Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
Meffert SM; Neylan TC; McCulloch CE; Blum K; Cohen CR; Bukusi EA; Verdeli H; Markowitz JC; Kahn JG; Bukusi D; Thirumurthy H; Rota G; Rota R; Oketch G; Opiyo E; Ongeri L · PLoS medicine · 2021 · Randomized controlled trial
Original publication · Original publication · Original publication · Original publication · Original publication
Recorded summary
At three months, IPT reduced odds of major depression and PTSD in the mixed-GBV cohort. Partnered-subgroup IPV findings were exploratory and vulnerable to attrition/relationship-status changes.
Recorded limitations
Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- rct
- is Randomized Controlled Trial
- true
- basis
- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- review Scope
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- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- review Scope
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- rating Scale
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- jadad
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- score
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- evidence
- evidence Type
- Randomized controlled trial
- intervention
- Interpersonal psychotherapy integrated with HIV care. Twelve weekly individual sessions of approximately one hour.
- comparator
- Waitlist plus usual clinic/social resources; waitlist received IPT after the three-month comparison.
- sample
- 256 randomized and included in longitudinal models; partnered baseline subgroup105 (56 IPT,49 control), with changing denominators later.
- measurement
- Major depression diagnosis; PTSD diagnosis; Physical IPV among partnered participants; Absenteeism
- timing
- Three months
- trial Id
- NCT02320799
- relationship Note
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable. See population and limitations; not a population-wide recommendation.
- measured Genes
- None recorded
- pathways
- None recorded
- source Access
- level
- full-text
- source URLs
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- retrieved At
- 2026-10-30T08:03:45.801817+00:00
- outcomes
- name
- Major depression diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .26;95% CI .11–.60; p=.002
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- PTSD diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .35;95% CI .14–.86; p=.02
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- Physical IPV among partnered participants
- follow Up
- Three months
- result
- Exploratory reduction; changing partnership and differential attrition limit interpretation.
- effect Estimate
- Not recorded
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Secondary, not powered
- name
- Absenteeism
- follow Up
- Three months
- result
- No statistically significant comparative improvement.
- effect Estimate
- Difference -3.35 days;95% CI -6.83–.14; p=.06
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Secondary
- quality
- risk Of Bias
- Provisional assessment; allocation, masking and missingness limitations explicitly retained.
- attrition
- At three months, 34/123 IPT versus16/133 control lost; overall90/256 did not complete all assessments. Completer primary data were also missing for13 IPT and1 control.
- confounding
- Random assignment supports group comparison; implementation, missingness and analysis remain relevant.
- adverse Findings
- Acute suicidality/GBV danger was screened and referred with escorted transport; systematic adverse-event totals not established.
- transfer Limits
- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- jadad
- not established
- masking Roles
- participants
- Not established from accessed source.
- providers
- Therapists and coordinator not masked.
- assessors
- Baseline and follow-up evaluators masked.
- analysts
- Not established from accessed source.
- population
- relation
- context
- population
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- exposure Evidence
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- rationale
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable.
- transfer Limit
- See population and limitations; not a population-wide recommendation.
Topics and recorded topic scores
- key
- language:domestic-family-violence
- title
- Domestic & Family Violence
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- dv-adult-therapy-33428625
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- count
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- Not recorded
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- language
- Not recorded
Complete approved library record
- publication Approval
- status
- approved-for-publication
- approved By
- Ben Korbel
- approved At
- 2026-11-01
- assessment
- AI assessed; human approved for publication
- scope
- Qualified research-library summaries. No professional clinical peer review or treatment recommendation is claimed.
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- 7ee0d1141e4378dc9e52b7e89863a001bd1a30574844469b38267997689e9e22
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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- claim Check
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- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- applied Proposals
- None recorded
- method
- AI editorial assessment of all 130 publication records: compare identity, headline finding, design, relevance and limitations with indexed abstracts or available primary material; adjudicate retained source-supported methods amendments. This is a source-limited publication audit, not an independent full-text systematic review or a clinical guideline.
