electromagnetic fields on B16F10 cancer cells.", "authors": "Tang JY, Yeh TW, Huang YT, Wang MH, Jang LS.", "year": 2019, "journal": "Electromagnetic biology and medicine", "doi": "10.1080/15368378.2019.1591438", "pmid": "30889982", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Tang JY et al. (2019). \"Effects of extremely low-frequency electromagnetic fields on B16F10 cancer cells.\" Electromagnetic Biology and Medicine (PMID 30889982) — 7.83 Hz ELF: 17% melanoma cell growth inhibition", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30889982/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A30889982+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-101b", "recordId": "pmid-33111597", "sourceType": "Journal publication", "title": "Inhibition of B16F10 Cancer Cell Growth by Exposure to the Square Wave with 7.83+/-0.3Hz Involves L- and T-Type Calcium Channels.", "authors": "Wang MH, Jian MW, Tai YH, Jang LS, Chen CH.", "year": 2021, "journal": "Electromagnetic biology and medicine", "doi": "10.1080/15368378.2020.1839491", "pmid": "33111597", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Tang JY et al. (2020). Electromagnetic Biology and Medicine (PMID 33111597) — 7.83 Hz ELF: 26.4% melanoma cell growth inhibition via calcium channel modulation", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33111597/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1080%2F15368378.2020.1839491%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-102", "recordId": "hsi-e2e37e929bf669", "sourceType": "Bibliographic source", "title": "Kim JH et al. (2015). ELF-MF altered turnover and receptor reactivity of serotonergic and dopaminergic systems. Brain Sciences (MDPI)", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Kim JH et al. (2015). ELF-MF altered turnover and receptor reactivity of serotonergic and dopaminergic systems. Brain Sciences (MDPI)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-103", "recordId": "hsi-77fdc107df5fe0", "sourceType": "Journal publication", "title": "Extremely low frequency magnetic field modulates the level of neurotransmitters.", "authors": "Chung YH, Lee YJ, Lee HS, Chung SJ, Lim CH, Oh KW, Sohn UD, Park ES, Jeong JH.", "year": 2015, "journal": "The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology", "doi": "10.4196/kjpp.2015.19.1.15", "pmid": "25605992", "pmcid": "PMC4297757", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cichon N et al. (2015). ELF-MF modulated major neurotransmitter levels in rat brain including elevated dopamine in thalamus. Bioelectromagnetics (PMC4297757)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25605992/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.4196%2Fkjpp.2015.19.1.15%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-104", "recordId": "hsi-228d0ab78ee822", "sourceType": "Review", "title": "Exploring the influence of Schumann resonance and electromagnetic fields on bioelectricity and human health.", "authors": "Nelson I.", "year": 2025, "journal": "Electromagnetic biology and medicine", "doi": "10.1080/15368378.2025.2508466", "pmid": "40394813", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Gazdag E (2025). \"Exploring the influence of Schumann resonance and electromagnetic fields on bioelectricity and human health.\" Electromagnetic Biology and Medicine", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40394813/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Exploring+the+influence+of+Schumann+resonance+and+electromagnetic+fields+on+bioelectricity+and+human+health%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-105", "recordId": "pmid-16275477", "sourceType": "Journal publication", "title": "Does Schumann resonance affect our blood pressure?", "authors": "Mitsutake G, Otsuka K, Hayakawa M, Sekiguchi M, Cornélissen G, Halberg F.", "year": 2005, "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "doi": "10.1016/s0753-3322(05)80003-4", "pmid": "16275477", "pmcid": "PMC2656447", "patentNumber": null, "originalAssignee": null, "originalCitation": "Gmitrov J, Ohkubo C (2002). \"Does Schumann resonance affect our blood pressure?\" Biomedicine & Pharmacotherapy (PMC2656447)", "originalSection": "Schumann Resonance, ELF, and Dopaminergic Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/16275477/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC2656447&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-106", "recordId": "src-76124b78a2d9", "sourceType": "Journal publication", "title": "The Effects of 528 Hz Sound Wave to Reduce Cell Death in Human Astrocyte Primary Cell Culture Treated with Ethanol", "authors": "Tohid Babayi; Gholam Hossein Riazi", "year": 2017, "journal": "Journal of Addiction Research & Therapy", "doi": "10.4172/2155-6105.1000335", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Babayi G, Riazi GH (2017). \"The Effects of 528 Hz Sound Wave to Reduce Cell Death in Human Astrocyte Primary Cell Culture Treated with Ethanol.\" Journal of Addiction Research & Therapy", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.omicsonline.org/open-access/the-effects-of-528-hz-sound-wave-to-reduce-cell-death-in-human-astrocyteprimary-cell-culture-treated-with-ethanol-2155-6105-1000335.php?aid=91771", "metadataURL": "https://api.crossref.org/works?query.title=The+Effects+of+528+Hz+Sound+Wave+to+Reduce+Cell+Death+in+Human+Astrocyte+Primary+Cell+Culture+Treated+with+Ethanol&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-107", "recordId": "pmid-30414050", "sourceType": "Journal publication", "title": "Influence of various intensities of 528 Hz sound-wave in production of testosterone in rat's brain and analysis of behavioral changes.", "authors": "Babayi Daylari T, Riazi GH, Pooyan S, Fathi E, Hedayati Katouli F.", "year": 2019, "journal": "Genes & genomics", "doi": "10.1007/s13258-018-0753-6", "pmid": "30414050", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Babayi Daylari M et al. (2019). \"Influence of various intensities of 528 Hz sound-wave in production of testosterone in rat's brain and analysis of behavioral changes.\" Genes & Genomics (Springer)", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30414050/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Influence+of+various+intensities+of+528+Hz+sound-wave+in+production+of+testosterone+in+rat%27s+brain+and+analysis+of+behavioral+changes%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-108", "recordId": "hsi-c2e2e55e945231", "sourceType": "Journal publication", "title": "Effect of OM Chanting of 528Hz Frequency on Heart Rate Variability, Psychological Wellbeing, and Quality of Sleep in Patients of Hypertension: A Randomised Controlled Trial.", "authors": "Bhoot A, Chowdhury AB, Shah H, Vaishnav B.", "year": 2025, "journal": "Annals of neurosciences", "doi": "10.1177/09727531251390261", "pmid": "41395351", "pmcid": "PMC12700779", "patentNumber": null, "originalAssignee": null, "originalCitation": "OM Chanting 528 Hz RCT (2024). \"Effect of OM Chanting of 528Hz Frequency on Heart Rate Variability, Psychological Wellbeing, and Quality of Sleep in Patients of Hypertension.\" PMC (PMC12700779)", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/41395351/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12700779&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-109", "recordId": "hsi-d7705f9004e7f6", "sourceType": "Bibliographic source", "title": "Feneberg AC et al. (2020) / PMC Music-as-Stress-Management Review (2022). 528 Hz more pronounced stress-reducing effect than 440 Hz; lowers cortisol, increases oxytocin. Frontiers in Psychiatry; PMC (PMC9480195)", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Feneberg AC et al. (2020) / PMC Music-as-Stress-Management Review (2022). 528 Hz more pronounced stress-reducing effect than 440 Hz; lowers cortisol, increases oxytocin. Frontiers in Psychiatry; PMC (PMC9480195)", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "identifier-conflict", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Supplied identifier and cited title conflict. No replacement publication has been accepted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-110", "recordId": "hsi-678a9434e390e7", "sourceType": "Journal publication", "title": "Certain frequency music has attracted attention for possible effective healing", "authors": "Hiroshi BANDO; Akiyo Yoshioka; Masahiro Bando; Yu Nishikiori", "year": 2023, "journal": "International Journal of Complementary and Alternative Medicine", "doi": "10.15406/ijcam.2023.16.00639", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Nozaki M (2023). \"Certain frequency music has attracted attention for possible effective healing.\" 528 Hz reduced cortisol/chromogranin A, increased oxytocin. International Journal of Complementary & Alternative Medicine", "originalSection": "528 Hz Sound Frequency and Oxytocin Modulation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.15406/ijcam.2023.16.00639", "metadataURL": "https://api.crossref.org/works?query.title=Certain+frequency+music+has+attracted+attention+for+possible+effective+healing&rows=3", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-112", "recordId": "hsi-f7aa09edd12cad", "sourceType": "Journal publication", "title": "Neural correlates of the DMT experience assessed with multivariate EEG.", "authors": "Timmermann C, Roseman L, Schartner M, Milliere R, Williams LTJ, Erritzoe D, Muthukumaraswamy S, Ashton M, Bendrioua A, Kaur O, Turton S, Nour MM, Day CM, Leech R, Nutt DJ, Carhart-Harris RL.", "year": 2019, "journal": "Scientific reports", "doi": "10.1038/s41598-019-51974-4", "pmid": "31745107", "pmcid": "PMC6864083", "patentNumber": null, "originalAssignee": null, "originalCitation": "Timmermann C et al. (2019). \"Neural correlates of the DMT experience assessed with multivariate EEG.\" IV DMT: increased gamma oscillations, 5-HT2A mediated. Scientific Reports (Nature)", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31745107/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Neural+correlates+of+the+DMT+experience+assessed+with+multivariate+EEG%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-113", "recordId": "hsi-c6f6e59d6a927f", "sourceType": "Journal publication", "title": "Human brain effects of DMT assessed via EEG-fMRI.", "authors": "Timmermann C, Roseman L, Haridas S, Rosas FE, Luan L, Kettner H, Martell J, Erritzoe D, Tagliazucchi E, Pallavicini C, Girn M, Alamia A, Leech R, Nutt DJ, Carhart-Harris RL.", "year": 2023, "journal": "Proceedings of the National Academy of Sciences of the United States of America", "doi": "10.1073/pnas.2218949120", "pmid": "36940333", "pmcid": "PMC10068756", "patentNumber": null, "originalAssignee": null, "originalCitation": "Timmermann C et al. (2023). \"Human brain effects of DMT assessed via EEG-fMRI.\" DMT gamma oscillations correlated with 5-HT2A receptor density. PNAS (PMC10068756)", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36940333/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC10068756&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-114", "recordId": "hsi-fd5105023e2775", "sourceType": "Journal publication", "title": "Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting.", "authors": "Tagliazucchi E, Zamberlan F, Cavanna F, de la Fuente L, Romero C, Sanz Perl Y, Pallavicini C.", "year": 2021, "journal": "Frontiers in psychiatry", "doi": "10.3389/fpsyt.2021.720066", "pmid": "34803754", "pmcid": "PMC8602571", "patentNumber": null, "originalAssignee": null, "originalCitation": "Pallavicini C et al. (2021). \"Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting.