Universal Informatics · Research reading room

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K. · Medical gas research · 2011 · randomised controlled trial, double blind

Original publication · Original publication · Original publication

Attributed extracts from the research record

“Hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM polymyositis/dermatomyositis”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial, double blind
assessment
Not recorded
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/22146674/ · https://doi.org/10.1186/2045-9912-1-24

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-22146674
doi
10.1186/2045-9912-1-24
pmid
22146674
citation Snapshot
Not recorded
citations By Collection
language
70
general
70
Complete approved library record
id
pmid-22146674
publication Key
Not recorded
aliases
None recorded
title
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies
journal
Medical gas research
neurotransmitters
None recorded
year
2011
authors
Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K.
design
randomised controlled trial, double blind
kind
Journal article
identity Conflict
Not recorded
doi
10.1186/2045-9912-1-24
pmid
22146674
urls

https://doi.org/10.1186/2045-9912-1-24 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3231939/ · https://pubmed.ncbi.nlm.nih.gov/22146674/

collections

language · general

categories

Molecular biomarkers

targets
None recorded
priority
1
quotes

“Hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM polymyositis/dermatomyositis”

summary
limitation
citation Count
70
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/22146674/ · https://doi.org/10.1186/2045-9912-1-24

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
70
general
70
topics
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
journal Key
medicalgasresearch
journal Label
Medical gas research
chapter Entries
  1. id
    language-vi-pmid-22146674
    record Id
    pmid-22146674
    title
    Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies
    journal
    Medical gas research
    year
    2011
    authors
    Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K.
    design
    randomised controlled trial, double blind
    urls

    https://doi.org/10.1186/2045-9912-1-24 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3231939/ · https://pubmed.ncbi.nlm.nih.gov/22146674/

    quotes
      1. text
        “Hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM polymyositis/dermatomyositis”
        emphasis
        false
    citation Count
    70
    source Pages

    25

    targets
    None recorded
    categories

    Molecular biomarkers

    doi
    10.1186/2045-9912-1-24
    pmid
    22146674
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22146674/ · https://doi.org/10.1186/2045-9912-1-24

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  2. id
    general-language-vi-pmid-22146674
    record Id
    pmid-22146674
    title
    Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies
    journal
    Medical gas research
    year
    2011
    authors
    Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K.
    design
    randomised controlled trial, double blind
    urls

    https://doi.org/10.1186/2045-9912-1-24 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3231939/ · https://pubmed.ncbi.nlm.nih.gov/22146674/

    quotes
      1. text
        “Hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM polymyositis/dermatomyositis”
        emphasis
        false
    citation Count
    70
    source Pages

    25

    targets
    None recorded
    categories

    Molecular biomarkers

    doi
    10.1186/2045-9912-1-24
    pmid
    22146674
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22146674/ · https://doi.org/10.1186/2045-9912-1-24

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    3
    topic Id
    language-vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

3

full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3231939/fullTextXML
pmcid
PMC3231939
rights
license
http://creativecommons.org/licenses/by/2.0
statement

Copyright ©2011 Ito et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

sha256
b9a765791463dd5ba1dabe085d24c39267038dac28544006dd382f223aaf1b0e
checked At
2026-10-24

Open this publication in the interactive library