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      "sample": "24 patients; EMDR or trauma-focused CBT for eight weeks",
      "finding": "Across both therapies, miR-132-3p decreased after correction for multiple testing. Several additional microRNA changes were nominal associations.",
      "limitation": "Therapy-specific subgroup findings and symptom correlations did not survive multiple-testing correction. The combined treatments do not isolate eye movements or spoken language.",
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      "title": "MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study",
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      "title": "Shared Transcriptomic and Epigenomic Signatures Between Traumatic Brain Injury and Music Exposure: An Integrative Proof of Concept",
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      "design": "Exploratory human pilot",
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      "finding": "The pilot detected exploratory RNA and microbial changes after music exposure, including signals involving HERC6, TSPAN5 and REM2.",
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      "limitation": "Treatment-response signals were suggestive rather than definitive epigenome-wide findings. Association does not establish that verbal communication caused the molecular changes.",
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      "design": "Three-arm randomized controlled trial",
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      "sample": "211 adults randomized to meditation, yoga or stress education",
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      "limitation": "Within-group improvement is not evidence of superiority. The study does not establish a distinctive meditation-related gene-expression effect.",
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      "title": "Psychological assessments, allostatic load and gene expression analyses in a randomized controlled trial comparing meditation, yoga, and stress education",
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      "year": 2025,
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      "authors": "Denninger JW, Joss D, Romero PM, Khalsa SBS, Hoge EA, Bhasin M, Lazar SW, Dusek JA, Macklin E, Libermann T, Fricchione GL, Benson H.",
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        "sample": "211 chronically stressed adults: 73 meditation, 68 yoga, 70 control",
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          "https://pmc.ncbi.nlm.nih.gov/articles/PMC12463968/",
          "https://pubmed.ncbi.nlm.nih.gov/41020112/",
          "https://doi.org/10.3389/fpsyg.2025.1653242"
        ],
        "checkedAt": "2026-10-23",
        "reviewScope": "Publication abstract and selected full-text methods; Jadad assessment pending"
      }
    },
    {
      "pmid": "38776115",
      "collections": [
        "vision"
      ],
      "strand": "Retinal CD38 & NAD+ biology",
      "design": "Mouse retinal-injury and gene-deletion experiments",
      "measurement": "NAD+ concentration, retinal proteins and ganglion-cell survival",
      "finding": "CD38 deletion reduced retinal injury and inflammatory responses, with evidence implicating the NAD+/Sirt1 pathway.",
      "limitation": "Gene deletion and retinal-injury models do not establish that visual exposure regulates CD38. NAD+ is a metabolite, not a gene.",
      "targets": [
        "CD38",
        "NAD+",
        "TNF"
      ],
      "categories": [
        "Genetics & genomics",
        "Molecular biomarkers"
      ],
      "relation": "Pathway context; no visual exposure tested",
      "id": "pmid-38776115",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/38776115/",
        "https://doi.org/10.1167/iovs.65.5.36"
      ],
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      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
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      "title": "CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic Nerve Crush Models",
      "doi": "10.1167/iovs.65.5.36",
      "year": 2024,
      "published": "2024-05-01",
      "authors": "Pang Y, Hu H, Xu K, Cao T, Wang Z, Nie J, Zheng H, Luo H, Wang F, Xiong C, Deng KY, Xin HB, Zhang X.",
      "journal": "Investigative ophthalmology & visual science",
      "publicationTypes": [
        "Research Support, Non-U.S. Gov't",
        "research-article",
        "Journal Article"
      ],
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        "assessedAt": "2026-10-27"
      },
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "38362742",
      "collections": [
        "vision",
        "language"
      ],
      "strand": "EMDR & trauma-focused psychotherapy",
      "design": "Prospective longitudinal human study",
      "measurement": "Genome-wide DNA methylation",
      "sample": "30 patients with treatment-resistant depression; 18 EMDR, 12 trauma-focused CBT",
      "finding": "Methylation changes were associated with treatment over time. The EMDR subgroup showed differentially methylated regions and enrichment involving inflammatory pathways, including TNF signalling.",
      "limitation": "Small clinical groups and concomitant treatment limit attribution. Methylation is not a direct measurement of transcription, and an EMDR effect is not an isolated vision effect.",
      "targets": [
        "TNF"
      ],
      "categories": [
        "Epigenetics"
      ],
      "id": "pmid-38362742",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/38362742/",
        "https://doi.org/10.1080/20008066.2024.2314913"
      ],
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      "originalNote": "",
      "sourceDesign": null,
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      "relation": "See measured outcome and limitations",
      "title": "DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study",
      "doi": "10.1080/20008066.2024.2314913",
      "year": 2024,
      "published": "2024-02-16",
      "authors": "Carvalho Silva R, Martini P, Hohoff C, Mattevi S, Bortolomasi M, Menesello V, Gennarelli M, Baune BT, Minelli A.",
      "journal": "European journal of psychotraumatology",
      "publicationTypes": [
        "Research Support, Non-U.S. Gov't",
        "research-article",
        "Journal Article"
      ],
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      "stars": 1,
      "ratingBasis": "Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 1,
        "scope": "Paper",
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        "basis": "Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/38362742/",
          "https://doi.org/10.1080/20008066.2024.2314913"
        ],
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        "assessedAt": "2026-10-27"
      },
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "39060246",
      "collections": [
        "vision",
        "language"
      ],
      "strand": "EMDR & trauma-focused psychotherapy",
      "design": "Human cohort with longitudinal treatment analysis",
      "measurement": "Saliva DNA methylation and cortisol",
      "sample": "87 young people with and without PTSD; treated participants received EMDR or trauma-focused CBT",
      "finding": "Treatment response was associated with methylation patterns, including longitudinal CRHR2 changes and a post-treatment C18orf63 signal.",
      "limitation": "The cohort size includes participants without PTSD. Peripheral methylation, treatment response and cortisol associations require replication and do not identify a visual mechanism.",
      "targets": [
        "CRHR2"
      ],
      "categories": [
        "Epigenetics",
        "Molecular biomarkers"
      ],
      "id": "pmid-39060246",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/39060246/",
        "https://doi.org/10.1038/s41398-024-02892-1"
      ],
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      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "See measured outcome and limitations",
      "title": "Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder",
      "doi": "10.1038/s41398-024-02892-1",
      "year": 2024,
      "published": "2024-07-26",
      "authors": "Ensink JBM, Henneman P, Venema A, Zantvoord JB, den Kelder RO, Mannens MMAM, Lindauer RJL.",
      "journal": "Translational psychiatry",
      "publicationTypes": [
        "research-article",
        "Journal Article"
      ],
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      "kind": "Journal article",
      "stars": 1,
      "ratingBasis": "Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
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        "score": 1,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": null,
        "blinding": "not-confirmed",
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        "basis": "Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/39060246/",
          "https://doi.org/10.1038/s41398-024-02892-1"
        ],
        "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.",
        "assessedAt": "2026-10-27"
      },
      "legacyArticleStars": 1,
      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "39680432",
      "collections": [
        "language"
      ],
      "strand": "Meditation & transcriptomics",
      "design": "Randomized controlled trial",
      "measurement": "mRNA sequencing; circulating IL-6 and DHEA-S",
      "sample": "78 students randomized to Heartfulness or control",
      "finding": "The study reported differences in gene-expression profiles and psychological outcomes. IL-6 declined in both groups, with the larger percentage decline reported in the control group.",
      "limitation": "Within-arm improvement cannot establish intervention-specific benefit. The IL-6 result is not evidence of superior anti-inflammatory action; RNA profiling and cytokine protein are separate measures.",
      "targets": [
        "IL6"
      ],
      "categories": [
        "Gene expression",
        "Molecular biomarkers",
        "Clinical & self-report"
      ],
      "direction": "Mixed findings",
      "id": "pmid-39680432",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/39680432/",
        "https://doi.org/10.2196/65506"
      ],
      "archiveEntries": [],
      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial",
      "doi": "10.2196/65506",
      "year": 2024,
      "published": "2024-12-16",
      "authors": "Thimmapuram J, Patel KD, Bhatt D, Chauhan A, Madhusudhan D, Bhatt KK, Deshpande S, Budhbhatti U, Joshi C.",
      "journal": "JMIR bioinformatics and biotechnology",
      "publicationTypes": [
        "research-article",
        "Journal Article"
      ],
      "verifiedAt": "2026-10-21",
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      "retracted": false,
      "kind": "Journal article",
      "stars": 2,
      "ratingBasis": "The article and ISRCTN record describe random allocation but do not report blinding. Blinding is not established by these sources.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 2,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": true,
        "blinding": "not-confirmed",
        "peerReviewed": true,
        "basis": "The article and ISRCTN record describe random allocation but do not report blinding. Blinding is not established by these sources.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/39680432/",
          "https://pmc.ncbi.nlm.nih.gov/articles/PMC11686021/",
          "https://doi.org/10.2196/65506",
          "https://www.isrctn.com/ISRCTN82860715"
        ],
        "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.",
        "assessedAt": "2026-10-27"
      },
      "legacyArticleStars": 1,
      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record.",
      "evidence": {
        "intervention": "Web-based Heartfulness meditation",
        "comparator": "Usual routine",
        "sample": "78 health-care students randomized; completer analysis",
        "measurement": "Whole blood; mRNA sequencing; circulating IL-6 and DHEA-S",
        "timing": "12 weeks",
        "trialId": "ISRCTN82860715",
        "measuredGenes": [],
        "pathways": [
          "Serotonergic signalling",
          "Circadian entrainment",
          "IL-17 signalling"
        ],
        "evidenceType": "RNA expression",
        "sourceURLs": [
          "https://pmc.ncbi.nlm.nih.gov/articles/PMC11686021/",
          "https://pubmed.ncbi.nlm.nih.gov/39680432/",
