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Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial

Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Ganz PA, Bower JE, Cole S. · Journal of the National Cancer Institute. Monographs · 2014 · randomised controlled trial

Original publication · Original publication

Attributed extracts from the research record

“Among breast cancer survivors with insomnia, 3 months of Tai Chi reduced cellular inflammatory responses, and reduced expression of genes encoding proinflammatory mediators. Given the link between inflammation and cancer, these findings provide an evidence-based molecular framework to understand the potential salutary effects of Tai Chi on cancer survivorship”
“Levels of toll-like receptor-4-activated monocyte production of IL-6 showed an overall reduction in Tai Chi”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial
assessment
Not recorded
trust Factor
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/25749595/ · https://doi.org/10.1093/jncimonographs/lgu028

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:iv
    title
    Mindfulness and related practices: IL-6, inflammation and mental health
    collection
    language
    trust Score
    2
Citation snapshot and identifiers
id
pmid-25749595
doi
10.1093/jncimonographs/lgu028
pmid
25749595
citation Snapshot
Not recorded
citations By Collection
language
93
Complete approved library record
id
pmid-25749595
publication Key
Not recorded
aliases
None recorded
title
Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial
journal
Journal of the National Cancer Institute. Monographs
neurotransmitters
None recorded
year
2014
authors
Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Ganz PA, Bower JE, Cole S.
design
randomised controlled trial
kind
Journal article
identity Conflict
Not recorded
doi
10.1093/jncimonographs/lgu028
pmid
25749595
urls

https://pubmed.ncbi.nlm.nih.gov/25749595/ · https://doi.org/10.1093/jncimonographs/lgu028

collections

language

categories

Gene expression · Molecular biomarkers

targets

IL6

priority
0
quotes

“Among breast cancer survivors with insomnia, 3 months of Tai Chi reduced cellular inflammatory responses, and reduced expression of genes encoding proinflammatory mediators. Given the link between inflammation and cancer, these findings provide an evidence-based molecular framework to understand the potential salutary effects of Tai Chi on cancer survivorship” · “Levels of toll-like receptor-4-activated monocyte production of IL-6 showed an overall reduction in Tai Chi”

summary
limitation
citation Count
93
paper Trust Assessment
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/25749595/ · https://doi.org/10.1093/jncimonographs/lgu028

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
93
topics
  1. key
    language:iv
    title
    Mindfulness and related practices: IL-6, inflammation and mental health
    collection
    language
    trust Score
    2
journal Key
journalofthenationalcancerinstitutemonographs
journal Label
Journal of the National Cancer Institute. Monographs
chapter Entries
  1. id
    language-iv-pmid-25749595
    record Id
    pmid-25749595
    title
    Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial
    journal
    Journal of the National Cancer Institute. Monographs
    year
    2014
    authors
    Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Ganz PA, Bower JE, Cole S.
    design
    randomised controlled trial
    urls

    https://pubmed.ncbi.nlm.nih.gov/25749595/ · https://doi.org/10.1093/jncimonographs/lgu028

    quotes
      1. text
        “Among breast cancer survivors with insomnia, 3 months of Tai Chi reduced cellular inflammatory responses, and reduced expression of genes encoding proinflammatory mediators. Given the link between inflammation and cancer, these findings provide an evidence-based molecular framework to understand the potential salutary effects of Tai Chi on cancer survivorship”
        emphasis
        false
      1. text
        “Levels of toll-like receptor-4-activated monocyte production of IL-6 showed an overall reduction in Tai Chi”
        emphasis
        false
    citation Count
    93
    source Pages

    18

    targets

    IL6

    categories

    Gene expression · Molecular biomarkers

    doi
    10.1093/jncimonographs/lgu028
    pmid
    25749595
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
    sources

    https://pubmed.ncbi.nlm.nih.gov/25749595/ · https://doi.org/10.1093/jncimonographs/lgu028

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    iv
    topic Title
    Mindfulness and related practices: IL-6, inflammation and mental health
    trust Score
    2
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    sleep
    evidence
    1. field
      title
      text
      Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial
      matched Text
      insomnia
conditions

sleep

topic Trust Scores

2

full Text
status
not-indexed
retrieval Available
false

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