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Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients

van Zuiden M, Frijling JL, Nawijn L, Koch SBJ, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Veltman DJ, Olff M. · Biological psychiatry · 2017 · randomised controlled trial

Original publication · Original publication

Attributed extracts from the research record

“participants with high acute clinician-rated PTSD symptom severity did show beneficial effects of oxytocin. Although replication is warranted, these findings suggest that oxytocin administration is a promising preventive intervention for PTSD for individuals with high acute PTSD symptoms.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial
assessment
Not recorded
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/28087128/ · https://doi.org/10.1016/j.biopsych.2016.11.012 · https://www.sciencedirect.com/science/article/abs/pii/S0006322316330670

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    sound
    trust Score
    3
  2. key
    general:sound-xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-28087128
doi
10.1016/j.biopsych.2016.11.012
pmid
28087128
citation Snapshot
Not recorded
citations By Collection
sound
86
general
86
Complete approved library record
id
pmid-28087128
publication Key
Not recorded
aliases
None recorded
title
Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
journal
Biological psychiatry
neurotransmitters
None recorded
year
2017
authors
van Zuiden M, Frijling JL, Nawijn L, Koch SBJ, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Veltman DJ, Olff M.
design
randomised controlled trial
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.biopsych.2016.11.012
pmid
28087128
urls

https://doi.org/10.1016/j.biopsych.2016.11.012 · https://pubmed.ncbi.nlm.nih.gov/28087128/

collections

sound · general

categories

Molecular biomarkers · Clinical & self-report

targets

OXT

priority
1
quotes

“participants with high acute clinician-rated PTSD symptom severity did show beneficial effects of oxytocin. Although replication is warranted, these findings suggest that oxytocin administration is a promising preventive intervention for PTSD for individuals with high acute PTSD symptoms.”

summary
limitation
citation Count
86
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
Indexed randomized trial and double-blind methods.
sources

https://pubmed.ncbi.nlm.nih.gov/28087128/ · https://doi.org/10.1016/j.biopsych.2016.11.012 · https://www.sciencedirect.com/science/article/abs/pii/S0006322316330670

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
86
general
86
topics
  1. key
    sound:xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    sound
    trust Score
    3
  2. key
    general:sound-xxxi
    title
    Oxytocin, empathy and intergroup relationships
    collection
    general
    trust Score
    3
journal Key
biologicalpsychiatry
journal Label
Biological psychiatry
chapter Entries
  1. id
    xxxi-pmid-28087128
    record Id
    pmid-28087128
    title
    Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
    journal
    Biological psychiatry
    year
    2017
    authors
    van Zuiden M, Frijling JL, Nawijn L, Koch SBJ, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Veltman DJ, Olff M.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.biopsych.2016.11.012 · https://pubmed.ncbi.nlm.nih.gov/28087128/

    quotes
      1. text
        “participants with high acute clinician-rated PTSD symptom severity did show beneficial effects of oxytocin. Although replication is warranted, these findings suggest that oxytocin administration is a promising preventive intervention for PTSD for individuals with high acute PTSD symptoms.”
        emphasis
        false
    citation Count
    86
    source Pages

    127

    targets

    OXT

    categories

    Molecular biomarkers · Clinical & self-report

    doi
    10.1016/j.biopsych.2016.11.012
    pmid
    28087128
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28087128/ · https://doi.org/10.1016/j.biopsych.2016.11.012 · https://www.sciencedirect.com/science/article/abs/pii/S0006322316330670

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    6
    topic Id
    xxxi
    topic Title
    Oxytocin, empathy and intergroup relationships
    trust Score
    3
  2. id
    general-xxxi-pmid-28087128
    record Id
    pmid-28087128
    title
    Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
    journal
    Biological psychiatry
    year
    2017
    authors
    van Zuiden M, Frijling JL, Nawijn L, Koch SBJ, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Veltman DJ, Olff M.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.biopsych.2016.11.012 · https://pubmed.ncbi.nlm.nih.gov/28087128/

    quotes
      1. text
        “participants with high acute clinician-rated PTSD symptom severity did show beneficial effects of oxytocin. Although replication is warranted, these findings suggest that oxytocin administration is a promising preventive intervention for PTSD for individuals with high acute PTSD symptoms.”
        emphasis
        false
    citation Count
    86
    source Pages

    127

    targets

    OXT

    categories

    Molecular biomarkers · Clinical & self-report

    doi
    10.1016/j.biopsych.2016.11.012
    pmid
    28087128
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    Indexed randomized trial and double-blind methods.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28087128/ · https://doi.org/10.1016/j.biopsych.2016.11.012 · https://www.sciencedirect.com/science/article/abs/pii/S0006322316330670

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    1
    topic Id
    sound-xxxi
    topic Title
    Oxytocin, empathy and intergroup relationships
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    ptsd
    evidence
    1. field
      title
      text
      Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
      matched Text
      Posttraumatic Stress
  2. id
    trauma
    evidence
    1. field
      title
      text
      Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
      matched Text
      Posttraumatic
  3. id
    stress
    evidence
    1. field
      title
      text
      Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
      matched Text
      Stress
conditions

ptsd · trauma · stress

topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

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