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Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans

Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M. · Proceedings of the National Academy of Sciences of the United States of America · 2011

Original publication · Original publication · Original publication

Attributed extracts from the research record

“Differential stress responses between the genotype groups were observed depending on the presence or absence of social support.”
“Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support.”
“These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108 · https://www.pnas.org/content/108/50/19937.short

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xxx
    title
    OXTR variation and psychological resources
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxx
    title
    OXTR variation and psychological resources
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
pmid-22123970
doi
10.1073/pnas.1113079108
pmid
22123970
citation Snapshot
Not recorded
citations By Collection
sound
279
general
279
Complete approved library record
id
pmid-22123970
publication Key
Not recorded
aliases
None recorded
title
Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
journal
Proceedings of the National Academy of Sciences of the United States of America
neurotransmitters
None recorded
year
2011
authors
Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.1073/pnas.1113079108
pmid
22123970
urls

https://pmc.ncbi.nlm.nih.gov/articles/PMC3250137/ · https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108

collections

sound · general

categories

Genetics & genomics · Molecular biomarkers

targets

OXTR · OXT

priority
0
quotes

“Differential stress responses between the genotype groups were observed depending on the presence or absence of social support.” · “Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support.” · “These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.”

summary
limitation
citation Count
279
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108 · https://www.pnas.org/content/108/50/19937.short

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
279
general
279
topics
  1. key
    sound:xxx
    title
    OXTR variation and psychological resources
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxx
    title
    OXTR variation and psychological resources
    collection
    general
    trust Score
    1
journal Key
proceedingsofthenationalacademyofsciencesoftheunitedstatesofamerica
journal Label
Proceedings of the National Academy of Sciences of the United States of America
chapter Entries
  1. id
    xxx-pmid-22123970
    record Id
    pmid-22123970
    title
    Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
    journal
    Proceedings of the National Academy of Sciences of the United States of America
    year
    2011
    authors
    Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M.
    design
    urls

    https://pmc.ncbi.nlm.nih.gov/articles/PMC3250137/ · https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108

    quotes
      1. text
        “Differential stress responses between the genotype groups were observed depending on the presence or absence of social support.”
        emphasis
        false
      1. text
        “Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support.”
        emphasis
        false
      1. text
        “These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.”
        emphasis
        false
    citation Count
    279
    source Pages

    122

    targets

    OXTR · OXT

    categories

    Genetics & genomics · Molecular biomarkers

    doi
    10.1073/pnas.1113079108
    pmid
    22123970
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108 · https://www.pnas.org/content/108/50/19937.short

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    6
    topic Id
    xxx
    topic Title
    OXTR variation and psychological resources
    trust Score
    1
  2. id
    general-xxx-pmid-22123970
    record Id
    pmid-22123970
    title
    Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
    journal
    Proceedings of the National Academy of Sciences of the United States of America
    year
    2011
    authors
    Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M.
    design
    urls

    https://pmc.ncbi.nlm.nih.gov/articles/PMC3250137/ · https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108

    quotes
      1. text
        “Differential stress responses between the genotype groups were observed depending on the presence or absence of social support.”
        emphasis
        false
      1. text
        “Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support.”
        emphasis
        false
      1. text
        “These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.”
        emphasis
        false
    citation Count
    279
    source Pages

    122

    targets

    OXTR · OXT

    categories

    Genetics & genomics · Molecular biomarkers

    doi
    10.1073/pnas.1113079108
    pmid
    22123970
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22123970/ · https://doi.org/10.1073/pnas.1113079108 · https://www.pnas.org/content/108/50/19937.short

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    1
    topic Id
    sound-xxx
    topic Title
    OXTR variation and psychological resources
    trust Score
    1
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    stress
    evidence
    1. field
      title
      text
      Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
      matched Text
      stress
conditions

stress

topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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