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Cytokinin signalling inhibitory fields provide robustness to phyllotaxis

Fabrice Besnard; Yassin Refahi; Valérie Morin; Benjamin Marteaux; Géraldine Brunoud; Pierre Chambrier; Frédérique Rozier; Vincent Mirabet; Jonathan Legrand; Stéphanie Lainé; Emmanuel Thévenon; Etienne Farcot; Coralie Cellier; Pradeep Das; Anthony Bishopp; Renaud Dumas; François Parcy; Ykä Helariutta; Arezki Boudaoud; Christophe Godin; Jan Traas; Yann Guédon; Teva Vernoux · Nature · 2014 · Plant developmental experiments and hormone-signalling model

Original publication · Original publication · Original publication

Recorded summary

The study identifies mobile AHP6-mediated inhibition of cytokinin signalling as a contributor to the timing and robustness of organ initiation, acting downstream of auxin in plant phyllotaxis.

Recorded limitations

The result concerns a specific plant developmental system. It is background on the robustness of phyllotactic patterns, with no test of a numerical rule in OXTR; appraisal here is abstract-level.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Plant developmental experiments and hormone-signalling model
assessment
is Randomized Controlled Trial
false
blinding
Not applicable to a clinical-trial grade
basis
Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
sources

https://www.nature.com/articles/nature12791

category
peer-reviewed
peer Reviewed
true
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
sources

https://pubmed.ncbi.nlm.nih.gov/24336201/ · https://www.nature.com/articles/nature12791

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
not-applicable
score
Not recorded
reason
Not a human randomized controlled trial.
evidence
evidence Type
Plant developmental experiments and hormone-signalling model
evidence Class
biological_experiment
measurement
Plant shoot apical meristems; AHP6 and cytokinin signalling
measured Genes

AHP6 (plant cytokinin-signalling inhibitor)

pathways
None recorded
relationship Note
Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
clinical Evidence
false
review Depth
Abstract and selected source passages: Abstract; publisher metadata.
full Paper Appraisal
Not completed; review depth states the material assessed.
Topics and recorded topic scores
  1. key
    general:fibonacci-biological-patterns
    title
    Biological patterns and developmental mechanisms
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
nature-fibonacci-nature12791
doi
10.1038/nature12791
pmid
24336201
citation Snapshot
count
264
source
Crossref cited-by count
retrieved At
2026-10-24
url
https://api.crossref.org/works/10.1038/nature12791
field
is-referenced-by-count
source Indexed At
2026-10-09T01:08:11Z
coverage Note
Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
citations By Collection
general
264
Complete approved library record
id
nature-fibonacci-nature12791
aliases
None recorded
title
Cytokinin signalling inhibitory fields provide robustness to phyllotaxis
journal
Nature
publisher Family
nature
publisher Family Label
Nature Portfolio
neurotransmitters
None recorded
year
2014
authors
Fabrice Besnard; Yassin Refahi; Valérie Morin; Benjamin Marteaux; Géraldine Brunoud; Pierre Chambrier; Frédérique Rozier; Vincent Mirabet; Jonathan Legrand; Stéphanie Lainé; Emmanuel Thévenon; Etienne Farcot; Coralie Cellier; Pradeep Das; Anthony Bishopp; Renaud Dumas; François Parcy; Ykä Helariutta; Arezki Boudaoud; Christophe Godin; Jan Traas; Yann Guédon; Teva Vernoux
design
Plant developmental experiments and hormone-signalling model
kind
Journal article
identity Conflict
Not recorded
doi
10.1038/nature12791
pmid
24336201
urls

https://www.nature.com/articles/nature12791 · https://doi.org/10.1038/nature12791 · https://pubmed.ncbi.nlm.nih.gov/24336201/

collections

general

categories

Fibonacci mathematics · Biological pattern formation

targets
None recorded
priority
1
quotes
None recorded
summary
The study identifies mobile AHP6-mediated inhibition of cytokinin signalling as a contributor to the timing and robustness of organ initiation, acting downstream of auxin in plant phyllotaxis.
limitation
The result concerns a specific plant developmental system. It is background on the robustness of phyllotactic patterns, with no test of a numerical rule in OXTR; appraisal here is abstract-level.
citation Count
264
citation Snapshot
count
264
source
Crossref cited-by count
retrieved At
2026-10-24
url
https://api.crossref.org/works/10.1038/nature12791
field
is-referenced-by-count
source Indexed At
2026-10-09T01:08:11Z
coverage Note
Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
study Design Assessment
is Randomized Controlled Trial
false
blinding
Not applicable to a clinical-trial grade
basis
Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
sources

https://www.nature.com/articles/nature12791

category
peer-reviewed
peer Reviewed
true
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
sources

https://pubmed.ncbi.nlm.nih.gov/24336201/ · https://www.nature.com/articles/nature12791

