Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial.
Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK, Sihota R, Sidhu T, Velpandian T, Kalaivani M, Pandey RM, Gao Y, Sabel BA, Dada R. · Journal of glaucoma · 2018 · Randomized controlled trial
Original publication · Original publication
Recorded summary
In 90 patients with primary open-angle glaucoma, a short mindfulness programme reduced intraocular pressure relative to waitlist and reported associated stress-biomarker and gene-expression changes.
Recorded limitations
A small, short-duration adjunctive trial with a waitlist comparator. Expression and biomarker associations do not prove mediation of pressure reduction or broad effects across diseases.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Mindfulness meditation
- comparator
- Waitlist
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rxs38wbv · https://europepmc.org/article/MED/30256277
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Gene-expression and stress-biomarker measurements with intraocular pressure
- measured Genes
- None recorded
- sample
- 90 glaucoma patients
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-30256277
- doi
- 10.1097/ijg.0000000000001088
- pmid
- 30256277
- citation Snapshot
- count
- 93
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30256277
- citations By Collection
- language
- 93
Complete approved library record
- id
- pmid-30256277
- publication Key
- doi:10.1097/ijg.0000000000001088
- aliases
- None recorded
- title
- Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial.
- journal
- Journal of glaucoma
- neurotransmitters
- None recorded
- year
- 2018
- authors
- Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK, Sihota R, Sidhu T, Velpandian T, Kalaivani M, Pandey RM, Gao Y, Sabel BA, Dada R.
- design
- Randomized controlled trial
- identity Conflict
- Not recorded
- doi
- 10.1097/ijg.0000000000001088
- pmid
- 30256277
- urls
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- collections
language
- categories
Gene expression · Molecular biomarkers
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- In 90 patients with primary open-angle glaucoma, a short mindfulness programme reduced intraocular pressure relative to waitlist and reported associated stress-biomarker and gene-expression changes.
- limitation
- A small, short-duration adjunctive trial with a waitlist comparator. Expression and biomarker associations do not prove mediation of pressure reduction or broad effects across diseases.
- citation Count
- 93
- citation Snapshot
- count
- 93
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30256277
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 93
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- journalofglaucoma
- journal Label
- Journal of glaucoma
- chapter Entries
- title
- Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial.
- journal
- Journal of glaucoma
- year
- 2018
- authors
- Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK, Sihota R, Sidhu T, Velpandian T, Kalaivani M, Pandey RM, Gao Y, Sabel BA, Dada R.
- design
- Randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- doi
- 10.1097/ijg.0000000000001088
- pmid
- 30256277
- targets
- None recorded
- categories
Gene expression · Molecular biomarkers
- citation Count
- 93
- citation Snapshot
- count
- 93
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30256277
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Mindfulness meditation
- comparator
- Waitlist
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rxs38wbv · https://europepmc.org/article/MED/30256277
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Gene-expression and stress-biomarker measurements with intraocular pressure
- measured Genes
- None recorded
- sample
- 90 glaucoma patients
- id
- language-mindfulness-rna-pmid-30256277
- record Id
- pmid-30256277
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 90 patients with primary open-angle glaucoma, a short mindfulness programme reduced intraocular pressure relative to waitlist and reported associated stress-biomarker and gene-expression changes.
- limitation
- A small, short-duration adjunctive trial with a waitlist comparator. Expression and biomarker associations do not prove mediation of pressure reduction or broad effects across diseases.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1097/ijg.0000000000001088
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Mindfulness meditation
- comparator
- Waitlist
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30256277/ · https://doi.org/10.1097/ijg.0000000000001088
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rxs38wbv · https://europepmc.org/article/MED/30256277
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Gene-expression and stress-biomarker measurements with intraocular pressure
- measured Genes
- None recorded
- sample
- 90 glaucoma patients
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false