Universal Informatics · Research reading room

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study

Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T. · International immunopharmacology · 2014 · randomized, double-blind, placebo-controlled pilot study

Original publication · Original publication

Attributed extracts from the research record

“we have demonstrated that intravenous infusion of H2 is effective in treating RA. This method could be useful not only for controlling RA but also for preventing age-related inflammatory diseases”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomized, double-blind, placebo-controlled pilot study
assessment
Not recorded
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  3. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
  4. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-24929023
doi
10.1016/j.intimp.2014.06.001
pmid
24929023
citation Snapshot
Not recorded
citations By Collection
language
47
general
47
Complete approved library record
id
pmid-24929023
publication Key
Not recorded
aliases
None recorded
title
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
journal
International immunopharmacology
neurotransmitters
None recorded
year
2014
authors
Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.
design
randomized, double-blind, placebo-controlled pilot study
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.intimp.2014.06.001
pmid
24929023
urls

https://doi.org/10.1016/j.intimp.2014.06.001 · https://pubmed.ncbi.nlm.nih.gov/24929023/

collections

language · general

categories

Molecular biomarkers · Methods & context

targets
None recorded
priority
1
quotes

“we have demonstrated that intravenous infusion of H2 is effective in treating RA. This method could be useful not only for controlling RA but also for preventing age-related inflammatory diseases”

summary
limitation
citation Count
47
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
47
general
47
topics
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  3. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
  4. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
journal Key
internationalimmunopharmacology
journal Label
International immunopharmacology
chapter Entries
  1. id
    language-vi-pmid-24929023
    record Id
    pmid-24929023
    title
    Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
    journal
    International immunopharmacology
    year
    2014
    authors
    Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.
    design
    randomized, double-blind, placebo-controlled pilot study
    urls

    https://doi.org/10.1016/j.intimp.2014.06.001 · https://pubmed.ncbi.nlm.nih.gov/24929023/

    quotes
      1. text
        “we have demonstrated that intravenous infusion of H2 is effective in treating RA. This method could be useful not only for controlling RA but also for preventing age-related inflammatory diseases”
        emphasis
        false
    citation Count
    47
    source Pages

    24

    targets
    None recorded
    categories

    Molecular biomarkers · Methods & context

    doi
    10.1016/j.intimp.2014.06.001
    pmid
    24929023
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  2. id
    language-vi-pmid-24929023-p24
    record Id
    pmid-24929023
    title
    Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study
    journal
    International immunopharmacology
    year
    2014
    authors
    Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.
    design
    randomized, double-blind, placebo-controlled pilot study
    urls

    https://doi.org/10.1016/j.intimp.2014.06.001 · https://pubmed.ncbi.nlm.nih.gov/24929023/

    quotes
    None recorded
    citation Count
    47
    source Pages

    24

    targets
    None recorded
    categories

    Molecular biomarkers · Methods & context

    doi
    10.1016/j.intimp.2014.06.001
    pmid
    24929023
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  3. id
    general-language-vi-pmid-24929023
    record Id
    pmid-24929023
    title
    Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
    journal
    International immunopharmacology
    year
    2014
    authors
    Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.
    design
    randomized, double-blind, placebo-controlled pilot study
    urls

    https://doi.org/10.1016/j.intimp.2014.06.001 · https://pubmed.ncbi.nlm.nih.gov/24929023/

    quotes
      1. text
        “we have demonstrated that intravenous infusion of H2 is effective in treating RA. This method could be useful not only for controlling RA but also for preventing age-related inflammatory diseases”
        emphasis
        false
    citation Count
    47
    source Pages

    24

    targets
    None recorded
    categories

    Molecular biomarkers · Methods & context

    doi
    10.1016/j.intimp.2014.06.001
    pmid
    24929023
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    3
    topic Id
    language-vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  4. id
    general-language-vi-pmid-24929023-p24
    record Id
    pmid-24929023
    title
    Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study
    journal
    International immunopharmacology
    year
    2014
    authors
    Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.
    design
    randomized, double-blind, placebo-controlled pilot study
    urls

    https://doi.org/10.1016/j.intimp.2014.06.001 · https://pubmed.ncbi.nlm.nih.gov/24929023/

    quotes
    None recorded
    citation Count
    47
    source Pages

    24

    targets
    None recorded
    categories

    Molecular biomarkers · Methods & context

    doi
    10.1016/j.intimp.2014.06.001
    pmid
    24929023
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/24929023/ · https://doi.org/10.1016/j.intimp.2014.06.001 · https://www.sciencedirect.com/science/article/pii/S1567576914002124

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    3
    topic Id
    language-vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

Open this publication in the interactive library