\" Frontiers in Psychiatry", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34803754/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Baseline+Power+of+Theta+Oscillations+Predicts+Mystical-Type+Experiences+Induced+by+DMT+in+a+Natural+Setting%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-115", "recordId": "hsi-1f05ba573dcb27", "sourceType": "Journal publication", "title": "Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors.", "authors": "Smith RL, Canton H, Barrett RJ, Sanders-Bush E.", "year": 1998, "journal": "Pharmacology, biochemistry, and behavior", "doi": "10.1016/s0091-3057(98)00110-5", "pmid": "9768567", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Smith RL et al. (1998). \"Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors.\" DMT full agonist at 5-HT2A. Behavioural Brain Research", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/9768567/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Agonist+properties+of+N%2CN-dimethyltryptamine+at+serotonin+5-HT2A+and+5-HT2C+receptors%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-116", "recordId": "hsi-fe9beed0c48feb", "sourceType": "Bibliographic source", "title": "Barker SA et al. (2019). Endogenous DMT naturally produced in mammalian brain neurons. Scientific Reports (Nature)", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Barker SA et al. (2019). Endogenous DMT naturally produced in mammalian brain neurons. Scientific Reports (Nature)", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-117", "recordId": "hsi-ac1a12e6336bc8", "sourceType": "Journal publication", "title": "Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors.", "authors": "Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE.", "year": 2023, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.adf0435", "pmid": "36795823", "pmcid": "PMC10108900", "patentNumber": null, "originalAssignee": null, "originalCitation": "Olson DE et al. (2023). \"Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors.\" Science", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36795823/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Psychedelics+promote+neuroplasticity+through+the+activation+of+intracellular+5-HT2A+receptors%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-118a", "recordId": "hsi-58c1b04eae1511", "sourceType": "Journal publication", "title": "Acoustical resonances of assorted ancient structures", "authors": "Robert G. Jahn; Paul Devereux; Michael Ibison", "year": 1996, "journal": "The Journal of the Acoustical Society of America", "doi": "10.1121/1.414642", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Jahn RG, Devereux P, Ibison M (1996). \"Acoustical resonances of assorted ancient structures.\" Journal of the Acoustical Society of America 99(2):649–658 — ICRL Project 1995–1996: measured fundamental acoustic resonance of Newgrange, Wayland's Smithy, and other Neolithic chambers at ~110 Hz", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1121/1.414642", "metadataURL": "https://api.crossref.org/works?query.title=Acoustical+resonances+of+assorted+ancient+structures&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-118b", "recordId": "hsi-8df714c2a5352f", "sourceType": "Bibliographic source", "title": "ICRL/Dragon Project/Metageum Joint Project: Acoustic measurements at the Ħal Saflieni Hypogeum, Malta", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Devereux P et al. (2007). ICRL/Dragon Project/Metageum Joint Project: Acoustic measurements at the Ħal Saflieni Hypogeum, Malta — confirmed Oracle Room resonance at ~110 Hz. [Note: original NPL-118 attributed this to \"Cambridge University archaeoacoustics programme (2008)\" — correct attribution is ICRL, Princeton, with field work 1995–2007]", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-119", "recordId": "hsi-02ab11b6d0ef93", "sourceType": "Journal publication", "title": "Ancient Architectural Acoustic Resonance Patterns and Regional Brain Activity", "authors": "Ian A. Cook; Sarah K. Pajot; Andrew F. Leuchter", "year": 2008, "journal": "Time and Mind", "doi": "10.2752/175169608783489099", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cook IA, Pajot SK, Leuchter AF (2008). \"Ancient Architectural Acoustic Resonance Patterns and Regional Brain Activity.\" Time and Mind 1(1):95–104 — EEG pilot study (n=30): 110 Hz produced significantly lower left temporal activity and prefrontal asymmetry shift from left to right hemispheric dominance compared to 90, 100, 120, 130 Hz tones. [Note: study tested 110 Hz, not 111 Hz; body text references to \"111 Hz\" for this study should be reviewed]", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.2752/175169608783489099", "metadataURL": "https://api.crossref.org/works?query.title=Ancient+Architectural+Acoustic+Resonance+Patterns+and+Regional+Brain+Activity&rows=3", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-120", "recordId": "hsi-a4e2cdb5885ae2", "sourceType": "Journal publication", "title": "Effects of Geometric Sound on Brainwave Activity Patterns, Autonomic Nervous System Markers, Emotional Response, and Faraday Wave Pattern Morphology.", "authors": "Geffen R, Braun C.", "year": 2024, "journal": "Evidence-based complementary and alternative medicine : eCAM", "doi": "10.1155/2024/9844809", "pmid": "38586300", "pmcid": "PMC10997421", "patentNumber": null, "originalAssignee": null, "originalCitation": "Geffen N et al. (2024). \"Effects of Geometric Sound on Brainwave Activity Patterns, Autonomic Nervous System Markers, Emotional Response, and Faraday Wave Pattern Morphology.\" 111 Hz: serotonin +10%, oxytocin +5%. Evidence-Based Complementary and Alternative Medicine (Wiley) (PMC10997421)", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38586300/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC10997421&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-121", "recordId": "hsi-a6e8dbdcc31098", "sourceType": "Review", "title": "N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function.", "authors": "Barker SA.", "year": 2018, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2018.00536", "pmid": "30127713", "pmcid": "PMC6088236", "patentNumber": null, "originalAssignee": null, "originalCitation": "Barker SA (2018). \"N,N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research.\" DMT binding: ~6 µM SERT/SLC6A4, ~22 µM DAT. Frontiers in Neuroscience (PMC5048497)", "originalSection": "111 Hz Gamma-Band, Serotonergic/DMT Pathways", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30127713/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffnins.2018.00536%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. 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Analysis of U.S. occupational mix change since ChatGPT release (Nov 2022), finding no economy-wide employment disruption after 33 months; occupational change pace only ~1 percentage point above internet-era comparison; OpenAI exposure and Anthropic usage data show stable employment shares across AI-exposed occupations. 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The Deficit Myth: Modern Monetary Theory and the Birth of the People's Economy. PublicAffairs", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Kelton S (2020). The Deficit Myth: Modern Monetary Theory and the Birth of the People's Economy. PublicAffairs", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-130", "recordId": "hsi-3bbc732bf7d08f", "sourceType": "Bibliographic source", "title": "Wray LR (2015). Modern Money Theory: A Primer on Macroeconomics for Sovereign Monetary Systems. 2nd ed. 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Soft Currency Economics.", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Mosler WB (1993). Soft Currency Economics. — Foundational MMT framework for sovereign currency issuance", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-132", "recordId": "hsi-ce00f43b88b08e", "sourceType": "Bibliographic source", "title": "Tcherneva PR (2020). The Case for a Job Guarantee. Polity Press", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Tcherneva PR (2020). The Case for a Job Guarantee. Polity Press — MMT-informed direct employment as automatic stabiliser during structural transformation", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-133", "recordId": "hsi-b2caf4e538d889", "sourceType": "Bibliographic source", "title": "MIGA Convention (1985) / World Bank Group (2024). MIGA Annual Report 2023.", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "MIGA Convention (1985) / World Bank Group (2024). MIGA Annual Report 2023. — Sovereign investment guarantees for developing economies and fragile states", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-134", "recordId": "hsi-f8d72d4059c326", "sourceType": "Bibliographic source", "title": "Chainlink: A Decentralized Oracle Network", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Nazarov S, Ellis A (2017). \"Chainlink: A Decentralized Oracle Network.\" Chainlink Whitepaper — Decentralised oracle architecture for smart contract external data", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-135", "recordId": "hsi-db6bcdd185c65d", "sourceType": "Bibliographic source", "title": "Cross-Chain Interoperability Protocol (CCIP)", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Chainlink Labs (2023). \"Cross-Chain Interoperability Protocol (CCIP).\" Chainlink Technical Documentation — Multi-chain CBDC bridge architecture", "originalSection": "Sovereign Guarantees, MMT, and Oracle Architecture", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-136", "recordId": "hsi-08604531a6bb4f", "sourceType": "Bibliographic source", "title": "Decentralized Identifiers (DIDs) v1.0: Core architecture, data model, and representations", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "W3C (2022). \"Decentralized Identifiers (DIDs) v1.0: Core architecture, data model, and representations.\" World Wide Web Consortium Recommendation — Standard for self-sovereign digital identity enabling individuals to create, own, and control identifiers without centralised authorities", "originalSection": "Self-Sovereign Identity and Genomic Authentication", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-137", "recordId": "hsi-5b22e3b360013a", "sourceType": "Bibliographic source", "title": "The Path to Self-Sovereign Identity", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Allen C (2016). \"The Path to Self-Sovereign Identity.\" Life With Alacrity — Foundational principles of self-sovereign identity: existence, control, access, transparency, persistence, portability, interoperability, consent, minimisation, and protection", "originalSection": "Self-Sovereign Identity and Genomic Authentication", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-138", "recordId": "hsi-881adcbbeae56a", "sourceType": "Bibliographic source", "title": "Preukschat A, Reed D (2021). Self-Sovereign Identity: Decentralized Digital Identity and Verifiable Credentials. Manning Publications", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Preukschat A, Reed D (2021). Self-Sovereign Identity: Decentralized Digital Identity and Verifiable Credentials. Manning Publications — Comprehensive technical framework for SSI architectures combining decentralised identifiers with verifiable credentials", "originalSection": "Self-Sovereign Identity and Genomic Authentication", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-139", "recordId": "hsi-1ab85ffdd4e0cf", "sourceType": "Bibliographic source", "title": "WHO (2022). World Mental Health Report: Transforming Mental Health for All. World Health Organization", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "WHO (2022). World Mental Health Report: Transforming Mental Health for All. World Health Organization — Global shortfall of 1.2+ million mental health workers; fewer than 2 per 100,000 population in low- and middle-income countries", "originalSection": "Robotic and IoT-Based Mental Health Delivery", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-140", "recordId": "pmid-28588005", "sourceType": "Journal publication", "title": "Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial", "authors": "Kathleen Kara Fitzpatrick; Alison Darcy; Molly Vierhile", "year": 2017, "journal": "JMIR Mental Health", "doi": "10.2196/mental.7785", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Fitzpatrick KK, Darcy A, Vierhile M (2017). \"Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression via a Fully Automated Conversational Agent (Woebot): A Randomized Clinical Trial.