Universal Informatics · Research reading room

Heat-rechargeable computation in DNA logic circuits and neural networks

Tianqi Song; Lulu Qian · Nature · 2025 · Engineered DNA-circuit experiments with simulations

Original publication · Original publication · Original publication

Recorded summary

Heat resets engineered DNA circuits for repeated computation. A feedforward logic circuit returns the first 16 Fibonacci-word elements from index inputs and maintains performance across 16 computation rounds with 15 resets.

Recorded limitations

The Fibonacci circuit uses a designed truth table and finite inputs. It does not autonomously generate an unbounded sequence or reveal a naturally occurring genomic computation.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Engineered DNA-circuit experiments with simulations
assessment
is Randomized Controlled Trial
false
blinding
Not applicable to a clinical-trial grade
basis
Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
sources

https://www.nature.com/articles/s41586-025-09570-2

category
peer-reviewed
peer Reviewed
true
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
sources

https://pubmed.ncbi.nlm.nih.gov/41034583/ · https://www.nature.com/articles/s41586-025-09570-2

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
not-applicable
score
Not recorded
reason
Not a human randomized controlled trial.
evidence
evidence Type
Engineered DNA-circuit experiments with simulations
evidence Class
engineered_biological_computation
measurement
Engineered DNA strands; fluorescence kinetics; 16 Fibonacci-word queries
measured Genes
None recorded
pathways
None recorded
relationship Note
Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
clinical Evidence
false
review Depth
Abstract and selected source passages: Abstract; Versatility; reset and fluorescence methods.
full Paper Appraisal
Not completed; review depth states the material assessed.
Topics and recorded topic scores
  1. key
    general:fibonacci-molecular-computation
    title
    Molecular enumeration and biological computation
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
nature-fibonacci-s41586-025-09570-2
doi
10.1038/s41586-025-09570-2
pmid
41034583
citation Snapshot
count
24
source
Crossref cited-by count
retrieved At
2026-10-24
url
https://api.crossref.org/works/10.1038/s41586-025-09570-2
field
is-referenced-by-count
source Indexed At
2026-10-21T00:35:53Z
coverage Note
Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
citations By Collection
general
24
Complete approved library record
id
nature-fibonacci-s41586-025-09570-2
aliases
None recorded
title
Heat-rechargeable computation in DNA logic circuits and neural networks
journal
Nature
publisher Family
nature
publisher Family Label
Nature Portfolio
neurotransmitters
None recorded
year
2025
authors
Tianqi Song; Lulu Qian
design
Engineered DNA-circuit experiments with simulations
kind
Journal article
identity Conflict
Not recorded
doi
10.1038/s41586-025-09570-2
pmid
41034583
urls

https://www.nature.com/articles/s41586-025-09570-2 · https://doi.org/10.1038/s41586-025-09570-2 · https://pubmed.ncbi.nlm.nih.gov/41034583/

collections

general

categories

Fibonacci mathematics · Molecular computation

targets
None recorded
priority
1
quotes
None recorded
summary
Heat resets engineered DNA circuits for repeated computation. A feedforward logic circuit returns the first 16 Fibonacci-word elements from index inputs and maintains performance across 16 computation rounds with 15 resets.
limitation
The Fibonacci circuit uses a designed truth table and finite inputs. It does not autonomously generate an unbounded sequence or reveal a naturally occurring genomic computation.
citation Count
24
citation Snapshot
count
24
source
Crossref cited-by count
retrieved At
2026-10-24
url
https://api.crossref.org/works/10.1038/s41586-025-09570-2
field
is-referenced-by-count
source Indexed At
2026-10-21T00:35:53Z
coverage Note
Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
study Design Assessment
is Randomized Controlled Trial
false
blinding
Not applicable to a clinical-trial grade
basis
Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
sources

https://www.nature.com/articles/s41586-025-09570-2

category
peer-reviewed
peer Reviewed
true
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
sources

https://pubmed.ncbi.nlm.nih.gov/41034583/ · https://www.nature.com/articles/s41586-025-09570-2

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
general
24
topics
  1. key
    general:fibonacci-molecular-computation
    title
    Molecular enumeration and biological computation
    collection
    general
    trust Score
    1
journal Key
nature
journal Label
Nature
chapter Entries
  1. id
    general-nature-fibonacci-s41586-025-09570-2
    title
    Heat-rechargeable computation in DNA logic circuits and neural networks
    journal
    Nature
    year
    2025
    authors
    Tianqi Song; Lulu Qian
    doi
    10.1038/s41586-025-09570-2
    pmid
    41034583
    urls

    https://www.nature.com/articles/s41586-025-09570-2 · https://doi.org/10.1038/s41586-025-09570-2 · https://pubmed.ncbi.nlm.nih.gov/41034583/

    design
    Engineered DNA-circuit experiments with simulations
    summary
    Heat resets engineered DNA circuits for repeated computation. A feedforward logic circuit returns the first 16 Fibonacci-word elements from index inputs and maintains performance across 16 computation rounds with 15 resets.
    limitation
    The Fibonacci circuit uses a designed truth table and finite inputs. It does not autonomously generate an unbounded sequence or reveal a naturally occurring genomic computation.
    citation Count
    24
    citation Snapshot
    count
    24
    source
    Crossref cited-by count
    retrieved At
    2026-10-24
    url
    https://api.crossref.org/works/10.1038/s41586-025-09570-2
    field
    is-referenced-by-count
    source Indexed At
    2026-10-21T00:35:53Z
    coverage Note
    Count reflects Crossref-deposited references and can differ from publisher or other database totals. It is not a quality or clinical-evidence score.
    categories

    Fibonacci mathematics · Molecular computation

    targets
    None recorded
    evidence
    evidence Type
    Engineered DNA-circuit experiments with simulations
    evidence Class
    engineered_biological_computation
    measurement
    Engineered DNA strands; fluorescence kinetics; 16 Fibonacci-word queries
    measured Genes
    None recorded
    pathways
    None recorded
    relationship Note
    Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
    clinical Evidence
    false
    review Depth
    Abstract and selected source passages: Abstract; Versatility; reset and fluorescence methods.
    full Paper Appraisal
    Not completed; review depth states the material assessed.
    record Id
    nature-fibonacci-s41586-025-09570-2
    quotes
    None recorded
    source Pages
    None recorded
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
    sources

    https://pubmed.ncbi.nlm.nih.gov/41034583/ · https://www.nature.com/articles/s41586-025-09570-2

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    is Randomized Controlled Trial
    false
    blinding
    Not applicable to a clinical-trial grade
    basis
    Engineered DNA-circuit experiments with simulations. No human randomized controlled trial is reported.
    sources

    https://www.nature.com/articles/s41586-025-09570-2

    category
    peer-reviewed
    peer Reviewed
    true
    collection
    general
    chapter Number
    9
    topic Id
    fibonacci-molecular-computation
    topic Title
    Molecular enumeration and biological computation
    trust Score
    1
evidence
evidence Type
Engineered DNA-circuit experiments with simulations
evidence Class
engineered_biological_computation
measurement
Engineered DNA strands; fluorescence kinetics; 16 Fibonacci-word queries
measured Genes
None recorded
pathways
None recorded
relationship Note
Background literature only. This paper does not test or validate an OXTR–Fibonacci relationship.
clinical Evidence
false
review Depth
Abstract and selected source passages: Abstract; Versatility; reset and fluorescence methods.
full Paper Appraisal
Not completed; review depth states the material assessed.
jadad
status
not-applicable
score
Not recorded
reason
Not a human randomized controlled trial.
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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