Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
Rosana Carvalho Silva; Vincenzo Dattilo; Giulia Perusi; Monica Mazzelli; Elisabetta Maffioletti; Roberta Bazzanella; Marco Bortolomasi; Annamaria Cattaneo; Massimo Gennarelli; Alessandra Minelli · Journal of EMDR Practice and Research · 2023 · Longitudinal gene-expression study
Recorded summary
In 21 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, whole-blood NR3C1, FKBP5 and SGK1 expression varied over time. FKBP5 and SGK1 fell significantly at eight weeks; transcript levels rebounded during follow-up.
Recorded limitations
EMDR and CBT participants were analysed together, alongside medication. The 2021 microRNA paper uses the same underlying cohort; this is not an independent replication or evidence of an isolated eye-movement effect.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal gene-expression study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Direct RNA expression
- intervention
- 24 sessions of EMDR or trauma-focused CBT alongside usual medication
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood mRNA using RT-qPCR
- timing
- Baseline, weeks 4, 8 and 12
- measured Genes
NR3C1 · FKBP5 · SGK1
- trial Id
- Brescia-TRD-21
- relationship Note
- Combined therapy cohort; no untreated molecular comparator.
Topics and recorded topic scores
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
Citation snapshot and identifiers
- id
- doi-14a5c17359f1dfcb
- doi
- 10.1891/emdr-2023-0019
- pmid
- Not recorded
- citation Snapshot
- count
- 4
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 4
Complete approved library record
- id
- doi-14a5c17359f1dfcb
- publication Key
- doi:10.1891/emdr-2023-0019
- aliases
- None recorded
- title
- Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
- journal
- Journal of EMDR Practice and Research
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Rosana Carvalho Silva; Vincenzo Dattilo; Giulia Perusi; Monica Mazzelli; Elisabetta Maffioletti; Roberta Bazzanella; Marco Bortolomasi; Annamaria Cattaneo; Massimo Gennarelli; Alessandra Minelli
- design
- Longitudinal gene-expression study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1891/emdr-2023-0019
- pmid
- Not recorded
- urls
https://doi.org/10.1891/emdr-2023-0019
- collections
vision
- categories
Genomics & gene expression
- targets
NR3C1 · FKBP5 · SGK1
- priority
- 0
- quotes
- None recorded
- summary
- In 21 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, whole-blood NR3C1, FKBP5 and SGK1 expression varied over time. FKBP5 and SGK1 fell significantly at eight weeks; transcript levels rebounded during follow-up.
- limitation
- EMDR and CBT participants were analysed together, alongside medication. The 2021 microRNA paper uses the same underlying cohort; this is not an independent replication or evidence of an isolated eye-movement effect.
- citation Count
- 4
- citation Snapshot
- count
- 4
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 4
- topics
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
- journal Key
- journalofemdrpracticeandresearch
- journal Label
- Journal of EMDR Practice and Research
- chapter Entries
- title
- Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
- journal
- Journal of EMDR Practice and Research
- year
- 2023
- authors
- Rosana Carvalho Silva; Vincenzo Dattilo; Giulia Perusi; Monica Mazzelli; Elisabetta Maffioletti; Roberta Bazzanella; Marco Bortolomasi; Annamaria Cattaneo; Massimo Gennarelli; Alessandra Minelli
- design
- Longitudinal gene-expression study
- urls
https://doi.org/10.1891/emdr-2023-0019
- doi
- 10.1891/emdr-2023-0019
- pmid
- Not recorded
- targets
NR3C1 · FKBP5 · SGK1
- categories
Genomics & gene expression
- citation Count
- 4
- citation Snapshot
- count
- 4
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Direct RNA expression
- intervention
- 24 sessions of EMDR or trauma-focused CBT alongside usual medication
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood mRNA using RT-qPCR
- timing
- Baseline, weeks 4, 8 and 12
- measured Genes
NR3C1 · FKBP5 · SGK1
- trial Id
- Brescia-TRD-21
- relationship Note
- Combined therapy cohort; no untreated molecular comparator.
- record Id
- doi-14a5c17359f1dfcb
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 21 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, whole-blood NR3C1, FKBP5 and SGK1 expression varied over time. FKBP5 and SGK1 fell significantly at eight weeks; transcript levels rebounded during follow-up.
- limitation
- EMDR and CBT participants were analysed together, alongside medication. The 2021 microRNA paper uses the same underlying cohort; this is not an independent replication or evidence of an isolated eye-movement effect.
- id
- vision-rna-doi-14a5c17359f1dfcb
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Longitudinal observational molecular analysis of a combined EMDR/TF-CBT cohort. No randomized masked molecular comparison.
- sources
https://spj.science.org/doi/10.1891/EMDR-2023-0019
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1891/emdr-2023-0019
- collection
- vision
- chapter Number
- 4
- topic Id
- rna
- topic Title
- EMDR and trauma-focused psychotherapy: gene expression
- trust Score
- Not recorded
- evidence
- evidence Type
- Direct RNA expression
- intervention
- 24 sessions of EMDR or trauma-focused CBT alongside usual medication
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood mRNA using RT-qPCR
- timing
- Baseline, weeks 4, 8 and 12
- measured Genes
NR3C1 · FKBP5 · SGK1
- trial Id
- Brescia-TRD-21
- relationship Note
- Combined therapy cohort; no untreated molecular comparator.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- trauma
- evidence
- field
- title
- text
- Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
- matched Text
- Trauma
- id
- depression
- evidence
- field
- title
- text
- Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
- matched Text
- Depression
- id
- stress
- evidence
- field
- title
- text
- Transcriptional Modulation of Stress-Related Genes in Association with Early Life Stress Exposure and Trauma-Focused Psychotherapy in Treatment-Resistant Depression Patients
- matched Text
- Stress
- conditions
trauma · depression · stress
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false