Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial.
Hoffman CJ, Ersser SJ, Hopkinson JB, Nicholls PG, Harrington JE, Thomas PW. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012 · Randomized controlled trial
Original publication · Original publication
Recorded summary
In 229 breast-cancer survivors, eight-week MBSR improved mood, breast- and endocrine-related quality of life and wellbeing relative to standard care, with several benefits retained at 12 weeks.
Recorded limitations
A waitlist-style standard-care comparison leaves nonspecific support effects unresolved. These are supportive-care outcomes rather than evidence of anticancer activity.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Eight-week MBSR
- comparator
- Standard care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/22430268
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-22430268
- doi
- 10.1200/jco.2010.34.0331
- pmid
- 22430268
- citation Snapshot
- count
- 228
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/22430268
- citations By Collection
- language
- 228
Complete approved library record
- id
- pmid-22430268
- publication Key
- doi:10.1200/jco.2010.34.0331
- aliases
- None recorded
- title
- Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial.
- journal
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- neurotransmitters
- None recorded
- year
- 2012
- authors
- Hoffman CJ, Ersser SJ, Hopkinson JB, Nicholls PG, Harrington JE, Thomas PW.
- design
- Randomized controlled trial
- identity Conflict
- Not recorded
- doi
- 10.1200/jco.2010.34.0331
- pmid
- 22430268
- urls
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In 229 breast-cancer survivors, eight-week MBSR improved mood, breast- and endocrine-related quality of life and wellbeing relative to standard care, with several benefits retained at 12 weeks.
- limitation
- A waitlist-style standard-care comparison leaves nonspecific support effects unresolved. These are supportive-care outcomes rather than evidence of anticancer activity.
- citation Count
- 228
- citation Snapshot
- count
- 228
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/22430268
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 228
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- journalofclinicaloncology
- journal Label
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- chapter Entries
- title
- Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial.
- journal
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- year
- 2012
- authors
- Hoffman CJ, Ersser SJ, Hopkinson JB, Nicholls PG, Harrington JE, Thomas PW.
- design
- Randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- doi
- 10.1200/jco.2010.34.0331
- pmid
- 22430268
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 228
- citation Snapshot
- count
- 228
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/22430268
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Eight-week MBSR
- comparator
- Standard care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/22430268
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- language-mindfulness-clinical-pmid-22430268
- record Id
- pmid-22430268
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 229 breast-cancer survivors, eight-week MBSR improved mood, breast- and endocrine-related quality of life and wellbeing relative to standard care, with several benefits retained at 12 weeks.
- limitation
- A waitlist-style standard-care comparison leaves nonspecific support effects unresolved. These are supportive-care outcomes rather than evidence of anticancer activity.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1200/jco.2010.34.0331
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- Eight-week MBSR
- comparator
- Standard care
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/22430268/ · https://doi.org/10.1200/jco.2010.34.0331
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/22430268
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false