Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
Polusny MA, Erbes CR, Thuras P, Moran A, Lamberty GJ, Collins RC, Rodman JL, Lim KO. · JAMA · 2015 · Randomized controlled trial; single-blind (clinical assessors)
Original publication · Original publication
Recorded summary
MBSR produced greater improvement in self-reported PTSD symptoms than present-centred therapy. More participants achieved clinically significant symptom improvement, but loss of PTSD diagnosis did not differ significantly.
Recorded limitations
The mean advantage was modest, and treatment-session duration differed between groups. This study did not measure gene expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; single-blind (clinical assessors)
- assessment
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- MBSR
- comparator
- Present-centred group therapy
- sample
- 116 veterans with PTSD
- measurement
- Self-reported PTSD symptoms; clinician assessments
- timing
- 9 sessions; follow-up at 2 months
- trial Id
- NCT01548742
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-26241597
- doi
- 10.1001/jama.2015.8361
- pmid
- 26241597
- citation Snapshot
- count
- 280
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2015.8361
- citations By Collection
- language
- 280
Complete approved library record
- id
- pmid-26241597
- aliases
- None recorded
- title
- Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
- journal
- JAMA
- neurotransmitters
- None recorded
- year
- 2015
- authors
- Polusny MA, Erbes CR, Thuras P, Moran A, Lamberty GJ, Collins RC, Rodman JL, Lim KO.
- design
- Randomized controlled trial; single-blind (clinical assessors)
- identity Conflict
- Not recorded
- doi
- 10.1001/jama.2015.8361
- pmid
- 26241597
- urls
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- MBSR produced greater improvement in self-reported PTSD symptoms than present-centred therapy. More participants achieved clinically significant symptom improvement, but loss of PTSD diagnosis did not differ significantly.
- limitation
- The mean advantage was modest, and treatment-session duration differed between groups. This study did not measure gene expression.
- citation Count
- 280
- citation Snapshot
- count
- 280
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2015.8361
- study Design Assessment
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 280
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- jama
- journal Label
- JAMA
- chapter Entries
- id
- language-mindfulness-clinical-pmid-26241597
- record Id
- pmid-26241597
- title
- Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
- journal
- JAMA
- year
- 2015
- authors
- Polusny MA, Erbes CR, Thuras P, Moran A, Lamberty GJ, Collins RC, Rodman JL, Lim KO.
- design
- Randomized controlled trial; single-blind (clinical assessors)
- urls
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361
- quotes
- None recorded
- summary
- MBSR produced greater improvement in self-reported PTSD symptoms than present-centred therapy. More participants achieved clinically significant symptom improvement, but loss of PTSD diagnosis did not differ significantly.
- limitation
- The mean advantage was modest, and treatment-session duration differed between groups. This study did not measure gene expression.
- citation Count
- 280
- citation Snapshot
- count
- 280
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2015.8361
- study Design Assessment
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Clinical & self-report
- doi
- 10.1001/jama.2015.8361
- pmid
- 26241597
- evidence
- intervention
- MBSR
- comparator
- Present-centred group therapy
- sample
- 116 veterans with PTSD
- measurement
- Self-reported PTSD symptoms; clinician assessments
- timing
- 9 sessions; follow-up at 2 months
- trial Id
- NCT01548742
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The publication and authors’ follow-up confirm blinded clinical interviews. Participants knew their treatment. The register labels investigators and assessors as double masked; this classification follows the confirmed assessor blinding in the published study.
- sources
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361 · https://clinicaltrials.gov/study/NCT01548742 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10688415/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- MBSR
- comparator
- Present-centred group therapy
- sample
- 116 veterans with PTSD
- measurement
- Self-reported PTSD symptoms; clinician assessments
- timing
- 9 sessions; follow-up at 2 months
- trial Id
- NCT01548742
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26241597/ · https://doi.org/10.1001/jama.2015.8361
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
- matched Text
- Posttraumatic Stress
- field
- evidence.sample
- text
- 116 veterans with PTSD
- matched Text
- PTSD
- field
- evidence.measurement
- text
- Self-reported PTSD symptoms; clinician assessments
- matched Text
- PTSD
- id
- trauma
- evidence
- field
- title
- text
- Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
- matched Text
- Posttraumatic
- id
- stress
- evidence
- field
- title
- text
- Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial
- matched Text
- Stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false