{ "version": 1, "title": "Molecular Atlas", "records": [ { "id": "OXTR", "pdb": "7QVM", "name": "Oxytocin receptor", "context": "Oxytocin signalling", "genes": [ "OXTR" ], "geneIds": [ 5021 ], "chains": [ "E" ], "ligandChains": [ "D" ], "contextChains": [ "A", "B", "C", "F" ], "note": "Engineered receptor complex. Receptor chain R and oxytocin chain L are shown initially. The complete deposited model also contains a G-protein chimera and an antibody fragment.", "title": "Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex", "resolution": 3.25, "method": "ELECTRON MICROSCOPY", "source": "https://www.rcsb.org/structure/7QVM", "sha256": "9df96fcec74a5008a318b50311b95a9faa814126517460c9732414c3190f4242", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "E", "authorChain": "R", "name": "Oxytocin receptor", "sequence": "MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTYRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGK", "length": 359 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "Nat Commun", "journal_id_ISSN": "2041-1723", "journal_volume": "13", "page_first": "4153", "page_last": "4153", "pdbx_database_id_DOI": "10.1038/s41467-022-31325-0", "pdbx_database_id_PubMed": 35851571, "rcsb_ORCID_identifiers": [ "0000-0001-5564-4303", "?", "0000-0002-6570-7336", "0000-0002-2221-6238", "0000-0003-0994-2937", "0000-0003-4191-5306" ], "rcsb_authors": [ "Waltenspuhl, Y.", "Ehrenmann, J.", "Vacca, S.", "Thom, C.", "Medalia, O.", "Pluckthun, A." ], "rcsb_journal_abbrev": "Nat Commun", "title": "Structural basis for the activation and ligand recognition of the human oxytocin receptor.", "year": 2022 }, "depositedLigands": [] }, { "id": "SLC6A4", "pdb": "5I6X", "name": "Serotonin transporter", "context": "Serotonin transport", "genes": [ "SLC6A4" ], "geneIds": [ 6532 ], "chains": [ "A" ], "ligands": [ "8PR" ], "contextChains": [ "B", "C" ], "note": "Thermostabilised human serotonin transporter with paroxetine. Antibody chains are available in the complex layer. This is an engineered experimental construct.", "title": "X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site", "resolution": 3.14, "method": "X-RAY DIFFRACTION", "source": "https://www.rcsb.org/structure/5I6X", "sha256": "29b8d278efa9ed9a9c5a64ea72718e84a6563dda26a7b978d71c7520cadecf61", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "Sodium-dependent serotonin transporter", "sequence": "GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTLVPR", "length": 549 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "Nature", "journal_id_ASTM": "NATUAS", "journal_id_CSD": "0006", "journal_id_ISSN": "1476-4687", "journal_volume": "532", "page_first": "334", "page_last": "339", "pdbx_database_id_DOI": "10.1038/nature17629", "pdbx_database_id_PubMed": 27049939, "rcsb_ORCID_identifiers": [ "?", "?", "?" ], "rcsb_authors": [ "Coleman, J.A.", "Green, E.M.", "Gouaux, E." ], "rcsb_journal_abbrev": "Nature", "title": "X-ray structures and mechanism of the human serotonin transporter.", "year": 2016 }, "depositedLigands": [ { "id": "NAG", "name": "2-acetamido-2-deoxy-beta-D-glucopyranose" }, { "id": "CLR", "name": "CHOLESTEROL" }, { "id": "LMT", "name": "DODECYL-BETA-D-MALTOSIDE" }, { "id": "8PR", "name": "Paroxetine" }, { "id": "CL", "name": "CHLORIDE ION" }, { "id": "NA", "name": "SODIUM ION" } ] }, { "id": "DRD2", "pdb": "6CM4", "name": "Dopamine D2 receptor", "context": "Dopamine signalling", "genes": [ "DRD2" ], "geneIds": [ 1813 ], "chains": [ "A" ], "ligands": [ "8NU" ], "contextChains": [], "note": "Risperidone-bound