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Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study

Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS. · Psychoneuroendocrinology · 2014

Original publication · Original publication

Attributed extracts from the research record

“The results indicated that the OXTR rs53576 is connected with the striatal dopamine transporter DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/25001970/ · https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
pmid-25001970
doi
10.1016/j.psyneuen.2014.05.020
pmid
25001970
citation Snapshot
Not recorded
citations By Collection
sound
50
general
50
Complete approved library record
id
pmid-25001970
publication Key
Not recorded
aliases
None recorded
title
Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study
journal
Psychoneuroendocrinology
neurotransmitters
None recorded
year
2014
authors
Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.psyneuen.2014.05.020
pmid
25001970
urls

https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://pubmed.ncbi.nlm.nih.gov/25001970/

collections

sound · general

categories

Genetics & genomics · Molecular biomarkers

targets

OXTR · OXT

priority
0
quotes

“The results indicated that the OXTR rs53576 is connected with the striatal dopamine transporter DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems.”

summary
limitation
citation Count
50
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/25001970/ · https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
50
general
50
topics
  1. key
    sound:xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    general
    trust Score
    1
journal Key
psychoneuroendocrinology
journal Label
Psychoneuroendocrinology
chapter Entries
  1. id
    xxix-pmid-25001970
    record Id
    pmid-25001970
    title
    Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study
    journal
    Psychoneuroendocrinology
    year
    2014
    authors
    Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS.
    design
    urls

    https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://pubmed.ncbi.nlm.nih.gov/25001970/

    quotes
      1. text
        “The results indicated that the OXTR rs53576 is connected with the striatal dopamine transporter DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems.”
        emphasis
        false
    citation Count
    50
    source Pages

    117

    targets

    OXTR · OXT

    categories

    Genetics & genomics · Molecular biomarkers

    doi
    10.1016/j.psyneuen.2014.05.020
    pmid
    25001970
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/25001970/ · https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    6
    topic Id
    xxix
    topic Title
    Oxytocin pathways, dopamine and serotonin
    trust Score
    1
  2. id
    general-xxix-pmid-25001970
    record Id
    pmid-25001970
    title
    Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study
    journal
    Psychoneuroendocrinology
    year
    2014
    authors
    Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS.
    design
    urls

    https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://pubmed.ncbi.nlm.nih.gov/25001970/

    quotes
      1. text
        “The results indicated that the OXTR rs53576 is connected with the striatal dopamine transporter DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems.”
        emphasis
        false
    citation Count
    50
    source Pages

    117

    targets

    OXTR · OXT

    categories

    Genetics & genomics · Molecular biomarkers

    doi
    10.1016/j.psyneuen.2014.05.020
    pmid
    25001970
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/25001970/ · https://doi.org/10.1016/j.psyneuen.2014.05.020 · https://www.sciencedirect.com/science/article/abs/pii/S0306453014002042

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    1
    topic Id
    sound-xxix
    topic Title
    Oxytocin pathways, dopamine and serotonin
    trust Score
    1
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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