Methylation of <i>FKBP5</i> and <i>SLC6A4</i> in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.
Bishop JR, Lee AM, Mills LJ, Thuras PD, Eum S, Clancy D, Erbes CR, Polusny MA, Lamberty GJ, Lim KO. · Frontiers in psychiatry · 2018 · Exploratory responder analysis
Original publication · Original publication · Original publication · Original publication
Recorded summary
In 22 veterans receiving MBSR, responders showed increased FKBP5 methylation while nonresponders showed decreased methylation, following the corrected direction reported in the 2021 corrigendum.
Recorded limitations
The exploratory responder comparison was not randomised; its multiplicity-adjusted p value was 0.052. SLC6A4 did not show a corresponding positive result. Blood DNA methylation is distinct from brain gene expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Exploratory responder analysis
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- not-applicable
- score
- Not recorded
- evidence
- intervention
- MBSR
- comparator
- Responders versus nonresponders to the same MBSR programme
- evidence Type
- Epigenetics
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- checked At
- 2026-10-26
- review Scope
- Abstract, full-text participant selection and limitations, and 2021 corrigendum checked.
- discovery Sources
https://daytab.com/study/d68s6qxz · https://europepmc.org/article/MED/30279666
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Blood DNA methylation
- measured Genes
FKBP5 · SLC6A4
- sample
- 22 veterans
- relationship Note
- NCT01548742; responder subsample
- correction URL
- https://doi.org/10.3389/fpsyt.2021.642245
Topics and recorded topic scores
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-30279666
- doi
- 10.3389/fpsyt.2018.00418
- pmid
- 30279666
- citation Snapshot
- count
- 63
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30279666
- citations By Collection
- language
- 63
Complete approved library record
- id
- pmid-30279666
- publication Key
- doi:10.3389/fpsyt.2018.00418
- aliases
- None recorded
- title
- Methylation of <i>FKBP5</i> and <i>SLC6A4</i> in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.
- journal
- Frontiers in psychiatry
- neurotransmitters
- None recorded
- year
- 2018
- authors
- Bishop JR, Lee AM, Mills LJ, Thuras PD, Eum S, Clancy D, Erbes CR, Polusny MA, Lamberty GJ, Lim KO.
- design
- Exploratory responder analysis
- identity Conflict
- Not recorded
- doi
- 10.3389/fpsyt.2018.00418
- pmid
- 30279666
- urls
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- collections
language
- categories
Epigenetics
- targets
FKBP5 · SLC6A4
- priority
- 0
- quotes
- None recorded
- summary
- In 22 veterans receiving MBSR, responders showed increased FKBP5 methylation while nonresponders showed decreased methylation, following the corrected direction reported in the 2021 corrigendum.
- limitation
- The exploratory responder comparison was not randomised; its multiplicity-adjusted p value was 0.052. SLC6A4 did not show a corresponding positive result. Blood DNA methylation is distinct from brain gene expression.
- citation Count
- 63
- citation Snapshot
- count
- 63
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30279666
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 63
- topics
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
- journal Key
- frontiersinpsychiatry
- journal Label
- Frontiers in psychiatry
- chapter Entries
- title
- Methylation of <i>FKBP5</i> and <i>SLC6A4</i> in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.
- journal
- Frontiers in psychiatry
- year
- 2018
- authors
- Bishop JR, Lee AM, Mills LJ, Thuras PD, Eum S, Clancy D, Erbes CR, Polusny MA, Lamberty GJ, Lim KO.
- design
- Exploratory responder analysis
- urls
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- doi
- 10.3389/fpsyt.2018.00418
- pmid
- 30279666
- targets
FKBP5 · SLC6A4
- categories
Epigenetics
- citation Count
- 63
- citation Snapshot
- count
- 63
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30279666
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- MBSR
- comparator
- Responders versus nonresponders to the same MBSR programme
- evidence Type
- Epigenetics
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- checked At
- 2026-10-26
- review Scope
- Abstract, full-text participant selection and limitations, and 2021 corrigendum checked.
- discovery Sources
https://daytab.com/study/d68s6qxz · https://europepmc.org/article/MED/30279666
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Blood DNA methylation
- measured Genes
FKBP5 · SLC6A4
- sample
- 22 veterans
- relationship Note
- NCT01548742; responder subsample
- correction URL
- https://doi.org/10.3389/fpsyt.2021.642245
- id
- language-mindfulness-epigenetics-pmid-30279666
- record Id
- pmid-30279666
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 22 veterans receiving MBSR, responders showed increased FKBP5 methylation while nonresponders showed decreased methylation, following the corrected direction reported in the 2021 corrigendum.
- limitation
- The exploratory responder comparison was not randomised; its multiplicity-adjusted p value was 0.052. SLC6A4 did not show a corresponding positive result. Blood DNA methylation is distinct from brain gene expression.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.3389/fpsyt.2018.00418
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-epigenetics
- topic Title
- Mindfulness, DNA methylation and genetic variation
- trust Score
- 1
- evidence
- intervention
- MBSR
- comparator
- Responders versus nonresponders to the same MBSR programme
- evidence Type
- Epigenetics
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30279666/ · https://doi.org/10.3389/fpsyt.2018.00418 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6153325/ · https://doi.org/10.3389/fpsyt.2021.642245
- checked At
- 2026-10-26
- review Scope
- Abstract, full-text participant selection and limitations, and 2021 corrigendum checked.
- discovery Sources
https://daytab.com/study/d68s6qxz · https://europepmc.org/article/MED/30279666
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Blood DNA methylation
- measured Genes
FKBP5 · SLC6A4
- sample
- 22 veterans
- relationship Note
- NCT01548742; responder subsample
- correction URL
- https://doi.org/10.3389/fpsyt.2021.642245
- jadad
- status
- not-applicable
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- curated primary-source summary
- text
- In 22 veterans receiving MBSR, responders showed increased FKBP5 methylation while nonresponders showed decreased methylation, following the corrected direction reported in the 2021 corrigendum.
- matched Text
- ptsd
- conditions
ptsd
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false