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
general
264
topics
  1. key
    general:fibonacci-biological-patterns
    title
    Biological patterns and developmental mechanisms
    collection
    general
    trust Score
    1
journal Key
nature
journal Label
Nature
chapter Entries
  1. id
    general-nature-fibonacci-nature12791
    title
    Cytokinin signalling inhibitory fields provide robustness to phyllotaxis
    journal
    Nature
    year
    2014
    authors
    Fabrice Besnard; Yassin Refahi; Valérie Morin; Benjamin Marteaux; Géraldine Brunoud; Pierre Chambrier; Frédérique Rozier; Vincent Mirabet; Jonathan Legrand; Stéphanie Lainé; Emmanuel Thévenon; Etienne Farcot; Coralie Cellier; Pradeep Das; Anthony Bishopp; Renaud Dumas; François Parcy; Ykä Helariutta; Arezki Boudaoud; Christophe Godin; Jan Traas; Yann Guédon; Teva Vernoux
    doi
    10.1038/nature12791
    pmid
    24336201
    urls

    https://www.nature.com/articles/nature12791 · https://doi.org/10.1038/nature12791 · https://pubmed.ncbi.nlm.nih.gov/24336201/

    design
    Plant developmental experiments and hormone-signalling model
    summary
    The study identifies mobile AHP6-mediated inhibition of cytokinin signalling as a contributor to the timing and robustness of organ initiation, acting downstream of auxin in plant phyllotaxis.
    limitation
    The result concerns a specific plant developmental system. It is background on the robustness of phyllotactic patterns, with no test of a numerical rule in OXTR; appraisal here is abstract-level.
    citation Count
    264
    citation Snapshot
    count
    264
    source
    Crossref cited-by count
    retrieved At
    2026-10-24
    url
    https://api.crossref.org/works/10.1038/nature12791
    field
    is-referenced-by-count
    source Indexed At
    2026-10-09T01:08:11Z
    coverage Note
    Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
    categories

    Fibonacci mathematics · Biological pattern formation

    targets
    None recorded
    evidence
    evidence Type
    Plant developmental experiments and hormone-signalling model
    evidence Class
    biological_experiment
    measurement
    Plant shoot apical meristems; AHP6 and cytokinin signalling
    measured Genes

    AHP6 (plant cytokinin-signalling inhibitor)

    pathways
    None recorded
    relationship Note
    Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
    clinical Evidence
    false
    review Depth
    Abstract and selected source passages: Abstract; publisher metadata.
    full Paper Appraisal
    Not completed; review depth states the material assessed.
    record Id
    nature-fibonacci-nature12791
    quotes
    None recorded
    source Pages
    None recorded
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24336201/ · https://www.nature.com/articles/nature12791

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    is Randomized Controlled Trial
    false
    blinding
    Not applicable to a clinical-trial grade
    basis
    Plant developmental experiments and hormone-signalling model. No human randomized controlled trial is reported.
    sources

    https://www.nature.com/articles/nature12791

    category
    peer-reviewed
    peer Reviewed
    true
    collection
    general
    chapter Number
    9
    topic Id
    fibonacci-biological-patterns
    topic Title
    Biological patterns and developmental mechanisms
    trust Score
    1
evidence
evidence Type
Plant developmental experiments and hormone-signalling model
evidence Class
biological_experiment
measurement
Plant shoot apical meristems; AHP6 and cytokinin signalling
measured Genes

AHP6 (plant cytokinin-signalling inhibitor)

pathways
None recorded
relationship Note
Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
clinical Evidence
false
review Depth
Abstract and selected source passages: Abstract; publisher metadata.
full Paper Appraisal
Not completed; review depth states the material assessed.
jadad
status
not-applicable
score
Not recorded
reason
Not a human randomized controlled trial.
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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