Possible neural mechanisms of psychotherapy for trauma-related symptoms: cerebral responses to the neuropsychological treatment of post-traumatic stress disorder model individuals
Tamaki Amano; Motomi Toichi · Scientific Reports · 2016 · Human experimental neuroimaging study
Original publication · Original publication · Original publication · Original publication
Recorded summary
During an EMDR-related procedure, healthy volunteers recalled moderately unpleasant memories while researchers measured cortical haemodynamic responses. The study examined temporal and orbitofrontal activity as possible correlates of memory processing.
Recorded limitations
Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Human experimental neuroimaging study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27698453/ · https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Healthy volunteers recalling moderately unpleasant memories
- measurement
- Functional near-infrared spectroscopy and subjective responses
- measured Genes
- None recorded
- relationship Note
- Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
- source URLs
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- vision:bilateral-mechanisms
- title
- Bilateral visual stimulation and memory processing
- collection
- vision
- trust Score
- Not recorded
Citation snapshot and identifiers
- id
- pmid-27698453
- doi
- 10.1038/srep34610
- pmid
- 27698453
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep34610
- citations By Collection
- vision
- 10
Complete approved library record
- id
- pmid-27698453
- aliases
- None recorded
- title
- Possible neural mechanisms of psychotherapy for trauma-related symptoms: cerebral responses to the neuropsychological treatment of post-traumatic stress disorder model individuals
- journal
- Scientific Reports
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2016
- authors
- Tamaki Amano; Motomi Toichi
- design
- Human experimental neuroimaging study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/srep34610
- pmid
- 27698453
- urls
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- collections
vision
- categories
Brain & nervous system
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- During an EMDR-related procedure, healthy volunteers recalled moderately unpleasant memories while researchers measured cortical haemodynamic responses. The study examined temporal and orbitofrontal activity as possible correlates of memory processing.
- limitation
- Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
- citation Count
- 10
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep34610
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27698453/ · https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 10
- topics
- key
- vision:bilateral-mechanisms
- title
- Bilateral visual stimulation and memory processing
- collection
- vision
- trust Score
- Not recorded
- journal Key
- scientificreports
- journal Label
- Scientific Reports
- chapter Entries
- title
- Possible neural mechanisms of psychotherapy for trauma-related symptoms: cerebral responses to the neuropsychological treatment of post-traumatic stress disorder model individuals
- journal
- Scientific Reports
- year
- 2016
- authors
- Tamaki Amano; Motomi Toichi
- design
- Human experimental neuroimaging study
- urls
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- doi
- 10.1038/srep34610
- pmid
- 27698453
- targets
- None recorded
- neurotransmitters
- None recorded
- categories
Brain & nervous system
- citation Count
- 10
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/srep34610
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Brain & nervous system
- sample
- Healthy volunteers recalling moderately unpleasant memories
- measurement
- Functional near-infrared spectroscopy and subjective responses
- measured Genes
- None recorded
- relationship Note
- Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
- source URLs
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- checked At
- 2026-10-23
- id
- vision-bilateral-mechanisms-pmid-27698453
- record Id
- pmid-27698453
- quotes
- None recorded
- source Pages
- None recorded
- summary
- During an EMDR-related procedure, healthy volunteers recalled moderately unpleasant memories while researchers measured cortical haemodynamic responses. The study examined temporal and orbitofrontal activity as possible correlates of memory processing.
- limitation
- Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Human experimental neuroimaging study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27698453/ · https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- vision
- chapter Number
- 5
- topic Id
- bilateral-mechanisms
- topic Title
- Bilateral visual stimulation and memory processing
- trust Score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Healthy volunteers recalling moderately unpleasant memories
- measurement
- Functional near-infrared spectroscopy and subjective responses
- measured Genes
- None recorded
- relationship Note
- Participants were model volunteers, not a clinical PTSD cohort. The study does not establish treatment efficacy or a gene-expression effect.
- source URLs
https://www.nature.com/articles/srep34610 · https://doi.org/10.1038/srep34610 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5048146/ · https://pubmed.ncbi.nlm.nih.gov/27698453/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://pmc-oa-opendata.s3.amazonaws.com/PMC5048146.1/PMC5048146.1.xml?md5=2c1caf497908e442a72fe5646abb7d06
- pmcid
- PMC5048146
- rights
- license
- CC BY
- use
- Attribution-preserving reuse
- public Fulltext Redistribution
- false
- provider Upload
- false
- model Training
- false
- basis
- https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
- article Rights
Copyright © 2016, The Author(s) 2016 The Author(s) https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- sha256
- 0f842024e5403491f134edd9f82d0cf61076255d2b40e3eaa2ff6372e3902b8b
- checked At
- 2026-10-24