Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women
K N Harkess; J Ryan; P H Delfabbro; S Cohen-Woods · Translational Psychiatry · 2016 · Exploratory molecular substudy of a yoga trial
Original publication · Original publication · Original publication · Original publication
Recorded summary
An exploratory substudy in chronically stressed women reported lower methylation in a TNF region following a brief yoga intervention. Comparable regional changes were not found for IL6 or CRP, and a reduction in circulating inflammatory markers was not established.
Recorded limitations
The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Exploratory molecular substudy of a yoga trial
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27898068/ · https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Epigenetics
- sample
- 28 chronically stressed women from a larger trial
- measurement
- Targeted DNA methylation and inflammatory proteins
- measured Genes
TNF · IL6 · CRP
- relationship Note
- The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
- source URLs
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-27898068
- doi
- 10.1038/tp.2016.234
- pmid
- 27898068
- citation Snapshot
- count
- 75
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/tp.2016.234
- citations By Collection
- language
- 75
Complete approved library record
- id
- pmid-27898068
- aliases
- None recorded
- title
- Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women
- journal
- Translational Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2016
- authors
- K N Harkess; J Ryan; P H Delfabbro; S Cohen-Woods
- design
- Exploratory molecular substudy of a yoga trial
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/tp.2016.234
- pmid
- 27898068
- urls
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- collections
language
- categories
Epigenetics
- targets
TNF · IL6
- priority
- 0
- quotes
- None recorded
- summary
- An exploratory substudy in chronically stressed women reported lower methylation in a TNF region following a brief yoga intervention. Comparable regional changes were not found for IL6 or CRP, and a reduction in circulating inflammatory markers was not established.
- limitation
- The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
- citation Count
- 75
- citation Snapshot
- count
- 75
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/tp.2016.234
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27898068/ · https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 75
- topics
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
- journal Key
- translationalpsychiatry
- journal Label
- Translational Psychiatry
- chapter Entries
- title
- Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women
- journal
- Translational Psychiatry
- year
- 2016
- authors
- K N Harkess; J Ryan; P H Delfabbro; S Cohen-Woods
- design
- Exploratory molecular substudy of a yoga trial
- urls
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- doi
- 10.1038/tp.2016.234
- pmid
- 27898068
- targets
TNF · IL6
- neurotransmitters
- None recorded
- categories
Epigenetics
- citation Count
- 75
- citation Snapshot
- count
- 75
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/tp.2016.234
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Epigenetics
- sample
- 28 chronically stressed women from a larger trial
- measurement
- Targeted DNA methylation and inflammatory proteins
- measured Genes
TNF · IL6 · CRP
- relationship Note
- The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
- source URLs
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- checked At
- 2026-10-23
- id
- language-mindfulness-epigenetics-pmid-27898068
- record Id
- pmid-27898068
- quotes
- None recorded
- source Pages
- None recorded
- summary
- An exploratory substudy in chronically stressed women reported lower methylation in a TNF region following a brief yoga intervention. Comparable regional changes were not found for IL6 or CRP, and a reduction in circulating inflammatory markers was not established.
- limitation
- The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Exploratory molecular substudy of a yoga trial. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/27898068/ · https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-epigenetics
- topic Title
- Mindfulness, DNA methylation and genetic variation
- trust Score
- 1
- evidence
- evidence Type
- Epigenetics
- sample
- 28 chronically stressed women from a larger trial
- measurement
- Targeted DNA methylation and inflammatory proteins
- measured Genes
TNF · IL6 · CRP
- relationship Note
- The molecular sample contained 28 women. Its retrospective and uncontrolled longitudinal components limit causal interpretation, despite recruitment from a larger randomized trial.
- source URLs
https://www.nature.com/articles/tp2016234 · https://doi.org/10.1038/tp.2016.234 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5290356/ · https://pubmed.ncbi.nlm.nih.gov/27898068/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://pmc-oa-opendata.s3.amazonaws.com/PMC5290356.1/PMC5290356.1.xml?md5=d493f169df41e4a98ca18e5fa54f2fe2
- pmcid
- PMC5290356
- rights
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- CC BY
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- Attribution-preserving reuse
- public Fulltext Redistribution
- false
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- https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
- article Rights
Copyright © 2016 The Author(s) 2016 The Author(s) https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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- 92d4f6c179d12821bd23ac6fff7beb6095ce55643d0811b0810b4c8f4364c925
- checked At
- 2026-10-24