          "https://doi.org/10.2196/65506"
        ],
        "checkedAt": "2026-10-23",
        "reviewScope": "Publication abstract and selected full-text methods; Jadad assessment pending"
      }
    },
    {
      "pmid": "39295112",
      "collections": [
        "language"
      ],
      "strand": "Parent–infant communication & psychotherapy",
      "design": "Randomized parent–infant psychotherapy trial",
      "measurement": "Saliva methylation at NR3C1, SLC6A4, BDNF and LINE1",
      "sample": "73 mother–child pairs at baseline",
      "finding": "Infant BDNF methylation showed a possible decrease after the home-visiting psychotherapy programme. Most maternal molecular associations and intervention effects were absent.",
      "limitation": "The intervention includes multiple relational components. The results do not isolate particular spoken words, and the molecular findings were mixed.",
      "targets": [
        "NR3C1",
        "SLC6A4",
        "BDNF"
      ],
      "categories": [
        "Epigenetics"
      ],
      "direction": "Mixed findings",
      "id": "pmid-39295112",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/39295112/",
        "https://doi.org/10.1002/brb3.70035"
      ],
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      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Longitudinal DNA methylation in parent-infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting",
      "doi": "10.1002/brb3.70035",
      "year": 2024,
      "published": "2024-09-01",
      "authors": "Petroff RL, Jester J, Riggs J, Alfafara E, Springer K, Kerr N, Issa M, Hall A, Rosenblum K, Goodrich JM, Muzik M, Michigan Collaborative for Infant Mental Health Research.",
      "journal": "Brain and behavior",
      "publicationTypes": [
        "research-article",
        "Randomized Controlled Trial",
        "Journal Article"
      ],
      "verifiedAt": "2026-10-21",
      "publicationStatus": "PubMed-indexed publication",
      "retracted": false,
      "kind": "Journal article",
      "stars": 2,
      "ratingBasis": "Randomized controlled design recorded in the publication-specific design or bibliographic indexing.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 2,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": true,
        "blinding": "not-confirmed",
        "peerReviewed": true,
        "basis": "Randomized controlled design recorded in the publication-specific design or bibliographic indexing.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/39295112/",
          "https://doi.org/10.1002/brb3.70035"
        ],
        "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.",
        "assessedAt": "2026-10-27"
      },
      "legacyArticleStars": 1,
      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "37982547",
      "collections": [
        "language"
      ],
      "strand": "Mindfulness & inflammatory regulation",
      "design": "Randomized trial with active comparator",
      "measurement": "Blood RNA profiling; plasma IL-6 and CRP",
      "sample": "190 lonely older adults randomized to MBSR or health enhancement",
      "finding": "MBSR reduced inferred NF-κB transcriptional activity relative to the comparator. It did not reduce circulating IL-6 or CRP relative to that comparator.",
      "limitation": "This separates a gene-regulation signal from protein biomarkers. The findings do not establish direct IL6 transcription changes or an OXTR mechanism.",
      "targets": [
        "IL6"
      ],
      "categories": [
        "Gene expression",
        "Molecular biomarkers"
      ],
      "direction": "Mixed findings",
      "id": "pmid-37982547",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/37982547/",
        "https://doi.org/10.1097/psy.0000000000001264"
      ],
      "archiveEntries": [],
      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Mindfulness-Based Stress Reduction Reduces Proinflammatory Gene Regulation But Not Systemic Inflammation Among Older Adults: A Randomized Controlled Trial",
      "doi": "10.1097/psy.0000000000001264",
      "year": 2024,
      "published": "2023-11-17",
      "authors": "Lindsay EK, Marsland AL, Cole SW, Dutcher JM, Greco CM, Wright AGC, Brown KW, Creswell JD.",
      "journal": "Psychosomatic medicine",
      "publicationTypes": [
        "research-article",
        "Randomized Controlled Trial",
        "Journal Article"
      ],
      "verifiedAt": "2026-10-21",
      "publicationStatus": "PubMed-indexed publication",
      "retracted": false,
      "kind": "Journal article",
      "stars": 2,
      "ratingBasis": "Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 2,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": true,
        "blinding": "single",
        "peerReviewed": true,
        "basis": "Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/37982547/",
          "https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/",
          "https://doi.org/10.1097/psy.0000000000001264",
          "https://clinicaltrials.gov/study/NCT02888600"
        ],
        "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.",
        "assessedAt": "2026-10-27"
      },
      "legacyArticleStars": 1,
      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record.",
      "evidence": {
        "intervention": "Mindfulness-based stress reduction (MBSR)",
        "comparator": "Health Enhancement Program",
        "sample": "190 lonely adults aged 65–85",
        "measurement": "Peripheral blood mononuclear cells; RNA profiling and promoter analysis",
        "timing": "8 weeks; follow-up at 3 months",
        "trialId": "NCT02888600",
        "measuredGenes": [],
        "pathways": [
          "NF-κB",
          "CREB",
          "IRF",
          "Glucocorticoid receptor signalling"
        ],
        "evidenceType": "RNA expression",
        "sourceURLs": [
          "https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/",
          "https://pubmed.ncbi.nlm.nih.gov/37982547/",
          "https://doi.org/10.1097/psy.0000000000001264"
        ],
        "checkedAt": "2026-10-23",
        "reviewScope": "Publication abstract and selected full-text methods; Jadad assessment pending"
      }
    },
    {
      "pmid": "39098435",
      "collections": [
        "language"
      ],
      "strand": "Precision psychosocial research",
      "design": "Prediction analyses across two randomized trials",
      "measurement": "Baseline blood RNA and inferred transcription-factor activity",
      "finding": "Baseline CREB activity predicted selected psychological responses to compassion-based meditation in two datasets. The same relationship was not seen for mindfulness meditation.",
      "limitation": "The study concerns prediction from baseline expression rather than a demonstrated therapy-induced transcriptional mechanism. Clinical deployment requires further validation.",
      "targets": [],
      "categories": [
        "Gene expression"
      ],
      "id": "pmid-39098435",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/39098435/",
        "https://doi.org/10.1016/j.bbi.2024.08.004"
      ],
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      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Predicting psychosocial intervention response from baseline gene expression",
      "doi": "10.1016/j.bbi.2024.08.004",
      "year": 2024,
      "published": "2024-08-02",
      "authors": "Ricon-Becker I, West TN, Fredrickson BL, Kaplan DM, Mehl MR, Raison CL, Cole SW.",
      "journal": "Brain, behavior, and immunity",
      "publicationTypes": [
        "Randomized Controlled Trial",
        "Journal Article",
        "Research Support, N.I.H., Extramural"
      ],
      "verifiedAt": "2026-10-21",
      "publicationStatus": "PubMed-indexed publication",
      "retracted": false,
      "kind": "Journal article",
      "stars": 2,
      "ratingBasis": "Randomized controlled design recorded in the publication-specific design or bibliographic indexing.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 2,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": true,
        "blinding": "not-confirmed",
        "peerReviewed": true,
        "basis": "Randomized controlled design recorded in the publication-specific design or bibliographic indexing.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/39098435/",
          "https://doi.org/10.1016/j.bbi.2024.08.004"
        ],
        "reviewScope": "Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.",
        "assessedAt": "2026-10-27"
      },
      "legacyArticleStars": 1,
      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "38671329",
      "collections": [
        "language"
      ],
      "strand": "Meditation & epigenomics",
      "design": "Secondary genetic and epigenetic analysis",
      "measurement": "SLC6A4 and FKBP5 genotype and DNA methylation",
      "sample": "72 veterans across two meditation studies",
      "finding": "SLC6A4 genotype and changes at a set of FKBP5 CpG sites were associated with symptom improvement after meditation-based treatment.",
      "limitation": "Associations with response do not establish that a particular mantra caused the changes. Genotype, methylation and measured gene expression are different quantities.",
      "targets": [
        "SLC6A4",
        "FKBP5"
      ],
      "categories": [
        "Epigenetics",
        "Genetics & genomics"
      ],
      "id": "pmid-38671329",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/38671329/",
        "https://doi.org/10.1007/s12035-024-04096-6"
      ],
      "archiveEntries": [],
      "provenance": [],
      "priority": 0,
      "originalNote": "",
      "sourceDesign": null,
      "sourceGrade": null,
      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD",
      "doi": "10.1007/s12035-024-04096-6",
      "year": 2024,
      "published": "2024-04-27",
      "authors": "Lee A, Thuras P, Baller J, Jiao C, Guo B, Erbes CR, Polusny MA, Liu C, Wu B, Lim KO, Bishop JR.",
      "journal": "Molecular neurobiology",
      "publicationTypes": [
        "Journal Article"
      ],
      "verifiedAt": "2026-10-21",
      "publicationStatus": "PubMed-indexed publication",
      "retracted": false,
      "kind": "Journal article",
      "stars": 1,
      "ratingBasis": "The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 1,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": null,
        "blinding": "not-confirmed",
        "peerReviewed": true,
        "basis": "The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/38671329/",
          "https://doi.org/10.1007/s12035-024-04096-6"
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        "assessedAt": "2026-10-27"
      },
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    },
    {
      "pmid": "37764116",
      "collections": [
        "sound"
      ],
      "strand": "Auditory exposure & animal biology",
      "design": "Controlled mouse experiment",
      "measurement": "Immune-related qPCR, microbiome and antioxidant assays",
      "finding": "Music and white-noise exposures produced different immune-related, microbial and oxidative-stress profiles in mice.",
      "limitation": "Animal exposure conditions do not establish a human music benefit. Gene assays, microbial composition and serum enzyme activity are distinct outcomes.",
      "targets": [],
      "categories": [
        "Gene expression",
        "Molecular biomarkers"
      ],
      "id": "pmid-37764116",
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        "https://pubmed.ncbi.nlm.nih.gov/37764116/",
        "https://doi.org/10.3390/microorganisms11092272"
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      "title": "Effects of Music and White Noise Exposure on the Gut Microbiota, Oxidative Stress, and Immune-Related Gene Expression of Mice",
      "doi": "10.3390/microorganisms11092272",
      "year": 2023,
      "published": "2023-09-10",
      "authors": "Zhang Z, Wu Y, Zhou S, Fu P, Yan H.",
      "journal": "Microorganisms",
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        "Journal Article"
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          "https://doi.org/10.3390/microorganisms11092272"
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    {
      "pmid": "36658116",
      "collections": [
        "language"
      ],
      "strand": "Talking therapies & epigenomics",
      "design": "Longitudinal psychotherapy cohort",