- limitations
Abstract-only records do not establish allocation concealment, complete harms reporting or full risk of bias. · No formal independent RoB 2, GRADE appraisal or numerical reconstruction of every effect was performed. · Source-access labels describe retained appraisal evidence; fuller prior appraisals were checked through their source ledgers and selected material, not independently repeated in full. · Publication counts are not independent trial or participant counts; cohort links and overlapping review evidence remain provisional. · A randomized design cross does not indicate benefit, low risk of bias or human approval. No double-blind trial is verified in this release. · No professional clinical peer review is claimed. Recommended content is limited to accurately qualified research summaries.
- study Family Id
- NCT02320799
- family Linkage Uncertain
- false
- approaches
- None recorded
- id
- dv-adult-therapy-33428625
- aliases
- None recorded
- title
- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
- journal
- PLoS medicine
- neurotransmitters
- None recorded
- year
- 2021
- authors
- Meffert SM; Neylan TC; McCulloch CE; Blum K; Cohen CR; Bukusi EA; Verdeli H; Markowitz JC; Kahn JG; Bukusi D; Thirumurthy H; Rota G; Rota R; Oketch G; Opiyo E; Ongeri L
- design
- Randomized controlled trial
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1371/journal.pmed.1003468
- pmid
- 33428625
- urls
https://doi.org/10.1371/journal.pmed.1003468 · https://pubmed.ncbi.nlm.nih.gov/33428625/ · https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- At three months, IPT reduced odds of major depression and PTSD in the mixed-GBV cohort. Partnered-subgroup IPV findings were exploratory and vulnerable to attrition/relationship-status changes.
- limitation
- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- citation Count
- Not recorded
- citation Snapshot
- count
- Not recorded
- source
- Not recorded
- retrieved At
- Not recorded
- status
- not-assessed
- study Design Assessment
- category
- rct
- is Randomized Controlled Trial
- true
- basis
- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- review Scope
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- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- review Scope
- full-text
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- providers
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- assessors
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- rating Scale
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- citations By Collection
- language
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- topics
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- language:domestic-family-violence
- title
- Domestic & Family Violence
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- 2
- journal Key
- plosmedicine
- journal Label
- PLoS medicine
- chapter Entries
- id
- language-dv-dv-adult-therapy-33428625
- aliases
- None recorded
- title
- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
- authors
- Meffert SM; Neylan TC; McCulloch CE; Blum K; Cohen CR; Bukusi EA; Verdeli H; Markowitz JC; Kahn JG; Bukusi D; Thirumurthy H; Rota G; Rota R; Oketch G; Opiyo E; Ongeri L
- year
- 2021
- journal
- PLoS medicine
- doi
- 10.1371/journal.pmed.1003468
- pmid
- 33428625
- urls
https://doi.org/10.1371/journal.pmed.1003468 · https://pubmed.ncbi.nlm.nih.gov/33428625/ · https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- collections
language
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Clinical & self-report
- targets
- None recorded
- neurotransmitters
- None recorded
- conditions
ptsd · trauma · depression
- condition Evidence
- id
- ptsd
- evidence
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- title
- text
- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
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- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
- matched Text
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- scope
- Study population or investigated outcome; not a diagnosis or efficacy claim.
- id
- depression
- evidence
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- text
- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
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- text
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- matched Text
- depression
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- text
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- matched Text
- depression
- scope
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- age Groups
adults
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- record Id
- dv-adult-therapy-33428625
- collections
language
- groups
adults
- reported Ages
- Eligibility at least 18; mean age about 37 years.