D2 receptor\u2013endolysin fusion. The displayed chain includes the engineered fusion domain; it is not a complete native receptor.", "title": "Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone", "resolution": 2.867, "method": "X-RAY DIFFRACTION", "source": "https://www.rcsb.org/structure/6CM4", "sha256": "4ef8156b7a0ce71b4c012b8979b6f1ec051173456c4322c329a338393e534daa", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "D(2) dopamine receptor, endolysin chimera", "sequence": "NYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASALNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKLSQQKEKKATQMAAIVAGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC", "length": 430 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "Nature", "journal_id_ASTM": "NATUAS", "journal_id_CSD": "0006", "journal_id_ISSN": "1476-4687", "journal_volume": "555", "page_first": "269", "page_last": "273", "pdbx_database_id_DOI": "10.1038/nature25758", "pdbx_database_id_PubMed": 29466326, "rcsb_ORCID_identifiers": [ "?", "?", "?", "?", "?", "?" ], "rcsb_authors": [ "Wang, S.", "Che, T.", "Levit, A.", "Shoichet, B.K.", "Wacker, D.", "Roth, B.L." ], "rcsb_journal_abbrev": "Nature", "title": "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.", "year": 2018 }, "depositedLigands": [ { "id": "8NU", "name": "3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one" }, { "id": "PEG", "name": "DI(HYDROXYETHYL)ETHER" }, { "id": "OLA", "name": "OLEIC ACID" } ] }, { "id": "NMDA", "pdb": "9IYQ", "name": "NMDA receptor", "context": "Learning & memory \u00b7 synaptic plasticity", "genes": [ "GRIN1", "GRIN2B" ], "geneIds": [ 2902, 2904 ], "chains": [ "A", "B", "C", "D" ], "ligands": [ "GLY", "7RC" ], "contextChains": [], "note": "Human GluN1/GluN2B receptor in the Mg\u00b2\u207a-free experimental state, with glycine and the antagonist 7RC. This is one NMDA receptor subtype in a specific ligand-bound state. Unresolved and truncated regions are absent from the coordinates.", "title": "Structure of the human GluN1-N2B NMDA receptors in the Mg2+ free state", "resolution": 3.18, "method": "ELECTRON MICROSCOPY", "source": "https://www.rcsb.org/structure/9IYQ", "sha256": "ed7a363d615476ca41fb7158e55de9e59775fd9488bcce42eaf3be87485f59ca", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "Glutamate receptor ionotropic, NMDA 1", "sequence": "MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ", "length": 847 }, { "chain": "C", "authorChain": "C", "name": "Glutamate receptor ionotropic, NMDA 1", "sequence": "MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ", "length": 847 }, { "chain": "B", "authorChain": "B", "name": "Glutamate receptor ionotropic, NMDA 2B", "sequence": "MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF", "length": 842 }, { "chain": "D", "authorChain": "D", "name": "Glutamate receptor ionotropic, NMDA 2B", "sequence": "MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF", "length": 842 } ], "citation": { "country": "US", "id": "primary", "journal_abbrev": "Neuron", "journal_id_ASTM": "NERNET", "journal_id_CSD": "2038", "journal_id_ISSN": "0896-6273", "journal_volume": "113", "page_first": "1006", "pdbx_database_id_DOI": "10.1016/j.neuron.2025.01.021", "pdbx_database_id_PubMed": 40010346, "rcsb_ORCID_identifiers": [ "?", "?", "?", "?", "?", "?", "?" ], "rcsb_authors": [ "Huang, X.", "Sun, X.", "Wang, Q.", "Zhang, J.", "Wen, H.", "Chen, W.J.", "Zhu, S." ], "rcsb_journal_abbrev": "Neuron", "title": "Structural insights into the diverse actions