The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility
Flasbeck V, Moser D, Kumsta R, Brüne M. · Frontiers in Psychiatry · 2018
Original publication · Original publication · Original publication
Attributed extracts from the research record
“homozygous carriers of the G-allele of the single nucleotide polymorphism rs53576 have been reported to display more trust, empathy, and prosocial behavior and were less sensitive toward stress and maltreatment during childhood when compared to A-allele carriers.”
“In A-allele carriers of rs53576, childhood trauma was differentially associated with empathy for psychological pain, which was not apparent in GG carriers.”
“the present study demonstrates an association of childhood maltreatment and empathy for psychological pain which was mediated by rs53576 genotype, suggesting that the A-allele may convey genetic plasticity to environmental factors”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30135663/ · https://doi.org/10.3389/fpsyt.2018.00359 · https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxx
- title
- OXTR variation and psychological resources
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxx
- title
- OXTR variation and psychological resources
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-30135663
- doi
- 10.3389/fpsyt.2018.00359
- pmid
- 30135663
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 16
- general
- 16
Complete approved library record
- id
- pmid-30135663
- publication Key
- Not recorded
- aliases
- None recorded
- title
- The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility
- journal
- Frontiers in Psychiatry
- publisher Family
- frontiers
- publisher Family Label
- Frontiers
- neurotransmitters
- None recorded
- year
- 2018
- authors
- Flasbeck V, Moser D, Kumsta R, Brüne M.
- design
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.3389/fpsyt.2018.00359
- pmid
- 30135663
- urls
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full · https://doi.org/10.3389/fpsyt.2018.00359 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6092568/
- collections
sound · general
- categories
Genetics & genomics · Clinical & self-report
- targets
OXTR
- priority
- 0
- quotes
“homozygous carriers of the G-allele of the single nucleotide polymorphism rs53576 have been reported to display more trust, empathy, and prosocial behavior and were less sensitive toward stress and maltreatment during childhood when compared to A-allele carriers.” · “In A-allele carriers of rs53576, childhood trauma was differentially associated with empathy for psychological pain, which was not apparent in GG carriers.” · “the present study demonstrates an association of childhood maltreatment and empathy for psychological pain which was mediated by rs53576 genotype, suggesting that the A-allele may convey genetic plasticity to environmental factors”
- summary
- limitation
- citation Count
- 16
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30135663/ · https://doi.org/10.3389/fpsyt.2018.00359 · https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 16
- general
- 16
- topics
- key
- sound:xxx
- title
- OXTR variation and psychological resources
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxx
- title
- OXTR variation and psychological resources
- collection
- general
- trust Score
- 1
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- frontiersinpsychiatry
- journal Label
- Frontiers in Psychiatry
- chapter Entries
- id
- xxx-pmid-30135663
- record Id
- pmid-30135663
- title
- The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility
- journal
- Frontiers in Psychiatry
- year
- 2018
- authors
- Flasbeck V, Moser D, Kumsta R, Brüne M.
- design
- urls
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full · https://doi.org/10.3389/fpsyt.2018.00359 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6092568/
- quotes
- text
- “homozygous carriers of the G-allele of the single nucleotide polymorphism rs53576 have been reported to display more trust, empathy, and prosocial behavior and were less sensitive toward stress and maltreatment during childhood when compared to A-allele carriers.”
- emphasis
- false
- text
- “In A-allele carriers of rs53576, childhood trauma was differentially associated with empathy for psychological pain, which was not apparent in GG carriers.”
- emphasis
- false
- text
- “the present study demonstrates an association of childhood maltreatment and empathy for psychological pain which was mediated by rs53576 genotype, suggesting that the A-allele may convey genetic plasticity to environmental factors”
- emphasis
- false
- citation Count
- 16
- source Pages
121
- targets
OXTR
- categories
Genetics & genomics · Clinical & self-report
- doi
- 10.3389/fpsyt.2018.00359
- pmid
- 30135663
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30135663/ · https://doi.org/10.3389/fpsyt.2018.00359 · https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 6
- topic Id
- xxx
- topic Title
- OXTR variation and psychological resources
- trust Score
- 1
- id
- general-xxx-pmid-30135663
- record Id
- pmid-30135663
- title
- The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility
- journal
- Frontiers in Psychiatry
- year
- 2018
- authors
- Flasbeck V, Moser D, Kumsta R, Brüne M.
- design
- urls
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full · https://doi.org/10.3389/fpsyt.2018.00359 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6092568/
- quotes
- text
- “homozygous carriers of the G-allele of the single nucleotide polymorphism rs53576 have been reported to display more trust, empathy, and prosocial behavior and were less sensitive toward stress and maltreatment during childhood when compared to A-allele carriers.”
- emphasis
- false
- text
- “In A-allele carriers of rs53576, childhood trauma was differentially associated with empathy for psychological pain, which was not apparent in GG carriers.”
- emphasis
- false
- text
- “the present study demonstrates an association of childhood maltreatment and empathy for psychological pain which was mediated by rs53576 genotype, suggesting that the A-allele may convey genetic plasticity to environmental factors”
- emphasis
- false
- citation Count
- 16
- source Pages
121
- targets
OXTR
- categories
Genetics & genomics · Clinical & self-report
- doi
- 10.3389/fpsyt.2018.00359
- pmid
- 30135663
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30135663/ · https://doi.org/10.3389/fpsyt.2018.00359 · https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00359/full
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxx
- topic Title
- OXTR variation and psychological resources
- trust Score
- 1
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6092568/fullTextXML
- pmcid
- PMC6092568
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
Copyright © 2018 Flasbeck, Moser, Kumsta and Brüne. 2018 Flasbeck, Moser, Kumsta and Brüne https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- sha256
- 74d133bc8b571321da277cec2c1a5fafe8a77571a4e7ccca60bd5d3af66c7ffd
- checked At
- 2026-10-24