Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial
Cherkin DC, Sherman KJ, Balderson BH, Cook AJ, Anderson ML, Hawkes RJ, Hansen KE, Turner JA. · JAMA · 2016 · Randomized controlled trial; single-blind (interviewers)
Original publication · Original publication · Original publication
Recorded summary
At 26 weeks, meaningful functional improvement occurred in 60.5% receiving MBSR, 57.7% receiving CBT and 44.1% receiving usual care. Both active treatments improved pain outcomes; no significant difference separated MBSR and CBT.
Recorded limitations
These are clinical pain and function outcomes, not molecular measurements. The trial does not establish superiority over CBT.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; single-blind (interviewers)
- assessment
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- MBSR
- comparator
- Cognitive behavioural therapy or usual care
- sample
- 342 adults with chronic low-back pain
- measurement
- Pain bothersomeness and functional limitations
- timing
- 8 weeks; primary endpoint at 26 weeks; follow-up to 52 weeks
- trial Id
- NCT01467843
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-27002445
- doi
- 10.1001/jama.2016.2323
- pmid
- 27002445
- citation Snapshot
- count
- 661
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2016.2323
- citations By Collection
- language
- 661
Complete approved library record
- id
- pmid-27002445
- aliases
- None recorded
- title
- Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial
- journal
- JAMA
- neurotransmitters
- None recorded
- year
- 2016
- authors
- Cherkin DC, Sherman KJ, Balderson BH, Cook AJ, Anderson ML, Hawkes RJ, Hansen KE, Turner JA.
- design
- Randomized controlled trial; single-blind (interviewers)
- identity Conflict
- Not recorded
- doi
- 10.1001/jama.2016.2323
- pmid
- 27002445
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- At 26 weeks, meaningful functional improvement occurred in 60.5% receiving MBSR, 57.7% receiving CBT and 44.1% receiving usual care. Both active treatments improved pain outcomes; no significant difference separated MBSR and CBT.
- limitation
- These are clinical pain and function outcomes, not molecular measurements. The trial does not establish superiority over CBT.
- citation Count
- 661
- citation Snapshot
- count
- 661
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2016.2323
- study Design Assessment
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 661
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- jama
- journal Label
- JAMA
- chapter Entries
- id
- language-mindfulness-clinical-pmid-27002445
- record Id
- pmid-27002445
- title
- Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial
- journal
- JAMA
- year
- 2016
- authors
- Cherkin DC, Sherman KJ, Balderson BH, Cook AJ, Anderson ML, Hawkes RJ, Hansen KE, Turner JA.
- design
- Randomized controlled trial; single-blind (interviewers)
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323
- quotes
- None recorded
- summary
- At 26 weeks, meaningful functional improvement occurred in 60.5% receiving MBSR, 57.7% receiving CBT and 44.1% receiving usual care. Both active treatments improved pain outcomes; no significant difference separated MBSR and CBT.
- limitation
- These are clinical pain and function outcomes, not molecular measurements. The trial does not establish superiority over CBT.
- citation Count
- 661
- citation Snapshot
- count
- 661
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jama.2016.2323
- study Design Assessment
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Clinical & self-report
- doi
- 10.1001/jama.2016.2323
- pmid
- 27002445
- evidence
- intervention
- MBSR
- comparator
- Cognitive behavioural therapy or usual care
- sample
- 342 adults with chronic low-back pain
- measurement
- Pain bothersomeness and functional limitations
- timing
- 8 weeks; primary endpoint at 26 weeks; follow-up to 52 weeks
- trial Id
- NCT01467843
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article explicitly describes an interviewer-blind trial with follow-up interviewers masked to treatment group.
- sources
https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://doi.org/10.1001/jama.2016.2323 · https://clinicaltrials.gov/study/NCT01467843
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- MBSR
- comparator
- Cognitive behavioural therapy or usual care
- sample
- 342 adults with chronic low-back pain
- measurement
- Pain bothersomeness and functional limitations
- timing
- 8 weeks; primary endpoint at 26 weeks; follow-up to 52 weeks
- trial Id
- NCT01467843
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC4914381/ · https://pubmed.ncbi.nlm.nih.gov/27002445/ · https://doi.org/10.1001/jama.2016.2323
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- reuse-review
- retrieval Available
- false
- url
- https://pmc-oa-opendata.s3.amazonaws.com/PMC4914381.1/PMC4914381.1.xml?md5=77844e350d1cee4353165726962a61ee
- pmcid
- PMC4914381
- rights
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- TDM
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- Private text mining
- public Fulltext Redistribution
- false
- provider Upload
- false
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- false
- basis
- https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
- article Rights
This file is available for text mining. It may also be used consistent with the principles of fair use under the copyright law.
- sha256
- 63a3abee351d470b3614a194731f797ea948831506f7a85af4e621d52a44d942
- checked At
- 2026-10-24