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Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response

Sobue S, Inoue C, Hori F, Qiao S, Murate T, Ichihara M. · Biochemical and biophysical research communications · 2017

Original publication · Original publication

Attributed extracts from the research record

“our study suggests that H2 can induce beneficial effects through mtUPR activation via epigenetic histone modification and by modification of gene expression”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/28890349/ · https://doi.org/10.1016/j.bbrc.2017.09.024

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
Citation snapshot and identifiers
id
pmid-28890349
doi
10.1016/j.bbrc.2017.09.024
pmid
28890349
citation Snapshot
Not recorded
citations By Collection
language
16
general
16
Complete approved library record
id
pmid-28890349
publication Key
Not recorded
aliases
None recorded
title
Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response
journal
Biochemical and biophysical research communications
neurotransmitters
None recorded
year
2017
authors
Sobue S, Inoue C, Hori F, Qiao S, Murate T, Ichihara M.
design
kind
Journal article
identity Conflict
Not recorded
doi
10.1016/j.bbrc.2017.09.024
pmid
28890349
urls

https://doi.org/10.1016/j.bbrc.2017.09.024 · https://pubmed.ncbi.nlm.nih.gov/28890349/

collections

language · general

categories

Gene expression · Epigenetics

targets
None recorded
priority
0
quotes

“our study suggests that H2 can induce beneficial effects through mtUPR activation via epigenetic histone modification and by modification of gene expression”

summary
limitation
citation Count
16
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/28890349/ · https://doi.org/10.1016/j.bbrc.2017.09.024

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
16
general
16
topics
  1. key
    language:vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    language
    trust Score
    3
  2. key
    general:language-vi
    title
    Molecular hydrogen: inflammation, cognition and gene expression
    collection
    general
    trust Score
    3
journal Key
biochemicalandbiophysicalresearchcommunications
journal Label
Biochemical and biophysical research communications
chapter Entries
  1. id
    language-vi-pmid-28890349
    record Id
    pmid-28890349
    title
    Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response
    journal
    Biochemical and biophysical research communications
    year
    2017
    authors
    Sobue S, Inoue C, Hori F, Qiao S, Murate T, Ichihara M.
    design
    urls

    https://doi.org/10.1016/j.bbrc.2017.09.024 · https://pubmed.ncbi.nlm.nih.gov/28890349/

    quotes
      1. text
        “our study suggests that H2 can induce beneficial effects through mtUPR activation via epigenetic histone modification and by modification of gene expression”
        emphasis
        false
    citation Count
    16
    source Pages

    28

    targets
    None recorded
    categories

    Gene expression · Epigenetics

    doi
    10.1016/j.bbrc.2017.09.024
    pmid
    28890349
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28890349/ · https://doi.org/10.1016/j.bbrc.2017.09.024

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    language
    chapter Number
    1
    topic Id
    vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
  2. id
    general-language-vi-pmid-28890349
    record Id
    pmid-28890349
    title
    Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response
    journal
    Biochemical and biophysical research communications
    year
    2017
    authors
    Sobue S, Inoue C, Hori F, Qiao S, Murate T, Ichihara M.
    design
    urls

    https://doi.org/10.1016/j.bbrc.2017.09.024 · https://pubmed.ncbi.nlm.nih.gov/28890349/

    quotes
      1. text
        “our study suggests that H2 can induce beneficial effects through mtUPR activation via epigenetic histone modification and by modification of gene expression”
        emphasis
        false
    citation Count
    16
    source Pages

    28

    targets
    None recorded
    categories

    Gene expression · Epigenetics

    doi
    10.1016/j.bbrc.2017.09.024
    pmid
    28890349
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/28890349/ · https://doi.org/10.1016/j.bbrc.2017.09.024

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    3
    topic Id
    language-vi
    topic Title
    Molecular hydrogen: inflammation, cognition and gene expression
    trust Score
    3
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

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