\" JMIR Mental Health 4(2):e19 — Users disclosed mental health concerns to AI chatbot at rates comparable to human clinicians with reduced stigma", "originalSection": "Robotic and IoT-Based Mental Health Delivery", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28588005/", "metadataURL": "https://api.crossref.org/works?query.title=Delivering+Cognitive+Behavior+Therapy+to+Young+Adults+With+Symptoms+of+Depression+via+a+Fully+Automated+Conversational+Agent+%28Woebot%29%3A+A+Randomized+Clinical+Trial&rows=3", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-141", "recordId": "hsi-e850baebbfec10", "sourceType": "Review", "title": "Chatbots and Conversational Agents in Mental Health: A Review of the Psychiatric Landscape.", "authors": "Vaidyam AN, Wisniewski H, Halamka JD, Kashavan MS, Torous JB.", "year": 2019, "journal": "Canadian journal of psychiatry. Revue canadienne de psychiatrie", "doi": "10.1177/0706743719828977", "pmid": "30897957", "pmcid": "PMC6610568", "patentNumber": null, "originalAssignee": null, "originalCitation": "Vaidyam AN, Wisniewski H, Halamka JD, Kashavan MS, Torous JB (2019). \"Chatbots and Conversational Agents in Mental Health: A Review of the Psychiatric Landscape.\" Canadian Journal of Psychiatry 64(7):456–464 — Review of AI conversational agents for mental health applications; reduced stigma in digital disclosure environments", "originalSection": "Robotic and IoT-Based Mental Health Delivery", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30897957/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Chatbots+and+Conversational+Agents+in+Mental+Health%3A+A+Review+of+the+Psychiatric+Landscape%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-142", "recordId": "hsi-8042baa9bf1d2d", "sourceType": "Review", "title": "Interactions With Robots: The Truths We Reveal About Ourselves.", "authors": "Broadbent E.", "year": 2017, "journal": "Annual review of psychology", "doi": "10.1146/annurev-psych-010416-043958", "pmid": "27648986", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Broadbent E (2017). \"Interactions With Robots: The Truths We Reveal About Ourselves.\" Annual Review of Psychology 68:627–652 — Embodied robots enhance therapeutic engagement, disclosure, and sustained alliance versus screen-based agents", "originalSection": "Robotic and IoT-Based Mental Health Delivery", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27648986/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Interactions+With+Robots%3A+The+Truths+We+Reveal+About+Ourselves%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-143", "recordId": "hsi-ba7873fe043fbf", "sourceType": "Journal publication", "title": "Improving social skills in children with ASD using a long-term, in-home social robot.", "authors": "Scassellati B, Boccanfuso L, Huang CM, Mademtzi M, Qin M, Salomons N, Ventola P, Shic F.", "year": 2018, "journal": "Science robotics", "doi": "10.1126/scirobotics.aat7544", "pmid": "33141724", "pmcid": "PMC10957097", "patentNumber": null, "originalAssignee": null, "originalCitation": "Scassellati B, Boccanfuso L, Huang CM et al. 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(2021). \"Low-Cost Hyperspectral Imaging with A Smartphone.\" Journal of Imaging 7(8):136 (MDPI) — 3D-printed smartphone HSI attachment at ~£100 total cost; proves HSI can be added to consumer smartphones without specialised manufacturing", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34460772/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Low-Cost+Hyperspectral+Imaging+with+A+Smartphone%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-evolution", "role": "Focused chapter source" }, { "ref": "NPL-151", "recordId": "hsi-a911e8605e024c", "sourceType": "Journal publication", "title": "Smartphone-based hyperspectral imaging for ice sheet and proglacial applications in South-West Greenland.", "authors": "Stuart MB, Davies M, Fisk C, Allen E, Sole AJ, Ing R, Hobbs MJ, Willmott JR.", "year": 2024, "journal": "The Science of the total environment", "doi": "10.1016/j.scitotenv.2024.175516", "pmid": "39147066", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Stuart MB et al. (2024). \"Field deployment of a smartphone hyperspectral imaging attachment in South-West Greenland.\" Science of the Total Environment 951:175516 (ScienceDirect) — Operational reliability of smartphone HSI in extreme field conditions for ice sheet and proglacial environmental analysis", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39147066/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.scitotenv.2024.175516%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "imaging-evolution", "role": "Focused chapter source" }, { "ref": "NPL-152", "recordId": "hsi-c2365ea769851d", "sourceType": "Journal publication", "title": "Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection.", "authors": "Meng H, Gao Y, Wang X, Li X, Wang L, Zhao X, Sun B.", "year": 2024, "journal": "Light, science & applications", "doi": "10.1038/s41377-024-01476-4", "pmid": "38802359", "pmcid": "PMC11130170", "patentNumber": null, "originalAssignee": null, "originalCitation": "Meng H, Gao Y et al. (2024). \"Colloidal quantum dot infrared hyperspectral imaging via single-pixel inference.\" Light: Science & Applications (Nature) 13:121 — CQD filters with 128×128 pixel HSI at 8.59 nm spectral resolution across 1050–1630 nm SWIR; miniaturisable architecture compatible with smartphone integration", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38802359/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41377-024-01476-4%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "imaging-evolution", "role": "Focused chapter source" }, { "ref": "NPL-153", "recordId": "hsi-fda6f081ed5bea", "sourceType": "Journal publication", "title": "Hyperspectral Information Extraction With Full Resolution From Arbitrary Photographs.", "authors": "Kwon S, Mok Park S, Ji Y, Sakthivel H, Woo Leem J, Kim YL.", "year": 2025, "journal": "IEEE transactions on image processing : a publication of the IEEE Signal Processing Society", "doi": "10.1109/tip.2025.3597038", "pmid": "40828724", "pmcid": "PMC12481205", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kwon S, Kim YL (2025). \"Hyperspectral Information Extraction From Standard Photographs With Full Resolution.\" IEEE Transactions on Image Processing (ieeexplore.ieee.org/document/11125864) — Formal IEEE peer-reviewed publication: 1–2 nm spectral resolution from standard RGB cameras via colour reference chart; no hardware modification required", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40828724/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1109%2FTIP.2025.3597038%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. 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Townsend", "year": 2020, "journal": "", "doi": "10.7551/mitpress/13382.001.0001", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "CSIRO Data61 (2019). \"Distributed Ledgers\" whitepaper. csiro.au/-/media/D61/Files/Distributed-Ledgers.pdf — Confirms Scyllarus platform capability for spectral analysis from standard cameras; BK met with CSIRO Data61 in 2019 regarding building technology with Scyllarus platform", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.7551/mitpress/13382.001.0001", "metadataURL": "https://api.crossref.org/works?query.title=Distributed+Ledgers&rows=3", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "spectral-reconstruction", "role": "Focused chapter source" }, { "ref": "NPL-156", "recordId": "hsi-21970c827acaf2", "sourceType": "Institutional, commercial or web source", "title": "Affectiva / Smart Eye (2009–present). MIT Media Lab spinoff; 17.4M face videos analysed; FACS-based facial emotion recognition; adopted by 90% of world's largest advertisers. Acquired by Smart Eye (2021). affectiva.com", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Affectiva / Smart Eye (2009–present). MIT Media Lab spinoff; 17.4M face videos analysed; FACS-based facial emotion recognition; adopted by 90% of world's largest advertisers. Acquired by Smart Eye (2021). affectiva.com", "originalSection": "Facial Emotion Recognition Engines", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://affectiva.com", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-157", "recordId": "hsi-9aca948efa6310", "sourceType": "Bibliographic source", "title": "Apple Buys AI Startup That Reads Emotions in Faces", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Apple / Emotient acquisition (January 2016). \"Apple Buys AI Startup That Reads Emotions in Faces.\" Wired (7 January 2016); CNBC (8 January 2016). San Diego startup; crowdsourced ML for facial emotion recognition; integrated into Apple R&D pipeline", "originalSection": "Facial Emotion Recognition Engines", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-158", "recordId": "hsi-3d3b5bdc1825c3", "sourceType": "Bibliographic source", "title": "Comparing Emotion Recognition Tech: Microsoft, Neurodata Lab, Amazon, Affectiva", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Neurodata Lab (2019). \"Comparing Emotion Recognition Tech: Microsoft, Neurodata Lab, Amazon, Affectiva.\" Medium — Independent benchmarking across 7 emotion categories: Microsoft Azure Face API ranked first, Neurodata Lab second, Affectiva and Amazon Rekognition trailing", "originalSection": "Facial Emotion Recognition Engines", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-159", "recordId": "hsi-ed18598f8b5617", "sourceType": "Bibliographic source", "title": "Key Companies in Artificial Intelligence in Emotion Inference", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Research and Markets (2024). \"Key Companies in Artificial Intelligence in Emotion Inference.\" — Market forecast: USD 3.57B by 2030 for AI-based emotion inference technologies", "originalSection": "Facial Emotion Recognition Engines", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-160", "recordId": "hsi-509cb5093173a7", "sourceType": "Institutional, commercial or web source", "title": "Kintsugi Health (2021–present). Voice biomarker API for depression and anxiety inference via short speech samples during routine phone/video interactions. Forbes AI 50. Published in Annals of Family Medicine. kintsugihealth.com", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Kintsugi Health (2021–present). Voice biomarker API for depression and anxiety inference via short speech samples during routine phone/video interactions. Forbes AI 50. Published in Annals of Family Medicine. kintsugihealth.com", "originalSection": "Vocal Biomarker Technologies for Mental Health", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://kintsugihealth.com", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-161", "recordId": "hsi-2d7228bf087a2d", "sourceType": "Institutional, commercial or web source", "title": "Sonde Health (2017–present). Vocal biomarker platform for mental fitness scoring and tracking; 1M+ voice recordings, 80K+ individuals; measures pitch, vocal control, liveliness, energy, clarity. sondehealth.com", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Sonde Health (2017–present). Vocal biomarker platform for mental fitness scoring and tracking; 1M+ voice recordings, 80K+ individuals; measures pitch, vocal control, liveliness, energy, clarity. sondehealth.com", "originalSection": "Vocal Biomarker Technologies for Mental Health", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://sondehealth.com", "metadataURL": null, "corrections": [], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-162", "recordId": "hsi-68920f19acc589", "sourceType": "Bibliographic source", "title": "Vocal Biomarkers for Mental Health", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "American Psychiatric Association (January 2026). \"Vocal Biomarkers for Mental Health.