of magnesium on NMDA receptors.", "year": 2025 }, "depositedLigands": [ { "id": "GLY", "name": "GLYCINE" }, { "id": "NAG", "name": "2-acetamido-2-deoxy-beta-D-glucopyranose" }, { "id": "7RC", "name": "(2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid" } ] }, { "id": "IL6", "pdb": "1ALU", "name": "Interleukin-6", "context": "Cytokine signalling", "genes": [ "IL6" ], "geneIds": [ 3569 ], "chains": [ "A" ], "ligands": [], "contextChains": [], "note": "Crystal structure of human interleukin-6. The deposited model represents the cytokine; it does not include its receptor complex.", "title": "HUMAN INTERLEUKIN-6", "resolution": 1.9, "method": "X-RAY DIFFRACTION", "source": "https://www.rcsb.org/structure/1ALU", "sha256": "2b3f9bf4c873316e8d6300941dd0f741cda37b9104f6e4e7acb47255e824c03e", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "INTERLEUKIN-6", "sequence": "MAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM", "length": 186 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "EMBO J.", "journal_id_ASTM": "EMJODG", "journal_id_CSD": "0897", "journal_id_ISSN": "0261-4189", "journal_volume": "16", "page_first": "989", "page_last": "997", "pdbx_database_id_DOI": "10.1093/emboj/16.5.989", "pdbx_database_id_PubMed": 9118960, "rcsb_ORCID_identifiers": [ "?", "?", "?" ], "rcsb_authors": [ "Somers, W.", "Stahl, M.", "Seehra, J.S." ], "rcsb_journal_abbrev": "EMBO J", "title": "1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.", "year": 1997 }, "depositedLigands": [ { "id": "SO4", "name": "SULFATE ION" }, { "id": "TLA", "name": "L(+)-TARTARIC ACID" } ] }, { "id": "NR3C1", "pdb": "1M2Z", "name": "Glucocorticoid receptor", "context": "Glucocorticoid signalling", "genes": [ "NR3C1" ], "geneIds": [ 2908 ], "chains": [ "A", "C" ], "ligands": [ "DEX" ], "contextChains": [ "B", "D" ], "note": "Ligand-binding domains with dexamethasone and TIF2 coactivator motifs. This partial, engineered construct does not contain the full glucocorticoid receptor or its DNA-binding domain.", "title": "Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif", "resolution": 2.5, "method": "X-RAY DIFFRACTION", "source": "https://www.rcsb.org/structure/1M2Z", "sha256": "b85290f126ed2220beb5907b59d9311239a8a9e79d4ad28ff6da7328b445bd10", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "glucocorticoid receptor", "sequence": "VPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK", "length": 257 }, { "chain": "C", "authorChain": "D", "name": "glucocorticoid receptor", "sequence": "VPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK", "length": 257 } ], "citation": { "country": "US", "id": "primary", "journal_abbrev": "Cell(Cambridge,Mass.)", "journal_id_ASTM": "CELLB5", "journal_id_CSD": "0998", "journal_id_ISSN": "0092-8674", "journal_volume": "110", "page_first": "93", "page_last": "105", "pdbx_database_id_DOI": "10.1016/S0092-8674(02)00817-6", "pdbx_database_id_PubMed": 12151000, "rcsb_ORCID_identifiers": [ "?", "?", "?", "?", "?", "?", "?", "?", "?", "?", "?", "?", "?", "?" ], "rcsb_authors": [ "Bledsoe, R.B.", "Montana, V.G.", "Stanley, T.B.", "Delves, C.J.", "Apolito, C.J.", "Mckee, D.D.", "Consler, T.G.", "Parks, D.J.", "Stewart, E.L.", "Willson, T.M.", "Lambert, M.H.", "Moore, J.T.", "Pearce, K.H.", "Xu, H.E." ], "rcsb_journal_abbrev": "Cell", "title": "Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition", "year": 2002 }, "depositedLigands": [ { "id": "BOG", "name": "octyl beta-D-glucopyranoside" }, { "id": "DEX", "name": "DEXAMETHASONE" } ] }, { "id": "DOCK2", "pdb": "6TGB", "name": "Dedicator