Social stress induces neurovascular pathology promoting depression
Caroline Menard; Madeline L. Pfau; Georgia E. Hodes; Veronika Kana; Victoria X. Wang; Sylvain Bouchard; Aki Takahashi; Meghan E. Flanigan; Hossein Aleyasin; Katherine B. LeClair; William G. Janssen; Benoit Labonté; Eric M. Parise; Zachary S. Lorsch; Sam A. Golden; Mitra Heshmati; Carol Tamminga; Gustavo Turecki; Matthew Campbell; Zahi A. Fayad; Cheuk Ying Tang; Miriam Merad; Scott J. Russo · Nature Neuroscience · 2017 · Experimental mouse study with human postmortem comparison
Original publication · Original publication · Original publication · Original publication
Recorded summary
Chronic social stress reduced the tight-junction protein claudin-5 in susceptible mice, increasing blood–brain barrier permeability and allowing peripheral IL-6 into the brain. Reduced CLDN5 was also observed in postmortem tissue from people with depression.
Recorded limitations
Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental mouse study with human postmortem comparison
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse study with human postmortem comparison. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
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- randomized Controlled Trial
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- true
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- Experimental mouse study with human postmortem comparison. No masked human randomized trial classification is assigned.
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https://pubmed.ncbi.nlm.nih.gov/29184215/ · https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
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- Not recorded
- evidence
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- Molecular biomarkers
- sample
- Mice and human postmortem tissue
- measurement
- Blood–brain barrier permeability, CLDN5 expression and IL-6 protein
- measured Genes
CLDN5
- relationship Note
- Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
- source URLs
https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- checked At
- 2026-10-23
Topics and recorded topic scores
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- Stress, inflammation and synaptic plasticity
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- trust Score
- 1
Citation snapshot and identifiers
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Complete approved library record
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- Social stress induces neurovascular pathology promoting depression
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- Caroline Menard; Madeline L. Pfau; Georgia E. Hodes; Veronika Kana; Victoria X. Wang; Sylvain Bouchard; Aki Takahashi; Meghan E. Flanigan; Hossein Aleyasin; Katherine B. LeClair; William G. Janssen; Benoit Labonté; Eric M. Parise; Zachary S. Lorsch; Sam A. Golden; Mitra Heshmati; Carol Tamminga; Gustavo Turecki; Matthew Campbell; Zahi A. Fayad; Cheuk Ying Tang; Miriam Merad; Scott J. Russo
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https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- collections
general
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Molecular biomarkers
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IL6 · CLDN5
- priority
- 1
- quotes
- None recorded
- summary
- Chronic social stress reduced the tight-junction protein claudin-5 in susceptible mice, increasing blood–brain barrier permeability and allowing peripheral IL-6 into the brain. Reduced CLDN5 was also observed in postmortem tissue from people with depression.
- limitation
- Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
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- study Design Assessment
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- true
- basis
- Experimental mouse study with human postmortem comparison. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
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https://pubmed.ncbi.nlm.nih.gov/29184215/ · https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/
- review Scope
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- chapter Entries
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- Social stress induces neurovascular pathology promoting depression
- journal
- Nature Neuroscience
- year
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- authors
- Caroline Menard; Madeline L. Pfau; Georgia E. Hodes; Veronika Kana; Victoria X. Wang; Sylvain Bouchard; Aki Takahashi; Meghan E. Flanigan; Hossein Aleyasin; Katherine B. LeClair; William G. Janssen; Benoit Labonté; Eric M. Parise; Zachary S. Lorsch; Sam A. Golden; Mitra Heshmati; Carol Tamminga; Gustavo Turecki; Matthew Campbell; Zahi A. Fayad; Cheuk Ying Tang; Miriam Merad; Scott J. Russo
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https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
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IL6 · CLDN5
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https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- reviewed At
- 2026-10-23
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CLDN5
- relationship Note
- Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
- source URLs
https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- checked At
- 2026-10-23
- id
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- quotes
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- summary
- Chronic social stress reduced the tight-junction protein claudin-5 in susceptible mice, increasing blood–brain barrier permeability and allowing peripheral IL-6 into the brain. Reduced CLDN5 was also observed in postmortem tissue from people with depression.
- limitation
- Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse study with human postmortem comparison. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/29184215/ · https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/
- review Scope
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- assessed At
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- Mice and human postmortem tissue
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- measured Genes
CLDN5
- relationship Note
- Causal manipulations were performed in mice. IL-6 infiltration is a protein-level finding; the human comparison is observational.
- source URLs
https://www.nature.com/articles/s41593-017-0010-3 · https://doi.org/10.1038/s41593-017-0010-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC5726568/ · https://pubmed.ncbi.nlm.nih.gov/29184215/
- checked At
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Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
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