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Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions

W Romero-Fernandez; D O Borroto-Escuela; L F Agnati; K Fuxe · Molecular Psychiatry · 2012 · Laboratory receptor-interaction study; research letter

Original publication · Original publication · Original publication

Recorded summary

The authors report dopamine D2–oxytocin receptor complexes in the ventral and dorsal striatum, with facilitatory interactions between the receptors. The findings provide a molecular explanation to investigate alongside wider evidence linking dopamine and oxytocin to social behaviour.

Recorded limitations

Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Laboratory receptor-interaction study; research letter
assessment
category
peer-reviewed
peer Reviewed
true
basis
Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
sources

https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

reviewed At
2026-10-23
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/22824810/ · https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
evidence Type
Molecular biomarkers
sample
Laboratory receptor and rat striatal preparations
measurement
Receptor proximity and functional receptor interactions
measured Genes
None recorded
relationship Note
Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.
source URLs

https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

checked At
2026-10-23
Topics and recorded topic scores
  1. key
    general:neurotransmitter-signalling
    title
    Oxytocin, serotonin and dopamine signalling
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
pmid-22824810
doi
10.1038/mp.2012.103
pmid
22824810
citation Snapshot
count
149
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1038/mp.2012.103
citations By Collection
general
149
Complete approved library record
id
pmid-22824810
aliases
None recorded
source References
  1. ref
    NPL-19
    record Id
    pmid-22824810
    source Type
    Journal publication
    title
    Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor-receptor interactions.
    authors
    Romero-Fernandez W, Borroto-Escuela DO, Agnati LF, Fuxe K.
    year
    2013
    journal
    Molecular psychiatry
    doi
    10.1038/mp.2012.103
    pmid
    22824810
    pmcid
    Not recorded
    patent Number
    Not recorded
    original Assignee
    Not recorded
    original Citation
    Romero-Fernandez W, Borroto-Escuela DO, Agnati LF, Fuxe K (2013). "Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions." Molecular Psychiatry 18:849–850
    original Section
    OXTR Modulation of DRD2/SLC6A4
    metadata Status
    metadata-matched
    claim Review
    Not independently appraised
    source URL
    https://www.notion.so/3807b9c99c5680599be7d8337c817b15
    publication URL
    https://www.nature.com/articles/mp2012103
    metadata URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=TITLE%3A%22Evidence+for+the+existence+of+dopamine+D2-oxytocin+receptor+heteromers+in+the+ventral+and+dorsal+striatum+with+facilitatory+receptor%E2%80%93receptor+interactions%22&format=json&resultType=core&pageSize=4
    corrections
    None recorded
    topic Id
    Not recorded
    role
    Related context in complete bibliography
source Type
Journal publication
source Verification
Bibliographic metadata matched; scientific claims await appraisal.
source Collection
Hyperspectral Imaging · patent section 2.4
title
Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
journal
Molecular Psychiatry
publisher Family
nature
publisher Family Label
Nature Portfolio
neurotransmitters

Dopamine · Oxytocin

year
2012
authors
W Romero-Fernandez; D O Borroto-Escuela; L F Agnati; K Fuxe
design
Laboratory receptor-interaction study; research letter
kind
Journal article
identity Conflict
Not recorded
doi
10.1038/mp.2012.103
pmid
22824810
urls

https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

collections

general

categories

Molecular biomarkers

targets

DRD2 · OXTR

priority
1
quotes
None recorded
summary
The authors report dopamine D2–oxytocin receptor complexes in the ventral and dorsal striatum, with facilitatory interactions between the receptors. The findings provide a molecular explanation to investigate alongside wider evidence linking dopamine and oxytocin to social behaviour.
limitation
Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.
citation Count
149
citation Snapshot
count
149
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1038/mp.2012.103
study Design Assessment
category
peer-reviewed
peer Reviewed
true
basis
Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
sources

https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

reviewed At
2026-10-23
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/22824810/ · https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
general
149
topics
  1. key
    general:neurotransmitter-signalling
    title
    Oxytocin, serotonin and dopamine signalling
    collection
    general
    trust Score
    1
journal Key
molecularpsychiatry
journal Label
Molecular Psychiatry
chapter Entries
  1. title
    Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
    journal
    Molecular Psychiatry
    year
    2012
    authors
    W Romero-Fernandez; D O Borroto-Escuela; L F Agnati; K Fuxe
    design
    Laboratory receptor-interaction study; research letter
    urls

    https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

    doi
    10.1038/mp.2012.103
    pmid
    22824810
    targets

    DRD2 · OXTR

    neurotransmitters

    Dopamine · Oxytocin

    categories

    Molecular biomarkers

    citation Count
    149
    citation Snapshot
    count
    149
    source
    Crossref
    retrieved At
    2026-10-23
    url
    https://api.crossref.org/works/10.1038/mp.2012.103
    study Design Assessment
    category
    peer-reviewed
    peer Reviewed
    true
    basis
    Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
    sources

    https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

    reviewed At
    2026-10-23
    evidence
    evidence Type
    Molecular biomarkers
    sample
    Laboratory receptor and rat striatal preparations
    measurement
    Receptor proximity and functional receptor interactions
    measured Genes
    None recorded
    relationship Note
    Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.
    source URLs

    https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

    checked At
    2026-10-23
    id
    general-neurotransmitter-signalling-pmid-22824810
    record Id
    pmid-22824810
    quotes
    None recorded
    source Pages
    None recorded
    summary
    The authors report dopamine D2–oxytocin receptor complexes in the ventral and dorsal striatum, with facilitatory interactions between the receptors. The findings provide a molecular explanation to investigate alongside wider evidence linking dopamine and oxytocin to social behaviour.
    limitation
    Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Laboratory receptor-interaction study; research letter. No masked human randomized trial classification is assigned.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22824810/ · https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    8
    topic Id
    neurotransmitter-signalling
    topic Title
    Oxytocin, serotonin and dopamine signalling
    trust Score
    1
evidence
evidence Type
Molecular biomarkers
sample
Laboratory receptor and rat striatal preparations
measurement
Receptor proximity and functional receptor interactions
measured Genes
None recorded
relationship Note
Receptor interactions in laboratory preparations do not establish their clinical importance or demonstrate a change in gene expression.
source URLs

https://www.nature.com/articles/mp2012103 · https://doi.org/10.1038/mp.2012.103 · https://pubmed.ncbi.nlm.nih.gov/22824810/

checked At
2026-10-23
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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