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Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ( α TMS) on the Negative Symptoms of Schizophrenia

Jin Y, Potkin SG, Kemp AS, Huerta ST, Alva G, Thai TM, Carreon D, Bunney WE. · Schizophrenia bulletin · 2006 · Double-blind randomized crossover trial

Original publication · Original publication · Original publication

Attributed extracts from the research record

“These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Double-blind randomized crossover trial
assessment
category
double-blind-rct
peer Reviewed
true
basis
The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

assessed At
2026-10-27
review Scope
Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
sources

https://pubmed.ncbi.nlm.nih.gov/16254067/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xiv
    title
    Transcranial magnetic stimulation: stimulation frequencies and depression
    collection
    sound
    trust Score
    3
Citation snapshot and identifiers
id
pmid-16254067
doi
10.1093/schbul/sbj020
pmid
16254067
citation Snapshot
Not recorded
citations By Collection
sound
161
Complete approved library record
id
pmid-16254067
publication Key
Not recorded
aliases
None recorded
title
Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ( α TMS) on the Negative Symptoms of Schizophrenia
journal
Schizophrenia bulletin
neurotransmitters
None recorded
year
2006
authors
Jin Y, Potkin SG, Kemp AS, Huerta ST, Alva G, Thai TM, Carreon D, Bunney WE.
design
Double-blind randomized crossover trial
kind
Journal article
identity Conflict
Not recorded
doi
10.1093/schbul/sbj020
pmid
16254067
urls

https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/ · https://pubmed.ncbi.nlm.nih.gov/16254067/ · https://doi.org/10.1093/schbul/sbj020

collections

sound

categories

Brain & nervous system · Clinical & self-report

targets
None recorded
priority
1
quotes

“These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia”

summary
limitation
citation Count
161
study Design Assessment
category
double-blind-rct
peer Reviewed
true
basis
The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

assessed At
2026-10-27
review Scope
Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
sources

https://pubmed.ncbi.nlm.nih.gov/16254067/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
161
topics
  1. key
    sound:xiv
    title
    Transcranial magnetic stimulation: stimulation frequencies and depression
    collection
    sound
    trust Score
    3
journal Key
schizophreniabulletin
journal Label
Schizophrenia bulletin
chapter Entries
  1. id
    xiv-pmid-16254067
    record Id
    pmid-16254067
    title
    Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ( α TMS) on the Negative Symptoms of Schizophrenia
    journal
    Schizophrenia bulletin
    year
    2006
    authors
    Jin Y, Potkin SG, Kemp AS, Huerta ST, Alva G, Thai TM, Carreon D, Bunney WE.
    design
    Double-blind randomized crossover trial
    urls

    https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/ · https://pubmed.ncbi.nlm.nih.gov/16254067/ · https://doi.org/10.1093/schbul/sbj020

    quotes
      1. text
        “These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia”
        emphasis
        false
    citation Count
    161
    source Pages

    78

    targets
    None recorded
    categories

    Brain & nervous system · Clinical & self-report

    doi
    10.1093/schbul/sbj020
    pmid
    16254067
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
    sources

    https://pubmed.ncbi.nlm.nih.gov/16254067/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    category
    double-blind-rct
    peer Reviewed
    true
    basis
    The methods describe a double-blind crossover design, random treatment order, blinded patients and a technician unaware of treatment frequency.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC2632240/

    assessed At
    2026-10-27
    review Scope
    Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
    collection
    sound
    chapter Number
    4
    topic Id
    xiv
    topic Title
    Transcranial magnetic stimulation: stimulation frequencies and depression
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    schizophrenia
    evidence
    1. field
      title
      text
      Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ( α TMS) on the Negative Symptoms of Schizophrenia
      matched Text
      Schizophrenia
conditions

schizophrenia

topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

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