[{"id":"TFBS001","pmid":"7798245","species":"Homo sapiens","factor":"SP1; AP1; AP2; GATA1; MYB; NFIL6; APRE","label":"Historical promoter annotation","evidence_kind":"reported_motif_group","methods":"Gene sequencing / motif annotation","finding":"The original gene report annotates several regulatory motifs.","reported_position":"SP1 approximately 65 bp upstream of the reported TSS; two TSSs reported","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Legacy numbering and multiple TSSs need reconciliation. These annotations are not individual experimentally validated sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/7798245/","publication_id":"TFP01"},{"id":"TFBS002","pmid":"7798245","species":"Homo sapiens","factor":"Estrogen receptor family","label":"ERE half-sites","evidence_kind":"reported_motif_group","methods":"Gene sequencing / motif annotation","finding":"Three half-palindromic EREs were reported.","reported_position":null,"reported_sequence":null,"reported_count":3,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The report did not identify a classical complete ERE. Later ERE-like annotations use different regions and methods.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/7798245/","publication_id":"TFP01"},{"id":"TFBS003","pmid":"16569740","species":"Homo sapiens","factor":"AP1","label":"The original 15-site report","evidence_kind":"reported_motif_group","methods":"Computer analysis and EMSA; promoter assays","finding":"3 AP1 sites form part of the paper’s reported set of 15.","reported_position":null,"reported_sequence":null,"reported_count":3,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Individual site sequences and coordinates were not recovered. The abstract does not establish the same functional contribution for every site; these groups cannot yet be deduplicated against later papers.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","publication_id":"TFP02"},{"id":"TFBS004","pmid":"16569740","species":"Homo sapiens","factor":"C/EBP","label":"The original 15-site report","evidence_kind":"reported_motif_group","methods":"Computer analysis and EMSA; promoter assays","finding":"9 C/EBP sites form part of the paper’s reported set of 15.","reported_position":null,"reported_sequence":null,"reported_count":9,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Individual site sequences and coordinates were not recovered. The abstract does not establish the same functional contribution for every site; these groups cannot yet be deduplicated against later papers.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","publication_id":"TFP02"},{"id":"TFBS005","pmid":"16569740","species":"Homo sapiens","factor":"NF-kappaB","label":"The original 15-site report","evidence_kind":"reported_motif_group","methods":"Computer analysis and EMSA; promoter assays","finding":"3 NF-kappaB sites form part of the paper’s reported set of 15.","reported_position":null,"reported_sequence":null,"reported_count":3,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Individual site sequences and coordinates were not recovered. The abstract does not establish the same functional contribution for every site; these groups cannot yet be deduplicated against later papers.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","publication_id":"TFP02"},{"id":"TFBS006","pmid":"16569740","species":"Homo sapiens","factor":"C/EBPbeta; NF-kappaB","label":"Synergistic response region","evidence_kind":"functional_region","methods":"Deletion / reporter assays","finding":"A promoter region participates in the combined response.","reported_position":"−851 to −656 relative to the paper’s promoter origin","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Overlaps the more focused region investigated in PMID 21734268; do not count the two studies as independent sites.","related_evidence":"21734268","source_url":"https://pubmed.ncbi.nlm.nih.gov/16569740/","publication_id":"TFP02"},{"id":"TFBS007","pmid":"21734268","species":"Homo sapiens","factor":"CEBPB; RELA","label":"Shared 20-base region","evidence_kind":"functional_region","methods":"Deletion / DNA-binding / reporter assays","finding":"A 20-base region is required for synergy and binds both factors.","reported_position":"−712 to −692 in the paper’s promoter numbering","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"One shared region, not two independent sites. Historical endpoint convention retained; no genomic conversion applied.","related_evidence":"16569740","source_url":"https://pubmed.ncbi.nlm.nih.gov/21734268/","publication_id":"TFP03"},{"id":"TFBS008","pmid":"16888077","species":"Homo sapiens","factor":"NF-kappaB","label":"IL-1 recruitment region","evidence_kind":"occupancy_region","methods":"ChIP / RNA polymerase II assays","finding":"IL-1 recruits NF-kappaB while reducing promoter-associated RNA polymerase II.","reported_position":"Approximately −955 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"A reported position is not a motif extent. Regulatory direction depends on cellular and stimulus context.