- youth Scope
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- youth Source Note
- Not recorded
- source URL
- https://europepmc.org/article/MED/33428625
- basis Type
- source-limited-ai-editorial-assessment
- classification Note
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- community Matches
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- domestic-violence
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- Journal article
- design
- Randomized controlled trial
- origin
- approved-dv-20261101
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- quotes
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- finding
- At three months, IPT reduced odds of major depression and PTSD in the mixed-GBV cohort. Partnered-subgroup IPV findings were exploratory and vulnerable to attrition/relationship-status changes.
- summary
- At three months, IPT reduced odds of major depression and PTSD in the mixed-GBV cohort. Partnered-subgroup IPV findings were exploratory and vulnerable to attrition/relationship-status changes.
- limitation
- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- evidence
- evidence Type
- Randomized controlled trial
- intervention
- Interpersonal psychotherapy integrated with HIV care. Twelve weekly individual sessions of approximately one hour.
- comparator
- Waitlist plus usual clinic/social resources; waitlist received IPT after the three-month comparison.
- sample
- 256 randomized and included in longitudinal models; partnered baseline subgroup105 (56 IPT,49 control), with changing denominators later.
- measurement
- Major depression diagnosis; PTSD diagnosis; Physical IPV among partnered participants; Absenteeism
- timing
- Three months
- trial Id
- NCT02320799
- relationship Note
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable. See population and limitations; not a population-wide recommendation.
- measured Genes
- None recorded
- pathways
- None recorded
- source Access
- level
- full-text
- source URLs
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- retrieved At
- 2026-10-30T08:03:45.801817+00:00
- outcomes
- name
- Major depression diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .26;95% CI .11–.60; p=.002
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- PTSD diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .35;95% CI .14–.86; p=.02
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- Physical IPV among partnered participants
- follow Up
- Three months
- result
- Exploratory reduction; changing partnership and differential attrition limit interpretation.
- effect Estimate
- Not recorded
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Secondary, not powered
- name
- Absenteeism
- follow Up
- Three months
- result
- No statistically significant comparative improvement.
- effect Estimate
- Difference -3.35 days;95% CI -6.83–.14; p=.06
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Secondary
- quality
- risk Of Bias
- Provisional assessment; allocation, masking and missingness limitations explicitly retained.
- attrition
- At three months, 34/123 IPT versus16/133 control lost; overall90/256 did not complete all assessments. Completer primary data were also missing for13 IPT and1 control.
- confounding
- Random assignment supports group comparison; implementation, missingness and analysis remain relevant.
- adverse Findings
- Acute suicidality/GBV danger was screened and referred with escorted transport; systematic adverse-event totals not established.
- transfer Limits
- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- jadad
- not established
- masking Roles
- participants
- Not established from accessed source.
- providers
- Therapists and coordinator not masked.
- assessors
- Baseline and follow-up evaluators masked.
- analysts
- Not established from accessed source.
- population
- relation
- context
- population
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- exposure Evidence
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- rationale
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable.
- transfer Limit
- See population and limitations; not a population-wide recommendation.
- study Design Assessment
- category
- rct
- is Randomized Controlled Trial
- true
- basis
- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- review Scope
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- Paper
- status
- assessed
- score
- 2
- randomized Controlled Trial
- true
- peer Reviewed
- true
- blinding
- not-confirmed
- basis
- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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- status
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- Ben Korbel
- approved At
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- assessment
- AI assessed; human approved for publication
- scope
- Qualified research-library summaries. No professional clinical peer review or treatment recommendation is claimed.
- source Revision
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- retrieved At
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- study Family Id
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- source Pages
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- editorial Audit
- auditor
- Codex (AI)
- completed At
- 2026-10-31T05:11:05.655793+00:00
- prior Content Hash
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- continuation-10
- source Verification
- id
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- claim Check
- Headline finding/design/limitations compared with indexed abstract or accessible primary evidence; retained methods amendments separately adjudicated.
- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- applied Proposals
- None recorded
- method
- AI editorial assessment of all 130 publication records: compare identity, headline finding, design, relevance and limitations with indexed abstracts or available primary material; adjudicate retained source-supported methods amendments. This is a source-limited publication audit, not an independent full-text systematic review or a clinical guideline.
