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Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H. · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017 · randomised controlled trial

Original publication · Original publication

Attributed extracts from the research record

“H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial
assessment
Not recorded
trust Factor
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/28669654/ · https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-28669654
doi
10.1016/j.jstrokecerebrovasdis.2017.06.012
pmid
28669654
citation Snapshot
Not recorded
citations By Collection
language
59
general
59
Complete approved library record
id
pmid-28669654
publication Key
Not recorded
aliases
None recorded
title
Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
neurotransmitters
None recorded
year
2017
authors
Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H.
design
randomised controlled trial
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.jstrokecerebrovasdis.2017.06.012
pmid
28669654
urls

https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012 · https://pubmed.ncbi.nlm.nih.gov/28669654/

collections

language · general

categories

Methods & context

targets
None recorded
priority
1
quotes

“H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas.”

summary
limitation
citation Count
59
paper Trust Assessment
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
sources

https://pubmed.ncbi.nlm.nih.gov/28669654/ · https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
59
general
59
topics
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
journal Key
journalofstrokeandcerebrovasculardiseases
journal Label
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
chapter Entries
  1. id
    language-vi-pmid-28669654
    record Id
    pmid-28669654
    title
    Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
    journal
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    year
    2017
    authors
    Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012 · https://pubmed.ncbi.nlm.nih.gov/28669654/

    quotes
      1. text
        “H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas.”
        emphasis
        false
    citation Count
    59
    source Pages

    25

    targets
    None recorded
    categories

    Methods & context

    doi
    10.1016/j.jstrokecerebrovasdis.2017.06.012
    pmid
    28669654
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28669654/ · https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  2. id
    general-language-vi-pmid-28669654
    record Id
    pmid-28669654
    title
    Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
    journal
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    year
    2017
    authors
    Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H.
    design
    randomised controlled trial
    urls

    https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012 · https://pubmed.ncbi.nlm.nih.gov/28669654/

    quotes
      1. text
        “H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas.”
        emphasis
        false
    citation Count
    59
    source Pages

    25

    targets
    None recorded
    categories

    Methods & context

    doi
    10.1016/j.jstrokecerebrovasdis.2017.06.012
    pmid
    28669654
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28669654/ · https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    3
    topic Id
    language-vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

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