{"schema_version":"1.0","version":"oxtr-tfbs-2026-10-19-v1","collected_on":"2026-10-19","title":"OXTR binding-site catalogue","target_gene":"OXTR","status":"Source catalogue with a reproducible exploratory coordinate experiment","region":{"species":"Homo sapiens","assembly":"GRCh38 / hg38","chromosome":"chr3","start_0based":8740380,"end_exclusive":8779628,"length_bp":39248,"gene_id":"ENSG00000180914","canonical_transcript":"ENST00000316793.8","gene_start_1based":8750381,"gene_end_1based":8769628,"gene_strand":-1,"selection":"Ensembl OXTR gene body plus 10,000 bases on each genomic side","scope":"A defined locus window; distal regulatory elements outside it are not captured. Overlapping records may extend beyond its boundaries."},"summary":{"publications":26,"literature_evidence_records":45,"jaspar_all_predictions":217857,"jaspar_default_threshold":400,"jaspar_default_threshold_predictions":9164,"jaspar_distinct_matrices":1003,"jaspar_available_pfm_templates":1019,"encode_clusters":255,"encode_targets":133,"oreganno_regions":37,"unique_confirmed_oxtr_binding_site_total":null,"braintf_screened_observations":126,"braintf_protein_targets":43},"interpretation":"The original 15 sites are one human promoter study’s reported motif set. The catalogue expands the evidence base, but overlapping reports, broad regions, predictions and species are not added into one confirmed-site total.","coordinate_convention":"Database intervals are GRCh38/hg38, 0-based start and exclusive end. Literature coordinates retain their original TSS/ATG/CpG anchors and genome builds. Unrecovered values are null; CSV blanks represent null unless the typed schema says otherwise.","planned_views":["Original DNA line with biological coordinates","Full-position circle preserving relative spacing and a fixed origin","Modulus 9 view alongside the uncompressed positions"],"analysis_status":"Source observations remain unchanged. experiment-v1 supplies fixed DNA-line, full-circle and M9 mappings with computational checks. No enrichment test, new motif scan or biological significance score has been applied.","resources":[{"name":"JASPAR 2026","status":"Collected","url":"https://jaspar.elixir.no/docs/","evidence":"Published motif predictions and PFM templates","count":217857,"unit":"predicted motif matches","note":"9,164 meet UCSC’s default score >=400 display threshold. All 217,857 returned predictions are retained. Several models and strands can overlap one location. Score is a motif-match statistic, not an OXTR regulatory probability."},{"name":"ENCODE 3 / UCSC","status":"Collected","url":"https://www.encodeproject.org/chip-seq/transcription_factor/","evidence":"ChIP-seq clusters, release November 2018","count":255,"unit":"regional occupancy clusters","note":"133 assayed targets across aggregated experimental contexts. Includes coregulators; not 133 confirmed OXTR-regulating TFs. Provenance joins each cluster to its experiment and cell type."},{"name":"ORegAnno / UCSC","status":"Collected","url":"https://genome.ucsc.edu/cgi-bin/hgTrackUi?db=hg38&g=oreganno","evidence":"Regulatory annotations, UCSC snapshot October 2015","count":37,"unit":"overlapping regional annotations","note":"Annotation class and factor are unresolved for most returned rows. Regional overlap alone does not establish OXTR regulation."},{"name":"TRANSFAC","status":"Licensed access pending","url":"https://genexplain.com/transfac-database/","evidence":"Curated binding sites / regulatory knowledge","count":null,"unit":null,"note":"Public product documentation reviewed. No licensed export or redistribution permission available; no protected entries copied."},{"name":"TFBSdb","status":"Legacy endpoint unavailable","url":"https://tfbsdb.systemsbiology.net/viewgene/5021","evidence":"Historical hg19 motif / footprint resource","count":null,"unit":null,"note":"Indexed OXTR page returns HTTP 404. Search snippets are not imported as a verified database export."},{"name":"ReMap","status":"Resource identified; locus export pending","url":"https://remap.univ-amu.fr/download_page","evidence":"Independent ChIP-seq compendium","count":null,"unit":null,"note":"No additional ReMap records counted in this release."},{"name":"ChIP-Atlas","status":"Resource identified; locus export pending","url":"https://chip-atlas.org/target_genes","evidence":"ChIP-seq and target-gene context","count":null,"unit":null,"note":"Gene-target associations and precise binding intervals are distinct; no extra sites counted."},{"name":"Wolfram","status":"Planned analysis resource","url":"https://reference.wolfram.com/language/ref/BioSequence.html","evidence":"Sequence handling and symbolic analysis","count":null,"unit":null,"note":"A future analysis tool, not an experimental binding-site source."