- limitations
Abstract-only records do not establish allocation concealment, complete harms reporting or full risk of bias. · No formal independent RoB 2, GRADE appraisal or numerical reconstruction of every effect was performed. · Source-access labels describe retained appraisal evidence; fuller prior appraisals were checked through their source ledgers and selected material, not independently repeated in full. · Publication counts are not independent trial or participant counts; cohort links and overlapping review evidence remain provisional. · A randomized design cross does not indicate benefit, low risk of bias or human approval. No double-blind trial is verified in this release. · No professional clinical peer review is claimed. Recommended content is limited to accurately qualified research summaries.
- assessment Record
- id
- dv-adult-therapy-33428625
- title
- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
- authors
Meffert SM · Neylan TC · McCulloch CE · Blum K · Cohen CR · Bukusi EA · Verdeli H · Markowitz JC · Kahn JG · Bukusi D · Thirumurthy H · Rota G · Rota R · Oketch G · Opiyo E · Ongeri L
- year
- 2021
- journal
- PLoS medicine
- doi
- 10.1371/journal.pmed.1003468
- pmid
- 33428625
- trial Registration
NCT02320799
- collection
- language
- intervention Family
- Interpersonal psychotherapy integrated with HIV care.
- publication Type
- Primary intervention study
- study Family Id
- NCT02320799
- family Linkage Uncertain
- false
- existing Repository Matches
- None recorded
- relevance
- relation
- context
- population
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- exposure Evidence
- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- rationale
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable.
- transfer Limit
- See population and limitations; not a population-wide recommendation.
- age
- groups
adults
- reported Range
- Eligibility at least 18; mean age about 37 years.
- youth Scope
- Not recorded
- country
- Kenya
- setting
- FACES HIV clinic, Kisumu.
- sample Size
- randomized
- 256
- analyzed
- 256
- description
- 256 randomized and included in longitudinal models; partnered baseline subgroup105 (56 IPT,49 control), with changing denominators later.
- intervention
- description
- Interpersonal psychotherapy integrated with HIV care.
- dose
- Twelve weekly individual sessions of approximately one hour.
- provider
- Trained local female nonspecialists, with expert and peer supervision.
- comparator
- Waitlist plus usual clinic/social resources; waitlist received IPT after the three-month comparison.
- outcomes
- name
- Major depression diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .26;95% CI .11–.60; p=.002
- uncertainty
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- Provisional assessment; allocation, masking and missingness limitations explicitly retained.
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- Random assignment supports group comparison; implementation, missingness and analysis remain relevant.
- adverse Findings
- Acute suicidality/GBV danger was screened and referred with escorted transport; systematic adverse-event totals not established.
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- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- jadad
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article · Research Support, N.I.H., Extramural
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Original schema completed using primary source or explicit access limit. Frozen first-batch files were not changed. · Table1 denominator clarification:61% past-week physical IPV concerns the partnered subgroup, not all256 women. Mental-health effects refer to the full mixed-GBV cohort. Unclear IPV model units and textual risk ratios are not reproduced. · Newly screened in continuation; bibliographic source had previously been retrieved but left in the unscreened queue.
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- sources
https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- applied Proposals
- None recorded
- method
- AI editorial assessment of all 130 publication records: compare identity, headline finding, design, relevance and limitations with indexed abstracts or available primary material; adjudicate retained source-supported methods amendments. This is a source-limited publication audit, not an independent full-text systematic review or a clinical guideline.
- limitations
Abstract-only records do not establish allocation concealment, complete harms reporting or full risk of bias. · No formal independent RoB 2, GRADE appraisal or numerical reconstruction of every effect was performed. · Source-access labels describe retained appraisal evidence; fuller prior appraisals were checked through their source ledgers and selected material, not independently repeated in full. · Publication counts are not independent trial or participant counts; cohort links and overlapping review evidence remain provisional. · A randomized design cross does not indicate benefit, low risk of bias or human approval. No double-blind trial is verified in this release. · No professional clinical peer review is claimed. Recommended content is limited to accurately qualified research summaries.