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16888077/","publication_id":"TFP04"},{"id":"TFBS009","pmid":"15494465","species":"Homo sapiens","factor":"C/EBP; AP1","label":"Mechanical stretch response","evidence_kind":"regulatory_context","methods":"Primary myocytes / EMSA / reporter assays","finding":"Stretch increases factor binding; C/EBP overexpression activates the tested OXTR promoter.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Regulatory context; no additional individually mapped site is counted.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/15494465/","publication_id":"TFP05"},{"id":"TFBS010","pmid":"10218980","species":"Homo sapiens","factor":"GABPA; GABPB","label":"GABP element","evidence_kind":"functional_region","methods":"EMSA / immunoshift / mutation / reporter assays","finding":"A GABP element supports OXTR promoter activation in Hs578T breast cells.","reported_position":"−85 to −65 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Reported regulatory interval contains more than one element. GABP alpha/beta names are unrelated to Atlas sequence labels.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/10218980/","publication_id":"TFP06"},{"id":"TFBS011","pmid":"10218980","species":"Homo sapiens","factor":"CRE/AP1-like element","label":"Adjacent cooperating element","evidence_kind":"functional_region","methods":"Mutation / reporter assays","finding":"Mutation of the CRE/AP1-like element also removes promoter activation.","reported_position":"Within −85 to −65 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Exact motif endpoints and the binding factor at this element remain unresolved in the material reviewed.","related_evidence":"TFBS010","source_url":"https://pubmed.ncbi.nlm.nih.gov/10218980/","publication_id":"TFP06"},{"id":"TFBS012","pmid":"10221779","species":"Homo sapiens","factor":"Unresolved","label":"US-1 enhancer","evidence_kind":"sequence_supported","methods":"Differential EMSA / enhancer reporter","finding":"A sequence supports differential protein binding and enhancer activity.","reported_position":"Within a reported 20-base region","reported_sequence":"TCTGCCTTCATCCAGCC","reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The reported sequence has 17 bases; retain it separately from the 20-base region description. Factor identity and genomic mapping remain open.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/10221779/","publication_id":"TFP07"},{"id":"TFBS013","pmid":"10527846","species":"Homo sapiens","factor":"MAFF","label":"US-2 element","evidence_kind":"sequence_supported","methods":"Yeast one-hybrid / EMSA","finding":"Human MafF binds the reported US-2 sequence.","reported_position":null,"reported_sequence":"GGAATGATTACTCAGCTAGA","reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Sequence retained as reported; genomic placement has not been independently aligned.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/10527846/","publication_id":"TFP08"},{"id":"TFBS014","pmid":"16549056","species":"Homo sapiens","factor":"MAFF; MIP","label":"US-2 co-activation","evidence_kind":"regulatory_context","methods":"Tandem-element reporter / co-expression","finding":"MIP supports MafF-mediated activation in the US-2 reporter system.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Reuses US-2; not an additional binding site. MIP is a co-activator.","related_evidence":"TFBS013","source_url":"https://pubmed.ncbi.nlm.nih.gov/16549056/","publication_id":"TFP09"},{"id":"TFBS015","pmid":"33633538","species":"Homo sapiens","factor":"ESR2 / ERbeta","label":"ERE-like element","evidence_kind":"functional_region","methods":"Promoter mutation / reporter / ChIP","finding":"ERE-like elements participate in the reported OXTR response.","reported_position":"-1005 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":"ENST00000316793.7","coordinate_status":"Original report; genomic mapping unresolved","limitation":"Position labels, not recovered motif extents. ChIP supports regional occupancy; it does not resolve each motif separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS016","pmid":"33633538","species":"Homo sapiens","factor":"ESR2 / ERbeta","label":"ERE-like element","evidence_kind":"functional_region","methods":"Promoter mutation / reporter / ChIP","finding":"ERE-like elements participate in the reported OXTR response.","reported_position":"-944 