Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
de la Mora MP, Pérez-Carrera D, Crespo-Ramírez M, Tarakanov A, Fuxe K, Borroto-Escuela DO. · Biochimica et biophysica acta · 2016
Original publication · Original publication
Attributed extracts from the research record
“Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling.”
“Based on the current findings, the blockade of the anxiolytic effects of oxytocin by the simultaneous intra-CeA administration of raclopride can be explained by a lack of facilitatory protomer interactions in D2R-OTR heterocomplexes.”
“Dysfunction and/or disruption of such interactions in the central amygdala may lead to anxiety development. Restoration of such interactions may represent a new strategy for development of novel anxiolytic drugs.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/27425032/ · https://doi.org/10.1016/j.bbadis.2016.07.004 · https://www.sciencedirect.com/science/article/pii/S0925443916301648
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-27425032
- doi
- 10.1016/j.bbadis.2016.07.004
- pmid
- 27425032
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 30
- general
- 30
Complete approved library record
- id
- pmid-27425032
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
- journal
- Biochimica et biophysica acta
- neurotransmitters
- None recorded
- year
- 2016
- authors
- de la Mora MP, Pérez-Carrera D, Crespo-Ramírez M, Tarakanov A, Fuxe K, Borroto-Escuela DO.
- design
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.bbadis.2016.07.004
- pmid
- 27425032
- urls
https://doi.org/10.1016/j.bbadis.2016.07.004 · https://pubmed.ncbi.nlm.nih.gov/27425032/
- collections
sound · general
- categories
Molecular biomarkers · Brain & nervous system · Clinical & self-report
- targets
OXTR · OXT · DRD2
- priority
- 1
- quotes
“Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling.” · “Based on the current findings, the blockade of the anxiolytic effects of oxytocin by the simultaneous intra-CeA administration of raclopride can be explained by a lack of facilitatory protomer interactions in D2R-OTR heterocomplexes.” · “Dysfunction and/or disruption of such interactions in the central amygdala may lead to anxiety development. Restoration of such interactions may represent a new strategy for development of novel anxiolytic drugs.”
- summary
- limitation
- citation Count
- 30
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/27425032/ · https://doi.org/10.1016/j.bbadis.2016.07.004 · https://www.sciencedirect.com/science/article/pii/S0925443916301648
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 30
- general
- 30
- topics
- key
- sound:xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- general
- trust Score
- 1
- journal Key
- biochimicaetbiophysicaacta
- journal Label
- Biochimica et biophysica acta
- chapter Entries
- id
- xxix-pmid-27425032
- record Id
- pmid-27425032
- title
- Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
- journal
- Biochimica et biophysica acta
- year
- 2016
- authors
- de la Mora MP, Pérez-Carrera D, Crespo-Ramírez M, Tarakanov A, Fuxe K, Borroto-Escuela DO.
- design
- urls
https://doi.org/10.1016/j.bbadis.2016.07.004 · https://pubmed.ncbi.nlm.nih.gov/27425032/
- quotes
- text
- “Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling.”
- emphasis
- false
- text
- “Based on the current findings, the blockade of the anxiolytic effects of oxytocin by the simultaneous intra-CeA administration of raclopride can be explained by a lack of facilitatory protomer interactions in D2R-OTR heterocomplexes.”
- emphasis
- false
- text
- “Dysfunction and/or disruption of such interactions in the central amygdala may lead to anxiety development. Restoration of such interactions may represent a new strategy for development of novel anxiolytic drugs.”
- emphasis
- false
- citation Count
- 30
- source Pages
118
- targets
OXTR · OXT · DRD2
- categories
Molecular biomarkers · Brain & nervous system · Clinical & self-report
- doi
- 10.1016/j.bbadis.2016.07.004
- pmid
- 27425032
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/27425032/ · https://doi.org/10.1016/j.bbadis.2016.07.004 · https://www.sciencedirect.com/science/article/pii/S0925443916301648
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 6
- topic Id
- xxix
- topic Title
- Oxytocin pathways, dopamine and serotonin
- trust Score
- 1
- id
- general-xxix-pmid-27425032
- record Id
- pmid-27425032
- title
- Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
- journal
- Biochimica et biophysica acta
- year
- 2016
- authors
- de la Mora MP, Pérez-Carrera D, Crespo-Ramírez M, Tarakanov A, Fuxe K, Borroto-Escuela DO.
- design
- urls
https://doi.org/10.1016/j.bbadis.2016.07.004 · https://pubmed.ncbi.nlm.nih.gov/27425032/
- quotes
- text
- “Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling.”
- emphasis
- false
- text
- “Based on the current findings, the blockade of the anxiolytic effects of oxytocin by the simultaneous intra-CeA administration of raclopride can be explained by a lack of facilitatory protomer interactions in D2R-OTR heterocomplexes.”
- emphasis
- false
- text
- “Dysfunction and/or disruption of such interactions in the central amygdala may lead to anxiety development. Restoration of such interactions may represent a new strategy for development of novel anxiolytic drugs.”
- emphasis
- false
- citation Count
- 30
- source Pages
118
- targets
OXTR · OXT · DRD2
- categories
Molecular biomarkers · Brain & nervous system · Clinical & self-report
- doi
- 10.1016/j.bbadis.2016.07.004
- pmid
- 27425032
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/27425032/ · https://doi.org/10.1016/j.bbadis.2016.07.004 · https://www.sciencedirect.com/science/article/pii/S0925443916301648
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxix
- topic Title
- Oxytocin pathways, dopamine and serotonin
- trust Score
- 1
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false