\" APA Blogs — Identifies vocal biomarkers as promising frontier for mental health screening; notes clinical readiness not yet established", "originalSection": "Vocal Biomarker Technologies for Mental Health", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-163", "recordId": "hsi-8c4a775b474639", "sourceType": "Review", "title": "Use of voice features from smartphones for monitoring depressive disorders: Scoping review.", "authors": "Shin J, Bae SM.", "year": 2024, "journal": "Digital health", "doi": "10.1177/20552076241261920", "pmid": "38882248", "pmcid": "PMC11179519", "patentNumber": null, "originalAssignee": null, "originalCitation": "Low DM et al. (2024). \"Smartphone-derived voice features for depression monitoring: A scoping review.\" PMC (PMC11179519) — Smartphone voice features show promise for depression monitoring; sole predictive power requires further validation", "originalSection": "Vocal Biomarker Technologies for Mental Health", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38882248/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1177%2F20552076241261920%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": null, "role": "Related context in complete bibliography" }, { "ref": "NPL-164", "recordId": "hsi-bb8bd49cde6956", "sourceType": "Conference publication", "title": "Practical RGB Measurement of Fluorescence and Blood Distributions in Skin", "authors": "Emilie Nogué; Arvin Lin; Xiaohui Li; Giuseppe Claudio Guarnera; Abhijeet Ghosh", "year": 2024, "journal": "Color and Imaging Conference", "doi": "10.2352/cic.2024.32.1.24", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Nogué S, Maguire C, Sherlock A et al. (2024). \"Practical RGB Measurement of Fluorescence and Blood Distributions in Skin.\" Color and Imaging Conference 32(1):133–141 — Commodity RGB cameras isolate elastin fluorescence + haemoglobin/melanin chromophores via Donaldson re-radiation matrices; no UV capture or dense hyperspectral rig required", "originalSection": "RGB Measurement of Fluorescence and Blood Distributions in Skin", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.2352/cic.2024.32.1.24", "metadataURL": "https://api.crossref.org/works/10.2352%2FCIC.2024.32.1.24", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-165", "recordId": "hsi-db701719d4dfca", "sourceType": "Journal publication", "title": "Development of a Smartphone-Linked Immunosensing System for Oxytocin Determination.", "authors": "Sarubo M, Suzuki Y, Numazaki Y, Kudo H.", "year": 2025, "journal": "Biosensors", "doi": "10.3390/bios15040261", "pmid": "40277575", "pmcid": "PMC12025206", "patentNumber": null, "originalAssignee": null, "originalCitation": "Sarubo K, Ishida Y, Kawano S et al. (2025). \"Smartphone-Linked Optical Immunosensing for Oxytocin Determination in Human Saliva.\" Biosensors 15(4):261 (PMC 12025206) — LED backlight + CMOS camera ELISA readout; inference limit 5.26 pg/mL salivary OXT; r = 0.972 vs conventional ELISA. Invasive (saliva + reagents + physical cell attachment)", "originalSection": "Smartphone-Linked Immunosensing for Oxytocin Determination", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40277575/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fbios15040261%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-166", "recordId": "hsi-93d8a400352b6c", "sourceType": "Review", "title": "Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.", "authors": "Hashimoto H, Matsuura T, Ueta Y.", "year": 2014, "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2014.00213", "pmid": "25100939", "pmcid": "PMC4107947", "patentNumber": null, "originalAssignee": null, "originalCitation": "Hashimoto H, Matsuura T, Ueta Y (2014). \"Fluorescent Visualization of Oxytocin in the Hypothalamo-Neurohypophysial System.\" Frontiers in Neuroscience 8:213 (PMC 4107947) — OXT-mRFP1 transgenic rats; visible fluorescence in hypothalamic OXT neurons and posterior pituitary; 5–7× fluorescence increase with OXT expression under salt loading", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/25100939/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC4107947&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-167", "recordId": "hsi-8ad27b6daef8ac", "sourceType": "Journal publication", "title": "A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.", "authors": "Ino D, Tanaka Y, Hibino H, Nishiyama M.", "year": 2022, "journal": "Nature methods", "doi": "10.1038/s41592-022-01597-x", "pmid": "36138174", "pmcid": "PMC9550624", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ino D, Tanaka Y, Hibino H et al. (2022). \"A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.\" Nature Methods 19(10):1286–1294 (PMC 9550624) — MTRIA_OT GPCR-based green fluorescent OXT sensor; fiber photometry; ultradian ~2 hr \"OT oscillation\"; intranasal/IP OXT <1% reaches brain", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36138174/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC9550624&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-168", "recordId": "hsi-9e3caca1a18860", "sourceType": "Journal publication", "title": "Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor.", "authors": "Santonocito R, Tuccitto N, Pappalardo A, Trusso Sfrazzetto G.", "year": 2022, "journal": "Molecules (Basel, Switzerland)", "doi": "10.3390/molecules27217503", "pmid": "36364331", "pmcid": "PMC9654496", "patentNumber": null, "originalAssignee": null, "originalCitation": "Santonocito R, Tuccitto N, Pappalardo A, Trusso Sfrazzetto G (2022). \"Smartphone-Based Dopamine Inference by Fluorescent Supramolecular Sensor.\" Molecules 27(21):7503 (PMC 9654496) — Quinoxaline cavitand (Cav-4-Qx) on siloxane polymer; inference limit 1 pM; linear range 10 mM–100 pM; smartphone camera readout in dark chamber; good selectivity in artificial and real saliva; reusable via acid-base switching. Invasive (saliva + sensor strip + dark chamber)", "originalSection": "Smartphone-Based Dopamine Inference by Fluorescent Supramolecular Sensor", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36364331/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC9654496&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-169", "recordId": "hsi-d472a890e03c1b", "sourceType": "Review", "title": "Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.", "authors": "Heikal AA.", "year": 2010, "journal": "Biomarkers in medicine", "doi": "10.2217/bmm.10.1", "pmid": "20406068", "pmcid": "PMC2905054", "patentNumber": null, "originalAssignee": null, "originalCitation": "Heikal AA (2010). \"Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.\" Biomarkers in Medicine 4(2):241–263 (PMC 2924670) — NADPH autofluorescence as \"bellwether\" of intracellular redox states; directly couples metabolic activity to optical emission intensity", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/20406068/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Intracellular+coenzymes+as+natural+biomarkers+for+metabolic+activities+and+mitochondrial+anomalies%22&format=json&resultType=core&pageSize=4", "corrections": [ "A supplied identifier resolved to another title; the accepted record was matched separately by title." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-170", "recordId": "hsi-98a399171f2226", "sourceType": "Journal publication", "title": "A general model for the origin of allometric scaling laws in biology.", "authors": "West GB, Brown JH, Enquist BJ.", "year": 1997, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.276.5309.122", "pmid": "9082983", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "West GB, Brown JH, Enquist BJ (1997). \"A General Model for the Origin of Allometric Scaling Laws in Biology.\" Science 276(5309):122–126 — Fractal-like branching networks govern biological scaling laws from cellular metabolism to whole-organism physiology; theoretical basis for cross-scale signal propagation", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/9082983/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22A+General+Model+for+the+Origin+of+Allometric+Scaling+Laws+in+Biology%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-171", "recordId": "hsi-e7e54aaae200fa", "sourceType": "Journal publication", "title": "Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.", "authors": "Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L.", "year": 2020, "journal": "Cell", "doi": "10.1016/j.cell.2020.11.040", "pmid": "33333022", "pmcid": "PMC8025677", "patentNumber": null, "originalAssignee": null, "originalCitation": "Unger EK, Keller JP, Altermatt M et al. (2020). \"Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.\" Cell 183(7):1986–2002 (DOI: 10.1016/j.cell.2020.11.040; Addgene #128483, pRSET-iSeroSnFR, Lin Tian Lab, UC Davis) — ML-guided binding-pocket redesign (Rosetta + random forest + GLM) produced iSeroSnFR genetically encoded fluorescent 5-HT sensor; >5,000× improved affinity over iAChSnFR0.6; 800% ΔF/F₀; ~350 pM inference; millisecond kinetics; fiber photometry in freely behaving mice (fear conditioning, social interaction, sleep/wake); OSTA assay for hSERT/SLC6A4 pharmacology (SSRIs, cocaine, MDMA). Invasive (genetically encoded sensor + viral delivery + implanted fiber optics)", "originalSection": "Machine Learning-Directed Fluorescent Serotonin Sensor", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33333022/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.cell.2020.11.040%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-172", "recordId": "hsi-51ceed09e76ab1", "sourceType": "Journal publication", "title": "The self-organizing fractal theory as a universal discovery method: the phenomenon of life.", "authors": "Kurakin A.", "year": 2011, "journal": "Theoretical biology & medical modelling", "doi": "10.1186/1742-4682-8-4", "pmid": "21447162", "pmcid": "PMC3080324", "patentNumber": null, "originalAssignee": null, "originalCitation": "Kurakin A (2011). \"The self-organizing fractal theory as a universal discovery method: the phenomenon of life.\" Theoretical Biology and Medical Modelling 8:4 (PMC 3080324) — Self-organising fractal theory unifying biological organisation from molecular to organismal scale; fractal self-similarity as a universal design principle underlying metabolism, gene expression, and cellular dynamics", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21447162/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC3080324&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-173", "recordId": "hsi-970c306954834e", "sourceType": "Journal publication", "title": "Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.", "authors": "Lloyd D, Murray DB, Aon MA, Cortassa S, Roussel MR, Beckmann M, Poole RK.", "year": 2018, "journal": "Journal of biomedical optics", "doi": "10.1117/1.jbo.24.5.051404", "pmid": "30516036", "pmcid": "PMC6992908", "patentNumber": null, "originalAssignee": null, "originalCitation": "Lloyd D, Murray DB, Aon MA, Poole RK (2018). \"Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.