}],"publications":[{"id":"TFP01","pmid":"7798245","title":"Structural organization of the human oxytocin receptor gene.","authors":"Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, Kikuchi T, Kubota Y, Ogita K, Saji F.","doi":"10.1016/s0021-9258(18)31656-9","year":1994,"first_publication_date":"1994-12-01","journal":"The Journal of biological chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/7798245/","doi_url":"https://doi.org/10.1016/s0021-9258(18)31656-9","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP02","pmid":"16569740","title":"Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-beta.","authors":"Terzidou V, Lee Y, Lindström T, Johnson M, Thornton S, Bennett PR.","doi":"10.1210/jc.2005-2649","year":2006,"first_publication_date":"2006-03-28","journal":"The Journal of clinical endocrinology and metabolism","url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","doi_url":"https://doi.org/10.1210/jc.2005-2649","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP03","pmid":"21734268","title":"Synergistic regulation of human oxytocin receptor promoter by CCAAT/ enhancer-binding protein and RELA.","authors":"Khanjani S, Terzidou V, Lee YS, Thornton S, Johnson MR, Bennett PR.","doi":"10.1095/biolreprod.111.092304","year":2011,"first_publication_date":"2011-07-06","journal":"Biology of reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/21734268/","doi_url":"https://doi.org/10.1095/biolreprod.111.092304","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP04","pmid":"16888077","title":"Interleukin-1-induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells.","authors":"Soloff MS, Izban MG, Cook DL, Jeng YJ, Mifflin RC.","doi":"10.1093/molehr/gal067","year":2006,"first_publication_date":"2006-08-03","journal":"Molecular human reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/16888077/","doi_url":"https://doi.org/10.1093/molehr/gal067","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP05","pmid":"15494465","title":"Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes.","authors":"Terzidou V, Sooranna SR, Kim LU, Thornton S, Bennett PR, Johnson MR.","doi":"10.1210/jc.2004-0277","year":2005,"first_publication_date":"2004-10-19","journal":"The Journal of clinical endocrinology and metabolism","url":"https://pubmed.ncbi.nlm.nih.gov/15494465/","doi_url":"https://doi.org/10.1210/jc.2004-0277","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP06","pmid":"10218980","title":"Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.","authors":"Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.","doi":"10.1210/endo.140.5.6710","year":1999,"first_publication_date":"1999-05-01","journal":"Endocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/10218980/","doi_url":"https://doi.org/10.1210/endo.140.5.6710","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP07","pmid":"10221779","title":"Differential protein-DNA binding analysis identifies a novel enhancer element, US-1, involved in the upregulation of the oxytocin receptor gene in human myometrium at term.","authors":"Kimura T, Mizumoto Y, Ivell R.","doi":"10.1016/s0303-7207(98)00225-1","year":1999,"first_publication_date":"1999-02-01","journal":"Molecular and cellular endocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/10221779/","doi_url":"https://doi.org/10.1016/s0303-7207(98)00225-1","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP08","pmid":"10527846","title":"Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium.","authors":"Kimura T, Ivell R, Rust W, Mizumoto Y, Ogita K, Kusui C, Matsumura Y, Azuma C, Murata Y.","doi":"10.1006/bbrc.1999.1487","year":1999,"first_publication_date":"1999-10-01","journal":"Biochemical and biophysical research communications","url":"https://pubmed.ncbi.nlm.nih.gov/10527846/","doi_url":"https://doi.org/10.1006/bbrc.1999.1487","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP09","pmid":"16549056","title":"The novel human gene MIP functions as a co-activator of hMafF.","authors":"Ye X, Li Y, Huang Q, Yu Y, Yuan H, Wang P, Wan D, Gu J, Huo K, Li YY, Lu H.","doi":"10.1016/j.abb.2006.02.011","year":2006,"first_publication_date":"2006-03-06","journal":"Archives of biochemistry and biophysics","url":"https://pubmed.ncbi.nlm.nih.gov/16549056/","doi_url":"https://doi.org/10.1016/j.abb.2006.02.011","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP10","pmid":"33633538","title":"Maternal Diabetes-Induced Suppression of Oxytocin Receptor Contributes to Social Deficits in Offspring.","authors":"Liu J, Liang Y, Jiang X, Xu J, Sun Y, Wang Z, Lin L, Niu Y, Song S, Zhang H, Xue Z, Lu J, Yao P.","doi":"10.3389/fnins.2021.634781","year":2021,"first_publication_date":"2021-02-09","journal":"Frontiers in neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","doi_url":"https://doi.org/10.3389/fnins.2021.634781","pmcid":"PMC7900564","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP11","pmid":"23441222","title":"DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor.","authors":"Mamrut S, Harony H, Sood R, Shahar-Gold H, Gainer H, Shi YJ, Barki-Harrington L, Wagner S.","doi":"10.1371/journal.pone.0056869","year":2013,"first_publication_date":"2013-02-18","journal":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/23441222/","doi_url":"https://doi.org/10.1371/journal.pone.0056869","pmcid":"PMC3575498","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP12","pmid":"41109427","title":"Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.","authors":"Van-Quynh Duong T, Yaw AM, Zhou G, Sinha N, Cherukuri AS, Nguyen D, Cataldo K, Ly N, Sen A, Sempere LF, Detrie C, Seiler R, Olomu IN, Cortese R, Long R, Hoffmann HM.","doi":"10.1016/j.molmet.2025.102269","year":2026,"first_publication_date":"2025-10-16","journal":"Molecular metabolism","url":"https://pubmed.ncbi.nlm.nih.gov/41109427/","doi_url":"https://doi.org/10.1016/j.molmet.2025.102269","pmcid":"PMC12902303","source_review":"Selected full-text methods, results and captions","existing_register_id":"E03","trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP13","pmid":"21079000","title":"miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.","authors":"Renthal NE, Chen CC, Williams KC, Gerard RD, Prange-Kiel J, Mendelson CR.","doi":"10.1073/pnas.1008301107","year":2010,"first_publication_date":"2010-11-15","journal":"Proceedings of the National Academy of Sciences of the United States of America","url":"https://pubmed.ncbi.nlm.nih.gov/21079000/","doi_url":"https://doi.org/10.1073/pnas.1008301107","pmcid":"PMC2996411","source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP14","pmid":"30106994","title":"Oxytocin receptor is regulated by Peg3.","authors":"Frey WD, Sharma K, Cain TL, Nishimori K, Teruyama R, Kim J.","doi":"10.1371/journal.pone.0202476","year":2018,"first_publication_date":"2018-08-14","journal":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","doi_url":"https://doi.org/10.1371/journal.pone.0202476","pmcid":"PMC6091971","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP15","pmid":"36094838","title":"HIF-1α is essential for the augmentation of myometrial contractility during labor†.","authors":"Wen B, Zheng Z, Wang L, Qian X, Wang X, Chen Y, Bao J, Jiang Y, Ji K, Liu H.","doi":"10.1093/biolre/ioac174","year":2022,"first_publication_date":"2022-12-01","journal":"Biology of reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/36094838/","doi_url":"https://doi.org/10.1093/biolre/ioac174","pmcid":"PMC9752684","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP16","pmid":"38897566","title":"Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression","authors":"Kwak Youn-Tae; Montalbano Alina P; Kelleher Andrew M; Colon-Caraballo Mariano; Kraus W Lee; Mahendroo Mala; Mendelson Carole R","doi":"10.1016/j.jbc.2024.107484","year":2024,"first_publication_date":"2024-06-19","journal":"Journal of Biological Chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/38897566/","doi_url":"https://doi.org/10.1016/j.jbc.2024.107484","pmcid":"PMC11301068","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP17","pmid":"28049625","title":"Regulation of the macrophage oxytocin receptor in response to inflammation.","authors":"Szeto A, Sun-Suslow N, Mendez AJ, Hernandez RI, Wagner KV, McCabe PM.","doi":"10.1152/ajpendo.00346.2016","year":2017,"first_publication_date":"2017-01-03","journal":"American journal of physiology. Endocrinology and metabolism","url":"https://pubmed.ncbi.nlm.nih.gov/28049625/","doi_url":"https://doi.org/10.1152/ajpendo.00346.2016","pmcid":"PMC5374296","source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP18","pmid":"22030357","title":"Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.","authors":"Thanseem I, Anitha A, Nakamura K, Suda S, Iwata K, Matsuzaki H, Ohtsubo M, Ueki T, Katayama T, Iwata Y, Suzuki K, Minoshima S, Mori N.","doi":"10.1016/j.biopsych.2011.09.020","year":2012,"first_publication_date":"2011-10-26","journal":"Biological psychiatry","url":"https://pubmed.ncbi.nlm.nih.gov/22030357/","doi_url":"https://doi.org/10.1016/j.biopsych.2011.09.020","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP19","pmid":"16254027","title":"Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.","authors":"Fleming JG, Spencer TE, Safe SH, Bazer FW.","doi":"10.1210/en.2005-1120","year":2006,"first_publication_date":"2005-10-27","journal":"Endocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/16254027/","doi_url":"https://doi.org/10.1210/en.2005-1120","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP20","pmid":"9048622","title":"Cloning, novel promoter sequence, and