      "measurement": "Salivary NR3C1 DNA methylation",
      "sample": "153 conflict survivors receiving narrative exposure therapy",
      "finding": "Change at NR3C1 CpG cg25535999 was associated with PTSD symptom change after correction for multiple comparisons. Responders showed increased methylation at this site.",
      "limitation": "The study examines a complete therapy programme and an association with recovery. It does not establish a causal effect of individual words or show NR3C1 RNA changes.",
      "targets": [
        "NR3C1"
      ],
      "categories": [
        "Epigenetics"
      ],
      "id": "pmid-36658116",
      "origin": "update",
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        "https://pubmed.ncbi.nlm.nih.gov/36658116/",
        "https://doi.org/10.1038/s41398-023-02316-6"
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      "title": "Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy",
      "doi": "10.1038/s41398-023-02316-6",
      "year": 2023,
      "published": "2023-01-19",
      "authors": "Wilker S, Vukojevic V, Schneider A, Pfeiffer A, Inerle S, Pauly M, Elbert T, Papassotiropoulos A, de Quervain D, Kolassa IT.",
      "journal": "Translational psychiatry",
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        "Journal Article"
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    },
    {
      "pmid": "38222454",
      "collections": [
        "vision"
      ],
      "strand": "Light exposure & retinal inflammation",
      "design": "Mouse light-induced retinal injury model",
      "measurement": "Retinal RNA sequencing; vitreous cytokine protein",
      "finding": "Strong light exposure induced retinal inflammatory transcriptional changes. Vitreous IL-6 protein was approximately tenfold higher in the injury model.",
      "limitation": "The IL-6 fold change concerns vitreous protein. This is a harmful exposure model, not evidence for a therapeutic visual protocol.",
      "targets": [
        "IL6",
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      "categories": [
        "Gene expression",
        "Molecular biomarkers"
      ],
      "relation": "Exposure-related RNA and protein measurements",
      "id": "pmid-38222454",
      "origin": "update",
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        "https://pubmed.ncbi.nlm.nih.gov/38222454/",
        "https://doi.org/10.5281/zenodo.7870831"
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      "title": "Light damage induces inflammatory factors in mouse retina and vitreous humor",
      "doi": "10.5281/zenodo.7870831",
      "year": 2023,
      "published": "2023-10-15",
      "authors": "Liu W, Zhu X, Ge X, Chen Y, Li DW, Gong L.",
      "journal": "Molecular vision",
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          "https://doi.org/10.5281/zenodo.7870831"
        ],
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    },
    {
      "pmid": "38040763",
      "collections": [
        "sound"
      ],
      "strand": "Music & transcriptomics",
      "design": "Human before–after transcriptomic study",
      "measurement": "Peripheral-blood transcriptome",
      "sample": "60 participants; separate comparison with 1,269 MCI/Alzheimer disease and control transcriptomes",
      "finding": "A music session was associated with blood gene-expression changes in people with age-related cognitive disorders and healthy controls. Some affected pathways overlapped inversely with disease-associated expression patterns.",
      "limitation": "Before–after molecular associations and cross-dataset comparisons do not establish that music reverses dementia or changes brain gene expression.",
      "targets": [],
      "categories": [
        "Gene expression"
      ],
      "id": "pmid-38040763",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/38040763/",
        "https://doi.org/10.1038/s41598-023-48094-5"
      ],
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      "relation": "See measured outcome and limitations",
      "title": "Music compensates for altered gene expression in age-related cognitive disorders",
      "doi": "10.1038/s41598-023-48094-5",
      "year": 2023,
      "published": "2023-12-02",
      "authors": "Gómez-Carballa A, Navarro L, Pardo-Seco J, Bello X, Pischedda S, Viz-Lasheras S, Camino-Mera A, Currás MJ, Ferreirós I, Mallah N, Rey-Vázquez S, Redondo L, Dacosta-Urbieta A, Caamaño-Viña F, Rivero-Calle I, Rodriguez-Tenreiro C, Martinón-Torres F, Salas A.",
      "journal": "Scientific reports",
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      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
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    },
    {
      "pmid": "36819725",
      "collections": [
        "sound"
      ],
      "strand": "Music & transcriptomics",
      "design": "Literature synthesis and secondary omics analysis",
      "measurement": "Overlap across published transcriptomic and epigenomic datasets",
      "finding": "The authors compared music-related genes with Alzheimer disease datasets and identified overlapping pathways and candidate genes, including SLC6A4.",
      "limitation": "This is an integrative analysis of earlier evidence. It does not show that music directly changes SLC6A4 expression in a clinical experiment.",
      "targets": [
        "SLC6A4",
        "SNCA"
      ],
      "categories": [
        "Genetics & genomics",
        "Gene expression",
        "Epigenetics"
      ],
      "id": "pmid-36819725",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/36819725/",
        "https://doi.org/10.3389/fnagi.2023.1063536"
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      "relation": "See measured outcome and limitations",
      "title": "Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics",
      "doi": "10.3389/fnagi.2023.1063536",
      "year": 2023,
      "published": "2023-02-03",
      "authors": "Navarro L, Gómez-Carballa A, Pischedda S, Montoto-Louzao J, Viz-Lasheras S, Camino-Mera A, Hinault T, Martinón-Torres F, Salas A.",
      "journal": "Frontiers in aging neuroscience",
      "publicationTypes": [
        "Systematic Review",
        "systematic-review",
        "Journal Article"
      ],
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      "kind": "Review / synthesis",
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      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
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          "https://doi.org/10.3389/fnagi.2023.1063536"
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        "assessedAt": "2026-10-27"
      },
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "37560036",
      "collections": [
        "language"
      ],
      "strand": "Mantra & transcriptomics",
      "design": "Secondary analysis of a small matched observational study",
      "measurement": "Peripheral-blood mononuclear-cell RNA",
      "sample": "12 participants; long-term practitioners and matched controls",
      "finding": "Long-term Transcendental Meditation practitioners had lower expression of a prespecified adversity-related gene score than controls.",
      "limitation": "The observational comparison is small and does not separate practice effects from selection, lifestyle or other confounding.",
      "targets": [],
      "categories": [
        "Gene expression"
      ],
      "id": "pmid-37560036",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/37560036/",
        "https://doi.org/10.1016/j.bbih.2023.100672"
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      "originalNote": "",
      "sourceDesign": null,
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      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Transcendental Meditation practitioners show reduced expression of the Conserved Transcriptional Response to Adversity",
      "doi": "10.1016/j.bbih.2023.100672",
      "year": 2023,
      "published": "2023-08-02",
      "authors": "Walton KG, Wenuganen S, Cole SW.",
      "journal": "Brain, behavior, & immunity - health",
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        "Journal Article"
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      "ratingBasis": "A nonrandomized comparison of long-term practitioners and controls; the analysis does not meet the blinded randomized-trial categories.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
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          "https://pmc.ncbi.nlm.nih.gov/articles/PMC10407892/",
          "https://doi.org/10.1016/j.bbih.2023.100672"
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "36127701",
      "collections": [
        "vision"
      ],
      "strand": "Retinal OXTR signalling",
      "design": "Mouse retinal molecular and physiological experiments",
      "measurement": "Oxtr mRNA localization, receptor protein, dopamine and electroretinography",
      "finding": "Oxtr mRNA and receptor protein were detected in retinal amacrine cells. Applying oxytocin activated dopaminergic cells and altered retinal responses through receptor-dependent signalling.",
      "limitation": "This establishes a retinal signalling context. It does not show that a visual pattern changes OXTR transcription in humans.",
      "targets": [
        "OXTR",
        "OXT"
      ],
      "categories": [
        "Gene expression",
        "Brain & nervous system"
      ],
      "relation": "Expression localization and pathway context",
      "id": "pmid-36127701",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/36127701/",
        "https://doi.org/10.1186/s12915-022-01405-0"
      ],
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      "title": "Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling",
      "doi": "10.1186/s12915-022-01405-0",
      "year": 2022,
      "published": "2022-09-21",
      "authors": "Hu S, Wang Y, Han X, Dai M, Zhang Y, Ma Y, Weng S, Xiao L, Xiao L.",
      "journal": "BMC biology",
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      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
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        "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.",
        "sources": [
          "https://pubmed.ncbi.nlm.nih.gov/36127701/",
          "https://doi.org/10.1186/s12915-022-01405-0"
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      },
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "35544697",
      "collections": [
        "vision"
      ],
      "strand": "Retinal dopamine signalling",
      "design": "Human retinal pigment epithelial cell-line experiment",
      "measurement": "Dopamine-receptor and profibrotic gene expression; cell behaviour",
      "finding": "DRD2 and DRD5 were prominent receptors in ARPE-19 cells. Dopamine-receptor manipulation altered profibrotic gene expression and cellular fibrosis measures.",
      "limitation": "Pharmacological receptor manipulation provides ocular pathway context. It is not a test of light or visual-stimulation effects on DRD2 expression.",
      "targets": [
        "DRD2"
      ],
      "categories": [
        "Gene expression"
      ],
      "relation": "Pathway context; no visual exposure tested",
      "id": "pmid-35544697",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/35544697/",
        "https://doi.org/10.1152/ajpcell.00468.2021"
      ],
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      "title": "Dopamine receptor signaling regulates fibrotic activation of retinal pigmented epithelial cells",
      "doi": "10.1152/ajpcell.00468.2021",
      "year": 2022,
      "published": "2022-05-11",
      "authors": "Gao AY, Link PA, Bakri SJ, Haak AJ.",
      "journal": "American journal of physiology. Cell physiology",
      "publicationTypes": [
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        "Journal Article",
        "Research Support, N.I.H., Extramural"
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      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
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        "basis": "Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.",
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          "https://doi.org/10.1152/ajpcell.00468.2021"
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      },
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      "legacyRatingBasis": "Indexed journal paper; blinded-RCT criteria are not confirmed in the retrieved record."
