Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity.
Hoge EA, Bui E, Marques L, Metcalf CA, Morris LK, Robinaugh DJ, Worthington JJ, Pollack MH, Simon NM. · The Journal of clinical psychiatry · 2013 · Randomized controlled trial
Original publication · Original publication · Original publication
Recorded summary
In a 93-person generalised-anxiety trial, MBSR improved several secondary anxiety ratings and stress-challenge responses more than stress-management education.
Recorded limitations
The primary Hamilton Anxiety outcome improved in both arms without a significant between-group difference. The positive findings are secondary outcomes and laboratory stress responses.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Eight-week MBSR
- comparator
- Stress-management education
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/23541163
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- trial Id
- NCT01033851
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-23541163
- doi
- 10.4088/jcp.12m08083
- pmid
- 23541163
- citation Snapshot
- count
- 267
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/23541163
- citations By Collection
- language
- 267
Complete approved library record
- id
- pmid-23541163
- publication Key
- doi:10.4088/jcp.12m08083
- aliases
- None recorded
- title
- Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity.
- journal
- The Journal of clinical psychiatry
- neurotransmitters
- None recorded
- year
- 2013
- authors
- Hoge EA, Bui E, Marques L, Metcalf CA, Morris LK, Robinaugh DJ, Worthington JJ, Pollack MH, Simon NM.
- design
- Randomized controlled trial
- identity Conflict
- Not recorded
- doi
- 10.4088/jcp.12m08083
- pmid
- 23541163
- urls
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In a 93-person generalised-anxiety trial, MBSR improved several secondary anxiety ratings and stress-challenge responses more than stress-management education.
- limitation
- The primary Hamilton Anxiety outcome improved in both arms without a significant between-group difference. The positive findings are secondary outcomes and laboratory stress responses.
- citation Count
- 267
- citation Snapshot
- count
- 267
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/23541163
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 267
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- journalofclinicalpsychiatry
- journal Label
- The Journal of clinical psychiatry
- chapter Entries
- title
- Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity.
- journal
- The Journal of clinical psychiatry
- year
- 2013
- authors
- Hoge EA, Bui E, Marques L, Metcalf CA, Morris LK, Robinaugh DJ, Worthington JJ, Pollack MH, Simon NM.
- design
- Randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- doi
- 10.4088/jcp.12m08083
- pmid
- 23541163
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 267
- citation Snapshot
- count
- 267
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/23541163
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Eight-week MBSR
- comparator
- Stress-management education
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/23541163
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- trial Id
- NCT01033851
- id
- language-mindfulness-clinical-pmid-23541163
- record Id
- pmid-23541163
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In a 93-person generalised-anxiety trial, MBSR improved several secondary anxiety ratings and stress-challenge responses more than stress-management education.
- limitation
- The primary Hamilton Anxiety outcome improved in both arms without a significant between-group difference. The positive findings are secondary outcomes and laboratory stress responses.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.4088/jcp.12m08083
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- Eight-week MBSR
- comparator
- Stress-management education
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/23541163/ · https://doi.org/10.4088/jcp.12m08083 · https://pmc.ncbi.nlm.nih.gov/articles/PMC3772979/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/23541163
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- trial Id
- NCT01033851
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- anxiety
- evidence
- field
- curated primary-source summary
- text
- In a 93-person generalised-anxiety trial, MBSR improved several secondary anxiety ratings and stress-challenge responses more than stress-management education.
- matched Text
- anxiety
- conditions
anxiety
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false