\" Journal of Biomedical Optics (ResearchGate DOI: 10.1117/1.JBO.24.5.051404) — NAD(P)H autofluorescence as \"bellwether of intracellular redox states\"; cell as fractal multioscillator with self-similar temporal organisation from milliseconds to hours; two-photon fluorescence excitation at 740 nm, emission <490 nm for NAD(P)H imaging in cardiomyocytes and yeast", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/30516036/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1117%2F1.JBO.24.5.051404%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-174", "recordId": "hsi-f69919e90b4809", "sourceType": "Review", "title": "A healthy dose of chaos: Using fractal frameworks for engineering higher-fidelity biomedical systems.", "authors": "Korolj A, Wu HT, Radisic M.", "year": 2019, "journal": "Biomaterials", "doi": "10.1016/j.biomaterials.2019.119363", "pmid": "31376747", "pmcid": "PMC6759375", "patentNumber": null, "originalAssignee": null, "originalCitation": "Korolj A, Wu HT, Radisic M (2019). \"A healthy dose of chaos: Using fractal frameworks for engineering higher-fidelity biomedical systems.\" Biomaterials 219:119363 (PMC 6759375) — Fractal dimension as quantitative health metric across biological systems; fractal frameworks for biomedical engineering; healthy biological systems exhibit characteristic fractal complexity that degrades in disease states", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31376747/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC6759375&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-175", "recordId": "hsi-890a81b217c123", "sourceType": "Journal publication", "title": "Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.", "authors": "Dong B, Almassalha LM, Stypula-Cyrus Y, Urban BE, Chandler JE, Nguyen TQ, Sun C, Zhang HF, Backman V.", "year": 2016, "journal": "Proceedings of the National Academy of Sciences of the United States of America", "doi": "10.1073/pnas.1602202113", "pmid": "27535934", "pmcid": "PMC5024634", "patentNumber": null, "originalAssignee": null, "originalCitation": "Dong B, Almassalha LM et al. (2016). \"Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.\" Proceedings of the National Academy of Sciences 113(35):9716–9721 (DOI: 10.1073/pnas.1602202113) — Label-free DNA partial-wave spectroscopic (PWS) microscopy at sub-20 nm resolution; chromatin follows fractal globule power-law scaling (D ≈ 3) at nanoscale; intrinsic nucleic acid fluorescence used as endogenous contrast for chromatin organisation imaging", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27535934/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1073%2Fpnas.1602202113%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-176", "recordId": "hsi-c847bd10379570", "sourceType": "Journal publication", "title": "Short-time fractal analysis of biological autoluminescence.", "authors": "Dlask M, Kukal J, Poplová M, Sovka P, Cifra M.", "year": 2019, "journal": "PloS one", "doi": "10.1371/journal.pone.0214427", "pmid": "31348777", "pmcid": "PMC6660117", "patentNumber": null, "originalAssignee": null, "originalCitation": "Dlask M, Kukal J, Poplová M, Sovka P, Cifra M (2019). \"Short-time fractal analysis of biological autoluminescence.\" PLoS ONE 14(7):e0214427 (PMID 31348777) — Fractal analysis of biological autoluminescence (ultra-weak photon emission) time series; negative memory in photon count signals from germinating mung beans; Hurst exponent analysis reveals anti-persistent fractal dynamics in endogenous biophoton emission", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31348777/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A31348777+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-177", "recordId": "hsi-8b0c28afb02b86", "sourceType": "Review", "title": "Fractal geometry: a design principle for living organisms.", "authors": "Weibel ER.", "year": 1991, "journal": "The American journal of physiology", "doi": "10.1152/ajplung.1991.261.6.l361", "pmid": "1767856", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Weibel ER (1991). \"Fractal geometry: a design principle for living organisms.\" American Journal of Physiology 261(6 Pt 1):L361–L369 (PMID 1767856) — Foundational paper: fractal geometry as biological design principle; self-similar branching networks in lungs, vasculature, and bronchial trees; efficient genetic programming of biological form through fractal algorithms; fractal dimension as measure of space-filling efficiency across biological scales", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/1767856/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A1767856+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-178", "recordId": "hsi-3338d715ddefac", "sourceType": "Preprint", "title": "Fractal Analysis of Multiscale Biological Systems", "authors": "Muhammad Y.", "year": 2024, "journal": "", "doi": "10.20944/preprints202412.1952.v1", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Muhammad Y (2024). \"Fractal Analysis of Multiscale Biological Systems.\" Preprints.org 2024121952 (posted 23 December 2024; ResearchGate presentation, Ain Shams University, January 2025) — Comprehensive review of fractal analysis across biological scales: chromatin (fractal globule D ≈ 1.02–1.40 for normal-to-cancerous), cell surface (healthy D ≈ 1.1–1.3, cancerous D ≈ 1.3–1.6), branching networks (circulatory D ≈ 1.6–1.9, lungs D ≈ 1.8–2.2, kidneys D ≈ 1.7–2.0, nervous system D ≈ 1.4–1.6), radiomics, physiological signals; fractal dimension as unique signature for healthy-versus-pathological state transitions", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.20944/preprints202412.1952.v1", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Fractal+Analysis+of+Multiscale+Biological+Systems%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-179", "recordId": "hsi-a969f74bedb780", "sourceType": "Bibliographic source", "title": "A Fractal Approach to Pattern Formation in Biological Systems", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Dobrescu R, Ichim L, Mocanu S, Popa S (2008). \"A Fractal Approach to Pattern Formation in Biological Systems.\" WSEAS Transactions on Biology and Biomedicine 5(6):107–116 — Reaction-diffusion systems as fractal pattern generators; connection between morphogenesis, nonlinear dynamics, and fractal structures; diffusion-limited aggregation (DLA) model of bacterial colony growth; attractor theory linking fractal patterns to stable biological states", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-180", "recordId": "hsi-c97f9a5a073dee", "sourceType": "Journal publication", "title": "Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.", "authors": "Sakr N, Glazova O, Shevkova L, Onyanov N, Kaziakhmedova S, Shilova A, Vorontsova MV, Volchkov P.", "year": 2023, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms24043432", "pmid": "36834842", "pmcid": "PMC9968082", "patentNumber": null, "originalAssignee": null, "originalCitation": "Sakr N, Glazova O, Shevkova L, Onyanov N, Kaziakhmedova S, Shilova A, Vorontsova MV, Volchkov P (2023). \"Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.\" International Journal of Molecular Sciences 24(4):3432 (DOI: 10.3390/ijms24043432) — Broad-spectrum endogenous autofluorescence characterisation in adrenal cortex tissue; intracellular fluorophores (lipofuscin, lipids, NADH, flavins) emit across 405–488 nm excitation bands; autofluorescence originates from cortical cell cytoplasm; lipofuscin accumulation increases autofluorescence with age; lambda scanning quantification of autofluorescence emission profiles", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/36834842/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fijms24043432%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-181", "recordId": "hsi-a7e89452d57b51", "sourceType": "Journal publication", "title": "Classifying T cell activity in autofluorescence intensity images with convolutional neural networks.", "authors": "Wang ZJ, Walsh AJ, Skala MC, Gitter A.", "year": 2020, "journal": "Journal of biophotonics", "doi": "10.1002/jbio.201960050", "pmid": "31661592", "pmcid": "PMC7065628", "patentNumber": null, "originalAssignee": null, "originalCitation": "Wang ZJ, Walsh AJ, Skala MC, Gitter A (2020). \"Classifying T cell activity in autofluorescence intensity images with convolutional neural networks.\" Journal of Biophotonics 13(3):e201960050 (PMC 7065628) — CNN classification of T cell activation states from NAD(P)H autofluorescence intensity images; endogenous metabolic co-enzyme fluorescence reflects immune cell functional state; label-free optical metabolic imaging distinguishes quiescent from activated T cells", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31661592/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7065628&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-182", "recordId": "hsi-672c477cf92f2c", "sourceType": "Review", "title": "Fluorescence spectroscopy of neoplastic and non-neoplastic tissues.", "authors": "Ramanujam N.", "year": 2000, "journal": "Neoplasia (New York, N.Y.)", "doi": "10.1038/sj.neo.7900077", "pmid": "10933071", "pmcid": "PMC1531869", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ramanujam N (2000). \"Fluorescence Spectroscopy of Neoplastic and Non-Neoplastic Tissues.\" Neoplasia 2(1-2):89–117 (PMC 1531869) — Comprehensive review of endogenous tissue fluorophores (NADH, FAD, collagen, elastin, porphyrins) for non-invasive tissue characterisation; fluorophore distributions across tissue architectural layers; spectral signatures distinguish neoplastic from normal tissue; establishes fluorescence spectroscopy as diagnostic tool for tissue state determination", "originalSection": "Systems Biology Framework for Fractal Autofluorescence", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/10933071/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC1531869&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-183", "recordId": "hsi-b89b11771190f7", "sourceType": "Journal publication", "title": "[Imaging Analyses of Oxytocin: Visualization of Oxytocin and Its Implications].", "authors": "Nuriya M.", "year": 2023, "journal": "Brain and nerve = Shinkei kenkyu no shinpo", "doi": "10.11477/mf.1416202450", "pmid": "37537742", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 37537742 (2023). \"Imaging analyses of oxytocin: alkyne-tagging strategy for visualization of oxytocin and its implications for brain action.\" IGAKU-SHOIN — Alkyne-tagging chemical strategy for direct visualisation of oxytocin distribution; implications for understanding OXT brain action mechanisms", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37537742/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A37537742+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Published title reconciled with the metadata record.", "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-184", "recordId": "hsi-37b2d379bb9681", "sourceType": "Journal publication", "title": "Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.", "authors": "Paiva L, Lozic M, Allchorne A, Grinevich V, Ludwig M.", "year": 2021, "journal": "Journal of neuroendocrinology", "doi": "10.1111/jne.12970", "pmid": "33851744", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 33851744 (2021). \"Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.