    },
    {
      "pmid": "36278141",
      "collections": [
        "language"
      ],
      "strand": "Mindfulness and loving-kindness",
      "design": "Randomized comparison of two meditation programmes",
      "measurement": "Leukocyte adversity-related gene-expression profile",
      "sample": "88 adults raised in low socioeconomic conditions",
      "finding": "The adversity-related expression score declined with mindfulness but increased with loving-kindness training, opposite to the predicted relative benefit. Positive emotions increased in both groups.",
      "limitation": "Different practices did not produce a uniform molecular response. Increased positive emotion did not explain the gene-expression result.",
      "targets": [],
      "categories": [
        "Gene expression",
        "Clinical & self-report"
      ],
      "direction": "Opposite-to-prediction comparison",
      "id": "pmid-36278141",
      "origin": "update",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/36278141/",
        "https://doi.org/10.1007/s12671-022-01857-z"
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      "sourceDesign": null,
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      "relation": "Intervention-level evidence; specific-word effects not isolated",
      "title": "Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households",
      "doi": "10.1007/s12671-022-01857-z",
      "year": 2022,
      "published": "2022-03-16",
      "authors": "West TN, Zhou J, Brantley MM, Kim SL, Brantley J, Salzberg S, Cole SW, Fredrickson BL.",
      "journal": "Mindfulness",
      "publicationTypes": [
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      "retracted": false,
      "kind": "Journal article",
      "stars": 3,
      "ratingBasis": "The trial register lists participants, investigators and outcome assessors as masked. The paper confirms that lab-visit personnel were blind to condition. The classification reflects the registered masking design.",
      "ratingScope": "Study-design shorthand, not a risk-of-bias or certainty assessment.",
      "verification": "Abstract and publication metadata reviewed; full-paper appraisal pending",
      "paperTrustAssessment": {
        "score": 3,
        "scope": "Paper",
        "status": "assessed",
        "randomizedControlledTrial": true,
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        "basis": "The trial register lists participants, investigators and outcome assessors as masked. The paper confirms that lab-visit personnel were blind to condition. The classification reflects the registered masking design.",
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      "id": "pmid-30737392",
      "title": "Oxytocin pathway gene networks in the human brain",
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          "sourceText": "“Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT\n(structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).”\n“Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory\nregions and there was high co-expression with several dopaminergic and muscarinic acetylcholine\ngenes, reflecting an anatomical basis for critical gene pathway interactions.”\n“The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine\nsignaling to modulate cognitive state processes involved in complex human behaviors.”\nOxytocin pathway gene networks in the human brain\nNature\nhttps://www.nature.com/articles/s41467-019-08503-8\ncitations: 76",
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    {
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      "title": "Influence of various intensities of 528 Hz sound-wave in production of testosterone in rat's brain and analysis of behavioral changes",
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      "title": "Fibonacci Sequence Modulus 9 Pisano Period 24 (Fib M9 P24) is the digital root (modulus 9) of the Fibonacci sequence, as 3 nested fractals within a 24 cycle, an icositetragon (24 sided polygon) with interior angles summing to 3960 degrees.",
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      "originalNote": "[ I o H ] hypothesize these triplet of fibonacci sequences are universal across biological, cosmic and quantum levels, following nucleotide triplets within DNA through to fundamental sub atomic particles of electrons, protons & neutrons. What is revealed are three interlocking harmonic cycles of the one fibonacci sequence. [ I o H ] hypothesize Fib M9 P24 is a shadow of the 8th dimensional quasicrystal E8, proposed as the unified field by Garret Lisi & Quantum Gravity Research.\n\n“sound modulating water via cymascope photography experiments including life viewer patent by David Schiermeyer”\n\n“Results showed a significant correlation between celestial mechanics and Fibonacci numbers measured in 24-hour periods with an average deviation of less than 3%.”\n\n“Specifically, the Fibonacci series expressed in 24 hour-based units predicted the period of rotation, precession, and orbit across multiple time scales.”\n\n“The basic Fibonacci sine wave pattern has implications that might extend to quantum mechanics and the observable properties of a system. To draw such a conclusion or indication for quantum mechanics, it may be noted that the golden ratio and Fibonacci numbers appear in quantum mechanics”",
      "sourceText": "Fibonacci Sequence Modulus 9 Pisano Period 24 (Fib M9 P24) is the digital root (modulus 9) of\nthe Fibonacci sequence, as 3 nested fractals within a 24 cycle, an icositetragon (24 sided\npolygon) with interior angles summing to 3960 degrees.\n[ I o H ] hypothesize these triplet of fibonacci sequences are universal across biological, cosmic and\nquantum levels, following nucleotide triplets within DNA through to fundamental sub atomic\nparticles of electrons, protons & neutrons. What is revealed are three interlocking harmonic cycles\nof the one fibonacci sequence. [ I o H ] hypothesize Fib M9 P24 is a shadow of the 8th dimensional\nquasicrystal E8, proposed as the unified field by Garret Lisi & Quantum Gravity Research.\nFib M9 P24 fractal α ~ 7.83hz (9)\n| (7.83hz in modulus 9 =9)\nFib M9 P24 nested fractal sequence of 1, 1, 2, 3, 5, 8, 4, 3, 7, 1, 8, 9, 8, 8, 7, 6, 4, 1, 5, 6, 2, 8, 1, 9 forms a\nspiral\nFib M9 P24 fractal β ~ 111hz (3)\n| (111hz in modulus 9 =3)\nA mitosis nested fractal of 1, 2, 4, 8, 7, 5 modulates within this sequence as a hexagonal toroidal\ngeometry\nFib M9 P24 fractal γ ~ 528hz (6)\n| (528hz in modulus 9 = 6)\nA solfeggio nested fractal of 3, 6, 9, 3, 6, 9 modulates within this sequence in a hexagonal star\ntetrahedral geometry\nview workings here in science tab\nReverse Fibonacci sequence and its description\nAcademia | citations: 1\n7.83hz x 111hz + 528hz - 2D Fib M9 P 24 in 3D is toroidal 7.83hz x 111hz + 528hz - 3D\n“sound modulating water via cymascope photography experiments including life viewer patent\nby David Schiermeyer”\nCymatics for the cloaking of flexural vibrations in a structured plate\nNature\nhttps://www.nature.com/articles/srep23929\nFibonacci Sequence Mod 9, Pisano Period 24\n“Results showed a significant correlation between celestial mechanics and Fibonacci numbers\nmeasured in 24-hour periods with an average deviation of less than 3%.”\n“Specifically, the Fibonacci series expressed in 24 hour-based units predicted the period of rotation,\nprecession, and orbit across multiple time scales.”\n“The basic Fibonacci sine wave pattern has implications that might extend to quantum mechanics\nand the observable properties of a system. To draw such a conclusion or indication for quantum\nmechanics, it may be noted that the golden ratio and Fibonacci numbers appear in quantum\nmechanics”\nModeling Celestial Mechanics Using the Fibonacci Numbers\nResearchGate\nhttps://www.researchgate.net/profile/Robert_Sacco/publication/335313110_Modeling_Celestial_Mecha\nnics_Using_the_Fibonacci_Numbers/links/5d5d9396a6fdcc55e81ed976/Modeling-Celestial-Mechanic\ns-Using-the-Fibonacci-Numbers.pdf?origin=publication_detail\ncitations: 4",
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          "sourceText": "Fibonacci Sequence Modulus 9 Pisano Period 24 (Fib M9 P24) is the digital root (modulus 9) of\nthe Fibonacci sequence, as 3 nested fractals within a 24 cycle, an icositetragon (24 sided\npolygon) with interior angles summing to 3960 degrees.\n[ I o H ] hypothesize these triplet of fibonacci sequences are universal across biological, cosmic and\nquantum levels, following nucleotide triplets within DNA through to fundamental sub atomic\nparticles of electrons, protons & neutrons. What is revealed are three interlocking harmonic cycles\nof the one fibonacci sequence. [ I o H ] hypothesize Fib M9 P24 is a shadow of the 8th dimensional\nquasicrystal E8, proposed as the unified field by Garret Lisi & Quantum Gravity Research.\nFib M9 P24 fractal α ~ 7.83hz (9)\n| (7.83hz in modulus 9 =9)\nFib M9 P24 nested fractal sequence of 1, 1, 2, 3, 5, 8, 4, 3, 7, 1, 8, 9, 8, 8, 7, 6, 4, 1, 5, 6, 2, 8, 1, 9 forms a\nspiral\nFib M9 P24 fractal β ~ 111hz (3)\n| (111hz in modulus 9 =3)\nA mitosis nested fractal of 1, 2, 4, 8, 7, 5 modulates within this sequence as a hexagonal toroidal\ngeometry\nFib M9 P24 fractal γ ~ 528hz (6)\n| (528hz in modulus 9 = 6)\nA solfeggio nested fractal of 3, 6, 9, 3, 6, 9 modulates within this sequence in a hexagonal star\ntetrahedral geometry\nview workings here in science tab\nReverse Fibonacci sequence and its description\nAcademia | citations: 1\n7.83hz x 111hz + 528hz - 2D Fib M9 P 24 in 3D is toroidal 7.83hz x 111hz + 528hz - 3D\n“sound modulating water via cymascope photography experiments including life viewer patent\nby David Schiermeyer”\nCymatics for the cloaking of flexural vibrations in a structured plate\nNature\nhttps://www.nature.com/articles/srep23929\nFibonacci Sequence Mod 9, Pisano Period 24\n“Results showed a significant correlation between celestial mechanics and Fibonacci numbers\nmeasured in 24-hour periods with an average deviation of less than 3%.”\n“Specifically, the Fibonacci series expressed in 24 hour-based units predicted the period of rotation,\nprecession, and orbit across multiple time scales.”\n“The basic Fibonacci sine wave pattern has implications that might extend to quantum mechanics\nand the observable properties of a system. To draw such a conclusion or indication for quantum\nmechanics, it may be noted that the golden ratio and Fibonacci numbers appear in quantum\nmechanics”\nModeling Celestial Mechanics Using the Fibonacci Numbers\nResearchGate\nhttps://www.researchgate.net/profile/Robert_Sacco/publication/335313110_Modeling_Celestial_Mecha\nnics_Using_the_Fibonacci_Numbers/links/5d5d9396a6fdcc55e81ed976/Modeling-Celestial-Mechanic\ns-Using-the-Fibonacci-Numbers.pdf?origin=publication_detail\ncitations: 4",
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      "originalNote": "“The principal device of the Timewave Zero theory is a fractal function (constructed using numerical values derived from the King Wen Sequence of I Ching hexagrams) which maps time onto 'novelty'.”\n\n“the \"revealed\" axiom that all phenomena are at root constellated by a wave form which is the hierarchical summation of its constituent parts, morphogenetic patterns related to those in DNA. ... We argue that the theory of the hyperspatial nature of superconductive bonds, and the experiment we devised to test that theory, yielded ... a modular wave-hierarchy theory of the nature of time that we have been able to construe, using a particular mathematical treatment of the I Ching, into a general theory of systems, which illuminates the nature of time and organism and provides an idea model which explains the interconnection of physical and psychological phenomena from the submolecular to the macrocosmic level.”",
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      "id": "src-d8da0823ac49",
      "title": "Transduction of DNA information through water and electromagnetic waves",
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      "id": "src-e9b23a765f28",
      "title": "Yogic meditation reverses NF- κ B and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial",
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      "sourceText": "“A brief daily yogic meditation intervention may reverse the pattern of increased NF- κ B-related\ntranscription of pro-inflammatory cytokines and decreased IRF1-related transcription of innate\nantiviral response genes previously observed in healthy individuals confronting a significant life\nstressor”\nYogic meditation reverses NF- κ B and IRF-related transcriptome dynamics in leukocytes of\nfamily dementia caregivers in a randomized controlled trial\nPsychoneuroendocrinology\nhttps://www.sciencedirect.com/science/article/pii/S0306453012002260?via%3Dihub\nrandomised controlled trial\ncitations: 219",
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          "originalNote": "“A brief daily yogic meditation intervention may reverse the pattern of increased NF- κ B-related transcription of pro-inflammatory cytokines and decreased IRF1-related transcription of innate antiviral response genes previously observed in healthy individuals confronting a significant life stressor”",
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    {
      "pmid": "41974356",
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      "sample": "145 participants contributed biological data; singing 110, control 35",
      "finding": "After the first community-singing session, salivary IL-6 decreased by 26% in the singing group. The time-by-group interaction for IL-6 was significant. Later analyses also examined mother–infant cortisol synchrony and communication.",
      "limitation": "This measured salivary cytokine protein, not IL6 transcription. The biological subset was unbalanced, and speech correlations do not isolate the causal effect of particular words.",
      "targets": [
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      "title": "Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial",
      "doi": "10.1016/j.bbi.2026.106600",
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      "authors": "Kirkpatrick M, Priestley K, Bind RH, Rebecchini L, Borsini A, Estevao C, Hazelgrove K, Laijawala R, Alford S, Woods AJ, Crane N, Manoharan M, Burton A, Dye H, Osborn T, Greenwood L, Dazzan P, Fancourt D, Pariante C.",
