Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia.
Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, Coghill RC. · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015 · Randomized controlled experiment
Original publication · Original publication · Original publication
Recorded summary
In 75 healthy volunteers, brief mindfulness training reduced experimentally induced pain more than placebo conditioning or sham mindfulness, with different associated brain-activation patterns.
Recorded limitations
An acute laboratory pain experiment does not establish durable benefit for chronic pain. Neuroimaging associations do not identify a single exclusive therapeutic mechanism.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled experiment
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Four days of mindfulness meditation training
- comparator
- Placebo conditioning, sham mindfulness and book listening
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/26586819
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-26586819
- doi
- 10.1523/jneurosci.2542-15.2015
- pmid
- 26586819
- citation Snapshot
- count
- 235
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/26586819
- citations By Collection
- language
- 235
Complete approved library record
- id
- pmid-26586819
- publication Key
- doi:10.1523/jneurosci.2542-15.2015
- aliases
- None recorded
- title
- Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia.
- journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- neurotransmitters
- None recorded
- year
- 2015
- authors
- Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, Coghill RC.
- design
- Randomized controlled experiment
- identity Conflict
- Not recorded
- doi
- 10.1523/jneurosci.2542-15.2015
- pmid
- 26586819
- urls
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In 75 healthy volunteers, brief mindfulness training reduced experimentally induced pain more than placebo conditioning or sham mindfulness, with different associated brain-activation patterns.
- limitation
- An acute laboratory pain experiment does not establish durable benefit for chronic pain. Neuroimaging associations do not identify a single exclusive therapeutic mechanism.
- citation Count
- 235
- citation Snapshot
- count
- 235
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/26586819
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 235
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- journalofneuroscience
- journal Label
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- chapter Entries
- title
- Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia.
- journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- year
- 2015
- authors
- Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, Coghill RC.
- design
- Randomized controlled experiment
- urls
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- doi
- 10.1523/jneurosci.2542-15.2015
- pmid
- 26586819
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 235
- citation Snapshot
- count
- 235
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/26586819
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Four days of mindfulness meditation training
- comparator
- Placebo conditioning, sham mindfulness and book listening
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/26586819
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- language-mindfulness-clinical-pmid-26586819
- record Id
- pmid-26586819
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 75 healthy volunteers, brief mindfulness training reduced experimentally induced pain more than placebo conditioning or sham mindfulness, with different associated brain-activation patterns.
- limitation
- An acute laboratory pain experiment does not establish durable benefit for chronic pain. Neuroimaging associations do not identify a single exclusive therapeutic mechanism.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1523/jneurosci.2542-15.2015
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- Four days of mindfulness meditation training
- comparator
- Placebo conditioning, sham mindfulness and book listening
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/26586819/ · https://doi.org/10.1523/jneurosci.2542-15.2015 · https://pmc.ncbi.nlm.nih.gov/articles/PMC4649004/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/26586819
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false