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A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia

Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA. · Schizophrenia research · 2014 · randomised controlled trial

Original publication · Original publication

Attributed extracts from the research record

“Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial
assessment
Not recorded
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/24799299/ · https://doi.org/10.1016/j.schres.2014.04.009 · https://www.sciencedirect.com/science/article/abs/pii/S0920996414001674

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    sound
    trust Score
    3
  2. key
    general:sound-xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-24799299
doi
10.1016/j.schres.2014.04.009
pmid
24799299
citation Snapshot
Not recorded
citations By Collection
sound
82
general
82
Complete approved library record
id
pmid-24799299
publication Key
Not recorded
aliases
None recorded
title
A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
journal
Schizophrenia research
neurotransmitters
None recorded
year
2014
authors
Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA.
design
randomised controlled trial
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.schres.2014.04.009
pmid
24799299
urls

https://doi.org/10.1016/j.schres.2014.04.009 · https://pubmed.ncbi.nlm.nih.gov/24799299/

collections

sound · general

categories

Molecular biomarkers · Brain & nervous system · Clinical & self-report

targets

OXT

priority
1
quotes

“Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia.”

summary
limitation
citation Count
82
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/24799299/ · https://doi.org/10.1016/j.schres.2014.04.009 · https://www.sciencedirect.com/science/article/abs/pii/S0920996414001674

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
82
general
82
topics
  1. key
    sound:xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    sound
    trust Score
    3
  2. key
    general:sound-xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    general
    trust Score
    3
journal Key
schizophreniaresearch
journal Label
Schizophrenia research
chapter Entries
  1. id
    xxxi-pmid-24799299
    record Id
    pmid-24799299
    title
    A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
    journal
    Schizophrenia research
    year
    2014
    authors
    Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.schres.2014.04.009 · https://pubmed.ncbi.nlm.nih.gov/24799299/

    quotes
      1. text
        “Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia.”
        emphasis
        false
    citation Count
    82
    source Pages

    128

    targets

    OXT

    categories

    Molecular biomarkers · Brain & nervous system · Clinical & self-report

    doi
    10.1016/j.schres.2014.04.009
    pmid
    24799299
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24799299/ · https://doi.org/10.1016/j.schres.2014.04.009 · https://www.sciencedirect.com/science/article/abs/pii/S0920996414001674

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    6
    topic Id
    xxxi
    topic Title
    Oxytocin, empathy and intergroup relationships
    trust Score
    3
  2. id
    general-xxxi-pmid-24799299
    record Id
    pmid-24799299
    title
    A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
    journal
    Schizophrenia research
    year
    2014
    authors
    Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.schres.2014.04.009 · https://pubmed.ncbi.nlm.nih.gov/24799299/

    quotes
      1. text
        “Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia.”
        emphasis
        false
    citation Count
    82
    source Pages

    128

    targets

    OXT

    categories

    Molecular biomarkers · Brain & nervous system · Clinical & self-report

    doi
    10.1016/j.schres.2014.04.009
    pmid
    24799299
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24799299/ · https://doi.org/10.1016/j.schres.2014.04.009 · https://www.sciencedirect.com/science/article/abs/pii/S0920996414001674

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    1
    topic Id
    sound-xxxi
    topic Title
    Oxytocin, empathy and intergroup relationships
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    schizophrenia
    evidence
    1. field
      title
      text
      A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia
      matched Text
      schizophrenia
conditions

schizophrenia

topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

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