- study Design Assessment
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- Excel-generated random color sequence in blocks of ten; coordinator assigned next color after baseline, with the next allocation visible.
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
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- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
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- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable.
- transfer Limit
- See population and limitations; not a population-wide recommendation.
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- Interpersonal psychotherapy integrated with HIV care.
- dose
- Twelve weekly individual sessions of approximately one hour.
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- Trained local female nonspecialists, with expert and peer supervision.
- comparator
- Waitlist plus usual clinic/social resources; waitlist received IPT after the three-month comparison.
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- Major depression diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .26;95% CI .11–.60; p=.002
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
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- follow Up
- Three months
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- Lower odds with IPT plus usual care.
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- OR .35;95% CI .14–.86; p=.02
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- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
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- Physical IPV among partnered participants
- follow Up
- Three months
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- effect Estimate
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- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
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- name
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- follow Up
- Three months
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- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
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- Randomized controlled trial
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- Major depression diagnosis; PTSD diagnosis; Physical IPV among partnered participants; Absenteeism
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- NCT02320799
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- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable. See population and limitations; not a population-wide recommendation.
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https://europepmc.org/article/MED/33428625 · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7799784/fullTextXML · https://api.crossref.org/works/10.1371/journal.pmed.1003468
- retrieved At
- 2026-10-30T08:03:45.801817+00:00
- outcomes
- name
- Major depression diagnosis
- follow Up
- Three months
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- Lower odds with IPT plus usual care.
- effect Estimate
- OR .26;95% CI .11–.60; p=.002
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- PTSD diagnosis
- follow Up
- Three months
- result
- Lower odds with IPT plus usual care.
- effect Estimate
- OR .35;95% CI .14–.86; p=.02
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
- Primary
- name
- Physical IPV among partnered participants
- follow Up
- Three months
- result
- Exploratory reduction; changing partnership and differential attrition limit interpretation.
- effect Estimate
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- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
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- name
- Absenteeism
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- Three months
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- No statistically significant comparative improvement.
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- Difference -3.35 days;95% CI -6.83–.14; p=.06
- uncertainty
- Confidence intervals provided when source establishes them; otherwise unresolved.
- primary Status
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- Provisional assessment; allocation, masking and missingness limitations explicitly retained.
- attrition
- At three months, 34/123 IPT versus16/133 control lost; overall90/256 did not complete all assessments. Completer primary data were also missing for13 IPT and1 control.
- confounding
- Random assignment supports group comparison; implementation, missingness and analysis remain relevant.
- adverse Findings
- Acute suicidality/GBV danger was screened and referred with escorted transport; systematic adverse-event totals not established.
- transfer Limits
- Sequence visible to coordinator; differential attrition and mixed GBV exposure. Later follow-up lacks an untreated comparison and cannot establish persistent comparative benefit.
- jadad
- not established
- masking Roles
- participants
- Not established from accessed source.
- providers
- Therapists and coordinator not masked.
- assessors
- Baseline and follow-up evaluators masked.
- analysts
- Not established from accessed source.
- population
- relation
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- HIV-positive women with gender-based violence exposure, major depression and PTSD; IPV was assessed in the partnered subgroup.
- exposure Evidence
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- rationale
- Psychological intervention with explicitly reported domestic/IPV exposure; mixed-cohort transfer is qualified where applicable.
- transfer Limit
- See population and limitations; not a population-wide recommendation.
- jadad
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- condition Evidence
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- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
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- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
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- Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomized controlled trial.
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- Major depression diagnosis | PTSD diagnosis | Physical IPV among partnered participants | Absenteeism
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ptsd · trauma · depression
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