MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial.
Grossman P, Kappos L, Gensicke H, D'Souza M, Mohr DC, Penner IK, Steiner C. · Neurology · 2010 · Randomized controlled trial
Original publication · Original publication · Original publication
Recorded summary
In 150 people with multiple sclerosis, eight weeks of mindfulness training improved nonphysical quality of life, depression and fatigue relative to usual care, with benefits persisting at six months.
Recorded limitations
The comparison did not control for instructor attention, and outcomes concerned wellbeing rather than disease progression. The paper classifies its evidence as Class III.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Eight-week mindfulness training
- comparator
- Usual care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/20876468
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-20876468
- doi
- 10.1212/wnl.0b013e3181f4d80d
- pmid
- 20876468
- citation Snapshot
- count
- 239
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/20876468
- citations By Collection
- language
- 239
Complete approved library record
- id
- pmid-20876468
- publication Key
- doi:10.1212/wnl.0b013e3181f4d80d
- aliases
- None recorded
- title
- MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial.
- journal
- Neurology
- neurotransmitters
- None recorded
- year
- 2010
- authors
- Grossman P, Kappos L, Gensicke H, D'Souza M, Mohr DC, Penner IK, Steiner C.
- design
- Randomized controlled trial
- identity Conflict
- Not recorded
- doi
- 10.1212/wnl.0b013e3181f4d80d
- pmid
- 20876468
- urls
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In 150 people with multiple sclerosis, eight weeks of mindfulness training improved nonphysical quality of life, depression and fatigue relative to usual care, with benefits persisting at six months.
- limitation
- The comparison did not control for instructor attention, and outcomes concerned wellbeing rather than disease progression. The paper classifies its evidence as Class III.
- citation Count
- 239
- citation Snapshot
- count
- 239
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/20876468
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 239
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- neurology
- journal Label
- Neurology
- chapter Entries
- title
- MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial.
- journal
- Neurology
- year
- 2010
- authors
- Grossman P, Kappos L, Gensicke H, D'Souza M, Mohr DC, Penner IK, Steiner C.
- design
- Randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- doi
- 10.1212/wnl.0b013e3181f4d80d
- pmid
- 20876468
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 239
- citation Snapshot
- count
- 239
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/20876468
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Eight-week mindfulness training
- comparator
- Usual care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/20876468
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- language-mindfulness-clinical-pmid-20876468
- record Id
- pmid-20876468
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 150 people with multiple sclerosis, eight weeks of mindfulness training improved nonphysical quality of life, depression and fatigue relative to usual care, with benefits persisting at six months.
- limitation
- The comparison did not control for instructor attention, and outcomes concerned wellbeing rather than disease progression. The paper classifies its evidence as Class III.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1212/wnl.0b013e3181f4d80d
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- Eight-week mindfulness training
- comparator
- Usual care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/20876468/ · https://doi.org/10.1212/wnl.0b013e3181f4d80d · https://pmc.ncbi.nlm.nih.gov/articles/PMC3463050/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/20876468
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- curated primary-source summary
- text
- In 150 people with multiple sclerosis, eight weeks of mindfulness training improved nonphysical quality of life, depression and fatigue relative to usual care, with benefits persisting at six months.
- matched Text
- depression
- conditions
depression
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false