The effect of music performance on the transcriptome of professional musicians
Chakravarthi Kanduri; Tuire Kuusi; Minna Ahvenainen; Anju K. Philips; Harri Lähdesmäki; Irma Järvelä · Scientific Reports · 2015 · Controlled, non-randomized transcriptome study
Original publication · Original publication · Original publication · Original publication
Recorded summary
Whole-blood gene expression changed after a two-hour concert performed by professional musicians. Genes including SNCA, FOS and DUSP1 contributed to the reported response, with enrichment of pathways related to neuronal activity and plasticity.
Recorded limitations
Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Controlled, non-randomized transcriptome study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/25806429/ · https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Gene expression
- sample
- 10 professional performers and 10 controls
- measurement
- Whole-blood transcriptome before and after two hours
- measured Genes
SNCA · FOS · DUSP1
- relationship Note
- Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
- source URLs
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- sound:x
- title
- Music-making, gene expression and stress
- collection
- sound
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-25806429
- doi
- 10.1038/srep09506
- pmid
- 25806429
- citation Snapshot
- count
- 49
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep09506
- citations By Collection
- sound
- 49
Complete approved library record
- id
- pmid-25806429
- aliases
- None recorded
- title
- The effect of music performance on the transcriptome of professional musicians
- journal
- Scientific Reports
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2015
- authors
- Chakravarthi Kanduri; Tuire Kuusi; Minna Ahvenainen; Anju K. Philips; Harri Lähdesmäki; Irma Järvelä
- design
- Controlled, non-randomized transcriptome study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/srep09506
- pmid
- 25806429
- urls
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- collections
sound
- categories
Gene expression
- targets
SNCA · FOS · DUSP1
- priority
- 0
- quotes
- None recorded
- summary
- Whole-blood gene expression changed after a two-hour concert performed by professional musicians. Genes including SNCA, FOS and DUSP1 contributed to the reported response, with enrichment of pathways related to neuronal activity and plasticity.
- limitation
- Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
- citation Count
- 49
- citation Snapshot
- count
- 49
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep09506
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/25806429/ · https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 49
- topics
- key
- sound:x
- title
- Music-making, gene expression and stress
- collection
- sound
- trust Score
- 1
- journal Key
- scientificreports
- journal Label
- Scientific Reports
- chapter Entries
- title
- The effect of music performance on the transcriptome of professional musicians
- journal
- Scientific Reports
- year
- 2015
- authors
- Chakravarthi Kanduri; Tuire Kuusi; Minna Ahvenainen; Anju K. Philips; Harri Lähdesmäki; Irma Järvelä
- design
- Controlled, non-randomized transcriptome study
- urls
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- doi
- 10.1038/srep09506
- pmid
- 25806429
- targets
SNCA · FOS · DUSP1
- neurotransmitters
- None recorded
- categories
Gene expression
- citation Count
- 49
- citation Snapshot
- count
- 49
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep09506
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Gene expression
- sample
- 10 professional performers and 10 controls
- measurement
- Whole-blood transcriptome before and after two hours
- measured Genes
SNCA · FOS · DUSP1
- relationship Note
- Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
- source URLs
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- checked At
- 2026-10-23
- id
- sound-x-pmid-25806429
- record Id
- pmid-25806429
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Whole-blood gene expression changed after a two-hour concert performed by professional musicians. Genes including SNCA, FOS and DUSP1 contributed to the reported response, with enrichment of pathways related to neuronal activity and plasticity.
- limitation
- Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Controlled, non-randomized transcriptome study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/25806429/ · https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 3
- topic Id
- x
- topic Title
- Music-making, gene expression and stress
- trust Score
- 1
- evidence
- evidence Type
- Gene expression
- sample
- 10 professional performers and 10 controls
- measurement
- Whole-blood transcriptome before and after two hours
- measured Genes
SNCA · FOS · DUSP1
- relationship Note
- Ten performers were compared with ten music-free controls. Blood transcription does not directly measure gene expression in the brain, and allocation was not randomized.
- source URLs
https://www.nature.com/articles/srep09506 · https://doi.org/10.1038/srep09506 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5380155/ · https://pubmed.ncbi.nlm.nih.gov/25806429/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://pmc-oa-opendata.s3.amazonaws.com/PMC5380155.1/PMC5380155.1.xml?md5=7704e52e4f03a0dd0af7c4cb6b16d57b
- pmcid
- PMC5380155
- rights
- license
- CC BY
- use
- Attribution-preserving reuse
- public Fulltext Redistribution
- false
- provider Upload
- false
- model Training
- false
- basis
- https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
- article Rights
Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- sha256
- 11f498101ac88771b0be326e58059c1b39b11d45b5025165e3d2d61570c699ed
- checked At
- 2026-10-24