\" Journal of Neuroendocrinology — Confirmed OXT expression via fluorescence in enteric nervous system ganglia, pancreatic islets of Langerhans, and testicular Leydig cells using systemically applied AAV vector; demonstrates peripheral OXT-expressing cell populations beyond hypothalamus", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/33851744/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A33851744+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-185", "recordId": "hsi-4d0943da705896", "sourceType": "Journal publication", "title": "Specificity of oxytocin and vasopressin immunofluorescence.", "authors": "Swaab DF, Pool CW.", "year": 1975, "journal": "The Journal of endocrinology", "doi": "10.1677/joe.0.0660263", "pmid": "1100756", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "PMID 1100756 (1976). \"Specificity of oxytocin and vasopressin immunofluorescence.\" — Classic study on immunofluorescence specificity for OXT and AVP using CNBr-activated agarose beads and quantitative fluorescence measurement; demonstrated antibody purification for specific OXT/AVP visualisation including validation in Brattleboro rats (vasopressin-deficient model)", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/1100756/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A1100756+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-186", "recordId": "hsi-bb4d6be95a6fbf", "sourceType": "Journal publication", "title": "Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization.", "authors": "Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M, Kremsmayr T, Meunier FA, Langer T, Gruber CW, Keimpema E, Muttenthaler M.", "year": 2025, "journal": "Angewandte Chemie (International ed. in English)", "doi": "10.1002/anie.202515180", "pmid": "41001975", "pmcid": "PMC12603982", "patentNumber": null, "originalAssignee": null, "originalCitation": "Perisic Böhm V, Kalaba P et al. (2025). \"Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization.\" Angewandte Chemie International Edition 64(46):e202515180 (PMC 12603982) — Potent, selective, bright fluorescent peptide tracers for OTR; live-cell and post-hoc imaging; single-molecule tracking; FACS sorting of OTR-positive cells; simultaneous receptor activation and visualisation", "originalSection": "Fluorescent Visualisation and Real-Time Sensing of Oxytocin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/41001975/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC12603982&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-187", "recordId": "hsi-f85cb98f5b77d1", "sourceType": "Journal publication", "title": "Digital cutaneous fluorometry: correlation between blood flow and fluorescence.", "authors": "Bongard FS, Upton RA, Elings VB, Lewis FR.", "year": 1984, "journal": "Journal of vascular surgery", "doi": "10.1016/0741-5214(84)90128-9", "pmid": "6502833", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "\"Digital cutaneous fluorometry: Correlation between blood flow and fluorescence.\" Journal of Vascular Surgery 1(5):635–641 (1984) (ScienceDirect PII: 0741521484901289) — Established that tissue fluorescence intensity is linearly related to blood flow using digital cutaneous fluorometry; foundational evidence that perfusion conclusions can be drawn from relative fluorescence measurements in skin", "originalSection": "RGB Measurement of Fluorescence and Blood Distributions in Skin", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/6502833/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Digital+cutaneous+fluorometry%3A+Correlation+between+blood+flow+and+fluorescence%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-188", "recordId": "hsi-507bbc03f5d2eb", "sourceType": "Book or chapter", "title": "Protein Fluorescence", "authors": "Joseph R. Lakowicz", "year": 1999, "journal": "Principles of Fluorescence Spectroscopy", "doi": "10.1007/978-1-4757-3061-6_16", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Lakowicz JR (2006). Principles of Fluorescence Spectroscopy. 3rd ed. Springer. Ch. 16: \"Protein Fluorescence\" — Tryptophan indole ring (fused hexagonal benzene + pentagonal pyrrole) as dominant intrinsic protein fluorophore; excitation ~280 nm, emission ~340 nm; π→π* transitions of delocalised electrons across aromatic ring geometry; quantum yield sensitivity to local microenvironment; >90% of total protein UV fluorescence from tryptophan; molar extinction coefficient ~5,500 M⁻¹cm⁻¹ at 280 nm", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1007/978-1-4757-3061-6_16", "metadataURL": "https://api.crossref.org/works?query.title=Protein+Fluorescence&rows=3", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-189", "recordId": "hsi-a8977d72a1a256", "sourceType": "Journal publication", "title": "Intrinsic Tryptophan Fluorescence in the Detection and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques", "authors": "Amar Ghisaidoobe; Sang Chung", "year": 2014, "journal": "International Journal of Molecular Sciences", "doi": "10.3390/ijms151222518", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Ghisaidoobe ABT, Chung SJ (2014). \"Intrinsic Tryptophan Fluorescence in the Inference and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques.\" International Journal of Molecular Sciences 15(12):22518–22538 (PMC 4284740) — Comprehensive review of tryptophan intrinsic fluorescence; indole chromophore π→π* transitions; environmental sensitivity of emission wavelength and quantum yield; FRET applications exploiting tryptophan as endogenous donor", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.3390/ijms151222518", "metadataURL": "https://api.crossref.org/works?query.title=Intrinsic+Tryptophan+Fluorescence+in+the+Inference+and+Analysis+of+Proteins%3A+A+Focus+on+F%C3%B6rster+Resonance+Energy+Transfer+Techniques&rows=3", "corrections": [ "Published title reconciled with the metadata record.", "A supplied identifier resolved to another title; the accepted record was matched separately by title." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-190", "recordId": "hsi-d20e21db0f73d9", "sourceType": "Journal publication", "title": "Mechanisms of tryptophan fluorescence shifts in proteins.", "authors": "Vivian JT, Callis PR.", "year": 2001, "journal": "Biophysical journal", "doi": "10.1016/s0006-3495(01)76183-8", "pmid": "11325713", "pmcid": "PMC1301402", "patentNumber": null, "originalAssignee": null, "originalCitation": "Vivian JT, Callis PR (2001). \"Mechanisms of Tryptophan Fluorescence Shifts in Proteins.\" Biophysical Journal 80(5):2093–2109 (PMC 1301402) — Computational and experimental analysis of tryptophan fluorescence wavelength shifts; electrostatic interactions between indole ring π-electron system and local protein matrix; charge transfer states modulating emission", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/11325713/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC1301402&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-191", "recordId": "hsi-33dac4910c8d78", "sourceType": "Bibliographic source", "title": "¹Lₐ and ¹L_b Transitions of Tryptophan: Applications of Theory and Experiment", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Callis PR (1997). \"¹Lₐ and ¹L_b Transitions of Tryptophan: Applications of Theory and Experiment.\" Methods in Enzymology 278:113–150 — Theoretical treatment of the two overlapping electronic transitions (¹Lₐ and ¹L_b) in tryptophan indole ring; molecular orbital analysis of π-electron delocalisation pathways across hexagonal and pentagonal ring geometry; transition dipole directions and energies", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-192", "recordId": "hsi-50b42dd5c5b578", "sourceType": "Bibliographic source", "title": "Label-Free Tryptophan Fluorescence Lifetime Imaging as a Marker of Protein Conformational States in Cells", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Shah S, Bhatt A, Bhatt S et al. (2023). \"Label-Free Tryptophan Fluorescence Lifetime Imaging as a Marker of Protein Conformational States in Cells.\" — FLIM distinguishing protein conformational states, folding intermediates, and aggregation from endogenous tryptophan autofluorescence in living cells without exogenous labels; demonstrates tryptophan fluorescence lifetime as a non-invasive readout of protein structure and translation state", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "unresolved", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "metadataURL": null, "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-193", "recordId": "hsi-0d33d222d235dd", "sourceType": "Journal publication", "title": "Watching gene expression in color.", "authors": "Simpson JH.", "year": 2019, "journal": "eLife", "doi": "10.7554/elife.49414", "pmid": "31348001", "pmcid": "PMC6660214", "patentNumber": null, "originalAssignee": null, "originalCitation": "Simpson CL (2019). \"Transcriptional Reporters: Watching Gene Expression in Color.\" eLife 8:e49414 (PMC 6660214) — Insight on TransTimer dual-colour fluorescent transcriptional reporter; green-to-red colour shift encoding transcriptional history at single-cell resolution; protein translation as the mechanism linking gene transcription to visible fluorescence", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-reconciled", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/31348001/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.7554%2FeLife.49414%22&format=json&resultType=core&pageSize=4", "corrections": [ "Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison.", "Published title reconciled with the metadata record." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-194", "recordId": "hsi-7d176d0ecb2d26", "sourceType": "Journal publication", "title": "Tracking and measuring local protein synthesis in vivo.", "authors": "Kays I, Chen BE.", "year": 2024, "journal": "Development (Cambridge, England)", "doi": "10.1242/dev.202908", "pmid": "39373391", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Bhogale S, Bhatt T, Bhatt S et al. (2024). \"Tracking and measuring local protein synthesis in vivo.\" Development 151(21) — Review of technologies for direct measurement of nascent protein synthesis including fluorescent reporters, non-canonical amino acid labelling (FUNCAT/BONCAT), ribosome profiling, and single-molecule imaging; establishes protein translation as a measurable, fluorescence-detectable event in living organisms", "originalSection": "Tryptophan Autofluorescence as a Primary Optical Marker of Gene Transcription", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39373391/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Tracking+and+measuring+local+protein+synthesis+in+vivo%22&format=json&resultType=core&pageSize=4", "corrections": [ "Author attribution differs from the public metadata; canonical authors are shown in source details." ], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-195", "recordId": "hsi-320858d8be27a8", "sourceType": "Journal publication", "title": "A protein-tagging system for signal amplification in gene expression and fluorescence imaging.", "authors": "Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.", "year": 2014, "journal": "Cell", "doi": "10.1016/j.cell.2014.09.039", "pmid": "25307933", "pmcid": "PMC4252608", "patentNumber": null, "originalAssignee": null, "originalCitation": "Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD (2014). \"A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging.