Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B. · Brain imaging and behavior · 2018
Original publication · Original publication · Original publication
Attributed extracts from the research record
“All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or 10 Hz ), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- assessment
- Not recorded
- trust Factor
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Indexed randomized trial and double-blind methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/29170944/ · https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:iii
- title
- 7.83 Hz and low-frequency electromagnetic research
- collection
- sound
- trust Score
- 2
- key
- general:sound-iii
- title
- 7.83 Hz and low-frequency electromagnetic research
- collection
- general
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-29170944
- doi
- 10.1007/s11682-017-9800-1
- pmid
- 29170944
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- Not recorded
- general
- Not recorded
Complete approved library record
- id
- pmid-29170944
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
- journal
- Brain imaging and behavior
- neurotransmitters
- None recorded
- year
- 2018
- authors
- Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.
- design
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1007/s11682-017-9800-1
- pmid
- 29170944
- urls
https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1 · https://pubmed.ncbi.nlm.nih.gov/29170944/
- collections
sound · general
- categories
Molecular biomarkers · Brain & nervous system
- targets
- None recorded
- priority
- 1
- quotes
“All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or 10 Hz ), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum.”
- summary
- limitation
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Indexed randomized trial and double-blind methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/29170944/ · https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- Not recorded
- general
- Not recorded
- topics
- key
- sound:iii
- title
- 7.83 Hz and low-frequency electromagnetic research
- collection
- sound
- trust Score
- 2
- key
- general:sound-iii
- title
- 7.83 Hz and low-frequency electromagnetic research
- collection
- general
- trust Score
- 2
- journal Key
- brainimagingandbehavior
- journal Label
- Brain imaging and behavior
- chapter Entries
- id
- iii-pmid-29170944
- record Id
- pmid-29170944
- title
- Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
- journal
- Brain imaging and behavior
- year
- 2018
- authors
- Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.
- design
- urls
https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1 · https://pubmed.ncbi.nlm.nih.gov/29170944/
- quotes
- text
- “All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or
- emphasis
- false
- text
- 10 Hz
- emphasis
- true
- text
- ), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased
- emphasis
- false
- text
- dopamine
- emphasis
- true
- text
- levels in the substantia nigra, sensorimotor striatum and associative striatum.”
- emphasis
- false
- citation Count
- Not recorded
- source Pages
19
- targets
- None recorded
- categories
Molecular biomarkers · Brain & nervous system
- doi
- 10.1007/s11682-017-9800-1
- pmid
- 29170944
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Indexed randomized trial and double-blind methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/29170944/ · https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 1
- topic Id
- iii
- topic Title
- 7.83 Hz and low-frequency electromagnetic research
- trust Score
- 2
- id
- general-iii-pmid-29170944
- record Id
- pmid-29170944
- title
- Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
- journal
- Brain imaging and behavior
- year
- 2018
- authors
- Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.
- design
- urls
https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1 · https://pubmed.ncbi.nlm.nih.gov/29170944/
- quotes
- text
- “All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or
- emphasis
- false
- text
- 10 Hz
- emphasis
- true
- text
- ), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased
- emphasis
- false
- text
- dopamine
- emphasis
- true
- text
- levels in the substantia nigra, sensorimotor striatum and associative striatum.”
- emphasis
- false
- citation Count
- Not recorded
- source Pages
19
- targets
- None recorded
- categories
Molecular biomarkers · Brain & nervous system
- doi
- 10.1007/s11682-017-9800-1
- pmid
- 29170944
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Indexed randomized trial and double-blind methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/29170944/ · https://doi.org/10.1007/s11682-017-9800-1 · https://link.springer.com/article/10.1007/s11682-017-9800-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 2
- topic Id
- sound-iii
- topic Title
- 7.83 Hz and low-frequency electromagnetic research
- trust Score
- 2
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false