NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
C. Geoffrey Lau; R. Suzanne Zukin · Nature Reviews Neuroscience · 2007 · Narrative review
Original publication · Original publication · Original publication
Recorded summary
This review explains how NMDA receptor trafficking and subunit composition influence synaptic plasticity, and discusses their relevance to neuropsychiatric disorders. It provides background for interpreting activity-dependent changes in excitatory signalling.
Recorded limitations
NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Narrative review
- assessment
- category
- review
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17514195/ · https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Cellular, animal and neuropsychiatric literature
- measurement
- Review of receptor trafficking and synaptic plasticity
- measured Genes
- None recorded
- relationship Note
- NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
- source URLs
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- general:stress-plasticity
- title
- Stress, inflammation and synaptic plasticity
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-17514195
- doi
- 10.1038/nrn2153
- pmid
- 17514195
- citation Snapshot
- count
- 993
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nrn2153
- citations By Collection
- general
- 993
Complete approved library record
- id
- pmid-17514195
- aliases
- None recorded
- title
- NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
- journal
- Nature Reviews Neuroscience
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2007
- authors
- C. Geoffrey Lau; R. Suzanne Zukin
- design
- Narrative review
- kind
- Review
- identity Conflict
- Not recorded
- doi
- 10.1038/nrn2153
- pmid
- 17514195
- urls
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- collections
general
- categories
Brain & nervous system
- targets
NMDA
- priority
- 1
- quotes
- None recorded
- summary
- This review explains how NMDA receptor trafficking and subunit composition influence synaptic plasticity, and discusses their relevance to neuropsychiatric disorders. It provides background for interpreting activity-dependent changes in excitatory signalling.
- limitation
- NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
- citation Count
- 993
- citation Snapshot
- count
- 993
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nrn2153
- study Design Assessment
- category
- review
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17514195/ · https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- general
- 993
- topics
- key
- general:stress-plasticity
- title
- Stress, inflammation and synaptic plasticity
- collection
- general
- trust Score
- 1
- journal Key
- naturereviewsneuroscience
- journal Label
- Nature Reviews Neuroscience
- chapter Entries
- title
- NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
- journal
- Nature Reviews Neuroscience
- year
- 2007
- authors
- C. Geoffrey Lau; R. Suzanne Zukin
- design
- Narrative review
- urls
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- doi
- 10.1038/nrn2153
- pmid
- 17514195
- targets
NMDA
- neurotransmitters
- None recorded
- categories
Brain & nervous system
- citation Count
- 993
- citation Snapshot
- count
- 993
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nrn2153
- study Design Assessment
- category
- review
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Brain & nervous system
- sample
- Cellular, animal and neuropsychiatric literature
- measurement
- Review of receptor trafficking and synaptic plasticity
- measured Genes
- None recorded
- relationship Note
- NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
- source URLs
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- checked At
- 2026-10-23
- id
- general-stress-plasticity-pmid-17514195
- record Id
- pmid-17514195
- quotes
- None recorded
- source Pages
- None recorded
- summary
- This review explains how NMDA receptor trafficking and subunit composition influence synaptic plasticity, and discusses their relevance to neuropsychiatric disorders. It provides background for interpreting activity-dependent changes in excitatory signalling.
- limitation
- NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Narrative review. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/17514195/ · https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 8
- topic Id
- stress-plasticity
- topic Title
- Stress, inflammation and synaptic plasticity
- trust Score
- 1
- evidence
- evidence Type
- Brain & nervous system
- sample
- Cellular, animal and neuropsychiatric literature
- measurement
- Review of receptor trafficking and synaptic plasticity
- measured Genes
- None recorded
- relationship Note
- NMDA denotes a receptor family. This review does not establish a direct OXTR interaction or the efficacy of a particular intervention.
- source URLs
https://www.nature.com/articles/nrn2153 · https://doi.org/10.1038/nrn2153 · https://pubmed.ncbi.nlm.nih.gov/17514195/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false