\" Cell 159(3):635–646 — SunTag: repeating GCN4 peptide epitope array recruiting up to 24 copies of scFv-GFP fusion per translation event; 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DOI: 10.1038/srep41061", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28117353/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep41061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-202", "recordId": "hsi-640ffd898d4f0f", "sourceType": "Journal publication", "title": "DNA-guided transcription factor interactions extend human gene regulatory code.", "authors": "Xie Z, Sokolov I, Osmala M, Yue X, Bower G, Pett JP, Chen Y, Wang K, Cavga AD, Popov A, Teichmann SA, Morgunova E, Kvon EZ, Yin Y, Taipale J.", "year": 2025, "journal": "Nature", "doi": "10.1038/s41586-025-08844-z", "pmid": "40205063", "pmcid": "PMC12119339", "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Z, Sokolov I, Osmala M, Yue X et al. 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DOI: 10.1038/s41586-025-08844-z", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/40205063/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-025-08844-z%22&format=json&resultType=core&pageSize=4", "corrections": [ "Publication notice: Erratum in; 40461788" ], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-203", "recordId": "hsi-c1f30e3f5d4055", "sourceType": "Journal publication", "title": "Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity.", "authors": "Taylor SJ, Stauber J, Bohorquez O, Tatsumi G, Kumari R, Chakraborty J, Bartholdy BA, Schwenger E, Sundaravel S, Farahat AA, Wheat JC, Goldfinger M, Verma A, Kumar A, Boykin DW, Stengel KR, Poon GMK, Steidl U.", "year": 2024, "journal": "Nature genetics", "doi": "10.1038/s41588-024-01911-7", "pmid": "39294495", "pmcid": "PMC11525197", "patentNumber": null, "originalAssignee": null, "originalCitation": "Taylor SJ, Stauber J, Bohorquez O et al. 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DOI: 10.1038/s41588-024-01911-7", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39294495/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41588-024-01911-7%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-204", "recordId": "hsi-ce108c64ada154", "sourceType": "Journal publication", "title": "Position-dependent function of human sequence-specific transcription factors.", "authors": "Duttke SH, Guzman C, Chang M, Delos Santos NP, McDonald BR, Xie J, Carlin AF, Heinz S, Benner C.", "year": 2024, "journal": "Nature", "doi": "10.1038/s41586-024-07662-z", "pmid": "39020164", "pmcid": "PMC11269187", "patentNumber": null, "originalAssignee": null, "originalCitation": "Duttke SH, Guzman C, Chang M et al. 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DOI: 10.1038/s41586-024-07662-z", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39020164/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-024-07662-z%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-205", "recordId": "hsi-347e099d5780a1", "sourceType": "Journal publication", "title": "Modeling and designing enhancers by introducing and harnessing transcription factor binding units.", "authors": "Li J, Zhang P, Xi X, Liu L, Wei L, Wang X.", "year": 2025, "journal": "Nature communications", "doi": "10.1038/s41467-025-56749-2", "pmid": "39922842", "pmcid": "PMC11807178", "patentNumber": null, "originalAssignee": null, "originalCitation": "Li J, Zhang P, Xi X, Liu L, Wei L, Wang X (2025). \"Modeling and designing enhancers by introducing and harnessing transcription factor binding units.\" Nature Communications 16:1469. DOI: 10.1038/s41467-025-56749-2", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39922842/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41467-025-56749-2%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-206", "recordId": "hsi-3775d2078838e2", "sourceType": "Journal publication", "title": "Theoretical principles of transcription factor traffic on folded chromatin.", "authors": "Cortini R, Filion GJ.", "year": 2018, "journal": "Nature communications", "doi": "10.1038/s41467-018-04130-x", "pmid": "29712907", "pmcid": "PMC5928121", "patentNumber": null, "originalAssignee": null, "originalCitation": "Cortini R, Filion GJ (2018). \"Theoretical principles of transcription factor traffic on folded chromatin.\" Nature Communications 9:1740. 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DOI: 10.1038/s41588-024-01892-7", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/39363017/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41588-024-01892-7%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-208", "recordId": "hsi-a2182f3ffa9feb", "sourceType": "Journal publication", "title": "Positional distribution of transcription factor binding sites in Arabidopsis thaliana.", "authors": "Yu CP, Lin JJ, Li WH, Li WH.", "year": 2016, "journal": "Scientific reports", "doi": "10.1038/srep25164", "pmid": "27117388", "pmcid": "PMC4846880", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yu CP, Lin JJ, Li WH (2016). \"Positional distribution of transcription factor binding sites in Arabidopsis thaliana.\" Scientific Reports 6:25164. DOI: 10.1038/srep25164", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27117388/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep25164%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-209", "recordId": "hsi-ca225cf85be823", "sourceType": "Journal publication", "title": "The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.", "authors": "Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V.", "year": 2017, "journal": "Scientific reports", "doi": "10.1038/srep41061", "pmid": "28117353", "pmcid": "PMC5259786", "patentNumber": null, "originalAssignee": null, "originalCitation": "Almassalha LM, Silverstein SD, Bauer GM et al. (2017). \"The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.\" Scientific Reports 7:41061. DOI: 10.1038/srep41061", "originalSection": "Fractal TFBS Analysis", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/28117353/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fsrep41061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-210", "recordId": "hsi-e0d5c3805210ed", "sourceType": "Journal publication", "title": "Highly accurate protein structure prediction with AlphaFold.", "authors": "Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, Senior AW, Kavukcuoglu K, Kohli P, Hassabis D.", "year": 2021, "journal": "Nature", "doi": "10.1038/s41586-021-03819-2", "pmid": "34265844", "pmcid": "PMC8371605", "patentNumber": null, "originalAssignee": null, "originalCitation": "Jumper J, Evans R, Pritzel A et al. (2021). \"Highly accurate protein structure prediction with AlphaFold.\" Nature 596:583–589. DOI: 10.1038/s41586-021-03819-2 — AlphaFold2: atomic-accuracy protein structure prediction from amino acid sequence; won CASP14; 2024 Nobel Prize in Chemistry (Hassabis & Jumper)", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34265844/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-021-03819-2%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-211", "recordId": "hsi-a767ad286ab4ab", "sourceType": "Journal publication", "title": "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.", "authors": "Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, Žídek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S.", "year": 2022, "journal": "Nucleic acids research", "doi": "10.1093/nar/gkab1061", "pmid": "34791371", "pmcid": "PMC8728224", "patentNumber": null, "originalAssignee": null, "originalCitation": "Varadi M, Anyango S, Deshpande M et al. (2022). \"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.\" Nucleic Acids Research 50(D1):D439–D444. DOI: 10.1093/nar/gkab1061 — 200M+ predicted protein structures; EMBL-EBI partnership; 3M+ researchers across 190+ countries", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/34791371/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1093%2Fnar%2Fgkab1061%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-212", "recordId": "hsi-a69099559ecd76", "sourceType": "Journal publication", "title": "Accurate structure prediction of biomolecular interactions with AlphaFold 3.", "authors": "Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, Bodenstein SW, Evans DA, Hung CC, O'Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Žemgulytė A, Arvaniti E, Beattie C, Bertolli O, Bridgland A, Cherepanov A, Congreve M, Cowen-Rivers AI, Cowie A, Figurnov M, Fuchs FB, Gladman H, Jain R, Khan YA, Low CMR, Perlin K, Potapenko A, Savy P, Singh S, Stecula A, Thillaisundaram A, Tong C, Yakneen S, Zhong ED, Zielinski M, Žídek A, Bapst V, Kohli P, Jaderberg M, Hassabis D, Jumper JM.", "year": 2024, "journal": "Nature", "doi": "10.1038/s41586-024-07487-w", "pmid": "38718835", "pmcid": "PMC11168924", "patentNumber": null, "originalAssignee": null, "originalCitation": "Abramson J, Adler J, Dunger J et al. (2024). \"Accurate structure prediction of biomolecular interactions with AlphaFold 3.\" Nature 630:493–500. DOI: 10.1038/s41586-024-07487-w — Protein–DNA, protein–RNA, protein–ligand, and protein–ion complex structure prediction; ≥50% accuracy improvement over existing methods", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38718835/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41586-024-07487-w%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-213", "recordId": "hsi-adeb0509f25117", "sourceType": "Journal publication", "title": "Accurate proteome-wide missense variant effect prediction with AlphaMissense.", "authors": "Cheng J, Novati G, Pan J, Bycroft C, Žemgulytė A, Applebaum T, Pritzel A, Wong LH, Zielinski M, Sargeant T, Schneider RG, Senior AW, Jumper J, Hassabis D, Kohli P, Avsec Ž.", "year": 2023, "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.adg7492", "pmid": "37733863", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Cheng J, Novati G, Pan J et al. (2023). \"Accurate proteome-wide missense variant effect prediction with AlphaMissense.\" Science 381(6664):eadg7492. DOI: 10.1126/science.adg7492 — 71 million missense variants classified across human proteome; 89% categorised as likely benign or likely pathogenic", "originalSection": "AI-Driven Protein Structure Prediction (AlphaFold)", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37733863/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1126%2Fscience.adg7492%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-214", "recordId": "hsi-7ad76f3461e8f4", "sourceType": "Preprint", "title": "Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq", "authors": "Xie Y, Habibalahi A, Anwer AG, Wahi K, Gatt C, Johansson EMV, Holst J, Goldys E, Zanini F.", "year": 2024, "journal": "", "doi": "10.1101/2024.01.27.577536", "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Xie Y, Habibalahi A, Zanini F, Vukovic M, Nassiri R, Wang X, Cao Y, Anttila CJ, Dehkhoda F, Goldys EM, Tian L (2024). \"Integration of hyperspectral imaging and transcriptomics from individual cells with HyperSeq.\" bioRxiv preprint. DOI: 10.1101/2024.01.27.577536 — Combines hyperspectral autofluorescence imaging with scRNA-seq in MCF-7 breast cancer cells; correlates cellular optical signatures with gene expression profiles at single-cell resolution; provides ground-truth data linking autofluorescence molecular signatures to TFBS activity", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://doi.org/10.1101/2024.01.27.577536", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1101%2F2024.01.27.577536%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-215", "recordId": "hsi-33295070309002", "sourceType": "Journal publication", "title": "Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.", "authors": "Klatt J, Gerich CE, Gröbe A, Opitz J, Schreiber J, Hanken H, Salomon G, Heiland M, Kluwe L, Blessmann M.", "year": 2014, "journal": "Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery", "doi": "10.1016/j.jcms.2013.12.004", "pmid": "24444757", "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Klatt J, Gerich CE, Gröbe A, Opitz J, Horlitz F, Hanken H, Schwarz RA, Gilon A et al. (2014). \"Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.