Clinical efficacy of trauma-focused psychotherapies in treatment-resistant depression (TRD) in-patients: A randomized, controlled pilot-study.
Minelli A, Zampieri E, Sacco C, Bazzanella R, Mezzetti N, Tessari E, Barlati S, Bortolomasi M. · Psychiatry research · 2019 · Single-blind randomized controlled pilot trial
Original publication · Original publication
Recorded summary
In 22 treatment-resistant depression inpatients, both EMDR and trauma-focused CBT improved depressive symptoms; a post-hoc comparison favoured EMDR at the 12-week follow-up.
Recorded limitations
The small pilot and post-hoc nature of the comparison limit confidence in superiority. Benefits were only partly maintained at 24 weeks.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Single-blind randomized controlled pilot trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Therapist-delivered EMDR
- comparator
- Trauma-focused CBT
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/3snpkbrv · https://europepmc.org/article/MED/30711853
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- vision:i
- title
- EMDR for PTSD and related mental-health outcomes
- collection
- vision
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-30711853
- doi
- 10.1016/j.psychres.2019.01.070
- pmid
- 30711853
- citation Snapshot
- count
- 28
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30711853
- citations By Collection
- vision
- 28
Complete approved library record
- id
- pmid-30711853
- publication Key
- doi:10.1016/j.psychres.2019.01.070
- aliases
- None recorded
- title
- Clinical efficacy of trauma-focused psychotherapies in treatment-resistant depression (TRD) in-patients: A randomized, controlled pilot-study.
- journal
- Psychiatry research
- neurotransmitters
- None recorded
- year
- 2019
- authors
- Minelli A, Zampieri E, Sacco C, Bazzanella R, Mezzetti N, Tessari E, Barlati S, Bortolomasi M.
- design
- Single-blind randomized controlled pilot trial
- identity Conflict
- Not recorded
- doi
- 10.1016/j.psychres.2019.01.070
- pmid
- 30711853
- urls
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- collections
vision
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In 22 treatment-resistant depression inpatients, both EMDR and trauma-focused CBT improved depressive symptoms; a post-hoc comparison favoured EMDR at the 12-week follow-up.
- limitation
- The small pilot and post-hoc nature of the comparison limit confidence in superiority. Benefits were only partly maintained at 24 weeks.
- citation Count
- 28
- citation Snapshot
- count
- 28
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30711853
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 28
- topics
- key
- vision:i
- title
- EMDR for PTSD and related mental-health outcomes
- collection
- vision
- trust Score
- 2
- journal Key
- psychiatryresearch
- journal Label
- Psychiatry research
- chapter Entries
- title
- Clinical efficacy of trauma-focused psychotherapies in treatment-resistant depression (TRD) in-patients: A randomized, controlled pilot-study.
- journal
- Psychiatry research
- year
- 2019
- authors
- Minelli A, Zampieri E, Sacco C, Bazzanella R, Mezzetti N, Tessari E, Barlati S, Bortolomasi M.
- design
- Single-blind randomized controlled pilot trial
- urls
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- doi
- 10.1016/j.psychres.2019.01.070
- pmid
- 30711853
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 28
- citation Snapshot
- count
- 28
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/30711853
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Therapist-delivered EMDR
- comparator
- Trauma-focused CBT
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/3snpkbrv · https://europepmc.org/article/MED/30711853
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- vision-i-pmid-30711853
- record Id
- pmid-30711853
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 22 treatment-resistant depression inpatients, both EMDR and trauma-focused CBT improved depressive symptoms; a post-hoc comparison favoured EMDR at the 12-week follow-up.
- limitation
- The small pilot and post-hoc nature of the comparison limit confidence in superiority. Benefits were only partly maintained at 24 weeks.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.psychres.2019.01.070
- collection
- vision
- chapter Number
- 1
- topic Id
- i
- topic Title
- EMDR for PTSD and related mental-health outcomes
- trust Score
- 2
- evidence
- intervention
- Therapist-delivered EMDR
- comparator
- Trauma-focused CBT
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/30711853/ · https://doi.org/10.1016/j.psychres.2019.01.070
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/3snpkbrv · https://europepmc.org/article/MED/30711853
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- curated primary-source summary
- text
- In 22 treatment-resistant depression inpatients, both EMDR and trauma-focused CBT improved depressive symptoms; a post-hoc comparison favoured EMDR at the 12-week follow-up.
- matched Text
- depression
- conditions
depression
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false