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":"ENST00000316793.7","coordinate_status":"Original report; genomic mapping unresolved","limitation":"Position labels, not recovered motif extents. ChIP supports regional occupancy; it does not resolve each motif separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS017","pmid":"33633538","species":"Homo sapiens","factor":"GATA1","label":"Other motifs in the assayed region","evidence_kind":"reported_motif_group","methods":"Motif annotation / regional ChIP","finding":"Candidate motif annotations in the −1100 to −900 interval.","reported_position":"−1100 to −900 from TSS","reported_sequence":null,"reported_count":1,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Prediction is not proof of individual occupancy or regulatory function. The two ERE-like elements are recorded separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS018","pmid":"33633538","species":"Homo sapiens","factor":"SP1","label":"Other motifs in the assayed region","evidence_kind":"reported_motif_group","methods":"Motif annotation / regional ChIP","finding":"Candidate motif annotations in the −1100 to −900 interval.","reported_position":"−1100 to −900 from TSS","reported_sequence":null,"reported_count":1,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Prediction is not proof of individual occupancy or regulatory function. The two ERE-like elements are recorded separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS019","pmid":"33633538","species":"Homo sapiens","factor":"YY1","label":"Other motifs in the assayed region","evidence_kind":"reported_motif_group","methods":"Motif annotation / regional ChIP","finding":"Candidate motif annotations in the −1100 to −900 interval.","reported_position":"−1100 to −900 from TSS","reported_sequence":null,"reported_count":1,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Prediction is not proof of individual occupancy or regulatory function. The two ERE-like elements are recorded separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS020","pmid":"33633538","species":"Homo sapiens","factor":"CEBPA","label":"Other motifs in the assayed region","evidence_kind":"reported_motif_group","methods":"Motif annotation / regional ChIP","finding":"Candidate motif annotations in the −1100 to −900 interval.","reported_position":"−1100 to −900 from TSS","reported_sequence":null,"reported_count":2,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Prediction is not proof of individual occupancy or regulatory function. The two ERE-like elements are recorded separately.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/33633538/","publication_id":"TFP10"},{"id":"TFBS021","pmid":"23441222","species":"Mus musculus","factor":"Half ERE","label":"CpG-associated candidate element","evidence_kind":"candidate_region","methods":"Methylation / promoter mutation / reporter assays","finding":"The study tests methylation-sensitive Oxtr promoter regulation.","reported_position":"CpG position -932; not the motif start","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Coordinates label CpGs inside candidate elements. Direct occupancy by the named factor was not established by these assays.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/23441222/","publication_id":"TFP11"},{"id":"TFBS022","pmid":"23441222","species":"Mus musculus","factor":"Putative SP1","label":"CpG-associated candidate element","evidence_kind":"candidate_region","methods":"Methylation / promoter mutation / reporter assays","finding":"The study tests methylation-sensitive Oxtr promoter regulation.","reported_position":"CpG position -733; not the motif start","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Coordinates label CpGs inside candidate elements. Direct occupancy by the named factor was not established by these assays.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/23441222/","publication_id":"TFP11"},{"id":"TFBS023","pmid":"41109427","species":"Mus musculus","factor":"BMAL1 / clock complex","label":"E1 E′-box","evidence_kind":"tested_candidate","methods":"NIH3T3 promoter mutation / reporter assays","finding":"Mutation does not abolish the tested BMAL1-induced reporter response.","reported_position":"Within −1000 to +200 of mouse Oxtr promoter","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The four candidate sites belong to the mouse promoter. Published occupancy context includes male mouse liver; these are not four confirmed human or uterine ChIP sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/41109427/","publication_id":"TFP12"},{"id":"TFBS024","pmid":"41109427","species":"Mus musculus","factor":"BMAL1 / clock complex","label":"E2 E′-box","evidence_kind":"functional_candidate","methods":"NIH3T3 promoter mutation / reporter assays","finding":"Mutation