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Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats

De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC. · Frontiers in Physiology · 2016

Original publication · Original publication · Original publication

Attributed extracts from the research record

“Several studies have shown that OTergic drive from PVN to brainstem increases baroreflex sensitivity and improves autonomic control of the circulation”
“reduced PVN oxytocin protein levels were positively correlated with decreased baroreflex sensitivity”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/27790154/ · https://doi.org/10.3389/fphys.2016.00461 · https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
  2. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
Citation snapshot and identifiers
id
pmid-27790154
doi
10.3389/fphys.2016.00461
pmid
27790154
citation Snapshot
Not recorded
citations By Collection
sound
13
general
Not recorded
Complete approved library record
id
pmid-27790154
publication Key
Not recorded
aliases
None recorded
source References
  1. ref
    NPL-32
    record Id
    pmid-27790154
    source Type
    Journal publication
    title
    Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats.
    authors
    De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.
    year
    2016
    journal
    Frontiers in physiology
    doi
    10.3389/fphys.2016.00461
    pmid
    27790154
    pmcid
    PMC5063006
    patent Number
    Not recorded
    original Assignee
    Not recorded
    original Citation
    Martins AS et al. (2016). "Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus." Frontiers in Physiology (PMC 5063006)
    original Section
    Baroreflex Modulation by Oxytocin
    metadata Status
    metadata-reconciled
    claim Review
    Not independently appraised
    source URL
    https://www.notion.so/3807b9c99c5680599be7d8337c817b15
    publication URL
    https://pubmed.ncbi.nlm.nih.gov/27790154/
    metadata URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffphys.2016.00461%22&format=json&resultType=core&pageSize=4
    corrections

    Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison. · Published title reconciled with the metadata record. · Author attribution differs from the public metadata; canonical authors are shown in source details.

    topic Id
    optical-physiology
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    Focused chapter source
source Type
Journal publication
source Verification
Bibliographic metadata matched; scientific claims await appraisal.
source Collection
Hyperspectral Imaging · patent section 2.4
title
Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats
journal
Frontiers in Physiology
publisher Family
frontiers
publisher Family Label
Frontiers
neurotransmitters
None recorded
year
2016
authors
De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.3389/fphys.2016.00461
pmid
27790154
urls

https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full · https://doi.org/10.3389/fphys.2016.00461 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5063006/

collections

sound · general

categories

Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

targets

OXT

priority
1
quotes

“Several studies have shown that OTergic drive from PVN to brainstem increases baroreflex sensitivity and improves autonomic control of the circulation” · “reduced PVN oxytocin protein levels were positively correlated with decreased baroreflex sensitivity”

summary
limitation
citation Count
13
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/27790154/ · https://doi.org/10.3389/fphys.2016.00461 · https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
13
general
Not recorded
topics
  1. key
    sound:ix
    title
    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    collection
    sound
    trust Score
    1
  2. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
journal Key
frontiersinphysiology
journal Label
Frontiers in Physiology
chapter Entries
  1. id
    ix-pmid-27790154
    record Id
    pmid-27790154
    title
    Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats
    journal
    Frontiers in Physiology
    year
    2016
    authors
    De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.
    design
    urls

    https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full · https://doi.org/10.3389/fphys.2016.00461 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5063006/

    quotes
      1. text
        “Several studies have shown that OTergic drive from PVN to brainstem increases baroreflex sensitivity and improves autonomic control of the circulation”
        emphasis
        false
      1. text
        “reduced PVN oxytocin protein levels were positively correlated with decreased baroreflex sensitivity”
        emphasis
        false
    citation Count
    13
    source Pages

    62

    targets

    OXT

    categories

    Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

    doi
    10.3389/fphys.2016.00461
    pmid
    27790154
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/27790154/ · https://doi.org/10.3389/fphys.2016.00461 · https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
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    sound
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    Baroreflex, heart-rate variability and Mayer waves around 0.1 Hz
    trust Score
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    record Id
    pmid-27790154
    title
    Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats
    journal
    Frontiers in Physiology
    year
    2016
    authors
    De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.
    design
    urls

    https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full · https://doi.org/10.3389/fphys.2016.00461 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5063006/

    quotes
    None recorded
    summary
    related Versions
    None recorded
    limitation
    citation Count
    Not recorded
    source Pages
    None recorded
    doi
    10.3389/fphys.2016.00461
    pmid
    27790154
    targets

    OXT

    categories

    Molecular biomarkers · Heart rate & autonomic · Brain & nervous system

    source References
    1. ref
      NPL-32
      record Id
      pmid-27790154
      source Type
      Journal publication
      title
      Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats.
      authors
      De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC.
      year
      2016
      journal
      Frontiers in physiology
      doi
      10.3389/fphys.2016.00461
      pmid
      27790154
      pmcid
      PMC5063006
      patent Number
      Not recorded
      original Assignee
      Not recorded
      original Citation
      Martins AS et al. (2016). "Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus." Frontiers in Physiology (PMC 5063006)
      original Section
      Baroreflex Modulation by Oxytocin
      metadata Status
      metadata-reconciled
      claim Review
      Not independently appraised
      source URL
      https://www.notion.so/3807b9c99c5680599be7d8337c817b15
      publication URL
      https://pubmed.ncbi.nlm.nih.gov/27790154/
      metadata URL
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      corrections

      Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison. · Published title reconciled with the metadata record. · Author attribution differs from the public metadata; canonical authors are shown in source details.

      topic Id
      optical-physiology
      role
      Focused chapter source
    source Type
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    source Verification
    Bibliographic metadata matched; scientific claims await appraisal.
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    general
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    11
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    Optical Physiology and Tissue Imaging
    trust Score
    Not recorded
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/27790154/ · https://doi.org/10.3389/fphys.2016.00461 · https://www.frontiersin.org/articles/10.3389/fphys.2016.00461/full

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5063006/fullTextXML
pmcid
PMC5063006
rights
license
CC BY (version not specified in article)
statement

Copyright © 2016 De Melo, Saldanha, Dos Santos, Cruz, Lira, Santana-Filho and Michelini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

sha256
8a00b976195f98f3daac85a087004ec3f7d4bcbcb804489628a6b3c4c1da9729
checked At
2026-10-24

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