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    {
      "pmid": "42881739",
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      ],
      "strand": "Music & inflammatory biomarkers",
      "design": "Open-label randomized trial; secondary analysis",
      "measurement": "Serum IL-6 and prolactin; sedative requirements",
      "sample": "110 mechanically ventilated adults",
      "finding": "The trial found no significant adjusted between-group difference in serum IL-6 or prolactin. Propofol requirements decreased more in the music group among patients receiving that drug.",
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      "title": "Effects of a Standardized Music Intervention on Propofol Requirements and Serum Interleukin-6 and Prolactin in Deeply Sedated Mechanically Ventilated Adults: A Prespecified Secondary Analysis of a Randomized Clinical Trial",
      "doi": "10.3390/healthcare14193300",
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      "published": "2026-10-03",
      "authors": "Fernández-Álvarez C, Mosteiro-Díaz MP, Zuazua-Rico D, Maestro-González A.",
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    {
      "pmid": "42339887",
      "collections": [
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      "strand": "Spectral lighting & ocular biology",
      "design": "Controlled mouse lighting experiment",
      "measurement": "Ocular nNOS, IL-6 and TNF protein; tissue structure",
      "finding": "After 21 days, higher-colour-temperature lighting was associated with increased nNOS, IL-6, TNF and other signalling proteins, without detectable axial-length or structural changes.",
      "limitation": "Protein abundance is not an RNA-expression measurement. The result concerns a defined mouse exposure and includes inflammatory responses rather than an established benefit.",
      "targets": [
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      "id": "pmid-42339887",
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      "year": 2026,
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      "authors": "Chiang YW, Chang JY, Yeh KL, Lin RY, Yeh SM.",
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    {
      "pmid": "39103336",
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      ],
      "strand": "Visual stimulation & brain physiology",
      "design": "Controlled mouse visual-stimulation experiments",
      "measurement": "Glymphatic flow, adenosine signalling and aquaporin-4 localization",
      "finding": "40 Hz flickering light increased glymphatic influx and efflux in mice. Genetic and pharmacological tests implicated adenosine A2A receptor signalling and aquaporin-4.",
      "limitation": "This measures physiological and signalling mechanisms in mice. It does not establish OXTR transcription changes or a safe, effective human visual protocol.",
      "targets": [],
      "categories": [
        "Brain & nervous system",
        "Molecular biomarkers"
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      "relation": "Functional signalling context",
      "id": "pmid-39103336",
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      "title": "40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice",
      "doi": "10.1038/s41421-024-00701-z",
      "year": 2024,
      "published": "2024-08-06",
      "authors": "Sun X, Dias L, Peng C, Zhang Z, Ge H, Wang Z, Jin J, Jia M, Xu T, Guo W, Zheng W, He Y, Wu Y, Cai X, Agostinho P, Qu J, Cunha RA, Zhou X, Bai R, Chen JF.",
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    },
    {
      "pmid": "38418876",
      "collections": [
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        "sound"
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      "strand": "Multisensory stimulation & brain physiology",
      "design": "Mouse Alzheimer-disease model experiments",
      "measurement": "Brain-fluid movement, amyloid and cellular signalling",
      "finding": "Combined 40 Hz sensory stimulation increased brain-fluid clearance and reduced amyloid in the tested mouse model. Mechanistic experiments implicated VIP interneurons and glymphatic function.",
      "limitation": "This is multisensory animal research. It does not isolate visual effects, establish clinical efficacy or test OXTR–Fibonacci relationships.",
      "targets": [],
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      "relation": "Functional signalling context",
      "id": "pmid-38418876",
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      "title": "Multisensory gamma stimulation promotes glymphatic clearance of amyloid",
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      "authors": "Murdock MH, Yang CY, Sun N, Pao PC, Blanco-Duque C, Kahn MC, Kim T, Lavoie NS, Victor MB, Islam MR, Galiana F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai LH.",
      "journal": "Nature",
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    {
      "pmid": "36085433",
      "collections": [
        "vision"
      ],
      "strand": "Visual development & circadian pathways",
      "design": "Developmental light-deprivation experiment in rats",
      "measurement": "vGluT2 and NMDA-receptor GluN2B protein expression",
      "finding": "Constant-darkness rearing transiently reduced vGluT2 and GluN2B expression in the ventral suprachiasmatic nucleus; the differences were compensated at later stages.",
      "limitation": "Developmental protein expression in rats is not direct evidence of human GRIN2B transcription or an adult visual therapy effect.",
      "targets": [
        "NMDA"
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      "categories": [
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        "Brain & nervous system"
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      "relation": "Exposure-related receptor protein measurement",
      "id": "pmid-36085433",
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      "title": "Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus",
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    {
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      "design": "Randomized sham-controlled multicentre trial",
      "measurement": "Visual acuity, retinal anatomy and quality of life",
      "sample": "44 participants; 53 eyes",
      "finding": "The trial assessed repeated multiwavelength photobiomodulation in non-exudative macular degeneration and reported visual-acuity and anatomical outcomes.",
      "limitation": "This clinical trial did not measure target-gene expression. The reported complete-treatment analyses and eye-level outcomes need to be interpreted within the trial design.",
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      "title": "LIGHTSITE II Randomized Multicenter Trial: Evaluation of Multiwavelength Photobiomodulation in Non-exudative Age-Related Macular Degeneration",
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      "year": 2023,
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      "authors": "Burton B, Parodi MB, Jürgens I, Zanlonghi X, Hornan D, Roider J, Lorenz K, Munk MR, Croissant CL, Tedford SE, Walker M, Ruckert R, Tedford CE.",
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    {
      "pmid": "37531065",
      "collections": [
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      ],
      "strand": "Non-image-forming visual pathways",
      "design": "Mouse neural-circuit experiment",
      "measurement": "Oxytocin-neuron activity and social-recognition memory",
      "finding": "Acute light exposure impaired social-recognition memory through a retinal pathway that inhibited supraoptic oxytocin neurons. Experimental activation of these neurons altered the behavioural response.",
      "limitation": "Neural activity and behavioural changes are separate from OXTR gene expression. The animal circuit findings do not validate a human visual intervention.",
      "targets": [
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      ],
      "categories": [
        "Brain & nervous system"
      ],
      "relation": "Functional signalling context",
      "id": "pmid-37531065",
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      "authors": "Huang YF, Liao PY, Yu JH, Chen SK.",
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    },
    {
      "pmid": "37074407",
      "collections": [
        "vision"
      ],
      "strand": "Ocular photobiomodulation",
      "design": "Human scleral fibroblast experiment in vitro",
      "measurement": "COL1A1 and HIF-1α protein; extracellular collagen",
      "finding": "In hypoxic human scleral fibroblasts, 660 nm photobiomodulation increased collagen and reduced HIF-1α protein. HIF-1α overexpression attenuated the response.",
      "limitation": "The reported assays concern protein and cellular responses, not clinical myopia outcomes or direct COL1A1 RNA quantification.",
      "targets": [
        "COL1A1"
      ],
      "categories": [
        "Molecular biomarkers"
      ],
      "relation": "Exposure-related protein measurement",
      "id": "pmid-37074407",
      "origin": "update",
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      "title": "Photobiomodulation at 660 nm promotes collagen synthesis via downregulation of HIF-1α expression without photodamage in human scleral fibroblasts in vitro in a hypoxic environment",
      "doi": "10.1007/s00417-023-06066-5",
      "year": 2023,
      "published": "2023-04-19",
      "authors": "Zhang P, Zhang X, Zhu H.",
      "journal": "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie",
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    {
      "pmid": "36618821",
      "collections": [
        "sound",
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        "language"
      ],
      "strand": "OXTR pathway foundations",
      "categories": [
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        "Methods & context"
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      "targets": [
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        "OXT",
        "DRD2"
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      "design": "Narrative review of receptor-complex studies",
      "sample": "Predominantly cellular and animal receptor-interaction research",
      "measurement": "OXTR heteroreceptor complexes, allosteric signalling and receptor trafficking",
      "finding": "The review describes OXTR-containing receptor complexes, including dopamine D2 receptor–OXTR complexes reported in rat striatal regions, and discusses potential functional consequences for behaviour.",
      "limitation": "Receptor complex formation and signalling do not establish human DRD2 transcriptional regulation. This review does not test sensory interventions, the Fibonacci hypothesis or all proposed target relationships.",
      "relation": "Shared receptor-signalling context; no direct gene-expression intervention evidence",
      "id": "pmid-36618821",
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      "title": "The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior",
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      "authors": "Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.",
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      "id": "portal-66ebe89ad390",
      "title": "Effectiveness of the Group Traumatic Episode Protocol",
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          "title": "Effectiveness of the Group Traumatic Episode Protocol",
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      "title": "Theta binaural beats for pain, cognition and anxiety",
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          "title": "Theta binaural beats for pain, cognition and anxiety",
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          "limitation": "Overall pain evidence was low certainty, outcomes varied, and the review does not establish PTSD efficacy or validate a complete sound layer.",
          "url": "https://doi.org/10.1016/j.explore.2026.103471",
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    {
      "id": "pmid-40547443",
      "title": "Music therapy for the treatment of anxiety: a systematic review with multilevel meta-analyses",
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          "limitation": "Physiological outcomes were small and non-significant; 39.2% of included studies were rated weak.",
          "url": "https://pubmed.ncbi.nlm.nih.gov/40547443/",
          "source": "I AM portal research record",
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    },
    {
      "id": "portal-7c6d9225444d",
      "title": "Telehealth versus in-person EMDR for veterans",
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      "urls": [
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          "title": "Telehealth versus in-person EMDR for veterans",
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          "url": "https://doi.org/10.1037/tra0001917",
          "source": "I AM portal research record",
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    {
      "id": "pmid-39004412",
      "title": "Brain wave modulation and EEG power changes during auditory beats stimulation",
      "collections": [
        "sound"
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      "origin": "portal",
      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/39004412/",
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          "title": "Brain wave modulation and EEG power changes during auditory beats stimulation",
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          "limitation": "The stimulus alternated audible frequencies rather than using a conventional fixed-carrier isochronic tone and did not test Universal Mind's exact protocol. It measured short-term EEG responses, not a clinical outcome.",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39004412/",
          "source": "I AM portal research record",
          "sourceReviewedAt": "2026-08-15"
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      "published": "2024-07-14",
      "authors": "Dos Anjos T, Di Rienzo F, Benoit CE, Daligault S, Guillot A.",
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    },
