Genomic counter-stress changes induced by the relaxation response
Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA. · PloS one · 2008 · Gene-expression study; nonrandomized comparisons
Original publication · Original publication · Original publication · Original publication
Attributed extracts from the research record
“This study provides the first compelling evidence that the RR relaxation response elicits specific gene expression changes in short-term and long-term practitioners. Our results suggest consistent and constitutive changes in gene expression resulting from RR may relate to long term physiological effects.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Gene-expression study; nonrandomized comparisons
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/18596974/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2432467/ · https://doi.org/10.1371/journal.pone.0002576 · https://doi.org/10.1371/journal.pone.0172845
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- language:ii
- title
- Meditation, mindfulness and related practices: gene expression and epigenetics
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-18596974
- doi
- 10.1371/journal.pone.0002576
- pmid
- 18596974
- citation Snapshot
- Not recorded
- citations By Collection
- language
- 355
Complete approved library record
- id
- pmid-18596974
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Genomic counter-stress changes induced by the relaxation response
- journal
- PloS one
- neurotransmitters
- None recorded
- year
- 2008
- authors
- Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA.
- design
- Gene-expression study; nonrandomized comparisons
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1371/journal.pone.0002576
- pmid
- 18596974
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC2432467/ · https://pubmed.ncbi.nlm.nih.gov/18596974/ · https://doi.org/10.1371/journal.pone.0002576 · https://doi.org/10.1371/journal.pone.0172845
- collections
language
- categories
Gene expression
- targets
- None recorded
- priority
- 0
- quotes
“This study provides the first compelling evidence that the RR relaxation response elicits specific gene expression changes in short-term and long-term practitioners. Our results suggest consistent and constitutive changes in gene expression resulting from RR may relate to long term physiological effects.”
- summary
- limitation
- citation Count
- 355
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/18596974/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2432467/ · https://doi.org/10.1371/journal.pone.0002576 · https://doi.org/10.1371/journal.pone.0172845
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 355
- topics
- key
- language:ii
- title
- Meditation, mindfulness and related practices: gene expression and epigenetics
- collection
- language
- trust Score
- 2
- journal Key
- plosone
- journal Label
- PloS one
- chapter Entries
- id
- language-ii-pmid-18596974
- record Id
- pmid-18596974
- title
- Genomic counter-stress changes induced by the relaxation response
- journal
- PloS one
- year
- 2008
- authors
- Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA.
- design
- Gene-expression study; nonrandomized comparisons
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC2432467/ · https://pubmed.ncbi.nlm.nih.gov/18596974/ · https://doi.org/10.1371/journal.pone.0002576 · https://doi.org/10.1371/journal.pone.0172845
- quotes
- text
- “This study provides the first compelling evidence that the RR relaxation response elicits specific gene expression changes in short-term and long-term practitioners. Our results suggest consistent and constitutive changes in gene expression resulting from RR may relate to long term physiological effects.”
- emphasis
- false
- citation Count
- 355
- source Pages
15
- targets
- None recorded
- categories
Gene expression
- doi
- 10.1371/journal.pone.0002576
- pmid
- 18596974
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/18596974/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC2432467/ · https://doi.org/10.1371/journal.pone.0002576 · https://doi.org/10.1371/journal.pone.0172845
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 1
- topic Id
- ii
- topic Title
- Meditation, mindfulness and related practices: gene expression and epigenetics
- trust Score
- 2
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- stress
- evidence
- field
- title
- text
- Genomic counter-stress changes induced by the relaxation response
- matched Text
- stress
- conditions
stress
- topic Trust Scores
2
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2432467/fullTextXML
- pmcid
- PMC2432467
- rights
- license
- CC BY (version not specified in article)
- statement
Dusek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
- sha256
- 54f7b170ec448a7e23ecbd1952187560b0dc59d33e59e55e1b8f53b498b0ed61
- checked At
- 2026-10-24