Universal Informatics · Research reading room

Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice

Michelini LC, Marcelo MC, Amico J, Morris M. · American journal of physiology. Heart and circulatory physiology · 2003

Original publication · Original publication

Attributed extracts from the research record

“OT's role in BP and baroreflex/autonomic balance. The data provide the first experimental evidence for a role of endogenous OT in the maintenance of tonic BP”
“Alterations in baroreflex function were noted in mice lacking OT”
“There is much evidence to show that brain peptides regulate BP and autonomic balance”
“For the highly complementary peptides vasopressin and OT, there are effects on BP, HR, and baroreflex activity”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002 · https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2002

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
  2. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
Citation snapshot and identifiers
id
pmid-12531722
doi
10.1152/ajpheart.00774.2002
pmid
12531722
citation Snapshot
Not recorded
citations By Collection
sound
77
general
Not recorded
Complete approved library record
id
pmid-12531722
publication Key
Not recorded
aliases
None recorded
source References
  1. ref
    NPL-33
    record Id
    pmid-12531722
    source Type
    Journal publication
    title
    Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.
    authors
    Michelini LC, Marcelo MC, Amico J, Morris M.
    year
    2003
    journal
    American journal of physiology. Heart and circulatory physiology
    doi
    10.1152/ajpheart.00774.2002
    pmid
    12531722
    pmcid
    Not recorded
    patent Number
    Not recorded
    original Assignee
    Not recorded
    original Citation
    Michelini LC et al. (2003). "Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice." American Journal of Physiology – Heart and Circulatory Physiology 284(6):H2269–H2276
    original Section
    Baroreflex Modulation by Oxytocin
    metadata Status
    metadata-matched
    claim Review
    Not independently appraised
    source URL
    https://www.notion.so/3807b9c99c5680599be7d8337c817b15
    publication URL
    https://pubmed.ncbi.nlm.nih.gov/12531722/
    metadata URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocinergic+regulation+of+cardiovascular+function%3A+studies+in+oxytocin-deficient+mice%22&format=json&resultType=core&pageSize=4
    corrections
    None recorded
    topic Id
    optical-physiology
    role
    Focused chapter source
source Type
Journal publication
source Verification
Bibliographic metadata matched; scientific claims await appraisal.
source Collection
Hyperspectral Imaging · patent section 2.4
title
Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice
journal
American journal of physiology. Heart and circulatory physiology
neurotransmitters
None recorded
year
2003
authors
Michelini LC, Marcelo MC, Amico J, Morris M.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.1152/ajpheart.00774.2002
pmid
12531722
urls

https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002

collections

sound · general

categories

Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

targets

OXT

priority
1
quotes

“OT's role in BP and baroreflex/autonomic balance. The data provide the first experimental evidence for a role of endogenous OT in the maintenance of tonic BP” · “Alterations in baroreflex function were noted in mice lacking OT” · “There is much evidence to show that brain peptides regulate BP and autonomic balance” · “For the highly complementary peptides vasopressin and OT, there are effects on BP, HR, and baroreflex activity”

summary
limitation
citation Count
77
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002 · https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2002

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
77
general
Not recorded
topics
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
  2. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
journal Key
americanjournalofphysiologyheartandcirculatoryphysiology
journal Label
American journal of physiology. Heart and circulatory physiology
chapter Entries
  1. id
    ix-pmid-12531722
    record Id
    pmid-12531722
    title
    Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice
    journal
    American journal of physiology. Heart and circulatory physiology
    year
    2003
    authors
    Michelini LC, Marcelo MC, Amico J, Morris M.
    design
    urls

    https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002

    quotes
      1. text
        “OT's role in BP and baroreflex/autonomic balance. The data provide the first experimental evidence for a role of endogenous OT in the maintenance of tonic BP”
        emphasis
        false
      1. text
        “Alterations in baroreflex function were noted in mice lacking OT”
        emphasis
        false
      1. text
        “There is much evidence to show that brain peptides regulate BP and autonomic balance”
        emphasis
        false
      1. text
        “For the highly complementary peptides vasopressin and OT, there are effects on BP, HR, and baroreflex activity”
        emphasis
        false
    citation Count
    77
    source Pages

    63

    targets

    OXT

    categories

    Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

    doi
    10.1152/ajpheart.00774.2002
    pmid
    12531722
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002 · https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2002

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    2
    topic Id
    ix
    topic Title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    trust Score
    1
  2. id
    general-optical-physiology-pmid-12531722
    record Id
    pmid-12531722
    title
    Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice
    journal
    American journal of physiology. Heart and circulatory physiology
    year
    2003
    authors
    Michelini LC, Marcelo MC, Amico J, Morris M.
    design
    urls

    https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002

    quotes
    None recorded
    summary
    related Versions
    None recorded
    limitation
    citation Count
    Not recorded
    source Pages
    None recorded
    doi
    10.1152/ajpheart.00774.2002
    pmid
    12531722
    targets

    OXT

    categories

    Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

    source References
    1. ref
      NPL-33
      record Id
      pmid-12531722
      source Type
      Journal publication
      title
      Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.
      authors
      Michelini LC, Marcelo MC, Amico J, Morris M.
      year
      2003
      journal
      American journal of physiology. Heart and circulatory physiology
      doi
      10.1152/ajpheart.00774.2002
      pmid
      12531722
      pmcid
      Not recorded
      patent Number
      Not recorded
      original Assignee
      Not recorded
      original Citation
      Michelini LC et al. (2003). "Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice." American Journal of Physiology – Heart and Circulatory Physiology 284(6):H2269–H2276
      original Section
      Baroreflex Modulation by Oxytocin
      metadata Status
      metadata-matched
      claim Review
      Not independently appraised
      source URL
      https://www.notion.so/3807b9c99c5680599be7d8337c817b15
      publication URL
      https://pubmed.ncbi.nlm.nih.gov/12531722/
      metadata URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Oxytocinergic+regulation+of+cardiovascular+function%3A+studies+in+oxytocin-deficient+mice%22&format=json&resultType=core&pageSize=4
      corrections
      None recorded
      topic Id
      optical-physiology
      role
      Focused chapter source
    source Type
    Journal publication
    source Verification
    Bibliographic metadata matched; scientific claims await appraisal.
    collection
    general
    chapter Number
    11
    topic Id
    optical-physiology
    topic Title
    Optical Physiology and Tissue Imaging
    trust Score
    Not recorded
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/12531722/ · https://doi.org/10.1152/ajpheart.00774.2002 · https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2002

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

Open this publication in the interactive library