\" Journal of Cranio-Maxillo-Facial Surgery 42(6):852–854. PMID: 24444757 — Fractal D of tumour = 1.8 vs healthy = 1.6; 100% sensitivity, 86% specificity, AUC 99%; demonstrates fractal autofluorescence analysis as a tissue-state discriminator", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/24444757/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A24444757+AND+SRC%3AMED&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "autofluorescence-sensing", "role": "Focused chapter source" }, { "ref": "NPL-216", "recordId": "hsi-d4f9970183960d", "sourceType": "Journal publication", "title": "Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.", "authors": "Pettie KP, Dresch JM, Drewell RA.", "year": 2016, "journal": "Mechanisms of development", "doi": "10.1016/j.mod.2016.06.001", "pmid": "27264535", "pmcid": "PMC5441388", "patentNumber": null, "originalAssignee": null, "originalCitation": "Pettie KP, Dresch JM, Drewell RA (2016). \"Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.\" Mechanisms of Development 141:51–61. PMC5441388 — TFBS broadly distributed across ChIP peaks rather than narrowly centred; multiple sites per peak; establishes that TFBS positional distribution within regulatory regions carries functional significance", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/27264535/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC5441388&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-217", "recordId": "hsi-49e12e857b5371", "sourceType": "Journal publication", "title": "Transcription factor binding sites and other features in human and Drosophila proximal promoters.", "authors": "Vinson C, Chatterjee R, Fitzgerald P.", "year": 2011, "journal": "Sub-cellular biochemistry", "doi": "10.1007/978-90-481-9069-0_10", "pmid": "21557085", "pmcid": "PMC7394279", "patentNumber": null, "originalAssignee": null, "originalCitation": "Vinson C, Chatterjee R, Fitzgerald P (2011). \"Transcription Factor Binding Sites and Other Features in Human and Drosophila Proximal Promoters.\" Subcellular Biochemistry 52:205–222. PMC7394279 — TFBS architecture differs fundamentally between species; CpG islands play distinctive organisational role in human proximal promoters; cross-species comparative evidence for evolved TFBS positional grammar", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/21557085/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7394279&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-218", "recordId": "hsi-22a43f552b2b2f", "sourceType": "Journal publication", "title": "TF-COMB - Discovering grammar of transcription factor binding sites.", "authors": "Bentsen M, Heger V, Schultheis H, Kuenne C, Looso M.", "year": 2022, "journal": "Computational and structural biotechnology journal", "doi": "10.1016/j.csbj.2022.07.025", "pmid": "35983231", "pmcid": "PMC9358416", "patentNumber": null, "originalAssignee": null, "originalCitation": "Bentsen M, Heger V, Schütte H, Lim CH, Kchouk C, Braun T, Looso M (2022). \"TF-COMB — Discovering grammar of transcription factor binding sites.\" Computational and Structural Biotechnology Journal 20:4040–4051. DOI: 10.1016/j.csbj.2022.07.025 — Market basket analysis framework for global TF co-occurrence inference across eight ENCODE cell lines; reveals preferred binding distances, orientations, and network relationships; TF pairs exhibit grammar-level features (distance periodicity, directional preferences) encoding biological function", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/35983231/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1016%2Fj.csbj.2022.07.025%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-219", "recordId": "hsi-6963bd6166bcd0", "sourceType": "Journal publication", "title": "Predicting Transcription Factor Binding Sites with Deep Learning.", "authors": "Ghosh N, Santoni D, Saha I, Felici G.", "year": 2024, "journal": "International journal of molecular sciences", "doi": "10.3390/ijms25094990", "pmid": "38732207", "pmcid": "PMC11084193", "patentNumber": null, "originalAssignee": null, "originalCitation": "Ghosh N, Santoni D, Saha I, Felici G (2024). \"Predicting Transcription Factor Binding Sites with Deep Learning.\" International Journal of Molecular Sciences 25(9):4990. DOI: 10.3390/ijms25094990 — DNABERT-Cap: transformer-based capsule network for TFBS prediction; AUC > 0.91 across five ENCODE cell lines; cross-cell line prediction demonstrates intrinsic TFBS pattern transfer; TFs absent from training recognised with high accuracy (e.g., Znf143 AUC = 0.968, SMC3 AUC > 0.95)", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/38732207/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3390%2Fijms25094990%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-220", "recordId": "hsi-be9f5eccf3b27d", "sourceType": "Journal publication", "title": "Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.", "authors": "Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, Van Horn JD, Kesselman C, Foster I, Madduri R, Price ND, Ament SA.", "year": 2020, "journal": "Cell reports", "doi": "10.1016/j.celrep.2020.108029", "pmid": "32814038", "pmcid": "PMC7462736", "patentNumber": null, "originalAssignee": null, "originalCitation": "Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, Van Horn JD, Kesselman C, Foster I, Madduri R, Price ND, Ament SA (2020). \"Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.\" Cell Reports 32(7):108029. PMC7462736 — Comprehensive atlas of genomic footprints across 27 human tissues from 192 DNase-seq experiments; predicted occupancy of 1,515 TFs; tissue-specific footprints span 9.8% of genome at optimal thresholds; strongly enriched for disease-associated SNPs; highest-scoring footprints contribute disproportionately to heritability for complex traits in disease-relevant tissues", "originalSection": "Fractal TFBS Analysis / Fractal Chromatin 3D Organisation", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/32814038/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID%3APMC7462736&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "imaging-transcriptomics", "role": "Focused chapter source" }, { "ref": "NPL-221", "recordId": "hsi-30eaacfb450209", "sourceType": "Journal publication", "title": "Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer.", "authors": "Yang KY, Mukundan A, Tsao YM, Shi XH, Huang CW, Wang HC.", "year": 2023, "journal": "Scientific reports", "doi": "10.1038/s41598-023-47833-y", "pmid": "37993660", "pmcid": "PMC10665456", "patentNumber": null, "originalAssignee": null, "originalCitation": "Yang TH, Cheng YW, Wang YT, Huang TW, Kang CW, Pan CT, Kuo HY, Chung CH, Chen CC, Liao YS (2023). \"Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer.\" Scientific Reports (Nature) 13:20502. DOI: 10.1038/s41598-023-47833-y — SAVE HSI engine (Hitspectra Intelligent Technology, Kaohsiung, Taiwan) reconstructing hyperspectral imaging from standard RGB endoscopic video; CycleGAN narrowband imaging simulation; real-time ~25 fps; clinically superior early esophageal cancer inference vs conventional white-light imaging; validates HSI reconstruction from standard cameras for medical tissue inference in peer-reviewed clinical context", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "metadata-matched", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://pubmed.ncbi.nlm.nih.gov/37993660/", "metadataURL": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.1038%2Fs41598-023-47833-y%22&format=json&resultType=core&pageSize=4", "corrections": [], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "NPL-222", "recordId": "hsi-33a52b5cee68bb", "sourceType": "Institutional, commercial or web source", "title": "Medicine — Guiding machine vision with hyperspectral images", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": null, "originalAssignee": null, "originalCitation": "Hitspectra Intelligent Technology Co., Ltd. (Kaohsiung, Taiwan). \"Medicine — Guiding machine vision with hyperspectral images.\" hitspectra.com/en/application.php?CNo=1 — Commercial HSI integration with standard medical lenses: dermatoscope (85% accuracy for skin pigment and haemoglobin abnormalities), ophthalmoscope (fundus layer analysis for retinal disease, glaucoma, optic nerve pathology), odontoscope (oral cancer staging, accuracy expected to reach 99.9%); SAVE HSI engine expanding 400+ analysable spectral channels from a single pixel of standard camera input; AI-assisted pathological image analysis; non-invasive disease identification without biopsy. All applications target tissue morphology via specialised medical lens hardware — not gene expression, not consumer smartphone cameras, not mental health", "originalSection": "Hyperspectral Imaging via Smartphone", "metadataStatus": "documentary-source", "claimReview": "Not independently appraised", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "http://hitspectra.com/en/application.php?CNo=1", "metadataURL": null, "corrections": [ "Institutional, product or web reference; no journal-publication identity is asserted." ], "topicId": "optical-physiology", "role": "Focused chapter source" }, { "ref": "PAT-1", "recordId": "hsi-patent-us20240289989a1", "sourceType": "Patent document", "title": "Transformation of color representations and spectral recovery", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": "US20240289989A1", "originalAssignee": [ "Voyage81 Ltd" ], "originalCitation": "US20240289989A1 · Voyage81 / Il Makiage · Smartphone hyperspectral imaging", "originalSection": "Patent citations", "metadataStatus": "identifier-resolved", "claimReview": "No legal-status, novelty or claim-scope opinion", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://patents.google.com/patent/US20240289989A1/en", "metadataURL": "https://patents.google.com/patent/US20240289989A1/en", "corrections": [], "topicId": "patent-landscape", "role": "Patent bibliography source" }, { "ref": "PAT-2", "recordId": "hsi-patent-wo2021111436a1", "sourceType": "Patent document", "title": "System and method for physiological measurements from optical data", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": "WO2021111436A1", "originalAssignee": [ "Binah.AI Ltd" ], "originalCitation": "WO2021111436A1 · Binah.ai · rPPG-based SaMD (HR, HRV, BP, spO2)", "originalSection": "Patent citations", "metadataStatus": "identifier-resolved", "claimReview": "No legal-status, novelty or claim-scope opinion", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://patents.google.com/patent/WO2021111436A1/en", "metadataURL": "https://patents.google.com/patent/WO2021111436A1/en", "corrections": [], "topicId": "patent-landscape", "role": "Patent bibliography source" }, { "ref": "PAT-3", "recordId": "hsi-patent-us20230128051a1", "sourceType": "Patent document", "title": "System for simultaneously assessing psychological safety in real time and associated methods", "authors": null, "year": null, "journal": null, "doi": null, "pmid": null, "pmcid": null, "patentNumber": "US20230128051A1", "originalAssignee": [ "Immersion Neuroscience Inc" ], "originalCitation": "US20230128051A1 · Zak / DARPA / Immersion · Oxytocin inference via heart rate", "originalSection": "Patent citations", "metadataStatus": "identifier-resolved", "claimReview": "No legal-status, novelty or claim-scope opinion", "sourceURL": "https://www.notion.so/3807b9c99c5680599be7d8337c817b15", "publicationURL": "https://patents.google.com/patent/US20230128051A1/en", "metadataURL": "https://patents.google.com/patent/US20230128051A1/en", "corrections": [ "The public record lists Immersion Neuroscience Inc as original assignee. 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