of cytokinesis 2", "context": "RAC activation \u00b7 immune-cell migration", "genes": [ "DOCK2" ], "geneIds": [ 1794 ], "chains": [ "A", "C" ], "ligands": [], "contextChains": [ "B" ], "note": "DOCK2 from the deposited DOCK2\u2013ELMO1 complex. ELMO1 is available in the complex layer. At 5.50 \u00c5 resolution, fine atomic details require cautious interpretation.", "title": "CryoEM structure of the binary DOCK2-ELMO1 complex", "resolution": 5.5, "method": "ELECTRON MICROSCOPY", "source": "https://www.rcsb.org/structure/6TGB", "sha256": "6a42f297e03f533faa40bc6f5bbec85024395b3391c37634e38067deaec0d367", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "Dedicator of cytokinesis protein 2", "sequence": "MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIMMEHSQSDEYDILVFDALIYIIGLIADRKFQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL", "length": 1830 }, { "chain": "C", "authorChain": "D", "name": "Dedicator of cytokinesis protein 2", "sequence": "MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIMMEHSQSDEYDILVFDALIYIIGLIADRKFQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL", "length": 1830 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "Nat Commun", "journal_id_ISSN": "2041-1723", "journal_volume": "11", "page_first": "3464", "page_last": "3464", "pdbx_database_id_DOI": "10.1038/s41467-020-17271-9", "pdbx_database_id_PubMed": 32651375, "rcsb_ORCID_identifiers": [ "?", "?", "0000-0002-7819-8307", "0000-0003-1218-6714", "0000-0002-7268-9631", "0000-0001-9135-6253", "0000-0002-7848-3327", "?", "0000-0003-2896-9350", "0000-0001-7055-2642", "0000-0001-8810-950X" ], "rcsb_authors": [ "Chang, L.", "Yang, J.", "Jo, C.H.", "Boland, A.", "Zhang, Z.", "McLaughlin, S.H.", "Abu-Thuraia, A.", "Killoran, R.C.", "Smith, M.J.", "Cote, J.F.", "Barford, D." ], "rcsb_journal_abbrev": "Nat Commun", "title": "Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.", "year": 2020 }, "depositedLigands": [] }, { "id": "CD38", "pdb": "1YH3", "name": "CD38 extracellular domain", "context": "NAD metabolism \u00b7 calcium signalling", "genes": [ "CD38" ], "geneIds": [ 952 ], "chains": [ "A" ], "ligands": [], "contextChains": [ "B" ], "note": "Engineered extracellular domain of human CD38. The membrane-spanning region is absent. A second deposited copy is available in the complex layer.", "title": "Crystal structure of human CD38 extracellular domain", "resolution": 1.91, "method": "X-RAY DIFFRACTION", "source": "https://www.rcsb.org/structure/1YH3", "sha256": "067d78c80288a67a7437ccdb7422e67e0a8fbc11288993c09079198b21633632", "retrieved": "2026-10-21", "sequenceType": "Deposited protein construct", "sequences": [ { "chain": "A", "authorChain": "A", "name": "ADP-ribosyl cyclase 1", "sequence": "RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFATSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI", "length": 256 } ], "citation": { "country": "UK", "id": "primary", "journal_abbrev": "Structure", "journal_id_ASTM": "STRUE6", "journal_id_CSD": "2005", "journal_id_ISSN": "0969-2126", "journal_volume": "13", "page_first": "1331", "page_last": "1339", "pdbx_database_id_DOI": "10.1016/j.str.2005.05.012", "pdbx_database_id_PubMed": 16154090, "rcsb_ORCID_identifiers": [ "?", "?", "?", "?", "?", "?" ], "rcsb_authors": [ "Liu, Q.", "Kriksunov, I.A.", "Graeff, R.", "Munshi, C.", "Lee, H.C.", "Hao, Q." ], "rcsb_journal_abbrev": "Structure", "title": "Crystal structure of human CD38 extracellular domain.", "year": 2005 }, "depositedLigands": [] } ] }