Universal Informatics · Research reading room

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators

Kaliman P, Alvarez-López MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ. · Psychoneuroendocrinology · 2014 · Nonrandomized controlled study

Original publication · Original publication · Original publication

Recorded summary

After practice, meditators showed lower expression of HDAC2, HDAC3, HDAC9, RIPK2 and PTGS2 (COX-2), alongside changes in histone modification. RIPK2 and HDAC2 expression were associated with faster cortisol recovery.

Recorded limitations

Groups differed in prior meditation experience and were not randomized. Peripheral blood findings do not establish equivalent changes in brain tissue.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Nonrandomized controlled study
assessment
basis
Expert meditators and controls were compared without random allocation.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

assessed At
2026-10-23
registered Masking Basis
false
category
peer-reviewed
peer Reviewed
true
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Expert meditators and controls were compared without random allocation.
sources

https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
intervention
One day of intensive mindfulness in experienced practitioners
comparator
Leisure activities in people without meditation experience
sample
19 meditators and 21 controls
measurement
Peripheral blood mononuclear cells; qPCR and histone measures
timing
8 hours
trial Id
Not recorded
measured Genes

HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

pathways
None recorded
evidence Type
RNA expression
source URLs

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

checked At
2026-10-23
review Scope
Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
  1. key
    language:ii
    title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    collection
    language
    trust Score
    2
  2. key
    language:mindfulness-rna
    title
    Mindfulness interventions and gene expression
    collection
    language
    trust Score
    2
Citation snapshot and identifiers
id
pmid-24485481
doi
10.1016/j.psyneuen.2013.11.004
pmid
24485481
citation Snapshot
count
212
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1016/j.psyneuen.2013.11.004
citations By Collection
language
256
Complete approved library record
id
pmid-24485481
publication Key
Not recorded
aliases
None recorded
title
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
journal
Psychoneuroendocrinology
neurotransmitters
None recorded
year
2014
authors
Kaliman P, Alvarez-López MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ.
design
Nonrandomized controlled study
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.psyneuen.2013.11.004
pmid
24485481
urls

https://doi.org/10.1016/j.psyneuen.2013.11.004 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/

collections

language

categories

Gene expression

targets

HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

priority
0
quotes
None recorded
summary
After practice, meditators showed lower expression of HDAC2, HDAC3, HDAC9, RIPK2 and PTGS2 (COX-2), alongside changes in histone modification. RIPK2 and HDAC2 expression were associated with faster cortisol recovery.
limitation
Groups differed in prior meditation experience and were not randomized. Peripheral blood findings do not establish equivalent changes in brain tissue.
citation Count
256
citation Snapshot
count
212
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1016/j.psyneuen.2013.11.004
study Design Assessment
basis
Expert meditators and controls were compared without random allocation.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

assessed At
2026-10-23
registered Masking Basis
false
category
peer-reviewed
peer Reviewed
true
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-confirmed
peer Reviewed
true
basis
Expert meditators and controls were compared without random allocation.
sources

https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
256
topics
  1. key
    language:ii
    title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    collection
    language
    trust Score
    2
  2. key
    language:mindfulness-rna
    title
    Mindfulness interventions and gene expression
    collection
    language
    trust Score
    2
journal Key
psychoneuroendocrinology
journal Label
Psychoneuroendocrinology
chapter Entries
  1. id
    language-ii-pmid-24485481
    record Id
    pmid-24485481
    title
    Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
    journal
    Psychoneuroendocrinology
    year
    2014
    authors
    Kaliman P, Alvarez-López MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ.
    design
    urls

    https://doi.org/10.1016/j.psyneuen.2013.11.004 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/

    quotes
    None recorded
    citation Count
    256
    source Pages

    15

    targets
    None recorded
    categories

    Gene expression · Epigenetics · Molecular biomarkers

    doi
    10.1016/j.psyneuen.2013.11.004
    pmid
    24485481
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Expert meditators and controls were compared without random allocation.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    basis
    Expert meditators and controls were compared without random allocation.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    assessed At
    2026-10-23
    registered Masking Basis
    false
    category
    peer-reviewed
    peer Reviewed
    true
    collection
    language
    chapter Number
    1
    topic Id
    ii
    topic Title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    trust Score
    2
    evidence
    intervention
    One day of intensive mindfulness in experienced practitioners
    comparator
    Leisure activities in people without meditation experience
    sample
    19 meditators and 21 controls
    measurement
    Peripheral blood mononuclear cells; qPCR and histone measures
    timing
    8 hours
    trial Id
    Not recorded
    measured Genes

    HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

    pathways
    None recorded
    evidence Type
    RNA expression
    source URLs

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    checked At
    2026-10-23
    review Scope
    Publication abstract and selected full-text methods; Jadad assessment pending
  2. id
    language-mindfulness-rna-pmid-24485481
    record Id
    pmid-24485481
    title
    Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
    journal
    Psychoneuroendocrinology
    year
    2014
    authors
    Kaliman P, Alvarez-López MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ.
    design
    Nonrandomized controlled study
    urls

    https://doi.org/10.1016/j.psyneuen.2013.11.004 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/

    quotes
    None recorded
    summary
    After practice, meditators showed lower expression of HDAC2, HDAC3, HDAC9, RIPK2 and PTGS2 (COX-2), alongside changes in histone modification. RIPK2 and HDAC2 expression were associated with faster cortisol recovery.
    limitation
    Groups differed in prior meditation experience and were not randomized. Peripheral blood findings do not establish equivalent changes in brain tissue.
    citation Count
    212
    citation Snapshot
    count
    212
    source
    Crossref
    retrieved At
    2026-10-23
    url
    https://api.crossref.org/works/10.1016/j.psyneuen.2013.11.004
    study Design Assessment
    basis
    Expert meditators and controls were compared without random allocation.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    assessed At
    2026-10-23
    registered Masking Basis
    false
    category
    peer-reviewed
    peer Reviewed
    true
    source Pages
    None recorded
    targets

    HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

    categories

    Gene expression

    doi
    10.1016/j.psyneuen.2013.11.004
    pmid
    24485481
    evidence
    intervention
    One day of intensive mindfulness in experienced practitioners
    comparator
    Leisure activities in people without meditation experience
    sample
    19 meditators and 21 controls
    measurement
    Peripheral blood mononuclear cells; qPCR and histone measures
    timing
    8 hours
    trial Id
    Not recorded
    measured Genes

    HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

    pathways
    None recorded
    evidence Type
    RNA expression
    source URLs

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    checked At
    2026-10-23
    review Scope
    Publication abstract and selected full-text methods; Jadad assessment pending
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Expert meditators and controls were compared without random allocation.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    4
    topic Id
    mindfulness-rna
    topic Title
    Mindfulness interventions and gene expression
    trust Score
    2
evidence
intervention
One day of intensive mindfulness in experienced practitioners
comparator
Leisure activities in people without meditation experience
sample
19 meditators and 21 controls
measurement
Peripheral blood mononuclear cells; qPCR and histone measures
timing
8 hours
trial Id
Not recorded
measured Genes

HDAC2 · HDAC3 · HDAC9 · RIPK2 · PTGS2

pathways
None recorded
evidence Type
RNA expression
source URLs

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039194/ · https://pubmed.ncbi.nlm.nih.gov/24485481/ · https://doi.org/10.1016/j.psyneuen.2013.11.004

checked At
2026-10-23
review Scope
Publication abstract and selected full-text methods; Jadad assessment pending
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

2

full Text
status
reuse-review
retrieval Available
false
url
https://pmc-oa-opendata.s3.amazonaws.com/PMC4039194.1/PMC4039194.1.xml?md5=6cd8f6aac92c785fe0ef3aa3809fbe05
pmcid
PMC4039194
rights
license
TDM
use
Private text mining
public Fulltext Redistribution
false
provider Upload
false
model Training
false
basis
https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
article Rights

© 2013 Elsevier Ltd. All rights reserved. 2013 This file is available for text mining. It may also be used consistent with the principles of fair use under the copyright law.

sha256
514b181a9ab9bc13bd8c22c9bfaac95256bacd681ce5f654b3fe86d4386ed68d
checked At
2026-10-24

Open this publication in the interactive library