Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices
Jing-Jing Zheng; Shu-Jing Li; Xiao-Di Zhang; Wan-Ying Miao; Dinghong Zhang; Haishan Yao; Xiang Yu · Nature Neuroscience · 2014 · Experimental mouse study
Original publication · Original publication · Original publication
Recorded summary
Early sensory deprivation altered oxytocin synthesis and release and reduced excitatory synaptic transmission across sensory cortices in mice. Oxytocin treatment restored aspects of this transmission, linking early sensory experience to oxytocin-dependent cortical plasticity.
Recorded limitations
Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental mouse study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/24464043/ · https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Developing mice exposed to sensory deprivation
- measurement
- Oxytocin synthesis and release; cortical synaptic transmission
- measured Genes
- None recorded
- relationship Note
- Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
- source URLs
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- general:oxytocin-sensory
- title
- Oxytocin receptors and sensory experience
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-24464043
- doi
- 10.1038/nn.3634
- pmid
- 24464043
- citation Snapshot
- count
- 198
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nn.3634
- citations By Collection
- general
- 198
Complete approved library record
- id
- pmid-24464043
- aliases
- None recorded
- title
- Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices
- journal
- Nature Neuroscience
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
Oxytocin
- year
- 2014
- authors
- Jing-Jing Zheng; Shu-Jing Li; Xiao-Di Zhang; Wan-Ying Miao; Dinghong Zhang; Haishan Yao; Xiang Yu
- design
- Experimental mouse study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/nn.3634
- pmid
- 24464043
- urls
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- collections
general
- categories
Brain & nervous system
- targets
OXT
- priority
- 1
- quotes
- None recorded
- summary
- Early sensory deprivation altered oxytocin synthesis and release and reduced excitatory synaptic transmission across sensory cortices in mice. Oxytocin treatment restored aspects of this transmission, linking early sensory experience to oxytocin-dependent cortical plasticity.
- limitation
- Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
- citation Count
- 198
- citation Snapshot
- count
- 198
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nn.3634
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/24464043/ · https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- general
- 198
- topics
- key
- general:oxytocin-sensory
- title
- Oxytocin receptors and sensory experience
- collection
- general
- trust Score
- 1
- journal Key
- natureneuroscience
- journal Label
- Nature Neuroscience
- chapter Entries
- title
- Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices
- journal
- Nature Neuroscience
- year
- 2014
- authors
- Jing-Jing Zheng; Shu-Jing Li; Xiao-Di Zhang; Wan-Ying Miao; Dinghong Zhang; Haishan Yao; Xiang Yu
- design
- Experimental mouse study
- urls
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- doi
- 10.1038/nn.3634
- pmid
- 24464043
- targets
OXT
- neurotransmitters
Oxytocin
- categories
Brain & nervous system
- citation Count
- 198
- citation Snapshot
- count
- 198
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/nn.3634
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Brain & nervous system
- sample
- Developing mice exposed to sensory deprivation
- measurement
- Oxytocin synthesis and release; cortical synaptic transmission
- measured Genes
- None recorded
- relationship Note
- Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
- source URLs
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- checked At
- 2026-10-23
- id
- general-oxytocin-sensory-pmid-24464043
- record Id
- pmid-24464043
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Early sensory deprivation altered oxytocin synthesis and release and reduced excitatory synaptic transmission across sensory cortices in mice. Oxytocin treatment restored aspects of this transmission, linking early sensory experience to oxytocin-dependent cortical plasticity.
- limitation
- Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/24464043/ · https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 8
- topic Id
- oxytocin-sensory
- topic Title
- Oxytocin receptors and sensory experience
- trust Score
- 1
- evidence
- evidence Type
- Brain & nervous system
- sample
- Developing mice exposed to sensory deprivation
- measurement
- Oxytocin synthesis and release; cortical synaptic transmission
- measured Genes
- None recorded
- relationship Note
- Experiments in developing mice; the study does not test EMDR, music therapy or a human clinical intervention.
- source URLs
https://www.nature.com/articles/nn.3634 · https://doi.org/10.1038/nn.3634 · https://pubmed.ncbi.nlm.nih.gov/24464043/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false