estrogen regulation of a rat oxytocin receptor gene.","authors":"Bale TL, Dorsa DM.","doi":"10.1210/endo.138.3.4998","year":1997,"first_publication_date":"1997-03-01","journal":"Endocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/9048622/","doi_url":"https://doi.org/10.1210/endo.138.3.4998","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP21","pmid":"12604656","title":"Transcriptional regulation of the bovine oxytocin receptor gene.","authors":"Telgmann R, Bathgate RA, Jaeger S, Tillmann G, Ivell R.","doi":"10.1095/biolreprod.102.008961","year":2003,"first_publication_date":"2003-03-01","journal":"Biology of reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/12604656/","doi_url":"https://doi.org/10.1095/biolreprod.102.008961","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP22","pmid":"19439725","title":"Characterization of the cyclic adenosine monophosphate target site in the oxytocin receptor gene in rabbit amnion.","authors":"Jeng YJ, Soloff MS.","doi":"10.1095/biolreprod.109.077941","year":2009,"first_publication_date":"2009-05-13","journal":"Biology of reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/19439725/","doi_url":"https://doi.org/10.1095/biolreprod.109.077941","pmcid":null,"source_review":"Abstract and bibliographic metadata","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP23","pmid":"27108164","title":"Oxytocin receptor DNA methylation in postpartum depression.","authors":"Kimmel M, Clive M, Gispen F, Guintivano J, Brown T, Cox O, Beckmann MW, Kornhuber J, Fasching PA, Osborne LM, Binder E, Payne JL, Kaminsky Z.","doi":"10.1016/j.psyneuen.2016.04.008","year":2016,"first_publication_date":"2016-04-08","journal":"Psychoneuroendocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/27108164/","doi_url":"https://doi.org/10.1016/j.psyneuen.2016.04.008","pmcid":"PMC7152506","source_review":"Abstract and figure descriptions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP24","pmid":"37479681","title":"The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity.","authors":"Müller S, Sicorello M, Moser D, Frach L, Limberg A, Gumpp AM, Ramo-Fernandez L, Köhler-Dauner F, Fegert JM, Waller C, Kumsta R, Kolassa IT.","doi":"10.1038/s41398-023-02548-6","year":2023,"first_publication_date":"2023-07-21","journal":"Translational psychiatry","url":"https://pubmed.ncbi.nlm.nih.gov/37479681/","doi_url":"https://doi.org/10.1038/s41398-023-02548-6","pmcid":"PMC10362059","source_review":"Selected full-text methods, results and captions","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP25","pmid":"38831039","title":"Multiomic profiling of transcription factor binding and function in human brain.","authors":"Loupe JM, Anderson AG, Rizzardi LF, Rodriguez-Nunez I, Moyers B, Trausch-Lowther K, Jain R, Bunney WE, Bunney BG, Cartagena P, Sequeira A, Watson SJ, Akil H, Cooper GM, Myers RM.","doi":"10.1038/s41593-024-01658-8","year":2024,"first_publication_date":"2024-06-03","journal":"Nature neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/38831039/","doi_url":"https://doi.org/10.1038/s41593-024-01658-8","pmcid":"PMC12991031","source_review":"Public processed data, publication, supplementary tables and source metadata reviewed","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"},{"id":"TFP26","pmid":"39957428","title":"Functional characterization of OXTR-associated enhancers.","authors":"Laboy Cintrón D, Sheng RR, Ahituv N.","doi":"10.1093/hmg/ddaf022","year":2025,"first_publication_date":"2025-05-01","journal":"Human molecular genetics","url":"https://pubmed.ncbi.nlm.nih.gov/39957428/","doi_url":"https://doi.org/10.1093/hmg/ddaf022","pmcid":"PMC12056307","source_review":"Public processed data, publication, supplementary tables and source metadata reviewed","existing_register_id":null,"trust_score":null,"trust_status":"Not assigned; evidence type and review depth reported","jadad":"Not applicable: not a randomized clinical trial"}],"evidence":[{"id":"TFBS001","pmid":"7798245","species":"Homo sapiens","factor":"SP1; AP1; AP2; GATA1; MYB; NFIL6; APRE","label":"Historical promoter annotation","evidence_kind":"reported_motif_group","methods":"Gene sequencing / motif annotation","finding":"The original gene report annotates several regulatory motifs.","reported_position":"SP1 approximately 65 bp upstream of the reported TSS; two TSSs reported","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Legacy numbering and multiple TSSs need reconciliation. These annotations are not individual experimentally validated sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/7798245/","publication_id":"TFP01","notion_url":"https://app.notion.com/p/3fd7b9c99c5681b49f47d974017343d8","evidence_categories":["annotation_prediction"],"normalized_location":{"assembly":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"strand":null,"mapping_status":"Unresolved","reference_interval_id":null}},{"id":"TFBS002","pmid":"7798245","species":"Homo sapiens","factor":"Estrogen receptor family","label":"ERE half-sites","evidence_kind":"reported_motif_group","methods":"Gene sequencing / motif annotation","finding":"Three half-palindromic EREs were reported.","reported_position":null,"reported_sequence":null,"reported_count":3,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The report did not identify a classical complete ERE. Later ERE-like annotations use different regions and methods.