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What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

Buric I, Farias M, Jong J, Mee C, Brazil IA. · Frontiers in Immunology · 2017 · randomised controlled trial

Original publication · Original publication · Original publication

Attributed extracts from the research record

“The results of 18 studies that used gene expression analysis in research on meditation and related MBIs have overall found downregulation of NF- κ B-targeted genes, which can be understood as the reversal of the molecular signature of the effects of chronic stress”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
randomised controlled trial
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/28670311/ · https://doi.org/10.3389/fimmu.2017.00670 · https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:ii
    title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    collection
    language
    trust Score
    2
Citation snapshot and identifiers
id
pmid-28670311
doi
10.3389/fimmu.2017.00670
pmid
28670311
citation Snapshot
Not recorded
citations By Collection
language
121
Complete approved library record
id
pmid-28670311
publication Key
Not recorded
aliases
None recorded
title
What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices
journal
Frontiers in Immunology
publisher Family
frontiers
publisher Family Label
Frontiers
neurotransmitters
None recorded
year
2017
authors
Buric I, Farias M, Jong J, Mee C, Brazil IA.
design
randomised controlled trial
kind
Review / synthesis
identity Conflict
Not recorded
doi
10.3389/fimmu.2017.00670
pmid
28670311
urls

https://doi.org/10.3389/fimmu.2017.00670 · https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full · https://pmc.ncbi.nlm.nih.gov/articles/PMC5472657/

collections

language

categories

Gene expression

targets
None recorded
priority
0
quotes

“The results of 18 studies that used gene expression analysis in research on meditation and related MBIs have overall found downregulation of NF- κ B-targeted genes, which can be understood as the reversal of the molecular signature of the effects of chronic stress”

summary
limitation
citation Count
121
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/28670311/ · https://doi.org/10.3389/fimmu.2017.00670 · https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
121
topics
  1. key
    language:ii
    title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    collection
    language
    trust Score
    2
journal Key
frontiersinimmunology
journal Label
Frontiers in Immunology
chapter Entries
  1. id
    language-ii-pmid-28670311
    record Id
    pmid-28670311
    title
    What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices
    journal
    Frontiers in Immunology
    year
    2017
    authors
    Buric I, Farias M, Jong J, Mee C, Brazil IA.
    design
    randomised controlled trial
    urls

    https://doi.org/10.3389/fimmu.2017.00670 · https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full · https://pmc.ncbi.nlm.nih.gov/articles/PMC5472657/

    quotes
      1. text
        “The results of 18 studies that used gene expression analysis in research on meditation and related MBIs have overall found downregulation of NF- κ B-targeted genes, which can be understood as the reversal of the molecular signature of the effects of chronic stress”
        emphasis
        false
    citation Count
    121
    source Pages

    12

    targets
    None recorded
    categories

    Gene expression

    doi
    10.3389/fimmu.2017.00670
    pmid
    28670311
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-applicable
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28670311/ · https://doi.org/10.3389/fimmu.2017.00670 · https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    ii
    topic Title
    Meditation, mindfulness and related practices: gene expression and epigenetics
    trust Score
    2
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

2

full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5472657/fullTextXML
pmcid
PMC5472657
rights
license
CC BY (version not specified in article)
statement

Copyright © 2017 Buric, Farias, Jong, Mee and Brazil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

sha256
fb4e8365070098ff5644e3165b6f1c27321b68a84727c4d9c99f00b136491285
checked At
2026-10-24

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