    {
      "id": "pmid-40655918",
      "title": "Music interventions for posttraumatic stress disorder: A systematic review",
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        "sound"
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      "urls": [
        "https://pubmed.ncbi.nlm.nih.gov/40655918/",
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      "year": 2024,
      "journal": "Journal of mood and anxiety disorders",
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          "title": "Music interventions for posttraumatic stress disorder",
          "finding": "Fourteen studies were included; 13 reported decreased PTSD symptoms, and passive-listening studies also showed promise.",
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          "url": "https://pubmed.ncbi.nlm.nih.gov/40655918/",
          "source": "I AM portal research record",
          "sourceReviewedAt": "2026-08-15"
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      "id": "doi-2a203fb071ddfe54",
      "title": "“Online delivery gave me privacy and distance from others”: feasibility trial and qualitative evaluation of an online intervention for refugees and asylum seekers; LTP + EMDR G‐TEP",
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      "sourceText": "“synchronicity in the context of a mathematical system in which mind and matter play\ncomplementary roles in a reality that has a mathematical structure”\n“Jung recognized the conceptual value of postulating that synchronicity operated based on the\nFibonacci numbers because of their ubiquity in nature. Jung observed that “...synchronicity... is a\nsecondary effect of the primary coincidence of mental and physical events (as in the Fibonacci\nseries). The bridge seems to be formed by the numbers”\n“The central point to the FLCM (Fibonacci Life Chart Method) analysis of human development is\nthat human development depends on the self-organizing properties of the Fibonacci sequence.\nWhen the Fibonacci numbers progressively increase, therefore, the self-organizing and fractal\nproperties result in biological and psychological phase transition.\nPhase transitions can result from self-organization processes at multiple levels (e.g., molecules,\ngenes, cell, organ, organ system, organism, behavior, and environment) that can influence each\nother. The self-organized hierarchy begins at the mathematical and quantum level.”\n“synchronicity will operate based on Fibonacci numbers controlling the interplay of genes and\nbrain development, which change coherence of brain waves, which cycle around again to\ninfluence brain development.”\nFibonacci Harmonics: A New Mathematical Model of Synchronicity\nApplied Mathematics\nhttps://www.scirp.org/html/9-7403945_85739.htm\ncitations: 4",
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      "id": "pmid-19673817",
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          "sourceText": "“two specific music programs significantly reduced burnout symptoms after 5 weeks.”\n“The effects were maintained over a long time period.”\n“This newly developed method of receptive music therapy was also evaluated for the treatment of\ndepression and dysthymia, with significant outcomes.”\nMusic Programs Designed to Remedy Burnout Symptoms Show Significant Effects after Five\nWeeks\nAnnals of the New York Academy of Sciences\nhttps://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2009.04790.x\nrandomised controlled trial, double blind\ncitations: 40",
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    {
      "id": "pmid-20099470",
      "title": "Recreational music-making modulates immunological responses and mood states in older adults",
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      "originalNote": "“improvement in immunological profile and mood states in the older group and the low level of energy required for participation suggest this music-making protocol has potential as a health improvement strategy for older individuals”",
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    {
      "id": "pmid-19583647",
      "title": "Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial",
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      "title": "Take two aspirin and tweet me in the morning: how Twitter, Facebook, and other social media are reshaping health care",
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    {
      "id": "pmid-19028598",
      "title": "Two 'Golden Ratio' indices in fragment-based drug discovery",
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      "journal": "Drug discovery today",
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      "originalNote": "“Fragment-based drug discovery (FBDD) is complementary to high-throughput screening. The approach has two key stages: identifying the starting fragment hit to be developed and generating the lead compound from the starting fragment hit. Here, we provide an overview of FBDD and introduce two indices originally developed at Astellas Pharma.\n\nBoth indices are based on the ‘Golden Ratio’.”",
      "sourceText": "“Fragment-based drug discovery (FBDD) is complementary to high-throughput screening. The\napproach has two key stages: identifying the starting fragment hit to be developed and\ngenerating the lead compound from the starting fragment hit. Here, we provide an overview of\nFBDD and introduce two indices originally developed at Astellas Pharma.\nBoth indices are based on the ‘Golden Ratio’.”\nTwo ‘Golden Ratio’ indices in fragment-based drug discovery\nDrug Discovery Today\nhttps://www.sciencedirect.com/science/article/abs/pii/S1359644608003723\ncitations: 58",
      "sourceDesign": null,
      "historicalCitationCount": "citations: 58",
      "sourceSection": "fibonacci sequence modulates cardiovascular, cellular and DNA health iv. fibonacci sequence modulates cosmological, psychological and biological functions of all dna based life, via first, second and third order harmonics - Fibonacci Mod 9, Pisano Period 24 (Fib M9 P24)",
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    {
      "id": "pmid-11179406",
      "title": "Baroreflex and oscillation of heart period at 0.1 Hz studied by alpha-blockade and cross-spectral analysis in healthy humans",
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      "title": "Effects of preoperative binaural beats on the propofol dose for induction of general anesthesia: a randomized controlled trial.",
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      "title": "Immediate effects of binaural beat stimulation on prefrontal cortical activation after cycling exercise: an electroencephalography-based study.",
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      "title": "Effects of binaural beats on acute stress recovery and autonomic regulation in multiple sclerosis: a pilot double-blind randomized controlled trial.",
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      "authors": "Vaheb S, Hatef B, Mirani A, Shaygannejad V, Pirzad Jahromi G.",
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      "doi": "10.1089/jicm.2023.0804",
      "title": "Effect of Binaural Beats on Anxiety and Tolerance in Patients Undergoing Upper Gastrointestinal Endoscopy Without Sedation: A Randomized Controlled Trial.",
      "journal": "Journal of integrative and complementary medicine",
      "year": 2024,
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      "title": "Brainwave entrainment to minimise sedative drug doses in paediatric surgery: a randomised controlled trial.",
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      "doi": "10.3390/ijerph191610194",
      "title": "The Effect of Binaural Beat Audio on Operative Pain and Anxiety in Cataract Surgery under Topical Anaesthesia: A Randomized Controlled Trial.",
      "journal": "International journal of environmental research and public health",
      "year": 2022,
      "authors": "Loong LJ, Ling KK, Tai ELM, Kueh YC, Kuan G, Hussein A.",
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      "doi": "10.1111/ggi.14827",
      "title": "Examining the effects of binaural beat music on sleep quality, heart rate variability, and depression in older people with poor sleep quality in a long-term care institution: A randomized controlled trial.",
      "journal": "Geriatrics & gerontology international",
      "year": 2024,
      "authors": "Lin PH, Fu SH, Lee YC, Yang SY, Li YL.",
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      "finding": "Among 64 older adults with poor sleep in long-term care, binaural beats embedded in familiar music improved sleep measures and selected autonomic measures relative to the same music without beats over 14 days.",
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      "doi": "10.1002/ejp.1615",
      "title": "Reduced pain and analgesic use after acoustic binaural beats therapy in chronic pain - A double-blind randomized control cross-over trial.",
      "journal": "European journal of pain (London, England)",
      "year": 2020,
      "authors": "Gkolias V, Amaniti A, Triantafyllou A, Papakonstantinou P, Kartsidis P, Paraskevopoulos E, Bamidis PD, Hadjileontiadis L, Kouvelas D.",
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      "finding": "A sham-controlled crossover study reported lower pain ratings and analgesic use after 5 Hz binaural stimulation in people with chronic pain, together with increased EEG power at the stimulation frequency.",
      "limitation": "Sample size and participant flow require full-text appraisal. The short treatment periods and crossover design limit conclusions about sustained benefit or wider patient populations.",
      "evidence": {
        "intervention": "5 Hz binaural beats for chronic pain",
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      "id": "pmid-33107329",
      "pmid": "33107329",
      "doi": "10.1089/end.2020.0353",
      "title": "Effects of Listening to Binaural Beats on Anxiety Levels and Pain Scores in Male Patients Undergoing Cystoscopy and Ureteral Stent Removal: A Randomized Placebo-Controlled Trial.",
      "journal": "Journal of endourology",
      "year": 2021,
      "authors": "Ölçücü MT, Yılmaz K, Karamık K, Okuducu Y, Özsoy Ç, Aktaş Y, Çakır S, Ateş M.",
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      "design": "Randomized controlled trial",
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      "priority": 1,
      "finding": "In men undergoing cystoscopy or ureteral stent removal, binaural beats reduced pain compared with classical music and silent headphones; both sound interventions improved anxiety relative to silence.",
      "limitation": "The analysed procedure groups totalled 352 participants after exclusions. Procedure tolerance was less favourable with binaural beats, and results are specific to these urological settings.",
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        "intervention": "Binaural beats during cystoscopy or stent removal",
        "comparator": "Classical music and silent headphones",
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      "id": "pmid-32412916",
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      "doi": null,
      "title": "Binaural Beats Reduce Postoperative Morphine Consumption in Older adults After Total Knee Replacement Surgery.",
      "journal": "Alternative therapies in health and medicine",
      "year": 2021,
      "authors": "Tani A, Vagheggini G, Moretti F, Del Colombo V, Lehle J, Campana S, Labate A, Tomaiuolo F.",
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      "finding": "In 40 older adults undergoing knee replacement, preoperative 4 Hz binaural beats reduced first-day self-administered morphine from 11.85 to 5.75 mg compared with matched tones presented at the same frequency to both ears.",
      "limitation": "Pain ratings did not differ between groups. This small, single-centre trial supports an opioid-consumption finding in a specific surgical protocol, with broader effectiveness still requiring replication.",
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    {
      "id": "pmid-40269359",
      "pmid": "40269359",
      "doi": "10.47391/jpma.21023",
      "title": "Comparing binaural beats and 432 Hz music for reduction of preoperative anxiety in root canal patients: a randomized controlled trial.",
      "journal": "JPMA. The Journal of the Pakistan Medical Association",
      "year": 2025,
      "authors": "Zaki H, Ahmed S, Rehman Qazi FU, Fatima N, Ali YS.",
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        "sound"
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      "origin": "update",
      "design": "Double-blind randomized controlled trial",
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        "Clinical & self-report"
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      "finding": "In 99 root-canal patients, binaural beats and 432 Hz music each reduced preoperative anxiety relative to white noise. Participants and outcome assessors were described as blinded.",
      "limitation": "The two active audio conditions did not differ significantly. The trial does not demonstrate a unique therapeutic property of 432 Hz or superiority of binaural beats over music.",
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        "intervention": "Binaural beats or 432 Hz music",
        "comparator": "White noise and the other active audio condition",
        "evidenceType": "Clinical or experimental outcomes",
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    {
      "id": "pmid-36790246",
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      "doi": "10.1590/2177-6709.27.6.e2221150.oar",
      "title": "The effect of alpha binaural beat music on orthodontic pain after initial archwire placement: A randomized controlled trial.",
      "journal": "Dental press journal of orthodontics",
      "year": 2023,
      "authors": "Aly AE, Hansa I, Ferguson DJ, Vaid NR.",
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        "sound"
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      "origin": "update",
      "design": "Randomized controlled trial",
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        "Clinical & self-report"
