Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial
Kuyken W, Hayes R, Barrett B, Byng R, Dalgleish T, Kessler D, Lewis G, Watkins E, Brejcha C, Cardy J, Causley A, Cowderoy S, Evans A, Gradinger F, Kaur S, Lanham P, Morant N, Richards J, Shah P, Sutton H, Vicary R, Weaver A, Wilks J, Williams M, Taylor RS, Byford S. · Lancet (London, England) · 2015 · Randomized controlled trial; single-blind (research assessors)
Original publication · Original publication
Recorded summary
PREVENT found no evidence that MBCT with taper support was superior to maintenance antidepressants for preventing relapse over two years (HR 0.89; 95% CI 0.67–1.18).
Recorded limitations
This was a superiority trial. Absence of a significant difference does not establish equivalence or noninferiority. Medication changes were supported within the trial.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; single-blind (research assessors)
- assessment
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Mindfulness-based cognitive therapy with medication-taper support
- comparator
- Maintenance antidepressants
- sample
- 424 adults with recurrent depression
- measurement
- Time to depressive relapse or recurrence
- timing
- 24 months
- trial Id
- ISRCTN26666654
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-25907157
- doi
- 10.1016/s0140-6736(14)62222-4
- pmid
- 25907157
- citation Snapshot
- count
- 445
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s0140-6736(14)62222-4
- citations By Collection
- language
- 445
Complete approved library record
- id
- pmid-25907157
- aliases
- None recorded
- title
- Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial
- journal
- Lancet (London, England)
- neurotransmitters
- None recorded
- year
- 2015
- authors
- Kuyken W, Hayes R, Barrett B, Byng R, Dalgleish T, Kessler D, Lewis G, Watkins E, Brejcha C, Cardy J, Causley A, Cowderoy S, Evans A, Gradinger F, Kaur S, Lanham P, Morant N, Richards J, Shah P, Sutton H, Vicary R, Weaver A, Wilks J, Williams M, Taylor RS, Byford S.
- design
- Randomized controlled trial; single-blind (research assessors)
- identity Conflict
- Not recorded
- doi
- 10.1016/s0140-6736(14)62222-4
- pmid
- 25907157
- urls
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- PREVENT found no evidence that MBCT with taper support was superior to maintenance antidepressants for preventing relapse over two years (HR 0.89; 95% CI 0.67–1.18).
- limitation
- This was a superiority trial. Absence of a significant difference does not establish equivalence or noninferiority. Medication changes were supported within the trial.
- citation Count
- 445
- citation Snapshot
- count
- 445
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s0140-6736(14)62222-4
- study Design Assessment
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 445
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- lancet
- journal Label
- Lancet (London, England)
- chapter Entries
- id
- language-mindfulness-clinical-pmid-25907157
- record Id
- pmid-25907157
- title
- Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial
- journal
- Lancet (London, England)
- year
- 2015
- authors
- Kuyken W, Hayes R, Barrett B, Byng R, Dalgleish T, Kessler D, Lewis G, Watkins E, Brejcha C, Cardy J, Causley A, Cowderoy S, Evans A, Gradinger F, Kaur S, Lanham P, Morant N, Richards J, Shah P, Sutton H, Vicary R, Weaver A, Wilks J, Williams M, Taylor RS, Byford S.
- design
- Randomized controlled trial; single-blind (research assessors)
- urls
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- quotes
- None recorded
- summary
- PREVENT found no evidence that MBCT with taper support was superior to maintenance antidepressants for preventing relapse over two years (HR 0.89; 95% CI 0.67–1.18).
- limitation
- This was a superiority trial. Absence of a significant difference does not establish equivalence or noninferiority. Medication changes were supported within the trial.
- citation Count
- 445
- citation Snapshot
- count
- 445
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s0140-6736(14)62222-4
- study Design Assessment
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Clinical & self-report
- doi
- 10.1016/s0140-6736(14)62222-4
- pmid
- 25907157
- evidence
- intervention
- Mindfulness-based cognitive therapy with medication-taper support
- comparator
- Maintenance antidepressants
- sample
- 424 adults with recurrent depression
- measurement
- Time to depressive relapse or recurrence
- timing
- 24 months
- trial Id
- ISRCTN26666654
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The abstract explicitly identifies a single-blind trial: participants knew allocation and research assessors were masked.
- sources
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- Mindfulness-based cognitive therapy with medication-taper support
- comparator
- Maintenance antidepressants
- sample
- 424 adults with recurrent depression
- measurement
- Time to depressive relapse or recurrence
- timing
- 24 months
- trial Id
- ISRCTN26666654
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/25907157/ · https://doi.org/10.1016/s0140-6736(14)62222-4
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- title
- text
- Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial
- matched Text
- depressive
- field
- evidence.sample
- text
- 424 adults with recurrent depression
- matched Text
- depression
- field
- evidence.measurement
- text
- Time to depressive relapse or recurrence
- matched Text
- depressive
- conditions
depression
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false