abolishes the tested BMAL1-induced reporter response.","reported_position":"Within −1000 to +200 of mouse Oxtr promoter","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The four candidate sites belong to the mouse promoter. Published occupancy context includes male mouse liver; these are not four confirmed human or uterine ChIP sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/41109427/","publication_id":"TFP12"},{"id":"TFBS025","pmid":"41109427","species":"Mus musculus","factor":"BMAL1 / clock complex","label":"E3 E′-box","evidence_kind":"tested_candidate","methods":"NIH3T3 promoter mutation / reporter assays","finding":"Mutation does not abolish the tested BMAL1-induced reporter response.","reported_position":"Within −1000 to +200 of mouse Oxtr promoter","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The four candidate sites belong to the mouse promoter. Published occupancy context includes male mouse liver; these are not four confirmed human or uterine ChIP sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/41109427/","publication_id":"TFP12"},{"id":"TFBS026","pmid":"41109427","species":"Mus musculus","factor":"BMAL1 / clock complex","label":"E4 E′-box","evidence_kind":"functional_candidate","methods":"NIH3T3 promoter mutation / reporter assays","finding":"Mutation abolishes the tested BMAL1-induced reporter response.","reported_position":"Within −1000 to +200 of mouse Oxtr promoter","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"The four candidate sites belong to the mouse promoter. Published occupancy context includes male mouse liver; these are not four confirmed human or uterine ChIP sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/41109427/","publication_id":"TFP12"},{"id":"TFBS027","pmid":"21079000","species":"Homo sapiens","factor":"ZEB1; ZEB2","label":"Myometrial repression","evidence_kind":"regulatory_context","methods":"Overexpression / expression assays","finding":"ZEB1 and ZEB2 overexpression represses OXTR in human myometrial cells.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Abstract-level review; no human motif-level genomic interval recovered. Animal experiments in the same paper are not merged into this record.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/21079000/","publication_id":"TFP13"},{"id":"TFBS028","pmid":"30106994","species":"Mus musculus","factor":"PEG3","label":"BS1","evidence_kind":"binding_supported","methods":"Competitive EMSA","finding":"Competitive EMSA supports binding.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Site sequences require figure-level recovery. The paper describes a 225-bp ChIP region but also lists mm10 chr6:112488870–112489904, an inconsistent span; genomic normalization is withheld.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","publication_id":"TFP14"},{"id":"TFBS029","pmid":"30106994","species":"Mus musculus","factor":"PEG3","label":"BS2","evidence_kind":"tested_candidate","methods":"Competitive EMSA","finding":"The reported competitive EMSA did not support binding.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Site sequences require figure-level recovery. The paper describes a 225-bp ChIP region but also lists mm10 chr6:112488870–112489904, an inconsistent span; genomic normalization is withheld.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","publication_id":"TFP14"},{"id":"TFBS030","pmid":"30106994","species":"Mus musculus","factor":"PEG3","label":"BS3","evidence_kind":"binding_supported","methods":"Competitive EMSA","finding":"Competitive EMSA supports binding.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Site sequences require figure-level recovery. The paper describes a 225-bp ChIP region but also lists mm10 chr6:112488870–112489904, an inconsistent span; genomic normalization is withheld.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","publication_id":"TFP14"},{"id":"TFBS031","pmid":"30106994","species":"Mus musculus","factor":"PEG3","label":"BS4","evidence_kind":"binding_supported","methods":"Competitive EMSA / ChIP","finding":"Competitive EMSA supports binding. BS4 also lies in the ChIP-tested region.","reported_position":"Third-exon region","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Site sequences require figure-level recovery. The paper describes a 225-bp ChIP region but also lists mm10 chr6:112488870–112489904, an inconsistent span; genomic normalization is withheld.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","publication_id":"TFP14"},{"id":"TFBS032","pmid":"30106994","species":"Mus musculus","factor":"PEG3","label":"BS5","evidence_kind":"tested_candidate","methods":"Competitive EMSA","finding":"The reported competitive EMSA did not support binding.