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      "finding": "In 60 orthodontic patients, alpha binaural-beat music reduced several pain measures late in the first week after appliance placement relative to no music.",
      "limitation": "Pain did not differ between binaural-beat music and otherwise similar music without beats. The successful audio experience does not establish an additional beat-specific benefit.",
      "evidence": {
        "intervention": "Alpha binaural-beat music after orthodontic appliance placement",
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        "evidenceType": "Clinical or experimental outcomes",
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        "https://pubmed.ncbi.nlm.nih.gov/36790246/",
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        "url": "https://europepmc.org/article/MED/36790246"
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    {
      "id": "pmid-35713444",
      "pmid": "35713444",
      "doi": "10.1097/md.0000000000029392",
      "title": "The effect of binaural beat audio on anxiety in patients undergoing fiberoptic bronchoscopy: A prospective randomized controlled trial.",
      "journal": "Medicine",
      "year": 2022,
      "authors": "Opartpunyasarn P, Vichitvejpaisal P, Oer-Areemitr N.",
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        "sound"
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      "origin": "update",
      "design": "Randomized controlled trial",
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        "Clinical & self-report"
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      "priority": 1,
      "finding": "Among 112 bronchoscopy patients, the binaural-music arm showed a larger numerical reduction in state anxiety than plain music or no music, with reductions in blood pressure.",
      "limitation": "The abstract mainly reports within-group changes, so those numbers alone do not establish superiority over plain music. The trial was retrospectively registered.",
      "evidence": {
        "intervention": "Binaural-beat music around bronchoscopy",
        "comparator": "Plain music and no music",
        "evidenceType": "Clinical or experimental outcomes",
        "sourceURLs": [
          "https://pubmed.ncbi.nlm.nih.gov/35713444/",
          "https://doi.org/10.1097/md.0000000000029392",
          "https://pmc.ncbi.nlm.nih.gov/articles/PMC9276398/"
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        "checkedAt": "2026-10-26",
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      "pmid": "38982009",
      "doi": "10.1007/s40368-024-00921-7",
      "title": "Effectiveness of brainwave entrainment on pre-operative fear and anxiety in pediatric dental patients: a randomized controlled trial.",
      "journal": "European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry",
      "year": 2024,
      "authors": "Shehani F, Samuel V, Kavitha R, Mani R.",
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      "design": "Randomized controlled trial",
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        "Clinical & self-report"
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      "priority": 1,
      "finding": "A 252-child dental trial reported reduced preoperative fear, anxiety and physiological arousal with device-based brainwave entrainment compared with standard behaviour management.",
      "limitation": "The device combines stimulation components. The abstract does not establish a binaural-beat-only effect, and masking, allocation and registration timing require full-text appraisal.",
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        "intervention": "Device-based audiovisual brainwave entrainment",
        "comparator": "Standard behaviour management",
        "evidenceType": "Clinical or experimental outcomes",
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          "https://doi.org/10.1007/s40368-024-00921-7"
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        "retrievedAt": "2026-10-26",
        "url": "https://europepmc.org/article/MED/38982009"
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      "id": "pmid-42116620",
      "pmid": "42116620",
      "doi": "10.1093/pm/pnag064",
      "title": "The effects of neuromodulation through brainwave entrainment on pain in women with fibromyalgia: a randomized controlled clinical trial with follow-up.",
      "journal": "Pain medicine (Malden, Mass.)",
      "year": 2026,
      "authors": "de Souza G, Daux Buffon L, Hardt da Silva R, Galassi TO, Dutra AR, Medeiros N, de Paiva BC, de Brito VJ, Nienkotter L, Baldança HDS, Goedert SH, Rezin GT, da Silva MR, de Oliveira MP, Petronilho F, Mathias K, Tiscoski ADB, Mazzardo-Martins L, Traebert ESA, Piovezan AP, Traebert JL, Caumo W, Schleip R, Bobinski F, Cidral-Filho FJ, Martins DF.",
      "collections": [
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      "origin": "update",
      "design": "Randomized controlled trial",
      "categories": [
        "Clinical & self-report",
        "Molecular biomarkers"
      ],
      "targets": [],
      "priority": 1,
      "finding": "In 84 women with fibromyalgia, eight weeks of headset-based brainwave entrainment produced improvements in pain and anxiety, with changes in quality of life, oxidative stress and circulating BDNF also examined.",
      "limitation": "Music therapy improved several outcomes as well. The abstract does not provide a consistent set of between-group effect estimates; the mixed headset intervention and protein measurements do not establish a gene-expression mechanism.",
      "evidence": {
        "intervention": "BrainTap headset-based brainwave entrainment",
        "comparator": "Music therapy",
        "evidenceType": "Clinical or experimental outcomes",
        "sourceURLs": [
          "https://pubmed.ncbi.nlm.nih.gov/42116620/",
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      "id": "pmid-40621706",
      "pmid": "40621706",
      "doi": "10.1002/brb3.70671",
      "title": "Effects of Auditory Frequency Stimulation on Balance and Rehabilitation Outcomes in Patients With Stroke: A Randomized Case-Control Study.",
      "journal": "Brain and behavior",
      "year": 2025,
      "authors": "Chen R, Jin L, Song J, Dong J, Li Y.",
      "collections": [
        "sound"
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      "origin": "update",
      "design": "Randomized controlled pilot study",
      "categories": [
        "Clinical & self-report"
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      "targets": [],
      "priority": 1,
      "finding": "Among 27 stroke rehabilitation completers, the binaural-stimulation group improved daily-living and depression scores more than the music comparison group. Balance measures improved in both groups.",
      "limitation": "The small sample and combined rehabilitation context limit causal attribution to the beats. Correlations between functional measures do not prove a brain mechanism.",
      "evidence": {
        "intervention": "Binaural auditory stimulation during stroke rehabilitation",
        "comparator": "Music during rehabilitation",
        "evidenceType": "Clinical or experimental outcomes",
        "sourceURLs": [
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          "https://doi.org/10.1002/brb3.70671",
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        "checkedAt": "2026-10-26",
        "reviewScope": "Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.",
        "discoverySources": [
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      "doi": "10.1155/2022/8588272",
      "title": "Effects of the Alpha, Beta, and Gamma Binaural Beat Brain Stimulation and Short-Term Training on Simultaneously Assessed Visuospatial and Verbal Working Memories, Signal Detection Measures, Response Times, and Intrasubject Response Time Variabilities: A Within-Subject Randomized Placebo-Controlled Clinical Trial.",
      "journal": "BioMed research international",
      "year": 2022,
      "authors": "Rakhshan V, Hassani-Abharian P, Joghataei M, Nasehi M, Khosrowabadi R.",
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      "design": "Randomized placebo-controlled crossover experiment",
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      "limitation": "Effects were small and differed across sensory modalities; auditory-verbal measures did not show the same pattern. There were 155 condition sessions, not 155 independent participants, and no clinical outcome was tested.",
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      "doi": "10.1016/j.ajog.2025.07.051",
      "title": "Treatment of traumatic birth experience with postpartum early eye movement desensitization and reprocessing therapy: a randomized clinical trial.",
      "journal": "American journal of obstetrics and gynecology",
      "year": 2025,
      "authors": "Hendrix YMGA, van Pampus MG, Hofman A, Henrichs J, van der Horst HE, de Jongh A.",
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      "finding": "Of 151 women randomised after a traumatic birth, 143 entered the reported intention-to-treat analysis. Two early postpartum EMDR sessions reduced self-reported and clinician-rated PTSD symptom severity compared with two telephone contacts; the reported raw symptom differences were 8.7 and 3.8 points respectively.",
      "limitation": "Clinician-diagnosed PTSD rates did not differ significantly. The abstract contains an inconsistent confidence-interval entry, so that interval is not reproduced here; follow-up was nine weeks postpartum.",
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      "id": "pmid-40716437",
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      "doi": "10.1159/000547622",
      "title": "The Effectiveness of Eye Movement Desensitization and Reprocessing Therapy on Post-Traumatic Stress Disorder Symptoms and Diagnostic Status in Patients with a Personality Disorder: A Randomized Controlled Trial.",
      "journal": "Psychotherapy and psychosomatics",
      "year": 2025,
      "authors": "Hafkemeijer L, Hofman S, de Jongh A, de Roos D, van Velzen M, Starrenburg A, Slotema K.",
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        "Clinical & self-report"
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      "finding": "In 159 people with personality disorders, EMDR reduced PTSD symptoms more than a waitlist. Among participants with PTSD receiving EMDR, 65.5% no longer met the diagnosis after treatment and 73.1% at follow-up.",
      "limitation": "A waitlist does not control for therapeutic attention. The remission percentages describe the treated subgroup; they are not an absolute treatment effect or a general remission guarantee.",
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        "evidenceType": "Clinical or experimental outcomes",
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          "https://pmc.ncbi.nlm.nih.gov/articles/PMC12503563/"
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      "doi": "10.1037/tra0001643",
      "title": "Eye movement desensitization and reprocessing (EMDR) therapy compared to usual treatment for posttraumatic stress disorder in adults with psychosis in forensic settings: Randomized controlled trial.",
      "journal": "Psychological trauma : theory, research, practice and policy",
      "year": 2024,
      "authors": "Every-Palmer S, Flewett T, Dean S, Hansby O, Freeland A, Weatherall M, Bell E.",
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      "design": "Single-blind randomized controlled trial",
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        "Clinical & self-report"
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      "finding": "In 24 forensic patients with psychosis and PTSD, blinded assessments favoured EMDR over routine-care waitlist for clinician-rated PTSD symptoms. The estimated difference averaged across follow-ups was 11.4 points, with a 95% confidence interval of 1.3 to 21.4.",
      "limitation": "Recruitment was curtailed by pandemic restrictions, leaving a small sample. Psychotic symptoms and adverse events did not differ significantly, so effectiveness claims remain specific to the measured PTSD outcomes.",
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      "id": "pmid-39758524",
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      "doi": "10.1089/whr.2023.0110",
      "title": "Eye Movement Desensitization and Reprocessing: Efficacy in Improving Clinical, Neuropsychological, and Quality of Life in Women Victims of Violence.",
      "journal": "Women's health reports (New Rochelle, N.Y.)",
      "year": 2024,
      "authors": "Meneses AYM, Fernández-Gonzalo S, Vicente MJ.",
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      "design": "Randomized controlled trial",
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      "finding": "In 120 women exposed to violence, ten sessions of EMDR produced greater reported improvements in post-traumatic symptoms, anxiety, depression, quality of life and selected cognitive tests than narrative exposure therapy.",
      "limitation": "The abstract supplies significance levels without effect-size confidence intervals. Masking, multiple comparisons and durability require further appraisal before a high-confidence comparative claim.",
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        "intervention": "Therapist-delivered EMDR",
        "comparator": "Narrative exposure therapy",
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      "id": "pmid-42518933",
      "pmid": "42518933",
      "doi": "10.1016/j.eclinm.2026.104082",
      "title": "Eye movement desensitisation and reprocessing for post-traumatic stress in survivors of critical illness (EMERALD): a mixed-methods, randomised, single-blind, parallel group-controlled, feasibility trial.",
      "journal": "EClinicalMedicine",
      "year": 2026,
      "authors": "Bates A, Cusack R, Golding H, Moyses H, Southam H, Rushbrook S, Highfield J, Pattison N, Baldwin DS, Grocott MPW.",
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      "origin": "update",
      "design": "Single-blind randomized feasibility trial",
      "categories": [
        "Clinical & self-report"
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      "targets": [],
