Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis
Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S. · PloS one · 2015 · Meta-Analysis
Original publication · Original publication · Original publication
Attributed extracts from the research record
“In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Meta-Analysis
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/26121678/ · https://doi.org/10.1371/journal.pone.0131820 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxx
- title
- OXTR variation and psychological resources
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxx
- title
- OXTR variation and psychological resources
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-26121678
- doi
- 10.1371/journal.pone.0131820
- pmid
- 26121678
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 138
- general
- 138
Complete approved library record
- id
- pmid-26121678
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis
- journal
- PloS one
- neurotransmitters
- None recorded
- year
- 2015
- authors
- Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S.
- design
- Meta-Analysis
- kind
- Review / synthesis
- identity Conflict
- Not recorded
- doi
- 10.1371/journal.pone.0131820
- pmid
- 26121678
- urls
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820 · https://doi.org/10.1371/journal.pone.0131820 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4488068/
- collections
sound · general
- categories
Genetics & genomics · Molecular biomarkers
- targets
OXTR · OXT
- priority
- 0
- quotes
“In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.”
- summary
- limitation
- citation Count
- 138
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/26121678/ · https://doi.org/10.1371/journal.pone.0131820 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 138
- general
- 138
- topics
- key
- sound:xxx
- title
- OXTR variation and psychological resources
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxx
- title
- OXTR variation and psychological resources
- collection
- general
- trust Score
- 1
- journal Key
- plosone
- journal Label
- PloS one
- chapter Entries
- id
- xxx-pmid-26121678
- record Id
- pmid-26121678
- title
- Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis
- journal
- PloS one
- year
- 2015
- authors
- Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S.
- design
- Meta-Analysis
- urls
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820 · https://doi.org/10.1371/journal.pone.0131820 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4488068/
- quotes
- text
- “In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.”
- emphasis
- false
- citation Count
- 138
- source Pages
124
- targets
OXTR · OXT
- categories
Genetics & genomics · Molecular biomarkers
- doi
- 10.1371/journal.pone.0131820
- pmid
- 26121678
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/26121678/ · https://doi.org/10.1371/journal.pone.0131820 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 6
- topic Id
- xxx
- topic Title
- OXTR variation and psychological resources
- trust Score
- 1
- id
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- record Id
- pmid-26121678
- title
- Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis
- journal
- PloS one
- year
- 2015
- authors
- Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S.
- design
- Meta-Analysis
- urls
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820 · https://doi.org/10.1371/journal.pone.0131820 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4488068/
- quotes
- text
- “In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.”
- emphasis
- false
- citation Count
- 138
- source Pages
124
- targets
OXTR · OXT
- categories
Genetics & genomics · Molecular biomarkers
- doi
- 10.1371/journal.pone.0131820
- pmid
- 26121678
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/26121678/ · https://doi.org/10.1371/journal.pone.0131820 · https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131820
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxx
- topic Title
- OXTR variation and psychological resources
- trust Score
- 1
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4488068/fullTextXML
- pmcid
- PMC4488068
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
© 2015 Li et al 2015 Li et al https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
- sha256
- f734e14ace1c109a6bfc0e9aa55e3401a6164c266028f6e2576bb4631e16e8f2
- checked At
- 2026-10-24