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/7798245/","publication_id":"TFP01","notion_url":"https://app.notion.com/p/3fd7b9c99c568131a5e2facac9dc49ae","evidence_categories":["annotation_prediction"],"normalized_location":{"assembly":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"strand":null,"mapping_status":"Unresolved","reference_interval_id":null}},{"id":"TFBS003","pmid":"16569740","species":"Homo sapiens","factor":"AP1","label":"The original 15-site report","evidence_kind":"reported_motif_group","methods":"Computer analysis and EMSA; promoter assays","finding":"3 AP1 sites form part of the paper’s reported set of 15.","reported_position":null,"reported_sequence":null,"reported_count":3,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Individual site sequences and coordinates were not recovered. The abstract does not establish the same functional contribution for every site; these groups cannot yet be deduplicated against later papers.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","publication_id":"TFP02","notion_url":"https://app.notion.com/p/3fd7b9c99c56817ab807c2510a9e6524","evidence_categories":["laboratory_tested","binding_evidence"],"normalized_location":{"assembly":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"strand":null,"mapping_status":"Unresolved","reference_interval_id":null}},{"id":"TFBS004","pmid":"16569740","species":"Homo sapiens","factor":"C/EBP","label":"The original 15-site report","evidence_kind":"reported_motif_group","methods":"Computer analysis and EMSA; promoter assays","finding":"9 C/EBP sites form part of the paper’s reported set of 15.","reported_position":null,"reported_sequence":null,"reported_count":9,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Individual site sequences and coordinates were not recovered. 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The specific binding protein remains unresolved.","assay":"Differential electrophoretic mobility shift assay (EMSA)","context":"Nuclear extracts from human term-pregnant and non-pregnant myometrium (uterine muscle).","expression_effect":"Enhancer activity reported in an artificial reporter construct in cultured SKN cells; not a direct measurement of the element’s effect at its native OXTR locus.","review_depth":"Published abstract reviewed; full-text methods and controls not independently reassessed","source_url":"https://pubmed.ncbi.nlm.nih.gov/10221779/"},"TFBS013":{"status":"binding_detected","label":"Binding detected","resolution":"reported_sequence","result":"US-2 showed specific binding by human MafF in the reported experiments.","assay":"Yeast one-hybrid screening followed by EMSA","context":"Human term-myometrium cDNA library and follow-up protein–DNA binding assays.","expression_effect":"A role in OXTR upregulation was proposed; a causal effect on native OXTR expression is not established by the reviewed abstract.","review_depth":"Published abstract reviewed; full-text methods and controls not independently reassessed","source_url":"https://pubmed.ncbi.nlm.nih.gov/10527846/"},"TFBS044":{"status":"regional_association_detected","label":"Regional association detected","resolution":"region","result":"A screened BrainTF ChIP-seq peak records protein association across this region; an exact binding sequence is unresolved.","assay":"ChIP-seq peak calls","context":"Human postmortem brain; the context is retained on each observation.","expression_effect":"Effect on native OXTR expression not established by this occupancy measurement.","review_depth":"Public processed peaks, author replication tests, FRiP and HOT annotations reviewed; raw reads not reanalysed.","source_url":"https://doi.org/10.1038/s41593-024-01658-8"},"TFBS045":{"status":"not_classified","label":"Functional reporter evidence; binding unresolved","resolution":"unresolved","result":"The outcome has not been classified in this interpretation layer; consult the original finding.","assay":"See source record","context":"See source record","expression_effect":"Human OCE7 DNA enhanced reporter activity in mouse cells and drove mouse olfactory-bulb reporter activity. 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