      "priority": 1,
      "finding": "The 40-person EMERALD trial in critical-illness survivors achieved 98% clinician-rated follow-up at 12 months. Exploratory PTSD symptom change favoured EMDR plus usual care by 14.1 points, with a 95% confidence interval of 6.2 to 22.0 points.",
      "limitation": "Feasibility, acceptability and safety were the primary objectives. The symptom estimate is hypothesis-generating and does not establish definitive treatment effectiveness.",
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        "intervention": "Therapist-delivered EMDR",
        "comparator": "Treatment as usual",
        "evidenceType": "Clinical or experimental outcomes",
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      "authors": "Varese F, Sellwood W, Pulford D, Awenat Y, Bird L, Bhutani G, Carter LA, Davies L, Aseem S, Davis C, Hefferman-Clarke R, Hilton C, Horne G, Keane D, Logie R, Malkin D, Potter F, van den Berg D, Zia S, Bentall RP.",
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      "limitation": "The active treatments did not differ significantly. This supports EMDR as a promising structured treatment in this population, without establishing superiority to imagery rescripting.",
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      "doi": "10.1192/bjp.bp.111.099234",
      "title": "Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: randomised controlled trial.",
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      "authors": "Nijdam MJ, Gersons BP, Reitsma JB, de Jongh A, Olff M.",
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      "finding": "In 140 people with PTSD, EMDR and brief eclectic psychotherapy produced similar final improvements; EMDR achieved improvement more rapidly during treatment.",
      "limitation": "Dropout was substantial in both groups, approximately 29% and 36%. Faster improvement does not establish superior final outcomes or effectiveness of an automated EMDR-derived intervention.",
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      "doi": "10.1080/20008066.2025.2454191",
      "title": "Imagery Rescripting (ImRs) and Eye Movement Desensitization and Reprocessing (EMDR) as treatment of childhood-trauma related post-traumatic stress disorder (Ch-PTSD) in adults: effects on Schema Modes.",
      "journal": "European journal of psychotraumatology",
      "year": 2025,
      "authors": "Daniëls M, Meewisse ML, Nugter A, Rameckers SA, Fassbinder E, Arntz A.",
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      "design": "Secondary analysis of a randomized controlled trial",
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      "title": "Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial.",
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      "limitation": "Benefits varied by endpoint and time: standard relapse prevention delayed first drug use more effectively at six months. Results concern structured aftercare, not a stand-alone meditation cure for addiction.",
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      "authors": "Ma SH, Teasdale JD.",
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      "priority": 1,
      "finding": "In a 73-person recurrent-depression trial, MBCT reduced relapse among the 55 participants with three or more prior episodes: 36% relapsed versus 78% with usual care.",
      "limitation": "The 18-person subgroup with two prior episodes showed the opposite numerical pattern. The successful result applies to the specified recurrent-depression subgroup and cannot be generalised across all depression histories.",
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      "title": "Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia.",
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      "year": 2015,
      "authors": "Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, Coghill RC.",
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      "design": "Randomized controlled experiment",
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      "finding": "In 75 healthy volunteers, brief mindfulness training reduced experimentally induced pain more than placebo conditioning or sham mindfulness, with different associated brain-activation patterns.",
      "limitation": "An acute laboratory pain experiment does not establish durable benefit for chronic pain. Neuroimaging associations do not identify a single exclusive therapeutic mechanism.",
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      "title": "Individual Treatment of Posttraumatic Stress Disorder Using Mantram Repetition: A Randomized Clinical Trial.",
      "journal": "The American journal of psychiatry",
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      "title": "A spiritually based group intervention for combat veterans with posttraumatic stress disorder: feasibility study.",
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      "title": "Mindful attention increases and mediates psychological outcomes following mantram repetition practice in veterans with posttraumatic stress disorder.",
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      "authors": "Bormann JE, Oman D, Walter KH, Johnson BD.",
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      "finding": "In a 146-veteran trial, adding mantram repetition to usual care increased mindful attention; changes in mindful attention statistically mediated improvements in PTSD symptoms, depression and wellbeing.",
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      "title": "Targeting hyperarousal: Mantram Repetition Program for PTSD in US veterans.",
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      "authors": "Crawford JN, Talkovsky AM, Bormann JE, Lang AJ.",
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      "title": "An Internet Mantram Repetition Program to Promote Well-being in Breast Cancer Survivors: A Feasibility Randomized Controlled Trial.",
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      "year": 2024,
      "authors": "Hulett JM, Cheng AL, Bormann JE, Anbari AB, Armer JM, Hartman BM, Ann Bettencourt B, Sherwin LB, Sperling EL, Narkthong N, Reinero C, Rindt H, Schreiber K, Peterson LL, Albright E.",
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      "finding": "A 26-person internet mantram pilot in breast-cancer survivors established delivery feasibility and reported exploratory changes in stress, spiritual wellbeing and selected serum cytokines.",
      "limitation": "Clinical and cytokine outcomes were secondary. Pooled pre/post stress changes do not establish a randomised between-group effect; the small cytokine subset requires replication and measured proteins rather than gene expression.",
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      "doi": "10.1161/01.hyp.26.5.820",
      "title": "A randomised controlled trial of stress reduction for hypertension in older African Americans.",
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      "authors": "Schneider RH, Staggers F, Alxander CN, Sheppard W, Rainforth M, Kondwani K, Smith S, King CG.",
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      "finding": "A trial enrolling 127 older Black adults with hypertension found greater three-month blood-pressure reductions with Transcendental Meditation than progressive muscle relaxation or health education, using blinded blood-pressure observers.",
      "limitation": "Sixteen participants were lost to follow-up. The older, short-duration trial does not establish sustained cardiovascular-event reduction or replacement of antihypertensive care.",
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      "title": "Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.",
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      "year": 2021,
      "authors": "Chandran V, Bermúdez ML, Koka M, Chandran B, Pawale D, Vishnubhotla R, Alankar S, Maturi R, Subramaniam B, Sadhasivam S.",
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      "doi": "10.1016/j.dib.2018.03.086",
      "title": "Dataset on gene expression in the elderly after Mindfulness Awareness Practice or Health Education Program.",
      "journal": "Data in brief",
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      "authors": "Lim HW, Saw WY, Feng L, Lee YK, Mahendran R, Cheah IK, Rawtaer I, Kumar AP, Kua EH, Mahendran R, Tan EC.",
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      "finding": "A blood gene-expression dataset from 60 older adults with mild cognitive impairment compares mindful-awareness practice with health education over nine months. It provides a reusable resource for analysing intervention-associated molecular patterns.",
      "limitation": "This is a data publication, not independent proof of a successful clinical or molecular effect. Participant overlap with associated trial reports must be retained in any synthesis.",
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      "title": "Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.",
      "journal": "American journal of ophthalmology",
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      "authors": "Dada T, Bhai N, Midha N, Shakrawal J, Kumar M, Chaurasia P, Gupta S, Angmo D, Yadav R, Dada R, Sihota R.",
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      "finding": "In 60 glaucoma patients, a three-week meditation adjunct reduced intraocular pressure relative to medication alone and was associated with trabecular-meshwork expression changes involving nitric-oxide and inflammatory pathways.",
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      "title": "Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial.",
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      "authors": "Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK, Sihota R, Sidhu T, Velpandian T, Kalaivani M, Pandey RM, Gao Y, Sabel BA, Dada R.",
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      "finding": "In 90 patients with primary open-angle glaucoma, a short mindfulness programme reduced intraocular pressure relative to waitlist and reported associated stress-biomarker and gene-expression changes.",
      "limitation": "A small, short-duration adjunctive trial with a waitlist comparator. Expression and biomarker associations do not prove mediation of pressure reduction or broad effects across diseases.",
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      "title": "The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.",
      "journal": "Biological research for nursing",
      "year": 2025,
      "authors": "Park JY, Lengacher CA, Rodriguez CS, Meng H, Kip KE, Morgan S, Joshi A, Hueluer G, Wang JR, Tinsley S, Cox C, Kiluk J, Donovan KA, Moscoso M, Bornstein E, Lucas JM, Fonseca T, Krothapalli M, Padgett LS, Nidamanur S, Hornback E, Patel D, Chamkeri R, Reich RR.",
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      "origin": "update",
      "design": "Exploratory genetic analysis of a randomized trial",
      "categories": [
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      "targets": [
        "DRD2",
        "COMT",
        "ANKK1"
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      "priority": 0,
      "finding": "In 128 breast-cancer survivors randomised to MBSR or education/support, variants including DRD2 rs6277 were associated with differences in cognitive response to the intervention.",
      "limitation": "This was a small exploratory moderator analysis across multiple variants. It measured genotype, not altered gene expression, and is not a validated genetic predictor of treatment response.",
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      "doi": "10.7759/cureus.41377",
      "title": "Effects of Sudarshan KriyaYoga and Advanced Meditation Program on Genetic Expression of Pro-inflammatory and Antioxidants Genes.",
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      "year": 2023,
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      "title": "Changes in the expression of inflammatory and epigenetic-modulatory genes after an intensive meditation retreat.",
      "journal": "Comprehensive psychoneuroendocrinology",
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      "title": "PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.",
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      "year": 2025,
      "authors": "Joss D, Sevinc G, Denninger JW, Khalsa SBS, Hoge EA, Bhasin M, Dusek JA, Macklin E, Libermann TA, Fricchione GL, Benson H, Lazar SW.",
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      "doi": "10.1002/jts.22665",
      "title": "A Pilot Randomized Controlled Trial of Transcendental Meditation as Treatment for Posttraumatic Stress Disorder in Veterans.",
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      "authors": "Bellehsen M, Stoycheva V, Cohen BH, Nidich S.",
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      "finding": "In 181 male prisoners, Transcendental Meditation reduced self-reported trauma symptoms and perceived stress relative to usual care after four months.",
      "limitation": "The control did not match instructor attention. Self-reported trauma symptoms are distinct from independently confirmed PTSD remission, and findings do not establish an effect on reoffending.",
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      "doi": "10.1016/j.ajpc.2021.100279",
      "title": "Randomized controlled trial of stress reduction with meditation and health education in black men and women with high normal and normal blood pressure.",
      "journal": "American journal of preventive cardiology",
      "year": 2021,
      "authors": "Schneider RH, Grim C, Kotchen T, Marwaha K, Kotchen J, Salerno JW, King CG, Nidich S, Alexander CN.",
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      "finding": "Among 304 Black adults stratified by baseline blood pressure, meditation reduced systolic pressure by approximately 3.3 mmHg relative to health education in the high-normal-pressure group.",
      "limitation": "The benefit did not extend to the normal-pressure group or diastolic pressure. Hypertension-event differences were not significant, so the result is subgroup- and endpoint-specific.",
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