CD38 is critical for social behaviour by regulating oxytocin secretion
Duo Jin; Hong-Xiang Liu; Hirokazu Hirai; Takashi Torashima; Taku Nagai; Olga Lopatina; Natalia A. Shnayder; Kiyofumi Yamada; Mami Noda; Toshihiro Seike; Kyota Fujita; Shin Takasawa; Shigeru Yokoyama; Keita Koizumi; Yoshitake Shiraishi; Shigenori Tanaka; Minako Hashii; Toru Yoshihara; Kazuhiro Higashida; Mohammad Saharul Islam; Nobuaki Yamada; Kenshi Hayashi; Naoya Noguchi; Ichiro Kato; Hiroshi Okamoto; Akihiro Matsushima; Alla Salmina; Toshio Munesue; Nobuaki Shimizu; Sumiko Mochida; Masahide Asano; Haruhiro Higashida · Nature · 2007 · Experimental mouse study
Original publication · Original publication · Original publication
Recorded summary
Mice lacking CD38 had reduced oxytocin secretion and impaired maternal and social behaviour. Oxytocin administration or restoration of CD38 rescued aspects of the behavioural changes, linking CD38-dependent calcium signalling to oxytocin release.
Recorded limitations
A mechanistic animal study; it does not establish a clinical treatment effect in humans.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental mouse study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17287729/ · https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Molecular biomarkers
- sample
- Cd38-knockout and control mice
- measurement
- Oxytocin secretion, calcium signalling and social behaviour
- measured Genes
- None recorded
- relationship Note
- A mechanistic animal study; it does not establish a clinical treatment effect in humans.
- source URLs
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- general:neurotransmitter-signalling
- title
- Oxytocin, serotonin and dopamine signalling
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-17287729
- doi
- 10.1038/nature05526
- pmid
- 17287729
- citation Snapshot
- count
- 585
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nature05526
- citations By Collection
- general
- 585
Complete approved library record
- id
- pmid-17287729
- aliases
- None recorded
- title
- CD38 is critical for social behaviour by regulating oxytocin secretion
- journal
- Nature
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
Oxytocin
- year
- 2007
- authors
- Duo Jin; Hong-Xiang Liu; Hirokazu Hirai; Takashi Torashima; Taku Nagai; Olga Lopatina; Natalia A. Shnayder; Kiyofumi Yamada; Mami Noda; Toshihiro Seike; Kyota Fujita; Shin Takasawa; Shigeru Yokoyama; Keita Koizumi; Yoshitake Shiraishi; Shigenori Tanaka; Minako Hashii; Toru Yoshihara; Kazuhiro Higashida; Mohammad Saharul Islam; Nobuaki Yamada; Kenshi Hayashi; Naoya Noguchi; Ichiro Kato; Hiroshi Okamoto; Akihiro Matsushima; Alla Salmina; Toshio Munesue; Nobuaki Shimizu; Sumiko Mochida; Masahide Asano; Haruhiro Higashida
- design
- Experimental mouse study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/nature05526
- pmid
- 17287729
- urls
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- collections
general
- categories
Molecular biomarkers
- targets
CD38 · OXT
- priority
- 1
- quotes
- None recorded
- summary
- Mice lacking CD38 had reduced oxytocin secretion and impaired maternal and social behaviour. Oxytocin administration or restoration of CD38 rescued aspects of the behavioural changes, linking CD38-dependent calcium signalling to oxytocin release.
- limitation
- A mechanistic animal study; it does not establish a clinical treatment effect in humans.
- citation Count
- 585
- citation Snapshot
- count
- 585
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nature05526
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17287729/ · https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- general
- 585
- topics
- key
- general:neurotransmitter-signalling
- title
- Oxytocin, serotonin and dopamine signalling
- collection
- general
- trust Score
- 1
- journal Key
- nature
- journal Label
- Nature
- chapter Entries
- title
- CD38 is critical for social behaviour by regulating oxytocin secretion
- journal
- Nature
- year
- 2007
- authors
- Duo Jin; Hong-Xiang Liu; Hirokazu Hirai; Takashi Torashima; Taku Nagai; Olga Lopatina; Natalia A. Shnayder; Kiyofumi Yamada; Mami Noda; Toshihiro Seike; Kyota Fujita; Shin Takasawa; Shigeru Yokoyama; Keita Koizumi; Yoshitake Shiraishi; Shigenori Tanaka; Minako Hashii; Toru Yoshihara; Kazuhiro Higashida; Mohammad Saharul Islam; Nobuaki Yamada; Kenshi Hayashi; Naoya Noguchi; Ichiro Kato; Hiroshi Okamoto; Akihiro Matsushima; Alla Salmina; Toshio Munesue; Nobuaki Shimizu; Sumiko Mochida; Masahide Asano; Haruhiro Higashida
- design
- Experimental mouse study
- urls
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- doi
- 10.1038/nature05526
- pmid
- 17287729
- targets
CD38 · OXT
- neurotransmitters
Oxytocin
- categories
Molecular biomarkers
- citation Count
- 585
- citation Snapshot
- count
- 585
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nature05526
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Molecular biomarkers
- sample
- Cd38-knockout and control mice
- measurement
- Oxytocin secretion, calcium signalling and social behaviour
- measured Genes
- None recorded
- relationship Note
- A mechanistic animal study; it does not establish a clinical treatment effect in humans.
- source URLs
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- checked At
- 2026-10-23
- id
- general-neurotransmitter-signalling-pmid-17287729
- record Id
- pmid-17287729
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Mice lacking CD38 had reduced oxytocin secretion and impaired maternal and social behaviour. Oxytocin administration or restoration of CD38 rescued aspects of the behavioural changes, linking CD38-dependent calcium signalling to oxytocin release.
- limitation
- A mechanistic animal study; it does not establish a clinical treatment effect in humans.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17287729/ · https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 8
- topic Id
- neurotransmitter-signalling
- topic Title
- Oxytocin, serotonin and dopamine signalling
- trust Score
- 1
- evidence
- evidence Type
- Molecular biomarkers
- sample
- Cd38-knockout and control mice
- measurement
- Oxytocin secretion, calcium signalling and social behaviour
- measured Genes
- None recorded
- relationship Note
- A mechanistic animal study; it does not establish a clinical treatment effect in humans.
- source URLs
https://www.nature.com/articles/nature05526 · https://doi.org/10.1038/nature05526 · https://pubmed.ncbi.nlm.nih.gov/17287729/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false