Dynamic Methylation Changes in Alzheimer’s Disease-Related Genes During Mindfulness Practice – a Proof-of-Concept Study
Mindfulness · 2026 · Nonrandomized controlled pre/post study
Recorded summary
In 17 long-term meditators and 17 matched controls, researchers examined methylation at 19 CpG sites across seven genes. A month-long retreat was associated with changes at selected sites, including ABCA7 and HOXA3; some ADAM10 differences separated meditators from controls.
Recorded limitations
A small, nonrandomized blood-methylation study. It did not measure brain RNA or establish prevention or treatment of Alzheimer’s disease. Baseline average ADAM10 methylation did not remain significant after multiple-testing correction.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Nonrandomized controlled pre/post study
- assessment
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- One-month Vipassana retreat in long-term practitioners
- comparator
- Matched non-meditating controls
- sample
- 17 meditators and 17 controls
- measurement
- Peripheral blood leukocyte DNA; targeted CpG methylation
- timing
- Before and after one month
- evidence Type
- DNA methylation
- measured Genes
ABCA7 · ADAM10 · APOE · HOXA3 · NXN · TREM2 · TREML2
- pathways
- None recorded
- source URLs
https://link.springer.com/article/10.1007/s12671-026-02877-9
- checked At
- 2026-10-23
- review Scope
- Full-text methods and results; Jadad applicability pending
Topics and recorded topic scores
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
Citation snapshot and identifiers
- id
- doi-10.1007-s12671-026-02877-9
- doi
- 10.1007/s12671-026-02877-9
- pmid
- Not recorded
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12671-026-02877-9
- citations By Collection
- language
- 0
Complete approved library record
- id
- doi-10.1007-s12671-026-02877-9
- aliases
- None recorded
- title
- Dynamic Methylation Changes in Alzheimer’s Disease-Related Genes During Mindfulness Practice – a Proof-of-Concept Study
- journal
- Mindfulness
- neurotransmitters
- None recorded
- year
- 2026
- authors
- design
- Nonrandomized controlled pre/post study
- identity Conflict
- Not recorded
- doi
- 10.1007/s12671-026-02877-9
- urls
https://link.springer.com/article/10.1007/s12671-026-02877-9
- collections
language
- categories
Epigenetics
- targets
ABCA7 · ADAM10 · APOE · HOXA3 · NXN · TREM2 · TREML2
- priority
- 0
- quotes
- None recorded
- summary
- In 17 long-term meditators and 17 matched controls, researchers examined methylation at 19 CpG sites across seven genes. A month-long retreat was associated with changes at selected sites, including ABCA7 and HOXA3; some ADAM10 differences separated meditators from controls.
- limitation
- A small, nonrandomized blood-methylation study. It did not measure brain RNA or establish prevention or treatment of Alzheimer’s disease. Baseline average ADAM10 methylation did not remain significant after multiple-testing correction.
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12671-026-02877-9
- study Design Assessment
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 0
- topics
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
- journal Key
- mindfulness
- journal Label
- Mindfulness
- chapter Entries
- id
- language-mindfulness-epigenetics-doi-10.1007-s12671-026-02877-9
- record Id
- doi-10.1007-s12671-026-02877-9
- title
- Dynamic Methylation Changes in Alzheimer’s Disease-Related Genes During Mindfulness Practice – a Proof-of-Concept Study
- journal
- Mindfulness
- year
- 2026
- authors
- design
- Nonrandomized controlled pre/post study
- urls
https://link.springer.com/article/10.1007/s12671-026-02877-9
- quotes
- None recorded
- summary
- In 17 long-term meditators and 17 matched controls, researchers examined methylation at 19 CpG sites across seven genes. A month-long retreat was associated with changes at selected sites, including ABCA7 and HOXA3; some ADAM10 differences separated meditators from controls.
- limitation
- A small, nonrandomized blood-methylation study. It did not measure brain RNA or establish prevention or treatment of Alzheimer’s disease. Baseline average ADAM10 methylation did not remain significant after multiple-testing correction.
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12671-026-02877-9
- study Design Assessment
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- source Pages
- None recorded
- targets
ABCA7 · ADAM10 · APOE · HOXA3 · NXN · TREM2 · TREML2
- categories
Epigenetics
- doi
- 10.1007/s12671-026-02877-9
- pmid
- Not recorded
- evidence
- intervention
- One-month Vipassana retreat in long-term practitioners
- comparator
- Matched non-meditating controls
- sample
- 17 meditators and 17 controls
- measurement
- Peripheral blood leukocyte DNA; targeted CpG methylation
- timing
- Before and after one month
- evidence Type
- DNA methylation
- measured Genes
ABCA7 · ADAM10 · APOE · HOXA3 · NXN · TREM2 · TREML2
- pathways
- None recorded
- source URLs
https://link.springer.com/article/10.1007/s12671-026-02877-9
- checked At
- 2026-10-23
- review Scope
- Full-text methods and results; Jadad applicability pending
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experienced meditators and matched controls were compared without random allocation.
- sources
https://link.springer.com/article/10.1007/s12671-026-02877-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-epigenetics
- topic Title
- Mindfulness, DNA methylation and genetic variation
- trust Score
- 1
- evidence
- intervention
- One-month Vipassana retreat in long-term practitioners
- comparator
- Matched non-meditating controls
- sample
- 17 meditators and 17 controls
- measurement
- Peripheral blood leukocyte DNA; targeted CpG methylation
- timing
- Before and after one month
- evidence Type
- DNA methylation
- measured Genes
ABCA7 · ADAM10 · APOE · HOXA3 · NXN · TREM2 · TREML2
- pathways
- None recorded
- source URLs
https://link.springer.com/article/10.1007/s12671-026-02877-9
- checked At
- 2026-10-23
- review Scope
- Full-text methods and results; Jadad applicability pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- dementia
- evidence
- field
- title
- text
- Dynamic Methylation Changes in Alzheimer’s Disease-Related Genes During Mindfulness Practice – a Proof-of-Concept Study
- matched Text
- Alzheimer
- conditions
dementia
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false