Universal Informatics · Research reading room

Oxytocin Increases Heart Rate Variability in Humans at Rest: Implications for Social Approach-Related Motivation and Capacity for Social Engagement

Kemp AH, Quintana DS, Kuhnert RL, Griffiths K, Hickie IB, Guastella AJ. · PloS one · 2012

Original publication · Original publication · Original publication

Attributed extracts from the research record

“Together with the broader literature on OT and HRV, findings suggest that acute administration of OT may facilitate a fundamental psychophysiological feature of social behaviour, increasing capacity for social engagement.
Findings also suggest that HRV changes may provide a novel biomarker of response to OT nasal spray that can be incorporated into research on response to treatment.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/22937145/ · https://doi.org/10.1371/journal.pone.0044014 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
Citation snapshot and identifiers
id
pmid-22937145
doi
10.1371/journal.pone.0044014
pmid
22937145
citation Snapshot
Not recorded
citations By Collection
sound
123
Complete approved library record
id
pmid-22937145
publication Key
Not recorded
aliases
None recorded
title
Oxytocin Increases Heart Rate Variability in Humans at Rest: Implications for Social Approach-Related Motivation and Capacity for Social Engagement
journal
PloS one
neurotransmitters
None recorded
year
2012
authors
Kemp AH, Quintana DS, Kuhnert RL, Griffiths K, Hickie IB, Guastella AJ.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.1371/journal.pone.0044014
pmid
22937145
urls

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014 · https://doi.org/10.1371/journal.pone.0044014 · https://pubmed.ncbi.nlm.nih.gov/22937145/

collections

sound

categories

Molecular biomarkers · Heart rate & autonomic

targets

OXT

priority
1
quotes

“Together with the broader literature on OT and HRV, findings suggest that acute administration of OT may facilitate a fundamental psychophysiological feature of social behaviour, increasing capacity for social engagement. · Findings also suggest that HRV changes may provide a novel biomarker of response to OT nasal spray that can be incorporated into research on response to treatment.”

summary
limitation
citation Count
123
paper Trust Assessment
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/22937145/ · https://doi.org/10.1371/journal.pone.0044014 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
123
topics
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
journal Key
plosone
journal Label
PloS one
chapter Entries
  1. id
    ix-pmid-22937145
    record Id
    pmid-22937145
    title
    Oxytocin Increases Heart Rate Variability in Humans at Rest: Implications for Social Approach-Related Motivation and Capacity for Social Engagement
    journal
    PloS one
    year
    2012
    authors
    Kemp AH, Quintana DS, Kuhnert RL, Griffiths K, Hickie IB, Guastella AJ.
    design
    urls

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014 · https://doi.org/10.1371/journal.pone.0044014 · https://pubmed.ncbi.nlm.nih.gov/22937145/

    quotes
      1. text
        “Together with the broader literature on OT and HRV, findings suggest that acute administration of OT may facilitate a fundamental psychophysiological feature of social behaviour, increasing capacity for social engagement.
        emphasis
        false
      1. text
        Findings also suggest that HRV changes may provide a novel biomarker of response to OT nasal spray that can be incorporated into research on response to treatment.”
        emphasis
        false
    citation Count
    123
    source Pages

    68

    targets

    OXT

    categories

    Molecular biomarkers · Heart rate & autonomic

    doi
    10.1371/journal.pone.0044014
    pmid
    22937145
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
    sources

    https://pubmed.ncbi.nlm.nih.gov/22937145/ · https://doi.org/10.1371/journal.pone.0044014 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    2
    topic Id
    ix
    topic Title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    trust Score
    1
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3429409/fullTextXML
pmcid
PMC3429409
rights
license
http://creativecommons.org/licenses/by/4.0/
statement

© 2012 Kemp et al 2012 Kemp et al https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

sha256
5c802f38742f3861af06606355e842aae9903bd8f3d6f43f2ed31a16d6c5e902
checked At
2026-10-24

Open this publication in the interactive library