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Site sequences require figure-level recovery. The paper describes a 225-bp ChIP region but also lists mm10 chr6:112488870–112489904, an inconsistent span; genomic normalization is withheld.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30106994/","publication_id":"TFP14"},{"id":"TFBS033","pmid":"36094838","species":"Homo sapiens","factor":"HIF1A","label":"Hypoxia-associated coding-region occupancy","evidence_kind":"occupancy_region","methods":"ChIP-seq / hypoxia / knockdown","finding":"HIF1A occupancy is reported in the OXTR coding region with expression responses to hypoxia.","reported_position":"OXTR coding region","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"A ChIP region is not a resolved short binding motif. Exact peak coordinates were not recovered from the article.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/36094838/","publication_id":"TFP15"},{"id":"TFBS034","pmid":"38897566","species":"Mus musculus","factor":"PGR; CNOT1","label":"Progesterone receptor complex","evidence_kind":"regulatory_context","methods":"Myometrial ChIP / re-ChIP","finding":"The mouse Oxtr region shows PR binding; CNOT1 re-ChIP enrichment at Oxtr was not significant.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"CNOT1 is a coregulator, not an established sequence-specific DNA-binding factor. Human cell experiments in the paper are additional context, not merged site counts.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/38897566/","publication_id":"TFP16"},{"id":"TFBS035","pmid":"28049625","species":"Homo sapiens","factor":"NF-kappaB","label":"Inflammatory macrophage response","evidence_kind":"regulatory_context","methods":"Primary macrophages / THP-1 / pathway inhibition","finding":"Inflammatory induction of OXTR depends on NF-kappaB signalling in the studied cells.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Regulatory evidence without an additional mapped binding site.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/28049625/","publication_id":"TFP17"},{"id":"TFBS036","pmid":"22030357","species":"Homo sapiens","factor":"SP1","label":"Neural cell expression response","evidence_kind":"regulatory_context","methods":"Human tissue / SK-N-SH silencing / inhibitor","finding":"SP1 perturbation changes OXTR expression in the studied neural cells.","reported_position":null,"reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Expression dependence does not locate a binding site. Other genes in the study are not OXTR sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/22030357/","publication_id":"TFP18"},{"id":"TFBS037","pmid":"16254027","species":"Ovis aries","factor":"SP1","label":"GC-rich promoter element","evidence_kind":"functional_region","methods":"Promoter mutation / reporter assays","finding":"SP1 elements support basal and estrogen-mediated promoter activity.","reported_position":"-104 in the paper’s promoter numbering","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Ovine evidence; estrogen-mediated action at these elements is not a human ERE site.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16254027/","publication_id":"TFP19"},{"id":"TFBS038","pmid":"16254027","species":"Ovis aries","factor":"SP1","label":"GC-rich promoter element","evidence_kind":"functional_region","methods":"Promoter mutation / reporter assays","finding":"SP1 elements support basal and estrogen-mediated promoter activity.","reported_position":"-64 in the paper’s promoter numbering","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Ovine evidence; estrogen-mediated action at these elements is not a human ERE site.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/16254027/","publication_id":"TFP19"},{"id":"TFBS039","pmid":"9048622","species":"Rattus norvegicus","factor":"Estrogen receptor","label":"Upstream palindromic ERE","evidence_kind":"functional_region","methods":"EMSA / mutation / reporter assays","finding":"An upstream ERE supports estrogen-responsive transcription.","reported_position":"Approximately 4 kb upstream of translation start (ATG)","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Translation-start anchor, not TSS; approximate position only.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/9048622/","publication_id":"TFP20"},{"id":"TFBS040","pmid":"12604656","species":"Bos taurus","factor":"IRF1; IRF2","label":"Interferon-response element","evidence_kind":"functional_region","methods":"EMSA / reporter assays","finding":"An upstream element binds IRF1 and IRF2.","reported_position":"Approximately −2400 from TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"One shared bovine element, not two independent sites.