Universal Informatics · Research reading room

Alterations in brain and immune function produced by mindfulness meditation.

Davidson RJ, Kabat-Zinn J, Schumacher J, Rosenkranz M, Muller D, Santorelli SF, Urbanowski F, Harrington A, Bonus K, Sheridan JF. · Psychosomatic medicine · 2003 · Randomized controlled trial

Original publication · Original publication

Recorded summary

An eight-week workplace mindfulness study, with 25 meditators and 16 waitlist participants tested, reported greater left-anterior EEG activation and a stronger influenza-vaccine antibody response in the meditation group.

Recorded limitations

Small sample, waitlist comparator and physiological endpoints limit clinical inference. Antibody response and EEG activity are not measurements of gene expression.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Randomized controlled trial
assessment
category
peer-reviewed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

assessed At
2026-10-26
registered Masking Basis
false
trust Factor
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
intervention
Eight-week workplace mindfulness training
comparator
Waitlist
evidence Type
Clinical or experimental outcomes
source URLs

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

checked At
2026-10-26
review Scope
Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
discovery Sources

https://europepmc.org/article/MED/12883106

selection Policy
Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
  1. key
    language:mindfulness-clinical
    title
    Mindfulness-based interventions: controlled clinical trials
    collection
    language
    trust Score
    2
Citation snapshot and identifiers
id
pmid-12883106
doi
10.1097/01.psy.0000077505.67574.e3
pmid
12883106
citation Snapshot
count
847
source
Europe PMC
retrieved At
2026-10-26
url
https://europepmc.org/article/MED/12883106
citations By Collection
language
847
Complete approved library record
id
pmid-12883106
publication Key
doi:10.1097/01.psy.0000077505.67574.e3
aliases
None recorded
title
Alterations in brain and immune function produced by mindfulness meditation.
journal
Psychosomatic medicine
neurotransmitters
None recorded
year
2003
authors
Davidson RJ, Kabat-Zinn J, Schumacher J, Rosenkranz M, Muller D, Santorelli SF, Urbanowski F, Harrington A, Bonus K, Sheridan JF.
design
Randomized controlled trial
identity Conflict
Not recorded
doi
10.1097/01.psy.0000077505.67574.e3
pmid
12883106
urls

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

collections

language

categories

Clinical & self-report · Molecular biomarkers

targets
None recorded
priority
1
quotes
None recorded
summary
An eight-week workplace mindfulness study, with 25 meditators and 16 waitlist participants tested, reported greater left-anterior EEG activation and a stronger influenza-vaccine antibody response in the meditation group.
limitation
Small sample, waitlist comparator and physiological endpoints limit clinical inference. Antibody response and EEG activity are not measurements of gene expression.
citation Count
847
citation Snapshot
count
847
source
Europe PMC
retrieved At
2026-10-26
url
https://europepmc.org/article/MED/12883106
study Design Assessment
category
peer-reviewed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

assessed At
2026-10-26
registered Masking Basis
false
paper Trust Assessment
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
847
topics
  1. key
    language:mindfulness-clinical
    title
    Mindfulness-based interventions: controlled clinical trials
    collection
    language
    trust Score
    2
journal Key
psychosomaticmedicine
journal Label
Psychosomatic medicine
chapter Entries
  1. title
    Alterations in brain and immune function produced by mindfulness meditation.
    journal
    Psychosomatic medicine
    year
    2003
    authors
    Davidson RJ, Kabat-Zinn J, Schumacher J, Rosenkranz M, Muller D, Santorelli SF, Urbanowski F, Harrington A, Bonus K, Sheridan JF.
    design
    Randomized controlled trial
    urls

    https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

    doi
    10.1097/01.psy.0000077505.67574.e3
    pmid
    12883106
    targets
    None recorded
    categories

    Clinical & self-report · Molecular biomarkers

    citation Count
    847
    citation Snapshot
    count
    847
    source
    Europe PMC
    retrieved At
    2026-10-26
    url
    https://europepmc.org/article/MED/12883106
    study Design Assessment
    category
    peer-reviewed
    peer Reviewed
    true
    basis
    Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
    sources

    https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

    assessed At
    2026-10-26
    registered Masking Basis
    false
    evidence
    intervention
    Eight-week workplace mindfulness training
    comparator
    Waitlist
    evidence Type
    Clinical or experimental outcomes
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

    checked At
    2026-10-26
    review Scope
    Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
    discovery Sources

    https://europepmc.org/article/MED/12883106

    selection Policy
    Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
    id
    language-mindfulness-clinical-pmid-12883106
    record Id
    pmid-12883106
    quotes
    None recorded
    source Pages
    None recorded
    summary
    An eight-week workplace mindfulness study, with 25 meditators and 16 waitlist participants tested, reported greater left-anterior EEG activation and a stronger influenza-vaccine antibody response in the meditation group.
    limitation
    Small sample, waitlist comparator and physiological endpoints limit clinical inference. Antibody response and EEG activity are not measurements of gene expression.
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
    sources

    https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    publication Key
    doi:10.1097/01.psy.0000077505.67574.e3
    collection
    language
    chapter Number
    4
    topic Id
    mindfulness-clinical
    topic Title
    Mindfulness-based interventions: controlled clinical trials
    trust Score
    2
evidence
intervention
Eight-week workplace mindfulness training
comparator
Waitlist
evidence Type
Clinical or experimental outcomes
source URLs

https://pubmed.ncbi.nlm.nih.gov/12883106/ · https://doi.org/10.1097/01.psy.0000077505.67574.e3

checked At
2026-10-26
review Scope
Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
discovery Sources

https://europepmc.org/article/MED/12883106

selection Policy
Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    stress
    evidence
    1. field
      curated primary-source summary
      text
      An eight-week workplace mindfulness study, with 25 meditators and 16 waitlist participants tested, reported greater left-anterior EEG activation and a stronger influenza-vaccine antibody response in the meditation group.
      matched Text
      stress
conditions

stress

topic Trust Scores

2

full Text
status
not-indexed
retrieval Available
false

Open this publication in the interactive library