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/12604656/","publication_id":"TFP21"},{"id":"TFBS041","pmid":"19439725","species":"Oryctolagus cuniculus","factor":"CREB","label":"cAMP-responsive region","evidence_kind":"occupancy_region","methods":"DNase hypersensitivity / ChIP / reporter assays","finding":"A CREB-associated region participates in the amnion cAMP response.","reported_position":"A 200-bp region approximately 4.7 kb upstream of TSS","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"Broad region in rabbit amnion; exact motif endpoints were not recovered.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/19439725/","publication_id":"TFP22"},{"id":"TFBS042","pmid":"27108164","species":"Homo sapiens","factor":"ESR1; SP1","label":"Methylation-associated motif annotations","evidence_kind":"candidate_region","methods":"Motif prediction / published genomic tracks","finding":"The paper relates methylation measurements to candidate regulatory motifs.","reported_position":"hg19 CpGs chr3:8810078 and chr3:8810069","reported_sequence":null,"reported_count":null,"genome_build":null,"chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Original report; genomic mapping unresolved","limitation":"These coordinates are CpG anchors, not motif coordinates. No new binding-site count is inferred.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/27108164/","publication_id":"TFP23"},{"id":"TFBS043","pmid":"37479681","species":"Homo sapiens","factor":"EGR1","label":"OREG1492306","evidence_kind":"annotated_region","methods":"Published annotation / methylation study","finding":"The paper references an EGR1-associated ORegAnno region.","reported_position":"GRCh38 chr3:8767502–8768543 (BED)","reported_sequence":null,"reported_count":null,"genome_build":"GRCh38","chromosome":"chr3","start_0based":8767502,"end_exclusive":8768543,"motif_strand":null,"reference_transcript":null,"coordinate_status":"ORegAnno interval recovered; regional annotation","limitation":"Annotation reused by the paper, not a new EGR1 binding experiment.","related_evidence":"OREG1492306","source_url":"https://pubmed.ncbi.nlm.nih.gov/37479681/","publication_id":"TFP24"},{"id":"TFBS044","pmid":"38831039","species":"Homo sapiens","factor":"43 assayed protein targets","label":"BrainTF human brain occupancy","evidence_kind":"occupancy_region","methods":"Human postmortem brain ChIP-seq; review of author replication tests, FRiP and HOT-region annotations.","finding":"126 screened protein-occupancy observations overlap the OXTR window, representing 43 targets across 13 contexts. 114 overlap the defined proximal promoter.","reported_position":"Individual GRCh38 peak intervals are in study-additions-v1/braintf-peaks.json.","reported_sequence":null,"reported_count":null,"genome_build":"GRCh38","chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Individual regional observations retained separately; no single precise binding-site coordinate assigned","limitation":"Peak observations across assay contexts, not unique sites or independent donors. The experiments share four postmortem donors across regions. Repeated contexts do not establish population replication. Assayed targets include chromatin-associated proteins and cofactors as well as transcription factors. ChIP-seq measures regional occupancy; it does not locate a contact nucleotide.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/38831039/","publication_id":"TFP25"},{"id":"TFBS045","pmid":"39957428","species":"Homo sapiens","factor":"Factor not resolved","label":"OCE7 enhancer reporter evidence","evidence_kind":"functional_region","methods":"Human candidate enhancer DNA in mouse hypothalamic-cell luciferase assays and mouse reporter experiments.","finding":"OCE1, OCE5 and OCE7 enhanced reporter activity in mouse hypothalamic cells. The tested DNA was human. OCE7 also drove reporter activity in mouse olfactory bulb at P28 and P56; adult hypothalamic activity was not detected.","reported_position":"OCE7 reported hg38 chr3:8757366–8759184; candidate interval and tested construct boundaries retained separately.","reported_sequence":null,"reported_count":null,"genome_build":"GRCh38","chromosome":null,"start_0based":null,"end_exclusive":null,"motif_strand":null,"reference_transcript":null,"coordinate_status":"Individual regional observations retained separately; no single precise binding-site coordinate assigned","limitation":"Reporter activity does not establish a named transcription-factor binding site or causal regulation of native human OXTR. The reported OCE7 candidate interval and the Table 1 luciferase-primer span differ. Reported intervals and primer matches are retained separately, without a precise binding-site overlay.","related_evidence":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/39957428/","publication_id":"TFP26"}]